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Title: Synthesis and biological evaluation of quinazoline and quinoline bearing 2,2,6,6-tetramethylpiperidine-N-oxyl as potential epidermal growth factor receptor(EGFR) tyrosine kinase inhibitors and EPR bio-probe agents.
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Title: Structurally powered synergic 2,2,6,6-tetramethylpiperidine bimetallics: new reflections through lithium-mediated ortho aluminations.
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Title: Pure forms of the singlet oxygen sensors TEMP and TEMPD do not inhibit Photosystem II.
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Title: Amination of benzoxazoles and 1,3,4-oxadiazoles using 2,2,6,6-tetramethylpiperidine-N-oxoammonium tetrafluoroborate as an organic oxidant.
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Title: Diisopropylamide and TMP turbo-Grignard reagents: a structural rationale for their contrasting reactivities.
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Title: Novel bis-2,2,6,6-tetramethylpiperidine (bis-TMP) and bis-mecamylamine antagonists at neuronal nicotinic receptors mediating nicotine-evoked dopamine release.
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Title: Hand-held mass spectrometer for environmentally relevant analytes using a variety of sampling and ionization methods.
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Title: 2,2,6,6-Tetra-methyl-piperidinium triisopropoxysilanethiol-ate.
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Title: Using a two-step hydride transfer to achieve 1,4-reduction in the catalytic hydrogenation of an acyl pyridinium cation.
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Title: 2,2,6,6-tetramethylpiperidinogallium as a terminal and bridging ligand in homo- and heteroleptic chromium, nickel, and cobalt complexes.
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Title: Diffusion of 2,2,6,6-tetramethylpiperidine 1-oxyl derivatives of variable hydrophobicity in tropocollagen I solution.
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2,2,6,6-Tetramethylpiperidine serves as a versatile reactant in organic synthesis, offering a wide array of synthetic pathways. Its significance is evident in its role in various transformations, enabling the synthesis of diverse functional groups and compounds. Firstly, it participates in the allylic amination of allylic chlorides, facilitating the synthesis of allylated tertiary amines, a valuable class of compounds in organic chemistry. Additionally, it serves as a precursor in the oxidation reactions to yield hydroxylamines, essential intermediates in organic synthesis, using oxone as an oxidant. Furthermore, 2,2,6,6-Tetramethylpiperidine reacts with heterocyclic thiols in the presence of iodine as an oxidant to afford sulfenamide compounds, expanding its utility in sulfur-containing compound synthesis. Moreover, it enables the N-methylation of amines by reacting with CO2 and phenylsilane, providing a route to N-methylated amines, crucial building blocks in pharmaceutical and chemical industries. Lastly, it participates in three-component Mannich coupling reactions with aldehydes and alkynes to yield propargylamines, demonstrating its role in multi-component coupling reactions. With its diverse applications and synthetic capabilities, 2,2,6,6-Tetramethylpiperidine emerges as a valuable reagent in the toolbox of synthetic chemists for the construction of complex organic molecules.
