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760952-64-5,MFCD24497443
Catalog No.:AA00ICMI

760952-64-5 | 3-[2-(2,5-Dioxo-2,5-dihydro-1h-pyrrol-1-yl)ethoxy]propanoic acid

Pack Size
Purity
Availability
Price(USD)
Quantity
  
100mg
95%
in stock  
$200.00   $140.00
- +
250mg
95%
in stock  
$311.00   $218.00
- +
1g
95%
in stock  
$633.00   $443.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00ICMI
Chemical Name:
3-[2-(2,5-Dioxo-2,5-dihydro-1h-pyrrol-1-yl)ethoxy]propanoic acid
CAS Number:
760952-64-5
Molecular Formula:
C9H11NO5
Molecular Weight:
213.1873
MDL Number:
MFCD24497443
SMILES:
OC(=O)CCOCCN1C(=O)C=CC1=O
Properties
Computed Properties
 
Complexity:
292  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
15  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
6  
XLogP3:
-0.1  

Downstream Synthesis Route

[1]CurrentPatentAssignee:KTBTUMORFORSCHUNGSGMBH-WO2004/83223,2004,A1Locationinpatent:Page/Pagecolumn11-12

760952-64-5   
(S)-2-((2R,3R)-3-((S)-1-((3R,4S,5S)-4-((S)-2-((1R,3S,4S)-2-azabicyclo2.2.1heptane-3-carboxamido)-N,3-dimethylbutanamido)-3-methoxy-5-methylheptanoyl)pyrrolidin-2-yl)-3-methoxy-2-methylpropanamido)-3-phenylpropanoicacid 
 
(S)-2-((2R,3R)-3-((S)-1-((3R,4S,5S)-4-((S)-2-((1R,3S,4S)-2-(3-(2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethoxy)propanoyl)-2-azabicyclo2.2.1heptane-3-carboxamido)-N,3-dimethylbutanamido)-3-methoxy-5-methylheptanoyl)pyrrolidin-2-yl)-3-methoxy-2-methylpropanamido)-3-phenylpropanoicacid 

[1]CurrentPatentAssignee:NOVARTISAG;Novartis(w/oSandoz)-WO2015/95301,2015,A2Locationinpatent:Page/Pagecolumn131;132

[2]CurrentPatentAssignee:NOVARTISAG;Novartis(w/oSandoz)-WO2016/203432,2016,A1Locationinpatent:Paragraph00541

6066-82-6    760952-64-5   
2,5-dioxopyrrolidin-1-yl3-(2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethoxy)propanoate 

[1]Renault,Kévin;Jouanno,Laurie-Anne;Lizzul-Jurse,Antoine;Renard,Pierre-Yves;Sabot,Cyrille[Chemistry-AEuropeanJournal,2016,vol.22,#51,p.18522-18531]

760952-64-5   
C56H81N19O18 

[1]Renault,Kévin;Jouanno,Laurie-Anne;Lizzul-Jurse,Antoine;Renard,Pierre-Yves;Sabot,Cyrille[Chemistry-AEuropeanJournal,2016,vol.22,#51,p.18522-18531]

760952-64-5   
C49H77N15O17 

[1]Renault,Kévin;Jouanno,Laurie-Anne;Lizzul-Jurse,Antoine;Renard,Pierre-Yves;Sabot,Cyrille[Chemistry-AEuropeanJournal,2016,vol.22,#51,p.18522-18531]

Literature

Title: An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

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SDS
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Tags:760952-64-5 Molecular Formula|760952-64-5 MDL|760952-64-5 SMILES|760952-64-5 3-[2-(2,5-Dioxo-2,5-dihydro-1h-pyrrol-1-yl)ethoxy]propanoic acid