Title: New one-pot synthesis of spiro[furo[2,3-d]pyrimidine-6,5'-pyrimidine]pentaones and their sulfur analogues.
Journal: Molecular diversity 20110801
Title: Experimental and computational thermochemical study of barbituric acids: structure-energy relationship in 1,3-dimethylbarbituric acid.
Journal: The journal of physical chemistry. A 20110414
Title: Synthesis of 5-aryl-1,3-dimethyl-6-(alkyl- or aryl-amino) furo [2,3-d]pyrimidine derivatives by reaction between isocyanides and pyridinecarbaldehydes in the presence of 1,3-dimethylbarbituric acid.
Journal: Molecular diversity 20110201
Title: Sequential one-pot bimetallic Ir(III)/Pd(0) catalysed mono-/bis-alkylation and spirocyclisation processes of 1,3-dimethylbarbituric acid and allenes.
Journal: Chemical communications (Cambridge, England) 20061228
Title: Spectrophotometric kinetic and determination of quinones and barbiturates.
Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20011001
1,3-Dimethylbarbituric acid is a versatile compound utilized in various synthetic studies. Firstly, it is employed in the enantioselective synthesis of isochromene pyrimidinedione derivatives, which contain five stereocenters. This synthesis involves a one-pot Michael-Knoevenagel condensation-inverse-electron-demand hetero-Diels-Alder reaction. Additionally, 1,3-Dimethylbarbituric acid is utilized in the synthesis of 5-aryl-6-(alkyl- or aryl-amino)-1,3-dimethylfuro [2,3-d]pyrimidine derivatives. Furthermore, it plays a crucial role in the microwave-promoted indirect functionalization of alcohols through spirocyclization, employing a sequential one-pot Ir(III)/Pd(0) catalyzed process. Overall, 1,3-Dimethylbarbituric acid's multifunctional properties make it a valuable compound in synthetic chemistry, enabling the efficient preparation of diverse organic molecules with intricate structures.
