[1]CurrentPatentAssignee:GLAXOSMITHKLINEPLC-US6048852,2000,A
[1]CurrentPatentAssignee:SOCIETECIVILEBIOPROJET-US4513009,1985,A
76721-89-6
[1]Bergstrom,Alexander;Bretz,StaceyLowery;Cheng,Zishuo;Crowder,MichaelW.;Fullington,Sarah;Ju,Lin-Cheng;Miller,Callie;Page,RichardC.;Shurina,BenA.;Thomas,Caitlyn;Tierney,DavidL.;Yang,Kundi[JournalofBiologicalInorganicChemistry,2020]
Title: Dried blood spot on-card derivatization: an alternative form of sample handling to overcome the instability of thiorphan in biological matrix.
Journal: Biomedical chromatography : BMC 20121201
Title: Angiotensin-(1-7) receptor Mas agonist ameliorates progress of atherosclerosis in apoE-knockout mice.
Journal: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20120201
Title: Routine antenatal anti-D prophylaxis--is the protection adequate?
Journal: Transfusion medicine (Oxford, England) 20111201
Title: The role of neutral endopeptidase in caerulein-induced acute pancreatitis.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20111115
Title: Aβ-degrading enzymes: potential for treatment of Alzheimer disease.
Journal: Journal of neuropathology and experimental neurology 20111101
Title: Impaired β-amyloid secretion in Alzheimer's disease pathogenesis.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20111026
Title: Racecadotril for childhood gastroenteritis: an individual patient data meta-analysis.
Journal: Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 20110901
Title: Grading recommendations in clinical practice guidelines: randomised experimental evaluation of four different systems.
Journal: Archives of disease in childhood 20110801
Title: Collateral sensitivity of multidrug-resistant cells to the orphan drug tiopronin.
Journal: Journal of medicinal chemistry 20110728
Title: Inhibition of insulin degrading enzyme by racecadotril in the brain of Wistar rats.
Journal: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20110601
Title: Spectrophotometric and spectrofluorimetric methods for determination of Racecadotril.
Journal: Pakistan journal of pharmaceutical sciences 20110101
Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.
Journal: Bioorganic & medicinal chemistry letters 20101101
Title: Control of APN/CD13 and NEP/CD10 on sperm motility.
Journal: Asian journal of andrology 20101101
Title: A nonhuman primate model of Alzheimer's disease generated by intracranial injection of amyloid-β42 and thiorphan.
Journal: Metabolic brain disease 20100901
Title: Remarks and questions on the article 'Prospective randomized double-blind trial of racecadotril compared with loperamide in elderly people with gastroenteritis living in nursing homes'.
Journal: European journal of clinical pharmacology 20100801
Title: Increase of plasma insulin by racecadotril, an inhibitor of enkephalinase, in Wistar rats.
Journal: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20100401
Title: Prospective randomized double-blind trial of racecadotril compared with loperamide in elderly people with gastroenteritis living in nursing homes.
Journal: European journal of clinical pharmacology 20100201
Title: Diabetes-associated changes and role of N epsilon-(carboxymethyl)lysine in big ET-1-induced coronary vasoconstriction.
Journal: Peptides 20100201
Title: Possible role of tau in mediating pathological effects of apoE4 in vivo prior to and following activation of the amyloid cascade.
Journal: Neuro-degenerative diseases 20100101
Title: Amyloid-beta as a positive endogenous regulator of release probability at hippocampal synapses.
Journal: Nature neuroscience 20091201
Title: Stability-indicating methods for the determination of racecadotril in the presence of its degradation products.
Journal: Bioscience trends 20091201
Title: A scrutiny of the biochemical pathways from Ang II to Ang-(3-4) in renal basolateral membranes.
Journal: Regulatory peptides 20091127
Title: Synthesis and enzymatic evaluation of novel partially fluorinated thiol dual ACE/NEP inhibitors.
Journal: Bioorganic & medicinal chemistry letters 20090815
Title: Role of mu- and delta-opioid receptors in the nucleus accumbens in cocaine-seeking behavior.
Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20090701
Title: Use of racecadotril as outpatient treatment for acute gastroenteritis: a prospective, randomized, parallel study.
