Home Amines 74046-07-4
74046-07-4,MFCD00274076
Catalog No.:AA00FDPC

74046-07-4 | (S)-4-Aminohex-5-enoic acid

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100mg
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1 week  
$497.00   $348.00
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250mg
95%
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$902.00   $632.00
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1g
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$2,127.00   $1,489.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00FDPC
Chemical Name:
(S)-4-Aminohex-5-enoic acid
CAS Number:
74046-07-4
Molecular Formula:
C6H11NO2
Molecular Weight:
129.1570
MDL Number:
MFCD00274076
SMILES:
N[C@H](C=C)CCC(=O)O
Properties
Computed Properties
 
Complexity:
112  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
9  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
4  
XLogP3:
-2.2  

Downstream Synthesis Route

[1]Gheorghe,Alexandru;Schulte,Michael;Reiser,Oliver[JournalofOrganicChemistry,2006,vol.71,#5,p.2173-2176]

[1]Wei,Z.Y.;Knaus,EdwardE.[OrganicPreparationsandProceduresInternational,1994,vol.26,#5,p.567-570]

Literature

Title: Epilepsy in Korean patients with Angelman syndrome.

Journal: Korean journal of pediatrics 20120501

Title: [11C]flumazenil binding is increased in a dose-dependent manner with tiagabine-induced elevations in GABA levels.

Journal: PloS one 20120101

Title: Transition to absence seizures and the role of GABA(A) receptors.

Journal: Epilepsy research 20111201

Title: Experimental panic provocation in healthy man-a translational role in anti-panic drug development?

Journal: Dialogues in clinical neuroscience 20111201

Title: Neuronal mechanisms underlying development of nicotine dependence: implications for novel smoking-cessation treatments.

Journal: Addiction science & clinical practice 20110701

Title: Effects of GABA-transaminase inhibitor Vigabatrin on thermoregulation in rats.

Journal: Amino acids 20110501

Title: Repeated administration of the GABAB receptor positive modulator BHF177 decreased nicotine self-administration, and acute administration decreased cue-induced reinstatement of nicotine seeking in rats.

Journal: Psychopharmacology 20110501

Title: Depressogenic effects of medications: a review.

Journal: Dialogues in clinical neuroscience 20110301

Title: [West syndrome: aetiology, therapeutic options, clinical course and prognostic factors].

Journal: Revista de neurologia 20110116

Title: Oral Administration of Semicarbazide Limits Weight Gain together with Inhibition of Fat Deposition and of Primary Amine Oxidase Activity in Adipose Tissue.

Journal: Journal of obesity 20110101

Title: Severe myoclonic epilepsy of infancy (Dravet syndrome): Clinical and genetic features of nine Turkish patients.

Journal: Annals of Indian Academy of Neurology 20110101

Title: [Antiepileptic drug-induced encephalopathy].

Journal: Fortschritte der Neurologie-Psychiatrie 20101001

Title: Genoa syndrome and central diabetes insipidus: a case report.

Journal: Journal of clinical research in pediatric endocrinology 20100601

Title: Gamma-vinyl GABA increases nonvesicular release of GABA and glutamate in the nucleus accumbens in rats via action on anion channels and GABA transporters.

Journal: Psychopharmacology 20100301

Title: Clinical profile of vigabatrin as monotherapy for treatment of infantile spasms.

Journal: Neuropsychiatric disease and treatment 20100101

Title: Information about ADRs explored by pharmacovigilance approaches: a qualitative review of studies on antibiotics, SSRIs and NSAIDs.

Journal: BMC clinical pharmacology 20090101

Title: Gamma-vinyl GABA inhibits cocaine-triggered reinstatement of drug-seeking behavior in rats by a non-dopaminergic mechanism.

Journal: Drug and alcohol dependence 20081001

Title: The search for medications to treat stimulant dependence.

Journal: Addiction science & clinical practice 20080601

Title: Response: anticipating new medications.

Journal: Addiction science & clinical practice 20080601

Title: Subchronic treatment with antiepileptic drugs modifies pentylenetetrazol-induced seizures in mice: Its correlation with benzodiazepine receptor binding.

Journal: Neuropsychiatric disease and treatment 20080601

Title: The effectiveness of anticonvulsants in psychiatric disorders.

Journal: Dialogues in clinical neuroscience 20080301

Title: GABA(A) receptors in normal development and seizures: friends or foes?

Journal: Current neuropharmacology 20080301

Title: Neonatal DSP-4 treatment modifies GABAergic neurotransmission in the prefrontal cortex of adult rats.

Journal: Neurotoxicity research 20080101

Title: Activation instead of blocking mesolimbic dopaminergic reward circuitry is a preferred modality in the long term treatment of reward deficiency syndrome (RDS): a commentary.

Journal: Theoretical biology & medical modelling 20080101

Title: [Endocrine effects of antiepileptic drugs].

Journal: Przeglad lekarski 20080101

Title: Imaging the addicted human brain.

Journal: Science & practice perspectives 20070401

Title: Glucose inhibits GABA release by pancreatic beta-cells through an increase in GABA shunt activity.

Journal: American journal of physiology. Endocrinology and metabolism 20060301

Title: Demonstration of extensive GABA synthesis in the small population of GAD positive neurons in cerebellar cultures by the use of pharmacological tools.

