Home Amines 75438-57-2
75438-57-2,MFCD00865794
Catalog No.:AA005BFO

75438-57-2 | 4-Chloro-n-imidazolidin-2-ylidene-6-methoxy-2-methylpyrimidin-5-amine

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5mg
98%
in stock  
$7.00   $5.00
- +
10mg
98%
in stock  
$9.00   $7.00
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100mg
98%
in stock  
$35.00   $25.00
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250mg
98%
in stock  
$52.00   $36.00
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1g
98%
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$125.00   $88.00
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5g
98%
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$181.00   $127.00
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  • Technical Information
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA005BFO
Chemical Name:
4-Chloro-n-imidazolidin-2-ylidene-6-methoxy-2-methylpyrimidin-5-amine
CAS Number:
75438-57-2
Molecular Formula:
C9H13Cl2N5O
Molecular Weight:
278.1384
MDL Number:
MFCD00865794
SMILES:
COc1nc(C)nc(c1NC1=NCCN1)Cl.Cl
Properties
Properties
 
BP:
364.7°C at 760 mmHg  
Form:
Solid  
MP:
>209°C (dec.)  
Storage:
Inert atmosphere;2-8℃;  

Computed Properties
 
Complexity:
275  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
16  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
3  
XLogP3:
0.6  

Literature

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Title: Receptors involved in moxonidine-stimulated atrial natriuretic peptide release from isolated normotensive rat hearts.

Journal: European journal of pharmacology 20060710

Title: Moxonidine improves glycaemic control in mildly hypertensive, overweight patients: a comparison with metformin.

Journal: Diabetes, obesity & metabolism 20060701

Title: Antihypertensive responses elicited by central moxonidine in rats: possible role of nitric oxide.

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Title: Selective imidazoline agonist moxonidine in obese hypertensive patients.

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Title: Influence of central inhibition of sympathetic nervous activity on myocardial metabolism in chronic heart failure: acute effects of the imidazoline I1-receptor agonist moxonidine.

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Title: Effects of eprosartan on target organ protection.

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Title: Presynaptic I1-imidazoline receptors reduce GABAergic synaptic transmission in striatal medium spiny neurons.

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Title: Determination of moxonidine in human plasma by liquid chromatography-electrospray ionisation-mass spectrometry.

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Title: Insulin resistance and sympathetic overactivity in women.

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Title: Cause and consequences of sympathetic hyperactivity in chronic kidney disease.

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Title: Lipid-lowering actions of imidazoline antihypertensive agents in metabolic syndrome X.

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Title: Moxonidine: a review of its use in essential hypertension.

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Title: [Comparison of the effectiveness of moxonidine and prestarium in postmenopausal women with mild and moderate arterial hypertension].

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Title: [The use of moxonidine in women with arterial hypertension in postmenopausal period].

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Title: Centrally acting imidazolines stimulate vascular alpha 1A-adrenergic receptors in Rat-Tail Artery.

Journal: Cellular and molecular neurobiology 20060101

Title: Moxonidine well tolerated and effective in the treatment of viscerally obese, non-controlled hypertensive patients.

Journal: Cardiovascular journal of South Africa : official journal for Southern Africa Cardiac Society [and] South African Society of Cardiac Practitioners 20060101

Title: The effect of moxonidine on endothelial dysfunction in metabolic syndrome.

Journal: American journal of cardiovascular drugs : drugs, devices, and other interventions 20060101

Title: Imidazoline receptors in relaxation of acetylcholine-constricted isolated rat jejunum.

Journal: Pharmacological reports : PR 20060101

Title: Identification of the central imidazoline receptor subtype involved in modulation of halothane-epinephrine arrhythmias in rats.

Journal: Anesthesia and analgesia 20051201

Title: Use of moxonidine in elderly patients with resistant hypertension.

Journal: Journal of clinical pharmacy and therapeutics 20051001

Title: [Antihypertensive therapy and drug-drug interactions].

Journal: Revue medicale suisse 20050914

Title: Urinary responses to acute moxonidine are inhibited by natriuretic peptide receptor antagonist.

Journal: British journal of pharmacology 20050501

Title: Non-adrenergic inhibition at prejunctional sites by agmatine of purinergic vasoconstriction in rabbit saphenous artery.

Journal: Neuropharmacology 20050301

Title: Efficacy of moxonidine in the treatment of hypertension in obese, noncontrolled hypertensive patients.

Journal: Kidney international. Supplement 20050101

Title: Application of population pharmacokinetics to cladribine.

Journal: BMC pharmacology 20050101

Title: [Clinicogenetic aspects of carbohydrate metabolism disorders and efficacy of their correction with moxonidine and metformine in patients with arterial hypertension].

Journal: Terapevticheskii arkhiv 20050101

Title: [The role of alpha2-adrenergic and I1-imidazoline receptors in the effects of clonidine and moxonidine on isolated large intestine of mice].

Journal: Eksperimental'naia i klinicheskaia farmakologiia 20050101

Title: Imidazoline receptors associated with noradrenergic terminals in the rostral ventrolateral medulla mediate the hypotensive responses of moxonidine but not clonidine.

Journal: Neuroscience 20050101

Title: Moxonidine suitable for hypertensive menopausal women with metabolic syndrome.

Journal: Cardiovascular journal of South Africa : official journal for Southern Africa Cardiac Society [and] South African Society of Cardiac Practitioners 20050101

Title: Cardiovascular and survival effects of sympatho-inhibitors in adriamycin-induced cardiomyopathy in rats.

Journal: Fundamental & clinical pharmacology 20041201

Title: Different effects of losartan and moxonidine on endothelial function during sympathetic activation in essential hypertension.