Journal: The Journal of pediatrics 20090701
Title: Colon in acute intestinal infection.
Journal: Journal of pediatric gastroenterology and nutrition 20090401
Title: Angiotensin metabolism in rat stomach wall: prevalence of angiotensin-(1-7) formation.
Journal: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20090301
Title: [Changes in the activity of amyloid-degrading metallopeptidases leads to disruption of memory in rats].
Journal: Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova 20090101
Title: [Systematic review of the efficacy of racecadotril in the treatment of acute diarrhoea].
Journal: Anales de pediatria (Barcelona, Spain : 2003) 20081101
Title: Synergy between natriuretic peptides and phosphodiesterase 5 inhibitors ameliorates pulmonary arterial hypertension.
Journal: American journal of respiratory and critical care medicine 20081015
Title: Thiorphan-induced survival and proliferation of rat thymocytes by activation of Akt/survivin pathway and inhibition of caspase-3 activity.
Journal: The Journal of pharmacology and experimental therapeutics 20081001
Title: Acute infectious diarrhoea in children: new insights in antisecretory treatment with racecadotril.
Journal: Acta paediatrica (Oslo, Norway : 1992) 20080801
Title: The characterization of selected drugs with infrared laser desorption/tunable synchrotron vacuum ultraviolet photoionization mass spectrometry.
Journal: Rapid communications in mass spectrometry : RCM 20080801
Title: Expression of enkephalin-degrading enzymes in human semen and implications for sperm motility.
Journal: Fertility and sterility 20080501
Title: Immunocapture-based fluorometric assay for the measurement of neprilysin-specific enzyme activity in brain tissue homogenates and cerebrospinal fluid.
Journal: Journal of neuroscience methods 20080130
Title: A rapid and validated HPLC method to quantify racecadotril metabolite, thiorphan, in human plasma using solid-phase extraction.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20080101
Title: Changes in A-type natriuretic peptide and its receptors induced by a neutral endopeptidase inhibitor in a rat model of sepsis.
Journal: Surgery today 20080101
Title: Phosphodiesterase-5A and neutral endopeptidase activities in human adipocytes do not control atrial natriuretic peptide-mediated lipolysis.
Journal: British journal of pharmacology 20071201
Title: Metabolic inactivation of the circadian transmitter, pigment dispersing factor (PDF), by neprilysin-like peptidases in Drosophila.
Journal: The Journal of experimental biology 20071201
Title: [Prevention and treatment of acute diarrhea in infants].
Journal: Archives de pediatrie : organe officiel de la Societe francaise de pediatrie 20071101
Title: Characterisation of endothelin converting enzyme-1 shedding from endothelial cells.
Journal: FEBS letters 20070918
Title: Systematic review: racecadotril in the treatment of acute diarrhoea in children.
Journal: Alimentary pharmacology & therapeutics 20070915
Title: Quantitative analysis of racecadotril metabolite in human plasma using a liquid chromatography/tandem mass spectrometry.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070601
Title: Decrease of dehydrogenase activity of cerebral glyceraldehyde-3-phosphate dehydrogenase in different animal models of Alzheimer's disease.
Journal: Biochimica et biophysica acta 20070501
Title: Expression of NEP2, a soluble neprilysin-like endopeptidase, during embryogenesis in Drosophila melanogaster.
Journal: Peptides 20070101
Title: [Study of substrate specificity of a new peptide substrate of endothelin converting enzyme].
Journal: Biomeditsinskaia khimiia 20070101
Title: Inhibition of neutral endopeptidase by thiorphan does not modify coronary vascular responses to angiotensin I, angiotensin II and bradykinin in the isolated guinea pig heart.
Journal: Pharmacological reports : PR 20070101
Title: Thiorphan, a neutral endopeptidase inhibitor used for diarrhoea, is neuroprotective in newborn mice.
Journal: Brain : a journal of neurology 20061201
Title: Structural studies of racecadotril and its process impurities by NMR and mass spectroscopy.
Journal: Die Pharmazie 20061201
Title: P2Y receptor-mediated excitation in the posterior hypothalamus.
