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743420-02-2,MFCD18382123
Catalog No.:AA00FBFX

743420-02-2 | Chidamide

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$73.00   $51.00
- +
5mg
98%
in stock  
$77.00   $54.00
- +
25mg
98%
in stock  
$132.00   $93.00
- +
100mg
98%
in stock  
$267.00   $187.00
- +
1g
98%
in stock  
$974.00   $682.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA00FBFX
Chemical Name:
Chidamide
CAS Number:
743420-02-2
Molecular Formula:
C22H19FN4O2
Molecular Weight:
390.4103
MDL Number:
MFCD18382123
SMILES:
O=C(/C=C/c1cccnc1)NCc1ccc(cc1)C(=O)Nc1cc(F)ccc1N
Properties
Computed Properties
 
Complexity:
577  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
1  
Formal Charge:
0  
Heavy Atom Count:
29  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
3  
Isotope Atom Count:
0  
Rotatable Bond Count:
6  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
2.3  

Downstream Synthesis Route

[1]CurrentPatentAssignee:SHENZHENCHIPSCREENBIOSCIENCESCOLTD-EP2860174,2017,B1Locationinpatent:Paragraph0040;0041

[2]CurrentPatentAssignee:SHANDONGCHUANCHENGPHARMACEUTICAL-CN105949114,2016,ALocationinpatent:Paragraph0009;0021;0022

743420-02-2   
CASUnavailable 
 
CASUnavailable 

[1]Hou,Lei;Zhang,Yunchang;Huang,Ying;Fang,Zhen;Sang,Guangze;Chen,Tianheng;Ma,Zhiqiang;Yang,Feng[MolecularPharmaceutics,2022,vol.19,#8,p.2807-2817]

743420-02-2   
CASUnavailable 
 
CASUnavailable 

[1]Hou,Lei;Zhang,Yunchang;Huang,Ying;Fang,Zhen;Sang,Guangze;Chen,Tianheng;Ma,Zhiqiang;Yang,Feng[MolecularPharmaceutics,2022,vol.19,#8,p.2807-2817]

743420-02-2   
CASUnavailable 
 
CASUnavailable 

[1]Hou,Lei;Zhang,Yunchang;Huang,Ying;Fang,Zhen;Sang,Guangze;Chen,Tianheng;Ma,Zhiqiang;Yang,Feng[MolecularPharmaceutics,2022,vol.19,#8,p.2807-2817]

743420-02-2    1289218-74-1   
CASUnavailable 

[1]CurrentPatentAssignee:SOUTHCHINANORMALUNIVERSITY-CN115010725,2022,ALocationinpatent:Paragraph0054-0056;0059

Literature

Title: Chidamide, a novel histone deacetylase inhibitor, synergistically enhances gemcitabine cytotoxicity in pancreatic cancer cells.

Journal: Biochemical and biophysical research communications 20130426

Title: Increased PRAME-specific CTL killing of acute myeloid leukemia cells by either a novel histone deacetylase inhibitor chidamide alone or combined treatment with decitabine.

Journal: PloS one 20130101

Title: Phase I study of chidamide (CS055/HBI-8000), a new histone deacetylase inhibitor, in patients with advanced solid tumors and lymphomas.

Journal: Cancer chemotherapy and pharmacology 20120601

Title: Antitumor activity of Chidamide in hepatocellular carcinoma cell lines.

Journal: Molecular medicine reports 20120601

Title: CS055 (Chidamide/HBI-8000), a novel histone deacetylase inhibitor, induces G1 arrest, ROS-dependent apoptosis and differentiation in human leukaemia cells.

Journal: The Biochemical journal 20120501

Title: Chidamide (CS055/HBI-8000): a new histone deacetylase inhibitor of the benzamide class with antitumor activity and the ability to enhance immune cell-mediated tumor cell cytotoxicity.

Journal: Cancer chemotherapy and pharmacology 20120401

Title: Application of p21 and klf2 reporter gene assays to identify selective histone deacetylase inhibitors for cancer therapy.

Journal: Bioorganic & medicinal chemistry letters 20110101

Title: A novel histone deacetylase inhibitor Chidamide induces apoptosis of human colon cancer cells.

