77145-61-0,MFCD01756430
Catalog No.:AA00G325

77145-61-0 | SR 57227 HYDROCHLORIDE

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5mg
≥98%
in stock  
$122.00   $85.00
- +
10mg
≥98%
in stock  
$218.00   $152.00
- +
25mg
≥98%
in stock  
$482.00   $337.00
- +
100mg
95%
in stock  
$570.00   $399.00
- +
250mg
95%
in stock  
$887.00   $621.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA00G325
Chemical Name:
SR 57227 HYDROCHLORIDE
CAS Number:
77145-61-0
Molecular Formula:
C10H15Cl2N3
Molecular Weight:
248.1522
MDL Number:
MFCD01756430
SMILES:
NC1CCN(CC1)c1cccc(n1)Cl.Cl
Properties
Computed Properties
 
Complexity:
180  
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
15  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0  
Rotatable Bond Count:
1  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  

Literature

Title: Transient expression of functional serotonin 5-HT3 receptors by glutamatergic granule cells in the early postnatal mouse cerebellum.

Journal: The Journal of physiology 20111015

Title: Spinal 5-HT(3) receptor activation induces behavioral hypersensitivity via a neuronal-glial-neuronal signaling cascade.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20110907

Title: The pyramidal neurons in the medial prefrontal cortex show decreased response to 5-hydroxytryptamine-3 receptor stimulation in a rodent model of Parkinson's disease.

Journal: Brain research 20110412

Title: In vivo modulation of the firing activity of putative slow- and fast-spiking interneurons in the medial prefrontal cortex by 5-HT3 receptors in 6-hydroxydopamine-induced Parkinsonian rats.

Journal: Neuroscience 20100901

Title: Roles of serotonin 5-HT3 receptor in the formation of dendrites and axons in the rat cerebral cortex: an in vitro study.

Journal: Neuroscience research 20100101

Title: Seizure susceptibility alteration through 5-HT(3) receptor: modulation by nitric oxide.

Journal: Seizure 20100101

Title: Individual differences in the sensitivity to serotonergic drugs: a pharmacobehavioural approach using rats selected on the basis of their response to novelty.

Journal: Psychopharmacology 20090801

Title: Involvement of 5-HT receptors in the development and expression of methamphetamine-induced behavioral sensitization: 5-HT receptor channel and binding study.

Journal: Journal of neurochemistry 20061101

Title: Mode of action of gingerols and shogaols on 5-HT3 receptors: binding studies, cation uptake by the receptor channel and contraction of isolated guinea-pig ileum.

Journal: European journal of pharmacology 20060113

Title: Ionotropic 5-HT3 receptor agonist-induced motor responses in the hindlimbs of paraplegic mice.

Journal: Journal of neurophysiology 20051101

Title: Discriminative stimulus effects of 5.6 mg/kg pregnanolone in DBA/2J and C57BL/6J inbred mice.

Journal: Alcohol (Fayetteville, N.Y.) 20050801

Title: DARPP-32 mediates serotonergic neurotransmission in the forebrain.

Journal: Proceedings of the National Academy of Sciences of the United States of America 20020305

Title: Effects of the selective activation of 5-HT3 receptors on sleep: a polysomnographic study in healthy volunteers.

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20010801

Title: 5-HT3-like receptors in the rat medial prefrontal cortex: further pharmacological characterization.

Journal: Brain research 19960909

Title: Poncelet M, et al, Le Fur G. Antidepressant-like effects of SR 57227A, a 5-HT3 receptor agonist, in rodents. J Neural Transm Gen Sect. 1995;102(2):83‐90.

Title: Bachy A, et al. SR 57227A: a potent and selective agonist at central and peripheral 5-HT3 receptors in vitro and in vivo. Eur J Pharmacol. 1993;237(2-3):299‐309.

