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749234-11-5,MFCD08705322
Catalog No.:AA003OXQ

749234-11-5 | Dmat

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1mg
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$53.00   $37.00
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5mg
≥98%
in stock  
$230.00   $161.00
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10mg
≥98%
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$243.00   $170.00
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50mg
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  • Technical Information
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  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA003OXQ
Chemical Name:
Dmat
CAS Number:
749234-11-5
Molecular Formula:
C9H7Br4N3
Molecular Weight:
476.7880
MDL Number:
MFCD08705322
SMILES:
CN(c1[nH]c2c(n1)c(Br)c(c(c2Br)Br)Br)C
Properties
Properties
 
Form:
Solid  
MP:
>330℃ (Decomposition)  
Storage:
Room Temperature;  

Computed Properties
 
Complexity:
265  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
16  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
1  
XLogP3:
4.7  

Literature

Title: Protein kinase CK2 governs the molecular decision between encephalitogenic TH17 cell and Treg cell development.

Journal: Proceedings of the National Academy of Sciences of the United States of America 20160906

Title: Casein kinase 2α regulates multidrug resistance-associated protein 1 function via phosphorylation of Thr249.

Journal: Molecular pharmacology 20120901

Title: Modified tetrahalogenated benzimidazoles with CK2 inhibitory activity are active against human prostate cancer cells LNCaP in vitro.

Journal: Bioorganic & medicinal chemistry 20120715

Title: Protein kinase CK2 is implicated in early steps of the differentiation of pre-adipocytes into adipocytes.

Journal: Molecular and cellular biochemistry 20120601

Title: Structural determinants for rCNT2 sorting to the plasma membrane of polarized and non-polarized cells.

Journal: The Biochemical journal 20120315

Title: Protein kinase CK2 triggers cytosolic zinc signaling pathways by phosphorylation of zinc channel ZIP7.

Journal: Science signaling 20120207

Title: Characterization of ATM and DNA-PK wild-type and mutant cell lines upon DSB induction in the presence and absence of CK2 inhibitors.

Journal: International journal of oncology 20120201

Title: Nanoencapsulated anti-CK2 small molecule drug or siRNA specifically targets malignant cancer but not benign cells.

Journal: Cancer letters 20120201

Title: A pharmacologically-based array to identify targets of cyclosporine A-induced toxicity in cultured renal proximal tubule cells.

Journal: Toxicology and applied pharmacology 20120115

Title: CK2α and CK2α' subunits differ in their sensitivity to 4,5,6,7-tetrabromo- and 4,5,6,7-tetraiodo-1H-benzimidazole derivatives.

Journal: European journal of medicinal chemistry 20120101

Title: Influence of five potential anticancer drugs on wnt pathway and cell survival in human biliary tract cancer cells.

Journal: International journal of biological sciences 20120101

Title: GPCRs regulate the assembly of a multienzyme complex for purine biosynthesis.

Journal: Nature chemical biology 20111201

Title: Unbiased functional proteomics strategy for protein kinase inhibitor validation and identification of bona fide protein kinase substrates: application to identification of EEF1D as a substrate for CK2.

Journal: Journal of proteome research 20111104

Title: Protein kinase CK2 promotes cancer cell viability via up-regulation of cyclooxygenase-2 expression and enhanced prostaglandin E2 production.

Journal: Journal of cellular biochemistry 20111101

Title: Down-regulation of CK2 activity results in a decrease in the level of cdc25C phosphatase in different prostate cancer cell lines.

Journal: Molecular and cellular biochemistry 20111001

Title: Adiponectin receptor 1 interacts with both subunits of protein kinase CK2.

Journal: Molecular and cellular biochemistry 20111001

Title: CK2 phosphorylation of XRCC1 facilitates dissociation from DNA and single-strand break formation during base excision repair.

Journal: DNA repair 20110905

Title: Inhibition of experimental HCC growth in mice by use of the kinase inhibitor DMAT.

Journal: International journal of oncology 20110801

Title: The cytosolic protein kinase CK2 phosphorylates cardiac calsequestrin in intact cells.

Journal: Molecular and cellular biochemistry 20110701

Title: Protein kinase CK2/PTEN pathway plays a key role in platelet-activating factor-mediated murine anaphylactic shock.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20110601

Title: Kinase inhibitors modulate huntingtin cell localization and toxicity.

Journal: Nature chemical biology 20110529

Title: IL-6 stabilizes Twist and enhances tumor cell motility in head and neck cancer cells through activation of casein kinase 2.

Journal: PloS one 20110101

Title: Hyperphosphorylation as a defense mechanism to reduce TDP-43 aggregation.

Journal: PloS one 20110101

Title: Runx2 trans-activation mediated by the MSX2-interacting nuclear target requires homeodomain interacting protein kinase-3.

Journal: Molecular endocrinology (Baltimore, Md.) 20100701

Title: Bovine herpesvirus-1 US3 protein kinase: critical residues and involvement in the phosphorylation of VP22.

Journal: The Journal of general virology 20100501

Title: Phosphorylation of phosducin-like protein BDM-1 by protein kinase 2 (CK2) is required for virulence and G beta subunit stability in the fungal plant pathogen Cryphonectria parasitica.

Journal: Molecular microbiology 20100501

Title: Anti-neoplastic effect of protein kinase CK2 inhibitor, 2-dimethylamino-4,5,6,7-tetrabromobenzimidazole (DMAT), on growth and hormonal activity of human adrenocortical carcinoma cell line (H295R) in vitro.

Journal: Cell and tissue research 20100501

Title: Dynamic regulation of a metabolic multi-enzyme complex by protein kinase CK2.