Journal: The European journal of neuroscience 20060901
Title: Current status of anti-diarrheal and anti-secretory drugs in the management of acute childhood diarrhea.
Journal: Indian journal of pediatrics 20060801
Title: Hypersensitivity to racecadotril: a case report.
Journal: European journal of pediatrics 20060601
Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.
Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501
Title: Inhibition of neprilysin by infusion of thiorphan into the hippocampus causes an accumulation of amyloid Beta and impairment of learning and memory.
Journal: The Journal of pharmacology and experimental therapeutics 20060401
Title: Inhibition of neprilysin by thiorphan (i.c.v.) causes an accumulation of amyloid beta and impairment of learning and memory.
Journal: Behavioural brain research 20060315
Title: Neprilysin participates in skeletal muscle regeneration and is accumulated in abnormal muscle fibres of inclusion body myositis.
Journal: Journal of neurochemistry 20060201
Title: The effects of substance P on the biomechanic properties of ruptured rat Achilles' tendon.
Journal: Archives of physical medicine and rehabilitation 20060201
Title: Thiorphan, tiopronin, and related analogs as substrates and inhibitors of peptidylglycine alpha-amidating monooxygenase (PAM).
Journal: FEBS letters 20060123
Title: Neutral endopeptidase (EC 3.4.24.11) in cirrhotic liver: a new target to treat portal hypertension?
Journal: Journal of hepatology 20051101
Title: NEP inhibitors enhance C-type natriuretic peptide-induced relaxation in porcine isolated coronary artery.
Journal: Vascular pharmacology 20051001
Title: Exogenously administered substance P and neutral endopeptidase inhibitors stimulate fibroblast proliferation, angiogenesis and collagen organization during Achilles tendon healing.
Journal: Foot & ankle international 20051001
Title: Ascorbic acid decreases neutral endopeptidase activity in cultured osteoblastic cells.
Journal: Regulatory peptides 20050815
Title: Endothelin-1 (1-31) is an intermediate in the production of endothelin-1 after big endothelin-1 administration in vivo.
Journal: Hypertension (Dallas, Tex. : 1979) 20050701
Title: Racecadotril in acute diarrhea.
Journal: Indian pediatrics 20050501
Title: A blind, randomized comparison of racecadotril and loperamide for stopping acute diarrhea in adults.
Journal: World journal of gastroenterology 20050314
Title: Neutral endopeptidase inhibition augments vascular actions of bradykinin in patients treated with angiotensin-converting enzyme inhibition.
Journal: Hypertension (Dallas, Tex. : 1979) 20041201
Title: Racecadotril-is there enough evidence to recommend it for treatment of acute diarrhea?
Journal: Indian pediatrics 20041201
Title: Raacecadotril.
Journal: Indian pediatrics 20041201
Title: Further evidence on the anxiogenic-like effect of substance P evaluated in the elevated plus-maze in rats.
Journal: Behavioural brain research 20041005
Title: Angiotensin II-induced relaxation of anococcygeus smooth muscle via desensitization of AT1 receptor, and activation of AT2 receptor associated with nitric-oxide synthase pathway.
Journal: The Journal of pharmacology and experimental therapeutics 20041001
Title: Chronic morphine treatment reduces recovery from opioid desensitization.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20040901
Title: Cardiac length dependence of force and force redevelopment kinetics with altered cross-bridge cycling.
Journal: Biophysical journal 20040901
Title: The effect of acute angiotensin-converting enzyme and neutral endopeptidase 24.11 inhibition on plasma extravasation in the rat.
Journal: The Journal of pharmacology and experimental therapeutics 20040601
Title: [The new class of drugs-- metalloprotease inhibitors -- in the treatment of heart failure].
Journal: Klinicheskaia meditsina 20040101
Title: Thiorphan-induced neprilysin inhibition raises amyloid beta levels in rabbit cortex and cerebrospinal fluid.
Journal: Neuroscience letters 20031030
Title: Efficacy and tolerability of racecadotril in the treatment of cholera in adults: a double blind, randomised, controlled clinical trial.
Journal: Gut 20031001
Title: Effects of the neutral endopeptidase inhibitor thiorphan on cardiovascular and renal function in cirrhotic rats.
