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76081-98-6,MFCD00834620
Catalog No.:AA00G2BW

76081-98-6 | 2-METHYL-8-(PHENYLMETHOXY)IMIDAZO[1,2-A]PYRIDINE-3-ACETONITRILE

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1mg
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5mg
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$143.00   $100.00
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10mg
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00G2BW
Chemical Name:
2-METHYL-8-(PHENYLMETHOXY)IMIDAZO[1,2-A]PYRIDINE-3-ACETONITRILE
CAS Number:
76081-98-6
Molecular Formula:
C17H15N3O
Molecular Weight:
277.3205
MDL Number:
MFCD00834620
SMILES:
N#CCc1c(C)nc2n1cccc2OCc1ccccc1
Properties
Computed Properties
 
Complexity:
385  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
21  
Hydrogen Bond Acceptor Count:
3  
Rotatable Bond Count:
4  
XLogP3:
3.3  

Literature

Title: Potential role of sodium-proton exchangers in the low concentration arsenic trioxide-increased intracellular pH and cell proliferation.

Journal: PloS one 20120101

Title: Characterization of a novel potassium-competitive acid blocker of the gastric H,K-ATPase, 1-[5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine monofumarate (TAK-438).

Journal: The Journal of pharmacology and experimental therapeutics 20111101

Title: Deceleration of the E1P-E2P transition and ion transport by mutation of potentially salt bridge-forming residues Lys-791 and Glu-820 in gastric H+/K+-ATPase.

Journal: The Journal of biological chemistry 20101210

Title: 1-[5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine monofumarate (TAK-438), a novel and potent potassium-competitive acid blocker for the treatment of acid-related diseases.

Journal: The Journal of pharmacology and experimental therapeutics 20101001

Title: Pharmacological profiles of the murine gastric and colonic H,K-ATPases.

Journal: Biochimica et biophysica acta 20100901

Title: Heterogeneity of H-K-ATPase-mediated acid secretion along the mouse collecting duct.

Journal: American journal of physiology. Renal physiology 20100201

Title: Evaluation of basic, heterocyclic ring systems as templates for use as potassium competitive acid blockers (pCABs).

Journal: Bioorganic & medicinal chemistry letters 20091201

Title: Functional association between K+-Cl- cotransporter-4 and H+,K+-ATPase in the apical canalicular membrane of gastric parietal cells.

Journal: The Journal of biological chemistry 20090102

Title: Calcium-sensing receptor stimulates luminal K+-dependent H+ excretion in medullary thick ascending limbs of Henle's loop of mouse kidney.

Journal: The Tohoku journal of experimental medicine 20080901

Title: Sensory effects of intravenous cocaine on dopamine and non-dopamine ventral tegmental area neurons.

Journal: Brain research 20080707

Title: Soraprazan: setting new standards in inhibition of gastric acid secretion.

Journal: The Journal of pharmacology and experimental therapeutics 20070601

Title: [Structure-function relationship of gastric proton pump].

Journal: Seikagaku. The Journal of Japanese Biochemical Society 20070601

Title: Real time measurements of water flow in amphibian gastric glands: modulation via the extracellular Ca2+-sensing receptor.

Journal: The Journal of biological chemistry 20070504

Title: Mechanisms of secretion-associated shrinkage and volume recovery in cultured rabbit parietal cells.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20070301

Title: The human non-gastric H,K-ATPase has a different cation specificity than the rat enzyme.

Journal: Biochimica et biophysica acta 20070301

Title: Specific H+/K(+)-ATPase inhibitors decreased contractile responses of isolated rat vas deferens.

Journal: Pharmacological research 20061201

Title: Characteristics of the K+-competitive H+,K+-ATPase inhibitor AZD0865 in isolated rat gastric glands.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20061101

Title: Ion flow regulates left-right asymmetry in sea urchin development.

Journal: Development genes and evolution 20060501

Title: Functional complementation of the yeast P-type H-ATPase, PMA1, by the Pneumocystis carinii P-type H-ATPase, PCA1.

