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74513-62-5,MFCD00866261
Catalog No.:AA005JLC

74513-62-5 | 4-(2-{[2-(3,4-dimethoxyphenyl)ethyl]amino}-1-hydroxyethyl)phenol

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10mg
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA005JLC
Chemical Name:
4-(2-{[2-(3,4-dimethoxyphenyl)ethyl]amino}-1-hydroxyethyl)phenol
CAS Number:
74513-62-5
Molecular Formula:
C18H23NO4
Molecular Weight:
317.3795
MDL Number:
MFCD00866261
SMILES:
COc1cc(CCNCC(c2ccc(cc2)O)O)ccc1OC
Properties
Computed Properties
 
Complexity:
700  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
5  
Heavy Atom Count:
25  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
2  
XLogP3:
2.6  

Literature

Title: Contraceptives with novel benefits.

Journal: Expert opinion on investigational drugs 20120101

Title: Incorporating bazedoxifene/conjugated estrogens into the current paradigm of menopausal therapy.

Journal: International journal of women's health 20120101

Title: A randomized, controlled pilot trial of hormone therapy for menopausal insomnia.

Journal: Archives of women's mental health 20111201

Title: [Effect of trimegestone on mammary gland of castrated rats].

Journal: Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia 20110701

Title: Molecular mechanisms of steroid receptor-mediated actions by synthetic progestins used in HRT and contraception.

Journal: Steroids 20110601

Title: Metabolic effects of contraceptive steroids.

Journal: Reviews in endocrine & metabolic disorders 20110601

Title: The use of newer progestins for contraception.

Journal: Contraception 20101101

Title: The haunting of medical journals: how ghostwriting sold 'HRT'.

Journal: PLoS medicine 20100901

Title: Identification of genes influencing skeletal phenotypes in congenic P/NP rats.

Journal: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20100601

Title: Presence of steroid hormones and antibiotics in surface water of agricultural, suburban and mixed-use areas.

Journal: Environmental monitoring and assessment 20090701

Title: Cardiovascular risk markers during treatment with estradiol and trimegestone or dydrogesterone.

Journal: Maturitas 20090320

Title: Evaluation of extended and continuous use oral contraceptives.

Journal: Therapeutics and clinical risk management 20081001

Title: Inhibitors and activation markers of the haemostatic system during hormone therapy: a comparative study of oral estradiol (2 mg)/ dydrogesterone and estradiol (2 mg)/ trimegestone.

Journal: Thrombosis and haemostasis 20080801

Title: Parallel assessment of the impact of different hormone replacement therapies on breast density by radiologist- and computer-based analyses of mammograms.

Journal: Climacteric : the journal of the International Menopause Society 20080401

Title: Pharmacological profile of progestins.

Journal: Maturitas 20080101

Title: Classification and pharmacology of progestins.

Journal: Maturitas 20080101

Title: Free synthetic and natural estrogen hormones in influent and effluent of three municipal wastewater treatment plants.

Journal: Water environment research : a research publication of the Water Environment Federation 20070901

Title: Preclinical and clinical properties of trimegestone: a potent and selective progestin.

Journal: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20070601

Title: Current state of hormone replacement therapy: the case for using trimegestone.

Journal: Women's health (London, England) 20060701

Title: Which progestogen is more likely to increase the risk of fatal myocardial infarction: a combination of epidemiological and trial evidence.

Journal: Maturitas 20060520

Title: Trimegestone differentially modulates the expression of matrix metalloproteinases in the endometrial stromal cell.

Journal: Molecular human reproduction 20060301

Title: New progestagens for contraceptive use.

Journal: Human reproduction update 20060101

Title: Quantitative analysis of gene regulation by seven clinically relevant progestins suggests a highly similar mechanism of action through progesterone receptors in T47D breast cancer cells.

Journal: The Journal of steroid biochemistry and molecular biology 20051201

Title: Pharmacology of different progestogens: the special case of drospirenone.

Journal: Climacteric : the journal of the International Menopause Society 20051001

Title: Bleeding profile and endometrial safety of continuous combined regimens 1 mg 17beta-estradiol/trimegestone versus 1 or 2 mg 17beta-estradiol/norethisterone acetate in postmenopausal women.

Journal: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20050901

Title: Molecular and pharmacological properties of a potent and selective novel nonsteroidal progesterone receptor agonist tanaproget.

Journal: The Journal of biological chemistry 20050805

Title: Efficacy on climacteric symptoms of a continuous combined regimen of 1 mg 17beta-estradiol and trimegestone versus two regimens combining 1 or 2 mg 17beta-estradiol and norethisterone acetate.