Journal: British journal of pharmacology 20030501
Title: Methionine enkephalin suppresses metabolic activity of a leukemic cell line (NALM-1) and enhances CD10 expression.
Journal: International immunopharmacology 20030501
Title: Thiorphan enhances bradykinin-induced vascular relaxation in hypoxic/hyperkalaemic porcine coronary artery.
Journal: The Journal of pharmacy and pharmacology 20030301
Title: Racecadotril versus loperamide: antidiarrheal research revisited.
Journal: Digestive diseases and sciences 20030201
Title: Effect of neutral endopeptidase inhibition on vascular response induced by exogenous angiotensin I in the isolated rat lung.
Journal: Polish journal of pharmacology 20030101
Title: Pharmacological potentiation of natriuretic peptide limits polymorphonuclear neutrophil-vascular cell interactions.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20021101
Title: Effects of neutral endopeptidase 24.11 inhibition on myocardial infarct size and ischemic preconditioning in rabbits.
Journal: Naunyn-Schmiedeberg's archives of pharmacology 20021001
Title: Hormonal, renal, hemodynamic responses to acute neutral endopeptidase inhibition in heart transplant patients.
Journal: Journal of applied physiology (Bethesda, Md. : 1985) 20020801
Title: Characterization of PgPepO, a bacterial homologue of endothelin-converting enzyme-1.
Journal: Clinical science (London, England : 1979) 20020801
Title: Endothelin-1 (1-31) induces a thiorphan-sensitive release of eicosanoids via ET(B) receptors in the guinea pig perfused lung.
Journal: Clinical science (London, England : 1979) 20020801
Title: [Effect of racecadotril in the management of acute diarrhea in infants and children].
Journal: Archives de pediatrie : organe officiel de la Societe francaise de pediatrie 20020801
Title: Involvement of proteases in the action of IFN-gamma on WISH cells.
Journal: Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 20020801
Title: Racecadotril (acetorphan) in the treatment of acute watery diarrhoea in children.
Journal: Journal of the Indian Medical Association 20020801
Title: Possible involvement of placental peptidases that degrade gonadotropin-releasing hormone (GnRH) in the dynamic pattern of placental hCG secretion via GnRH degradation.
Journal: Placenta 20020701
Title: A multinational comparison of racecadotril and loperamide in the treatment of acute watery diarrhoea in adults.
Journal: Scandinavian journal of gastroenterology 20020601
Title: Strategies for access to enantiomerically pure ecadotril, dexecadotril and fasidotril: a review.
Journal: Mini reviews in medicinal chemistry 20020601
Title: Role of ACE and NEP in bradykinin-induced relaxation and contraction response of isolated porcine basilar artery.
Journal: Naunyn-Schmiedeberg's archives of pharmacology 20020501
Title: Effects of chronic neutral endopeptidase inhibition on the progression of left ventricular dysfunction and remodeling in dogs with moderate heart failure.
Journal: Cardiovascular drugs and therapy 20020501
Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.
Journal: The Journal of biological chemistry 20020419
Title: Intestinal metabolism and absorption of cholecystokinin analogs in rats.
Journal: Biochemical and biophysical research communications 20020405
Title: Beta-amyloid deposition in the brains of rats chronically infused with thiorphan or lipopolysaccharide: the role of ascorbic acid in the vehicle.
Journal: Neuroscience letters 20020405
Title: Toward an optimal joint recognition of the S1' subsites of endothelin converting enzyme-1 (ECE-1), angiotensin converting enzyme (ACE), and neutral endopeptidase (NEP).
Journal: Journal of medicinal chemistry 20020328
Title: Endogenous opioids in dopaminergic cell body regions modulate amphetamine-induced increases in extracellular dopamine levels in the terminal regions.
Journal: The Journal of pharmacology and experimental therapeutics 20020301
Title: Neutral endopeptidase knockout induces hyperalgesia in a model of visceral pain, an effect related to bradykinin and nitric oxide.
Journal: Journal of molecular neuroscience : MN 20020101
Title: Interaction between neuropeptide FF and opioids in the ventral tegmental area in the behavioral response to novelty.
