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73903-17-0,MFCD10565946
Catalog No.:AA005VUB

73903-17-0 | Piperazine, 1-[(5-chloro-1H-benzimidazol-2-yl)carbonyl]-4-methyl-

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10mg
99%
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$215.00   $150.00
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50mg
99%
in stock  
$608.00   $425.00
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  • Technical Information
  • Properties
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Technical Information
Catalog Number:
AA005VUB
Chemical Name:
Piperazine, 1-[(5-chloro-1H-benzimidazol-2-yl)carbonyl]-4-methyl-
CAS Number:
73903-17-0
Molecular Formula:
C13H15ClN4O
Molecular Weight:
278.7374
MDL Number:
MFCD10565946
SMILES:
CN1CCN(CC1)C(=O)c1nc2c([nH]1)ccc(c2)Cl
Properties
Computed Properties
 
Complexity:
346  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
19  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
1  
XLogP3:
1.7  

Literature

Title: Discovery and SAR of 6-alkyl-2,4-diaminopyrimidines as histamine H₄ receptor antagonists.

Journal: Journal of medicinal chemistry 20140327

Title: Histamine H4 receptor antagonists as potent modulators of mammalian vestibular primary neuron excitability.

Journal: British journal of pharmacology 20121001

Title: Synthesis of novel histamine H4 receptor antagonists.

Journal: Bioorganic & medicinal chemistry letters 20120115

Title: Ligand based design of novel histamine H₄ receptor antagonists; fragment optimization and analysis of binding kinetics.

Journal: Bioorganic & medicinal chemistry letters 20120101

Title: Discovery of a series of potent and selective human H4 antagonists using ligand efficiency and libraries to explore structure-activity relationship (SAR).

Journal: Bioorganic & medicinal chemistry letters 20111101

Title: Triamino pyrimidines and pyridines as histamine H(4) receptor modulators.

Journal: Bioorganic & medicinal chemistry letters 20110515

Title: Molecular determinants of ligand binding to H4R species variants.

Journal: Molecular pharmacology 20100501

Title: Histamine receptor H4R-selective ligands influence the STAT6 Transcription Activation Domain (TAD) and the DNA-binding.

Journal: Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20080101

Title: The histamine H(4) receptor: a novel modulator of inflammatory and immune disorders.

Journal: Pharmacology & therapeutics 20070301

Title: The histamine H4 receptor mediates allergic airway inflammation by regulating the activation of CD4+ T cells.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20060601

Title: Preparation and biological evaluation of indole, benzimidazole, and thienopyrrole piperazine carboxamides: potent human histamine h(4) antagonists.

Journal: Journal of medicinal chemistry 20051229

Title: Inhibitory effects of histamine H4 receptor antagonists on experimental colitis in the rat.

Journal: European journal of pharmacology 20051017

Title: Synthesis and structure-activity relationships of indole and benzimidazole piperazines as histamine H(4) receptor antagonists.

Journal: Bioorganic & medicinal chemistry letters 20041101

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Tags:73903-17-0 Molecular Formula|73903-17-0 MDL|73903-17-0 SMILES|73903-17-0 Piperazine, 1-[(5-chloro-1H-benzimidazol-2-yl)carbonyl]-4-methyl-