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7392-67-8,MFCD00022116
Catalog No.:AA005IUK

7392-67-8 | 1-(4-Chlorophenyl)-3-phenylthiourea

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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA005IUK
Chemical Name:
1-(4-Chlorophenyl)-3-phenylthiourea
CAS Number:
7392-67-8
Molecular Formula:
C13H11ClN2S
Molecular Weight:
262.7578
MDL Number:
MFCD00022116
SMILES:
S=C(Nc1ccccc1)Nc1ccc(cc1)Cl
Properties
Computed Properties
 
Complexity:
246  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
17  
Hydrogen Bond Acceptor Count:
1  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
2  
XLogP3:
2.8  

Downstream Synthesis Route

[1]Busch;Ulmer[ChemischeBerichte,1902,vol.35,p.1718]

[1]Nahakpam,Lokendrajit;Chingakham,BrajakishorS.;Laitonjam,WarjeetS.[JournalofHeterocyclicChemistry,2015,vol.52,#1,p.267-272]

[2]Gogoi,Prasanta;Paul,Bappi;Hazarika,Sukanya;Barman,Pranjit[RSCAdvances,2015,vol.5,#71,p.57433-57436]

[3]Dyson;Hunter;Soyka[JournaloftheChemicalSociety,1929,p.464]

[4]Hunteretal.[JournaloftheChemicalSociety,1958,p.1561,1565]

[1]Kim,YongHae;Kim,HyungJin;Yon,GyuHwan[JournaloftheChemicalSociety.Chemicalcommunications,1984,#16,p.1064-1065]

[2]Capps;Dehn[JournaloftheAmericanChemicalSociety,1932,vol.54,p.4301,4302]

[1]Dangate,PrasadS.;Akamanchi,KrishnacharyaG.[TetrahedronLetters,2012,vol.53,#50,p.6765-6767]

[2]Ashworthetal.[JournaloftheChemicalSociety,1949,p.475,479]

[1]Strukil,Vjekoslav;Igrc,MarinaD.;Fabian,Laszlo;Eckert-Maksic,Mirjana;Childs,ScottL.;Reid,DavidG.;Duer,MelindaJ.;Halasz,Ivan;Mottillo,Cristina;Friscic,Tomislav[GreenChemistry,2012,vol.14,#9,p.2462-2473]

[2]Locationinpatent:experimentalpartUberhande;Thakare;Berad[JournaloftheIndianChemicalSociety,2010,vol.87,#9,p.1137-1141]

[3]Rodríguez-Huerto,PaulaA.;Peña-Solórzano,Diana;Ochoa-Puentes,Cristian[ChemicalPapers,2021,vol.75,#12,p.6275-6283]

[4]Peng,Yanqing;Song,Gonghua;Xu,Xiaoyong[JournalofChemicalResearch,2004,#4,p.261-263]

[5]Locationinpatent:experimentalpartBegum,Saeedan;Choudhary,M.Iqbal;Khan,KhalidM.[NaturalProductResearch,2009,vol.23,#18,p.1719-1730]

[6]Kjellin[ChemischeBerichte,1903,vol.36,p.197]

[7]Kubota;Horie;Misra;Toyooka;Uda;Shibuya;Terada[ChemicalandPharmaceuticalBulletin,1985,vol.33,#2,p.662-666]

[8]Debroy,Abhijit;NandyMazumdar,Sujit;Barua,ParagD.;Mahajan,MahinderP.[BulletinoftheChemicalSocietyofJapan,1984,vol.57,#1,p.315-316]

[9]Locationinpatent:experimentalpartThanigaimalai,Pillaiyar;Lee,Ki-Cheul;Sharma,VinayK.;Joo,Cheonik;Cho,Won-Jea;Roh,Eunmiri;Kim,Youngsoo;Jung,Sang-Hun[BioorganicandMedicinalChemistryLetters,2011,vol.21,#22,p.6824-6828]

[10]Cai,Ming-Guang;Wu,Yang;Chang,Jun[BioorganicandMedicinalChemistryLetters,2016,vol.26,#10,p.2517-2520]

[11]Tiwari,Shailendra;Singh,KamalPratap;Ahmad,Akeel[IndianJournalofChemistry-SectionBOrganicandMedicinalChemistry,2016,vol.55B,#8,p.1007-1012]

[12]Wu,He;Sun,Yan-Fang;Zhang,Chen;Miao,Chun-Bao;Yang,Hai-Tao[TetrahedronLetters,2018,vol.59,#8,p.739-742]

[13]Siddiqui,Hina;Shafi,Sarah;Mukhtar,Farah;Ejaz,Asma;Atta-Ur-Rahman;Choudhary,M.Iqbal[MedicinalChemistry,2018,vol.14,#5,p.508-515]

Literature

Title: Structural requirement of phenylthiourea analogs for their inhibitory activity of melanogenesis and tyrosinase.

Journal: Bioorganic & medicinal chemistry letters 20111115

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