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733750-99-7,MFCD14706714
Catalog No.:AA00FBWJ

733750-99-7 | Ar 231453

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5mg
≥95%
in stock  
$133.00   $93.00
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10mg
in stock  
$236.00   $165.00
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25mg
≥95%
in stock  
$522.00   $365.00
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50mg
≥95%
in stock  
$912.00   $638.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00FBWJ
Chemical Name:
Ar 231453
CAS Number:
733750-99-7
Molecular Formula:
C21H24FN7O5S
Molecular Weight:
505.5226
MDL Number:
MFCD14706714
SMILES:
[O-][N+](=O)c1c(ncnc1N1CCC(CC1)c1onc(n1)C(C)C)Nc1ccc(cc1F)S(=O)(=O)C
Properties
Computed Properties
 
Complexity:
833  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
35  
Hydrogen Bond Acceptor Count:
12  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
6  
XLogP3:
3.9  

Downstream Synthesis Route

[1]Semple,Graeme;Fioravanti,Beatriz;Pereira,Guillherme;Calderon,Imelda;Uy,Jane;Choi,Karoline;Xiong,Yifeng;Ren,Albert;Morgan,Michael;Dave,Vibha;Thomsen,William;Unett,DavidJ.;Xing,Charles;Bossie,Stuart;Carroll,Chris;Chu,Zhi-Liang;Grottick,AndrewJ.;Hauser,ErinK.;Leonard,James;Jones,RobertM.[JournalofMedicinalChemistry,2008,vol.51,#17,p.5172-5175]

Literature

Title: Discovery of a second generation agonist of the orphan G-protein coupled receptor GPR119 with an improved profile.

Journal: Bioorganic & medicinal chemistry letters 20120215

Title: Stimulating β-cell replication and improving islet graft function by AR231453, A GPR119 agonist.

Journal: Transplantation proceedings 20111101

Title: Discovery of fused bicyclic agonists of the orphan G-protein coupled receptor GPR119 with in vivo activity in rodent models of glucose control.

Journal: Bioorganic & medicinal chemistry letters 20110515

Title: GPR119 regulates murine glucose homeostasis through incretin receptor-dependent and independent mechanisms.

Journal: Endocrinology 20110201

Title: Discovery of the first potent and orally efficacious agonist of the orphan G-protein coupled receptor 119.

Journal: Journal of medicinal chemistry 20080911

Title: A role for intestinal endocrine cell-expressed g protein-coupled receptor 119 in glycemic control by enhancing glucagon-like Peptide-1 and glucose-dependent insulinotropic Peptide release.

Journal: Endocrinology 20080501

Title: A role for beta-cell-expressed G protein-coupled receptor 119 in glycemic control by enhancing glucose-dependent insulin release.

Journal: Endocrinology 20070601

Title: Chu ZL, et al. A role for beta-cell-expressed G protein-coupled receptor 119 in glycemic control by enhancing glucose-dependent insulin release. Endocrinology. 2007 Jun;148(6):2601-9.

Title: J Gao, et al. Stimulating β-cell replication and improving islet graft function by AR231453, A GPR119 agonist. Transplant Proc. 2011 Nov;43(9):3217-20.

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SDS
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