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74003-18-2,MFCD00911569
Catalog No.:AA005IH6

74003-18-2 | Ozagrel hydrochloride

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  • Properties
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA005IH6
Chemical Name:
Ozagrel hydrochloride
CAS Number:
74003-18-2
Molecular Formula:
C13H13ClN2O2
Molecular Weight:
264.7075
MDL Number:
MFCD00911569
SMILES:
OC(=O)C=Cc1ccc(cc1)Cn1ccnc1.Cl
Properties
Computed Properties
 
Complexity:
283  
Covalently-Bonded Unit Count:
2  
Defined Bond Stereocenter Count:
1  
Heavy Atom Count:
18  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
4  

Literature

Title: Ozagrel for acute ischemic stroke: a meta-analysis of data from randomized controlled trials.

Journal: Neurological research 20120501

Title: Synthesis, crystal structure, and properties of a double-helical zinc(II) coordination polymer with Ozagrel drug.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20120201

Title: Fasudil and ozagrel in combination show neuroprotective effects on cerebral infarction after murine middle cerebral artery occlusion.

Journal: The Journal of pharmacology and experimental therapeutics 20110701

Title: [Effect of TXA2 inhibitor on the proliferation and apoptosis of hypoxic pulmonary artery smooth muscle cells of porcines].

Journal: Zhonghua yi xue za zhi 20110125

Title: Thromboxane-prostanoid receptor expression and antagonism in dextran-sodium sulfate-induced colitis.

Journal: Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20110101

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Thromboxane A(2) promotes soluble CD40 ligand release from human platelets.

Journal: Atherosclerosis 20100401

Title: A prostacyclin agonist with thromboxane inhibitory activity for airway allergic inflammation in mice.

Journal: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20100201

Title: [The study of relationship between platelet function and thrombus in patients with essential thrombocythaemia].

Journal: Zhonghua yi xue za zhi 20100126

Title: Platelet function and spontaneous thrombolytic activity of patients with cerebral infarction assessed by the global thrombosis test.

Journal: Pathophysiology of haemostasis and thrombosis 20100101

Title: Effect of combination therapy with sodium ozagrel and panax ginseng on transient cerebral ischemia model in rats.

Journal: Journal of biomedicine & biotechnology 20100101

Title: A selective thromboxane A2 (TXA2) synthase inhibitor, ozagrel, attenuates lung injury and decreases monocyte chemoattractant protein-1 and interleukin-8 mRNA expression in oleic acid-induced lung injury in guinea pigs.

Journal: Journal of pharmacological sciences 20091001

Title: [Effects of sodium ozagrel in primary thrombocytosis combined with thrombosis].

Journal: Zhongguo shi yan xue ye xue za zhi 20091001

Title: Thromboxane A(2) contributes to the mediation of flow-induced responses of skeletal muscle venules: role of cyclooxygenases 1 and 2.

Journal: Journal of vascular research 20090801

Title: Abnormalities of endothelium-dependent responses in mesenteric arteries from Otsuka Long-Evans Tokushima Fatty (OLETF) rats are improved by chronic treatment with thromboxane A2 synthase inhibitor.

Journal: Atherosclerosis 20090701

Title: Retinal artery embolization during carotid angioplasty and carotid artery stenting: case report.

Journal: Neurologia medico-chirurgica 20090501

Title: In vitro effect of ozagrel on mushroom tyrosinase.

Journal: The protein journal 20090501

Title: Edaravone (radical scavenger) versus sodium ozagrel (antiplatelet agent) in acute noncardioembolic ischemic stroke (EDO trial).

Journal: Cerebrovascular diseases (Basel, Switzerland) 20090101

Title: Ozagrel reverses streptozotocin-induced constriction of arterioles in rat retina.

Journal: Microvascular research 20081101

Title: [Diagnosis and management for acute ischemic stroke].

Journal: Rinsho shinkeigaku = Clinical neurology 20081101

Title: Inhibition of TXA synthesis with OKY-046 improves liver preservation by prolonged hypothermic machine perfusion in rats.

Journal: Journal of gastroenterology and hepatology 20080701

Title: Losartan and ozagrel reverse retinal arteriolar constriction in non-obese diabetic mice.

Journal: Microcirculation (New York, N.Y. : 1994) 20080701

Title: Up-regulated thromboxane production in the rat liver with biliary obstruction does not contribute to promote hepatic injury.

Journal: Shock (Augusta, Ga.) 20080601

Title: Safety and efficacy of fasudil monotherapy and fasudil-ozagrel combination therapy in patients with subarachnoid hemorrhage: sub-analysis of the post-marketing surveillance study.