Journal: The Journal of biological chemistry 20100409

Title: Halogenated imidazole derivatives block RNA polymerase II elongation along mitogen inducible genes.

Journal: BMC molecular biology 20100101

Title: Casein kinase 2 dependent phosphorylation of neprilysin regulates receptor tyrosine kinase signaling to Akt.

Journal: PloS one 20100101

Title: Major tegument protein VP8 of bovine herpesvirus 1 is phosphorylated by viral US3 and cellular CK2 protein kinases.

Journal: The Journal of general virology 20091201

Title: Efficacy and mechanism of anti-tumor action of new potential CK2 inhibitors toward glioblastoma cells.

Journal: International journal of oncology 20091101

Title: Selectivity analysis of protein kinase CK2 inhibitors DMAT, TBB and resorufin in cisplatin-induced stress responses.

Journal: International journal of oncology 20091101

Title: Protein kinase CK2 regulates cytoskeletal reorganization during ionizing radiation-induced senescence of human mesenchymal stem cells.

Journal: Cancer research 20091015

Title: Protein kinase CK2 interacts with adiponectin receptor 1 and participates in adiponectin signaling.

Journal: Cellular signalling 20090601

Title: DMAT, an inhibitor of protein kinase CK2 induces reactive oxygen species and DNA double strand breaks.

Journal: Oncology reports 20090601

Title: Trans-complementation of an NS2 defect in a late step in hepatitis C virus (HCV) particle assembly and maturation.

Journal: PLoS pathogens 20090501

Title: Alpha-synuclein aggregation and Ser-129 phosphorylation-dependent cell death in oligodendroglial cells.

Journal: The Journal of biological chemistry 20090410

Title: Erythrocytic casein kinase II regulates cytoadherence of Plasmodium falciparum-infected red blood cells.

Journal: The Journal of biological chemistry 20090306

Title: WAVE2 is regulated by multiple phosphorylation events within its VCA domain.

Journal: Cell motility and the cytoskeleton 20090101

Title: Peptide biosensors for the electrochemical measurement of protein kinase activity.

Journal: Analytical chemistry 20081215

Title: Casein kinase 2 regulates the active uptake of the organic osmolyte taurine in NIH3T3 mouse fibroblasts.

Journal: Pflugers Archiv : European journal of physiology 20081101

Title: The selectivity of inhibitors of protein kinase CK2: an update.

Journal: The Biochemical journal 20081101

Title: New inhibitors of protein kinase CK2, analogues of benzimidazole and benzotriazole.

Journal: Molecular and cellular biochemistry 20080901

Title: Hemoglobin neurotoxicity is attenuated by inhibitors of the protein kinase CK2 independent of heme oxygenase activity.

Journal: Current neurovascular research 20080801

Title: An unbiased evaluation of CK2 inhibitors by chemoproteomics: characterization of inhibitor effects on CK2 and identification of novel inhibitor targets.

Journal: Molecular & cellular proteomics : MCP 20080601

Title: Regulation of hepatitis C virion production via phosphorylation of the NS5A protein.

Journal: PLoS pathogens 20080301

Title: Phosphorylation of Nrf2 in the transcription activation domain by casein kinase 2 (CK2) is critical for the nuclear translocation and transcription activation function of Nrf2 in IMR-32 neuroblastoma cells.

Journal: Journal of biochemical and molecular toxicology 20080201

Title: CK2beta gene silencing increases cell susceptibility to influenza A virus infection resulting in accelerated virus entry and higher viral protein content.

Journal: Journal of molecular signaling 20080101

Title: Induction of cell death in antiestrogen resistant human breast cancer cells by the protein kinase CK2 inhibitor DMAT.

Journal: Cancer letters 20071028

Title: Induction of alkaline phosphatase activity by L-ascorbic acid in human osteoblastic cells: a potential role for CK2 and Ikaros.

Journal: Nutrition (Burbank, Los Angeles County, Calif.) 20071001

Title: Inhibition of protein kinase CK2 leads to a modulation of androgen receptor dependent transcription in prostate cancer cells.

Journal: The Prostate 20070201

Title: Treatment of P190 Bcr/Abl lymphoblastic leukemia cells with inhibitors of the serine/threonine kinase CK2.

Journal: Leukemia 20070101

Title: Inspecting the structure-activity relationship of protein kinase CK2 inhibitors derived from tetrabromo-benzimidazole.

Journal: Chemistry & biology 20051101

Title: Development and exploitation of CK2 inhibitors.

Journal: Molecular and cellular biochemistry 20050601

Title: Optimization of protein kinase CK2 inhibitors derived from 4,5,6,7-tetrabromobenzimidazole.

Journal: Journal of medicinal chemistry 20041202

Title: 2-Dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole: a novel powerful and selective inhibitor of protein kinase CK2.

Journal: Biochemical and biophysical research communications 20040903

Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

Journal: The Journal of biological chemistry 20020419

Title: Yde CW, et al. Induction of cell death in antiestrogen resistant human breast cancer cells by the protein kinase CK2 inhibitorDMAT. Cancer Lett. 2007 Oct 28;256(2):229-37.

Title: Lawnicka H, et al. Anti-neoplastic effect of protein kinase CK2 inhibitor, 2-dimethylamino-4,5,6,7-tetrabromobenzimidazole (DMAT), on growth and hormonal activity of human adrenocortical carcinoma cell line (H295R) in vitro. Cell Tissue Res. 2010 May;340(

Title: Pagano MA, et al. The selectivity of inhibitors of protein kinase CK2: an update. Biochem J. 2008 Nov 1;415(3):353-65.

Title: Sass G, et al. Inhibition of experimental HCC growth in mice by use of the kinase inhibitor DMAT. Int J Oncol. 2011 Aug;39(2):433-42.

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