Journal: Biochemical and biophysical research communications 20100205

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SDS
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Tags:743420-02-2 Molecular Formula|743420-02-2 MDL|743420-02-2 SMILES|743420-02-2 Chidamide
Catalog No.: AA00FBFX
743420-02-2,MFCD18382123
743420-02-2 | Chidamide
Pack Size： 1mg
Purity： 98%
in stock
$73.00 $51.00
Pack Size： 5mg
Purity： 98%
in stock
$77.00 $54.00
Pack Size： 25mg
Purity： 98%
in stock
$132.00 $93.00
Pack Size： 100mg
Purity： 98%
in stock
$267.00 $187.00
Pack Size： 1g
Purity： 98%
in stock
$974.00 $682.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA00FBFX
Chemical Name: Chidamide
CAS Number: 743420-02-2
Molecular Formula: C22H19FN4O2
Molecular Weight: 390.4103
MDL Number: MFCD18382123
SMILES: O=C(/C=C/c1cccnc1)NCc1ccc(cc1)C(=O)Nc1cc(F)ccc1N
Properties
Complexity: 577  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 1  
Formal Charge: 0  
Heavy Atom Count: 29  
Hydrogen Bond Acceptor Count: 5  
Hydrogen Bond Donor Count: 3  
Isotope Atom Count: 0  
Rotatable Bond Count: 6  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 2.3  
Downstream Synthesis Route
367-31-7    219964-34-8    743420-02-2 

[1]CurrentPatentAssignee:SHENZHENCHIPSCREENBIOSCIENCESCOLTD-EP2860174,2017,B1Locationinpatent:Paragraph0040;0041

[2]CurrentPatentAssignee:SHANDONGCHUANCHENGPHARMACEUTICAL-CN105949114,2016,ALocationinpatent:Paragraph0009;0021;0022

743420-02-2   
CASUnavailable 
 
CASUnavailable 

[1]Hou,Lei;Zhang,Yunchang;Huang,Ying;Fang,Zhen;Sang,Guangze;Chen,Tianheng;Ma,Zhiqiang;Yang,Feng[MolecularPharmaceutics,2022,vol.19,#8,p.2807-2817]

743420-02-2   
CASUnavailable 
 
CASUnavailable 

[1]Hou,Lei;Zhang,Yunchang;Huang,Ying;Fang,Zhen;Sang,Guangze;Chen,Tianheng;Ma,Zhiqiang;Yang,Feng[MolecularPharmaceutics,2022,vol.19,#8,p.2807-2817]

743420-02-2   
CASUnavailable 
 
CASUnavailable 

[1]Hou,Lei;Zhang,Yunchang;Huang,Ying;Fang,Zhen;Sang,Guangze;Chen,Tianheng;Ma,Zhiqiang;Yang,Feng[MolecularPharmaceutics,2022,vol.19,#8,p.2807-2817]

743420-02-2    1289218-74-1   
CASUnavailable 

[1]CurrentPatentAssignee:SOUTHCHINANORMALUNIVERSITY-CN115010725,2022,ALocationinpatent:Paragraph0054-0056;0059

Literature fold

Title: Chidamide, a novel histone deacetylase inhibitor, synergistically enhances gemcitabine cytotoxicity in pancreatic cancer cells.

Journal: Biochemical and biophysical research communications20130426

Title: Increased PRAME-specific CTL killing of acute myeloid leukemia cells by either a novel histone deacetylase inhibitor chidamide alone or combined treatment with decitabine.

Journal: PloS one20130101

Title: Phase I study of chidamide (CS055/HBI-8000), a new histone deacetylase inhibitor, in patients with advanced solid tumors and lymphomas.

Journal: Cancer chemotherapy and pharmacology20120601

Title: Antitumor activity of Chidamide in hepatocellular carcinoma cell lines.

Journal: Molecular medicine reports20120601

Title: CS055 (Chidamide/HBI-8000), a novel histone deacetylase inhibitor, induces G1 arrest, ROS-dependent apoptosis and differentiation in human leukaemia cells.

Journal: The Biochemical journal20120501

Title: Chidamide (CS055/HBI-8000): a new histone deacetylase inhibitor of the benzamide class with antitumor activity and the ability to enhance immune cell-mediated tumor cell cytotoxicity.

Journal: Cancer chemotherapy and pharmacology20120401

Title: Application of p21 and klf2 reporter gene assays to identify selective histone deacetylase inhibitors for cancer therapy.

Journal: Bioorganic & medicinal chemistry letters20110101

Title: A novel histone deacetylase inhibitor Chidamide induces apoptosis of human colon cancer cells.

Journal: Biochemical and biophysical research communications20100205

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