Journal: Journal of clinical hypertension (Greenwich, Conn.) 20041201

Title: Moxonidine normalizes sympathetic hyperactivity in patients with eprosartan-treated chronic renal failure.

Journal: Journal of the American Society of Nephrology : JASN 20041101

Title: The data monitoring experience in the MOXCON trial.

Journal: European heart journal 20041101

Title: New pharmacological strategies in chronic heart failure.

Journal: Cardiovascular drugs and therapy 20041101

Title: Modulation of gene expression by moxonidine in rats with chronic renal failure.

Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20040901

Title: Moxonidine in the treatment of overweight and obese patients with the metabolic syndrome: a postmarketing surveillance study.

Journal: Journal of human hypertension 20040901

Title: Imidazoline receptors but not alpha 2-adrenoceptors are regulated in spontaneously hypertensive rat heart by chronic moxonidine treatment.

Journal: The Journal of pharmacology and experimental therapeutics 20040801

Title: Imidazoline receptors in the heart: a novel target and a novel mechanism of action that involves atrial natriuretic peptides.

Journal: Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20040801

Title: Augmentation of moxonidine-induced increase in ANP release by atrial hypertrophy.

Journal: American journal of physiology. Heart and circulatory physiology 20040701

Title: Increased infarct size in uremic rats: reduced ischemia tolerance?

Journal: Journal of the American Society of Nephrology : JASN 20040601

Title: Central blockade of nitric oxide synthesis reduces moxonidine-induced hypotension.

Journal: British journal of pharmacology 20040601

Title: Effects of moxonidine vs. metoprolol on blood pressure and metabolic control in hypertensive subjects with type 2 diabetes.

Journal: Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 20040601

Title: Moxonidine and rilmenidine injected into the medial septal area reduces the salivation induced by pilocarpine.

Journal: Autonomic neuroscience : basic & clinical 20040531

Title: Effect of i1 imidazoline receptor agonist, moxonidine, in nitric oxide-deficient hypertension in pregnant rats.

Journal: Journal of cardiovascular pharmacology 20040501

Title: The I1-imidazoline agonist moxonidine decreases sympathetic tone under physical and mental stress.

Journal: British journal of clinical pharmacology 20040501

Title: Effect of moxonidine on lipid subfractions in patients with hypertension.

Journal: International journal of clinical practice 20040501

Title: Selective imidazoline agonist moxonidine plus the ACE inhibitor ramipril in hypertensive patients with impaired insulin sensitivity: partners in a successful MARRIAGE?

Journal: Current medical research and opinion 20040301

Title: The metabolic syndrome in women: implications for therapy.

Journal: International journal of clinical practice. Supplement 20040301

Title: Treatment of postmenopausal hypertension with moxonidine, a selective imidazoline receptor agonist.

Journal: International journal of clinical practice. Supplement 20040301

Title: Effect of moxonidine on contractile activity of isolated large intestine in mice: role of alpha2-adrenoceptors and Ii-imidazoline receptors.

Journal: Bulletin of experimental biology and medicine 20040301

Title: Pharmacological therapy can increase capillary density in post-infarction remodeled rat hearts.

Journal: Cardiovascular research 20040215

Title: Moxonidine, an antihypertensive agent, is permissive to alpha1-adrenergic receptor pathway in the rat-tail artery.

Journal: Journal of cardiovascular pharmacology 20040201

Title: The effects of imidazoline agents on the aggregation of human platelets.

Journal: The Journal of pharmacy and pharmacology 20040201

Title: Elevated sympathetic activity may promote insulin resistance syndrome by activating alpha-1 adrenergic receptors on adipocytes.

Journal: Medical hypotheses 20040101

Title: Effect of moxonidine on putative sympathetic neurons in the rostral ventrolateral medulla of the rat.

Journal: Neuro-Signals 20040101

Title: [Effect of moxonidine on parameters of lipid metabolism in patients with metabolic syndrome.].

Journal: Kardiologiia 20040101

Title: Activation of alpha2-adrenergic receptors into the lateral parabrachial nucleus enhances NaCl intake in rats.

Journal: Neuroscience 20040101

Title: [The role of hypersympathycotony in development of arterial hypertension in patients with metabolic syndrome: potential of pathogenetically sound therapy].

Journal: Terapevticheskii arkhiv 20040101

Title: Moxonidine and central alpha2 adrenergic receptors in sodium intake.

Journal: Brain research 20031212

Title: Contrasting metabolic effects of antihypertensive agents.

Journal: The Journal of pharmacology and experimental therapeutics 20031201

Title: Electrophysiological responses to imidazoline/alpha2-receptor agonists in rabbit sinoatrial node pacemaker cells.

Journal: Acta pharmacologica Sinica 20031201

Title: Identification and pharmacological characterization of a specific agmatine transport system in human tumor cell lines.

Journal: Annals of the New York Academy of Sciences 20031201

Title: Cardiac effects of moxonidine in spontaneously hypertensive obese rats.

Journal: Annals of the New York Academy of Sciences 20031201

Title: The role of I(1)-imidazoline receptors and alpha(2)-adrenergic receptors in the modulation of glucose and lipid metabolism in the SHROB model of metabolic syndrome X.

Journal: Annals of the New York Academy of Sciences 20031201

Title: Involvement of forebrain imidazoline and alpha(2)-adrenergic receptors in the antidipsogenic response to moxonidine.

Journal: Annals of the New York Academy of Sciences 20031201

Title: Moxonidine displays a presynaptic alpha-2-adrenoceptor-dependent synergistic sympathoinhibitory action at imidazoline-1 receptors.

Journal: Annals of the New York Academy of Sciences 20031201

Title: Norepinephrine release is reduced by I(1)-receptors in addition to alpha(2)-adrenoceptors.

Journal: Annals of the New York Academy of Sciences 20031201

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