Home Amines 745055-91-8
745055-91-8,MFCD06411607
Catalog No.:AA00FEIB

745055-91-8 | (S)-1-(2-AMINO-2-CARBOXYETHYL)-3-(2-CARBOXYBENZYL)PYRIMIDINE-2,4-DIONE

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1mg
≥98%
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$82.00   $57.00
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5mg
≥98%
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$276.00   $193.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00FEIB
Chemical Name:
(S)-1-(2-AMINO-2-CARBOXYETHYL)-3-(2-CARBOXYBENZYL)PYRIMIDINE-2,4-DIONE
CAS Number:
745055-91-8
Molecular Formula:
C15H15N3O6
Molecular Weight:
333.2961
MDL Number:
MFCD06411607
SMILES:
N[C@H](C(=O)O)Cn1ccc(=O)n(c1=O)Cc1ccccc1C(=O)O
Properties
Computed Properties
 
Complexity:
576  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
24  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
6  
XLogP3:
-3.2  

Literature

Title: A rat model of nerve agent exposure applicable to the pediatric population: The anticonvulsant efficacies of atropine and GluK1 antagonists.

Journal: Toxicology and applied pharmacology 20150415

Title: Presynaptic facilitation of glutamate release in the basolateral amygdala: a mechanism for the anxiogenic and seizurogenic function of GluK1 receptors.

Journal: Neuroscience 20120927

Title: 3-Substituted phenylalanines as selective AMPA- and kainate receptor ligands.

Journal: Bioorganic & medicinal chemistry 20090901

Title: Activation of iGluR5 kainate receptors inhibits neurogenic dural vasodilatation in an animal model of trigeminovascular activation.

Journal: British journal of pharmacology 20090601

Title: Soman induces ictogenesis in the amygdala and interictal activity in the hippocampus that are blocked by a GluR5 kainate receptor antagonist in vitro.

Journal: Neuroscience 20090303

Title: Subunit-dependent postsynaptic expression of kainate receptors on hippocampal interneurons in area CA1.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20090114

Title: Synthesis and pharmacological characterization of N3-substituted willardiine derivatives: role of the substituent at the 5-position of the uracil ring in the development of highly potent and selective GLUK5 kainate receptor antagonists.

Journal: Journal of medicinal chemistry 20070405

Title: Presynaptic inhibition by kainate receptors converges mechanistically with presynaptic inhibition by adenosine and GABAB receptors.

Journal: Neuropharmacology 20061101

Title: Structural investigation of the 7-chloro-3-hydroxy-1H-quinazoline-2,4-dione scaffold to obtain AMPA and kainate receptor selective antagonists. Synthesis, pharmacological, and molecular modeling studies.

Journal: Journal of medicinal chemistry 20061005

Title: Structure-activity relationship studies on N3-substituted willardiine derivatives acting as AMPA or kainate receptor antagonists.

Journal: Journal of medicinal chemistry 20060420

Title: Crystal structures of the kainate receptor GluR5 ligand binding core dimer with novel GluR5-selective antagonists.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20060315

Title: Synthesis and pharmacology of willardiine derivatives acting as antagonists of kainate receptors.

Journal: Journal of medicinal chemistry 20051201

Title: More JC, et al. Characterisation of UBP296: a novel, potent and selective kainate receptor antagonist. Neuropharmacology. 2004 Jul;47(1):46-64.

Title: Dolman NP, et al. Synthesis and pharmacology of willardiine derivatives acting as antagonists of kainate receptors. J Med Chem. 2005 Dec 1;48(24):7867-81.

Title: Apland JP, et al. The limitations of diazepam as a treatment for nerve agent-induced seizures and neuropathology in rats: comparison with UBP302. J Pharmacol Exp Ther. 2014 Nov;351(2):359-72.

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Tags:745055-91-8 Molecular Formula|745055-91-8 MDL|745055-91-8 SMILES|745055-91-8 (S)-1-(2-AMINO-2-CARBOXYETHYL)-3-(2-CARBOXYBENZYL)PYRIMIDINE-2,4-DIONE