Journal: Neurochemistry international 20060101

Title: Structural brain abnormalities in juvenile myoclonic epilepsy patients: volumetry and voxel-based morphometry.

Journal: Korean journal of radiology 20060101

Title: Alteration of thyroid hormone homeostasis by antiepileptic drugs in humans: involvement of glucuronosyltransferase induction.

Journal: European journal of clinical pharmacology 20051201

Title: GABAergic modulation of the expression of genes involved in GABA synaptic transmission and stress in the hypothalamus and telencephalon of the female goldfish (Carassius auratus).

Journal: Journal of neuroendocrinology 20050501

Title: Safety and efficacy of gamma-vinyl GABA (GVG) for the treatment of methamphetamine and/or cocaine addiction.

Journal: Synapse (New York, N.Y.) 20050201

Title: Catecholamine depletion modulates serum LH levels, GAD67 mRNA, and GABA synthesis in the goldfish.

Journal: General and comparative endocrinology 20050201

Title: New anticonvulsant agents.

Journal: Current topics in medicinal chemistry 20050101

Title: Gamma-vinyl GABA (vigabatrin) blocks the expression of toluene-induced conditioned place preference (CPP).

Journal: Synapse (New York, N.Y.) 20041201

Title: Increased GAD67 mRNA levels are correlated with in vivo GABA synthesis in the MPTP-treated catecholamine-depleted goldfish brain.

Journal: Brain research. Molecular brain research 20040928

Title: Synthesis of cyclopropane isosteres of the antiepilepsy drug vigabatrin and evaluation of their inhibition of GABA aminotransferase.

Journal: Journal of enzyme inhibition and medicinal chemistry 20040801

Title: Opiate tolerance by heroin self-administration: an fMRI study in rat.

Journal: Magnetic resonance in medicine 20040701

Title: Design, synthesis and anticonvulsive activity of analogs of gamma-vinyl GABA.

Journal: Farmaco (Societa chimica italiana : 1989) 20040501

Title: Adverse effects of new antiepileptic drugs.

Journal: Drugs of today (Barcelona, Spain : 1998) 20040401

Title: [Drug interactions with antiepileptic agents].

Journal: Wiener klinische Wochenschrift 20040227

Title: Positron emission tomography studies of potential mechanisms underlying phencyclidine-induced alterations in striatal dopamine.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20031201

Title: Treating cocaine addiction: from preclinical to clinical trial experience with gamma-vinyl GABA.

Journal: Synapse (New York, N.Y.) 20031201

Title: Enhancement of neuronal protection from oxidative stress by glutamic acid decarboxylase delivery with a defective herpes simplex virus vector.

Journal: Experimental neurology 20031101

Title: Design, synthesis and anticonvulsive activities of potential prodrugs linked by two-carbon chain.

Journal: Archives of pharmacal research 20031001

Title: [West's syndrome. Analysis, aetiological factors and therapeutic options].

Journal: Revista de neurologia 20030801

Title: Kinetic studies on the inhibition of GABA-T by gamma-vinyl GABA and taurine.

Journal: Journal of enzyme inhibition and medicinal chemistry 20030801

Title: Sub-chronic low dose gamma-vinyl GABA (vigabatrin) inhibits cocaine-induced increases in nucleus accumbens dopamine.

Journal: Psychopharmacology 20030701

Title: Gamma-vinyl GABA, an irreversible inhibitor of GABA transaminase, alters the acquisition and expression of cocaine-induced sensitization in male rats.

Journal: Synapse (New York, N.Y.) 20021215

Title: Symptomatic epilepsy associated with intracranial calcifications in children with acute lymphoblastic leukemia (ALL).

Journal: Collegium antropologicum 20021201

Title: GABAergic mechanisms of heroin-induced brain activation assessed with functional MRI.

Journal: Magnetic resonance in medicine 20021101

Title: Increased GABA neurotransmission via administration of gamma-vinyl GABA decreased nicotine self-administration in the rat.

Journal: Synapse (New York, N.Y.) 20020615

Title: The effect of water temperature on the GABAergic and reproductive systems in female and male goldfish (Carassius auratus).

Journal: General and comparative endocrinology 20020201

Title: Anticonvulsants: aspects of their mechanisms of action.

Journal: European journal of pain (London, England) 20020101

Title: Gamma vinyl-GABA differentially modulates NMDA antagonist-induced increases in mesocortical versus mesolimbic DA transmission.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20011101

Title: [Microcephaly, bilateral corneal opacity and congenital lobar holoprosencephaly with subsequent development of a rhabdomyosarcoma in a patient exposed to prenatal radiation].

Journal: Revista de neurologia 20011101

Title: Gamma-vinyl GABA (GVG) blocks expression of the conditioned place preference response to heroin in rats.

Journal: Synapse (New York, N.Y.) 20010901

Title: Paradoxical reduction of synaptic inhibition by vigabatrin.

Journal: Journal of neurophysiology 20010801

Title: Gamma-vinyl GABA reduces paired pulse inhibition in the rat dentate gyrus in vivo and in vitro.

Journal: Epilepsy research 20010501

Title: GABA transaminase inhibition induces spontaneous and enhances depolarization-evoked GABA efflux via reversal of the GABA transporter.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20010415

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Tags:74046-07-4 Molecular Formula|74046-07-4 MDL|74046-07-4 SMILES|74046-07-4 (S)-4-Aminohex-5-enoic acid