Journal: Neuroscience 20020101
Title: The treatment of acute diarrhea in the third millennium: a pediatrician's perspective.
Journal: Acta gastro-enterologica Belgica 20020101
Title: Neutral endopeptidase inhibition in diabetic wound repair.
Journal: Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 20020101
Title: Soluble recombinant neprilysin induces aggrecanase-mediated cleavage of aggrecan in cartilage explant cultures.
Journal: Archives of biochemistry and biophysics 20011215
Title: [Role of delta opioid receptors and their ligands in the development of adaptive heart protection against arrhythmogenesis].
Journal: Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova 20011201
Title: The neuropeptide FF analogue, 1DMe, acts as a functional opioid autoreceptor antagonist in the rat spinal cord.
Journal: European journal of pharmacology 20011102
Title: A possible role of lipoxygenase in the activation of vanilloid receptors by anandamide in the guinea-pig bronchus.
Journal: British journal of pharmacology 20010901
Title: Effect of neutral endopeptidase inhibition on the actions of adrenomedullin and endothelin-1 in resistance arteries from patients with chronic heart failure.
Journal: Hypertension (Dallas, Tex. : 1979) 20010901
Title: Adrenomedullin (ADM) in the human forearm vascular bed: effect of neutral endopeptidase inhibition and comparison with proadrenomedullin NH2-terminal 20 peptide (PAMP).
Journal: British journal of clinical pharmacology 20010801
Title: Neprilysin degrades both amyloid beta peptides 1-40 and 1-42 most rapidly and efficiently among thiorphan- and phosphoramidon-sensitive endopeptidases.
Journal: The Journal of biological chemistry 20010615
Title: Interactions of human matrix metalloproteinase 7 (matrilysin) with the inhibitors thiorphan and R-94138.
Journal: Journal of biochemistry 20010301
Title: Efficacy and tolerability of racecadotril in acute diarrhea in children.
Journal: Gastroenterology 20010301
Title: [Anti-arrhythmia effects of enkephalinase inhibitors].
Journal: Eksperimental'naia i klinicheskaia farmakologiia 20010101
Title: Characterization of delta-opioid receptors and effect of enkephalins on IRD 98 rat epithelial intestinal cell line.
Journal: Pflugers Archiv : European journal of physiology 20000301
Title: Potent and selective non-peptidic inhibitors of endothelin-converting enzyme-1 with sustained duration of action.
Journal: Journal of medicinal chemistry 20000210
Title: In vitro metabolism of an insect neuropeptide by neural membrane preparations from Lymantria dispar.
Journal: Peptides 19960101
Title: Jurkat T cells express a functional neutral endopeptidase activity (CALLA) involved in T cell activation.
Journal: The EMBO journal 19921101
Title: Effects of acetorphan, an enkephalinase inhibitor, on experimental and acute diarrhoea.
Journal: Gut 19920601
Title: Feedback inhibition of met-enkephalin release from the rat spinal cord in vivo.
Journal: Synapse (New York, N.Y.) 19920501
Title: Effect of resiniferatoxin on the isolated rabbit iris sphincter muscle: comparison with capsaicin and bradykinin.
Journal: European journal of pharmacology 19920324
Title: Opioid control of the in vitro release of cholecystokinin-like material from the rat substantia nigra.
Journal: Journal of neurochemistry 19920301
Title: Inhibition of apomorphine-induced yawning and penile erection by neurotensin.
Journal: Peptides 19910101
Title: Naloxone-reversible antidiarrheal effects of enkephalinase inhibitors.
Journal: European journal of pharmacology 19871201
Title: Pharmacological properties of acetorphan, a parenterally active 'enkephalinase' inhibitor.
Journal: The Journal of pharmacology and experimental therapeutics 19860601
Title: Angiotensin-converting enzyme inhibitors potentiate the analgesic activity of [Met]-enkephalin-Arg6-Phe7 by inhibiting its degradation in mouse brain.
Journal: Molecular pharmacology 19851201
Title: Thiorphan and analogs: lack of correlation between potency to inhibit 'enkephalinase A' in vitro and analgesic potency in vivo.
Journal: The Journal of pharmacology and experimental therapeutics 19850801