Journal: Neurologia medico-chirurgica 20080601

Title: Ozagrel attenuates early streptozotocin-induced constriction of arterioles in the mouse retina.

Journal: Experimental eye research 20080301

Title: Effect of sodium ozagrel on the activity of rat CYP2D6.

Journal: European journal of pharmacology 20071114

Title: [Adverse effects of thromboxane receptor antagonists and synthase inhibitors].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20071028

Title: Involvement of inducible nitric oxide synthase in blood flow decrease in vein induced by hen-egg white lysozyme.

Journal: Biological & pharmaceutical bulletin 20070701

Title: Mediators of CD18/P-selectin-dependent constriction of venule-paired arterioles in hypercholesterolemia.

Journal: Microvascular research 20070301

Title: Ibuprofen or ozagrel increases NO release and l-nitro arginine induces TXA(2) release from cultured porcine basilar arterial endothelial cells.

Journal: Vascular pharmacology 20070201

Title: [Antiplatelet therapy for acute ischemic stroke].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20061128

Title: Effect of a selective thromboxane A2 synthetase inhibitor on the systemic changes induced by circulating pancreatic phospholipase A2.

Journal: Journal of gastroenterology 20061101

Title: [Sodium ozagrel].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20061028

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Prostanoids as pharmacological targets in COPD and asthma.

Journal: European journal of pharmacology 20060308

Title: Selective thromboxane A2 synthase inhibition by OKY-046 prevents cardiopulmonary dysfunction after ovine smoke inhalation injury.

Journal: Anesthesiology 20050501

Title: Prominent unilateral convergence palsy in a patient with a tiny dorsal midbrain infarction.

Journal: European neurology 20050101

Title: Higher viscosity participates in the regulation of coronary flow via nitric oxide and indomethacin-sensitive contracting factor.

Journal: Canadian journal of physiology and pharmacology 20041201

Title: [Clinical guidelines for stroke].

Journal: Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 20041110

Title: Involvement of thromboxane A2 (TXA2) in the early stages of oleic acid-induced lung injury and the preventive effect of ozagrel, a TXA2 synthase inhibitor, in guinea-pigs.

Journal: The Journal of pharmacy and pharmacology 20040401

Title: Antithrombotic effects of FK419, a novel nonpeptide platelet GPIIb/IIIa antagonist, in a guinea pig photochemically induced middle cerebral artery thrombosis model: comparison with ozagrel and argatroban.

Journal: The Journal of pharmacology and experimental therapeutics 20040301

Title: Protective effect of FK506 and thromboxane synthase inhibitor on ischemia-reperfusion injury in non-heart-beating donor in rat orthotopic liver transplantation.

Journal: The journal of medical investigation : JMI 20040201

Title: Role of thromboxane derived from COX-1 and -2 in hepatic microcirculatory dysfunction during endotoxemia in mice.

Journal: Hepatology (Baltimore, Md.) 20040101

Title: Edaravone, a radical scavenger, may enhance or produce antiproliferative effects of fluvastatin, amlodipine, ozagrel, GF109203X and Y27632 on cultured basilar artery smooth muscle cells.

Journal: Biological & pharmaceutical bulletin 20031201

Title: [The clinical effect of combination therapy with edaravone and sodium ozagrel for acute cerebral infarction].

Journal: No to shinkei = Brain and nerve 20030701

Title: Differential effects of 5,6-EET on segmental pulmonary vasoactivity in the rabbit.

Journal: American journal of physiology. Heart and circulatory physiology 20030601

Title: Role for thromboxane A2 from glomerular thrombi in nephropathy with type 2 diabetic rats.

Journal: Life sciences 20030502

Title: Dissecting aneurysm of the anterior cerebral artery with severe subarachnoid hemorrhage during treatment for cerebral infarction.

Journal: Internal medicine (Tokyo, Japan) 20030501

Title: Endothelium-derived prostaglandin H2 evokes the stretch-induced contraction of rabbit pulmonary artery.

Journal: European journal of pharmacology 20030425

Title: Role of intracellular Ca2+ in endothelium-dependent contraction and relaxation of rabbit intrapulmonary arteries.

Journal: Life sciences 20030307

Title: Effects of selective cyclooxygenase inhibitors on ischemia/reperfusion-induced hepatic microcirculatory dysfunction in mice.

Journal: European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes 20030101

Title: Effect of ozagrel, a selective thromboxane A2-synthetase inhibitor, on cerebral infarction in rats. Comparative study with norphenazone, a free-radical scavenger.