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Tags:77145-61-0 Molecular Formula|77145-61-0 MDL|77145-61-0 SMILES|77145-61-0 SR 57227 HYDROCHLORIDE
Catalog No.: AA00G325
77145-61-0,MFCD01756430
77145-61-0 | SR 57227 HYDROCHLORIDE
Pack Size: 5mg
Purity: ≥98%
in stock
$122.00 $85.00
Pack Size: 10mg
Purity: ≥98%
in stock
$218.00 $152.00
Pack Size: 25mg
Purity: ≥98%
in stock
$482.00 $337.00
Pack Size: 100mg
Purity: 95%
in stock
$570.00 $399.00
Pack Size: 250mg
Purity: 95%
in stock
$887.00 $621.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA00G325
Chemical Name: SR 57227 HYDROCHLORIDE
CAS Number: 77145-61-0
Molecular Formula: C10H15Cl2N3
Molecular Weight: 248.1522
MDL Number: MFCD01756430
SMILES: NC1CCN(CC1)c1cccc(n1)Cl.Cl
Properties
Complexity: 180  
Covalently-Bonded Unit Count: 2  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 15  
Hydrogen Bond Acceptor Count: 3  
Hydrogen Bond Donor Count: 2  
Isotope Atom Count: 0  
Rotatable Bond Count: 1  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
Literature fold

Title: Transient expression of functional serotonin 5-HT3 receptors by glutamatergic granule cells in the early postnatal mouse cerebellum.

Journal: The Journal of physiology20111015

Title: Spinal 5-HT(3) receptor activation induces behavioral hypersensitivity via a neuronal-glial-neuronal signaling cascade.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience20110907

Title: The pyramidal neurons in the medial prefrontal cortex show decreased response to 5-hydroxytryptamine-3 receptor stimulation in a rodent model of Parkinson's disease.

Journal: Brain research20110412

Title: In vivo modulation of the firing activity of putative slow- and fast-spiking interneurons in the medial prefrontal cortex by 5-HT3 receptors in 6-hydroxydopamine-induced Parkinsonian rats.

Journal: Neuroscience20100901

Title: Roles of serotonin 5-HT3 receptor in the formation of dendrites and axons in the rat cerebral cortex: an in vitro study.

Journal: Neuroscience research20100101

Title: Seizure susceptibility alteration through 5-HT(3) receptor: modulation by nitric oxide.

Journal: Seizure20100101

Title: Individual differences in the sensitivity to serotonergic drugs: a pharmacobehavioural approach using rats selected on the basis of their response to novelty.

Journal: Psychopharmacology20090801

Title: Involvement of 5-HT receptors in the development and expression of methamphetamine-induced behavioral sensitization: 5-HT receptor channel and binding study.

Journal: Journal of neurochemistry20061101

Title: Mode of action of gingerols and shogaols on 5-HT3 receptors: binding studies, cation uptake by the receptor channel and contraction of isolated guinea-pig ileum.

Journal: European journal of pharmacology20060113

Title: Ionotropic 5-HT3 receptor agonist-induced motor responses in the hindlimbs of paraplegic mice.

Journal: Journal of neurophysiology20051101

Title: Discriminative stimulus effects of 5.6 mg/kg pregnanolone in DBA/2J and C57BL/6J inbred mice.

Journal: Alcohol (Fayetteville, N.Y.)20050801

Title: DARPP-32 mediates serotonergic neurotransmission in the forebrain.

Journal: Proceedings of the National Academy of Sciences of the United States of America20020305

Title: Effects of the selective activation of 5-HT3 receptors on sleep: a polysomnographic study in healthy volunteers.

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology20010801

Title: 5-HT3-like receptors in the rat medial prefrontal cortex: further pharmacological characterization.

Journal: Brain research19960909

Title: Poncelet M, et al, Le Fur G. Antidepressant-like effects of SR 57227A, a 5-HT3 receptor agonist, in rodents. J Neural Transm Gen Sect. 1995;102(2):83‐90.

Title: Bachy A, et al. SR 57227A: a potent and selective agonist at central and peripheral 5-HT3 receptors in vitro and in vivo. Eur J Pharmacol. 1993;237(2-3):299‐309.

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