Journal: The Journal of eukaryotic microbiology 20060101

Title: Functional consequences of the oligomeric form of the membrane-bound gastric H,K-ATPase.

Journal: Biochemistry 20051213

Title: The non-gastric H,K-ATPase is oligomycin-sensitive and can function as an H+,NH4(+)-ATPase.

Journal: The Journal of biological chemistry 20050930

Title: Positive inotropic and negative chronotropic effects of proton pump inhibitors in isolated rat atrium.

Journal: European journal of pharmacology 20050920

Title: Asn792 participates in the hydrogen bond network around the K+-binding pocket of gastric H,K-ATPase.

Journal: The Journal of biological chemistry 20050325

Title: The cavity structure for docking the K(+)-competitive inhibitors in the gastric proton pump.

Journal: The Journal of biological chemistry 20040402

Title: Divalent cations regulate acidity within the lumen and tubulovesicle compartment of gastric parietal cells.

Journal: Gastroenterology 20040101

Title: Identification and regulation of the gastric H+/K+-ATPase in the rat heart.

Journal: Acta physiologica Scandinavica 20031101

Title: Molecular modeling of SCH28080 binding to the gastric H,K-ATPase and MgATP interactions with SERCA- and Na,K-ATPases.

Journal: Annals of the New York Academy of Sciences 20030401

Title: Regulation of renal Na(+),K(+)-ATPase and ouabain-sensitive H(+),K(+)-ATPase by the cyclic AMP-protein kinase A signal transduction pathway.

Journal: Acta biochimica Polonica 20030101

Title: Factors affecting ammonium uptake by C11 clone of MDCK cells.

Journal: Pflugers Archiv : European journal of physiology 20021101

Title: Stable expression of gastric proton pump activity at the cell surface.

Journal: Journal of biochemistry 20020601

Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

Journal: The Journal of biological chemistry 20020419

Title: Acid secretion and proton conductance in human airway epithelium.

Journal: American journal of physiology. Cell physiology 20020401

Title: Novel Schering and ouabain-insensitive potassium-dependent proton secretion in the mouse cortical collecting duct.

Journal: American journal of physiology. Renal physiology 20020101

Title: Cibenzoline, an ATP-sensitive K(+) channel blocker, binds to the K(+)-binding site from the cytoplasmic side of gastric H(+),K(+)-ATPase.

Journal: British journal of pharmacology 20011201

Title: A model of reversible inhibitors in the gastric H+/K+-ATPase binding site determined by rotational echo double resonance NMR.

Journal: The Journal of biological chemistry 20011116

Title: Increased CO(2) stimulates K/Rb reabsorption mediated by H-K-ATPase in CCD of potassium-restricted rabbit.

Journal: American journal of physiology. Renal physiology 20010801

Title: Bafilomycin A1 at nanomolar concentrations saturably inhibits a portion of turtle bladder acidification current.

Journal: The Journal of experimental biology 20010801

Title: Mutational analysis of the K+-competitive inhibitor site of gastric H,K-ATPase.

Journal: Biochemistry 20010626

Title: Mimicking of K+ activation by double mutation of glutamate 795 and glutamate 820 of gastric H+,K+-ATPase.

Journal: Biochemistry 20010529

Title: Catalytic function of nongastric H,K-ATPase expressed in Sf-21 insect cells.

Journal: Biochemistry 20010515

Title: Leishmania plasma membrane Mg2+-ATPase is a H+/K+-antiporter involved in glucose symport. Studies with sealed ghosts and vesicles of opposite polarity.

Journal: The Journal of biological chemistry 20010223

Title: A hybrid between Na+,K+-ATPase and H+,K+-ATPase is sensitive to palytoxin, ouabain, and SCH 28080.

Journal: The Journal of biological chemistry 20010126

Title: Functional expression of the cDNA encoded by the human ATP1AL1 gene.

Journal: The American journal of physiology 19960901

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Tags:76081-98-6 Molecular Formula|76081-98-6 MDL|76081-98-6 SMILES|76081-98-6 2-METHYL-8-(PHENYLMETHOXY)IMIDAZO[1,2-A]PYRIDINE-3-ACETONITRILE