Journal: Arzneimittel-Forschung 20030101

Title: The effect of ozagrel sodium on photochemical thrombosis in rat: therapeutic window and combined therapy with heparin sodium.

Journal: Life sciences 20021108

Title: Intracoronary administration of a thromboxane A2 synthase inhibitor relieves acetylcholine-induced coronary spasm.

Journal: Circulation journal : official journal of the Japanese Circulation Society 20020901

Title: [A case of migrainous infarction accompanying idiopathic thrombocytopenic purpura].

Journal: Rinsho shinkeigaku = Clinical neurology 20020901

Title: Effect of TTC-909 in a middle cerebral artery thrombosis model in stroke-prone spontaneously hypertensive rats.

Journal: European journal of pharmacology 20020802

Title: Evaluation of the effects of anti-thromboxane agents in platelet-vessel wall interaction.

Journal: European journal of pharmacology 20020517

Title: Semiquantitative dynamic computed tomography to predict response to anti-platelet therapy in acute cerebral infarction.

Journal: Neuroradiology 20020401

Title: Effect of ozagrel hydrochloride, a thromboxane synthetase inhibitor, on alcoholic beverage-induced bronchoconstriction in asthmatic patients.

Journal: Prostaglandins, leukotrienes, and essential fatty acids 20020401

Title: Prostaglandin endoperoxides and thromboxane A2 activate the same receptor isoforms in human platelets.

Journal: Thrombosis and haemostasis 20020101

Title: Thromboxane A2 inhibition: therapeutic potential in bronchial asthma.

Journal: American journal of respiratory medicine : drugs, devices, and other interventions 20020101

Title: [Thromboxane A2 synthase inhibitor and receptor antagonist].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20011001

Title: Pharmacological profile of hydroxy fasudil as a selective rho kinase inhibitor on ischemic brain damage.

Journal: Life sciences 20010810

Title: Thrombin inhibition attenuates neurodegeneration and cerebral edema formation following transient forebrain ischemia.

Journal: Brain research 20010601

Title: [Endothelin receptor antagonist, phosphodiesterase inhibitor, thromboxane inhibitor].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20010601

Title: The combined use of prostaglandin I2 analogue (OP-2507) and thromboxane A2 synthetase inhibitor (OKY-046) strongly inhibits atherosclerosis of aortic allografts in rats.

Journal: Surgery 20010501

Title: Effect of thromboxane A2 (TXA2) synthase inhibitor and TXA2 receptor antagonist alone and in combination on antigen-induced bronchoconstriction in guinea pigs.

Journal: Prostaglandins & other lipid mediators 20010501

Title: Roles of thromboxane A2 and leukotriene B4 in radicular pain induced by herniated nucleus pulposus.

Journal: Journal of orthopaedic research : official publication of the Orthopaedic Research Society 20010501

Title: Thromboxane A(2) synthase inhibitor enhanced antithrombotic efficacy of GPIIb-IIIa receptor antagonist without increasing bleeding.

Journal: European journal of pharmacology 20010413

Title: L-Arginine improves endothelial function in renal artery of hypertensive Dahl rats.

Journal: Journal of hypertension 20010301

Title: Activation of TxA2/PGH2 receptors and protein kinase C contribute to coronary dysfunction in superoxide treated rat hearts.

Journal: Journal of molecular and cellular cardiology 20000601

Title: Structure-activity relationships of (E)-3-(1,4-benzoquinonyl)-2-[(3-pyridyl)-alkyl]-2-propenoic acid derivatives that inhibit both 5-lipoxygenase and thromboxane A2 synthetase.

Journal: Journal of medicinal chemistry 19960802

Title: Heparin-protamine complexes cause pulmonary hypertension in goats.

Journal: Anesthesiology 19951001

Title: Thromboxane A2 and development of genetic hypertension in the Lyon rat strain.

Journal: Hypertension (Dallas, Tex. : 1979) 19901201

Title: Essential fatty acid deficiency ameliorates acute renal dysfunction in the rat after the administration of the aminonucleoside of puromycin.

Journal: The Journal of clinical investigation 19901001

Title: Hypolipidemic effect and enhancement of peroxisomal beta-oxidation in the liver of rats by sodium-(E)-3-(4-(3-pyridylmethyl)phenyl)-2-methyl propenoate (OKY-1581), a potent inhibitor of TxA2 synthetase.

Journal: Journal of pharmacobio-dynamics 19861201

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Tags:74003-18-2 Molecular Formula|74003-18-2 MDL|74003-18-2 SMILES|74003-18-2 Ozagrel hydrochloride