Journal: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20050801

Title: A study of the control of climacteric symptoms in postmenopausal women following sequential regimens of 1 mg 17beta-estradiol and trimegestone compared with a regimen containing 1 mg estradiol valerate and norethisterone over a two-year period.

Journal: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20050801

Title: A comparative 2-year study of the effects of sequential regimens of 1 mg 17beta-estradiol and trimegestone with a regimen containing estradiol valerate and norethisterone on the bleeding profile and endometrial safety in postmenopausal women.

Journal: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20050801

Title: Differential effects of estrogens and progestins on the anticoagulant tissue factor pathway inhibitor in the rat.

Journal: The Journal of steroid biochemistry and molecular biology 20050301

Title: Sleep apnea and hormone replacement therapy: a pilot study and a literature review.

Journal: Acta obstetricia et gynecologica Scandinavica 20050101

Title: Randomized trial of effects of estradiol in combination with either norethisterone acetate or trimegestone on lipids and lipoproteins in postmenopausal women.

Journal: Climacteric : the journal of the International Menopause Society 20040901

Title: Pharmacological profile of progestins.

Journal: Maturitas 20040415

Title: Trimegestone in a low-dose, continuous-combined hormone therapy regimen prevents bone loss in osteopenic postmenopausal women.

Journal: Menopause (New York, N.Y.) 20040101

Title: New progestogens: a review of their effects in perimenopausal and postmenopausal women.

Journal: Drugs & aging 20040101

Title: Classification and pharmacology of progestins.

Journal: Maturitas 20031210

Title: The preclinical biology of a new potent and selective progestin: trimegestone.

Journal: Steroids 20031101

Title: Clinical experience with trimegestone as a new progestin in HRT.

Journal: Steroids 20031101

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20031101

Title: Hormone therapy and the cardiovascular system: the critical role of progestins.

Journal: Climacteric : the journal of the International Menopause Society 20031001

Title: Effect of hormone replacement therapy on plasma levels of the cardiovascular risk factor asymmetric dimethylarginine: a randomized, placebo-controlled 12-week study in healthy early postmenopausal women.

Journal: The Journal of clinical endocrinology and metabolism 20030901

Title: Increased resistance to activated protein C after short-term oral hormone replacement therapy in healthy post-menopausal women.

Journal: British journal of haematology 20021201

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20021201

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20021101

Title: Effects of hormone replacement therapy on blood platelets.

Journal: European journal of clinical investigation 20020801

Title: [Pharma-Clinics. Medication of the month. Totelle Cycle: new sequential estrogen/progesterone regimen for hormone replacement therapy in menopause].

Journal: Revue medicale de Liege 20020601

Title: The effect of a change in the dose of trimegestone on the pattern of bleeding in estrogen-treated post-menopausal women: 6 month extension of a dose-ranging study.

Journal: Human reproduction (Oxford, England) 20020501

Title: Assessment of the metabolic tolerance in postmenopausal women over a 1-year period of two hormone replacement therapies containing estradiol in combination with either norgestrel or trimegestone.

Journal: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20020401

Title: Oral oestradiol/trimegestone replacement reduces procarboxypeptidase U (TAFI): a randomized, placebo- controlled, 12-week study in early postmenopausal women.

Journal: Journal of internal medicine 20020301

Title: Progestogens in hormonal replacement therapy: new molecules, risks, and benefits.

Journal: Menopause (New York, N.Y.) 20020101

Title: Acceptability and patterns of endometrial bleeding in estradiol-based HRT regimens: a comparative study of cyclical sequential combinations of trimegestone or norethisterone acetate.

Journal: Climacteric : the journal of the International Menopause Society 20011201

Title: A 1-year comparison of the efficacy and clinical tolerance in postmenopausal women of two hormone replacement therapies containing estradiol in combination with either norgestrel or trimegestone.

Journal: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20011001

Title: Trimegestone: expanding therapeutic choices for the treatment of the menopause.

Journal: Expert opinion on investigational drugs 20010901

Title: Effects of 17 beta-estradiol and trimegestone alone, and in combination, on the bone and uterus of ovariectomized rats.

Journal: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20010801

Title: Rat uterine complement C3 expression as a model for progesterone receptor modulators: characterization of the new progestin trimegestone.

Journal: The Journal of steroid biochemistry and molecular biology 20010801

Title: Effect of trimegestone alone or in combination with estradiol on bone mass and bone turnover in an adult rat model of osteopenia.

Journal: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20010201

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Tags:74513-62-5 Molecular Formula|74513-62-5 MDL|74513-62-5 SMILES|74513-62-5 4-(2-{[2-(3,4-dimethoxyphenyl)ethyl]amino}-1-hydroxyethyl)phenol