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Title: Androgen receptor and heterogeneous nuclear ribonucleoprotein K colocalize in the nucleoplasm and are modulated by bicalutamide and 4-hydroxy-tamoxifen in prostatic cancer cell lines.
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Title: Effects of myricetin, an anticancer compound, on the bioavailability and pharmacokinetics of tamoxifen and its main metabolite, 4-hydroxytamoxifen, in rats.
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Title: A ΔRaf1-ER-inducible oncogenic zebrafish liver cell model identifies hepatocellular carcinoma signatures.
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Title: Locating the binding sites of anticancer tamoxifen and its metabolites 4-hydroxytamoxifen and endoxifen on bovine serum albumin.
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Title: Validation of MdmX as a therapeutic target for reactivating p53 in tumors.
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Title: Prolylcarboxypeptidase regulates proliferation, autophagy, and resistance to 4-hydroxytamoxifen-induced cytotoxicity in estrogen receptor-positive breast cancer cells.
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Title: A modulated empirical Bayes model for identifying topological and temporal estrogen receptor α regulatory networks in breast cancer.
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Title: A noncompetitive small molecule inhibitor of estrogen-regulated gene expression and breast cancer cell growth that enhances proteasome-dependent degradation of estrogen receptor {alpha}.
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Title: Tamoxifen-loaded folate-conjugate poly[(p-nitrophenyl acrylate)-co-(N-isopropylacrylamide)] sub-microgel as antitumoral drug delivery system.
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Title: Tamoxifen decreases ovarian follicular loss from experimental toxicant DMBA and chemotherapy agents cyclophosphamide and doxorubicin in the rat.
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Title: Development and validation of a test for environmental estrogens: Checking xeno-estrogen activity by CXCL12 secretion in BREAST CANCER CELL LINES (CXCL-test).
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Title: Effects of tamoxifen and ethynylestradiol cotreatment on uterine gene expression in immature, ovariectomized mice.
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Title: Targeting the receptor tyrosine kinase RET sensitizes breast cancer cells to tamoxifen treatment and reveals a role for RET in endocrine resistance.
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Title: A ferrocenyl derivative of hydroxytamoxifen elicits an estrogen receptor-independent mechanism of action in breast cancer cell lines.
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Title: Estradiol-induced proliferation of papillary and follicular thyroid cancer cells is mediated by estrogen receptors alpha and beta.
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Title: Sex differences in estrogen receptor subcellular location and activity in lung adenocarcinoma cells.
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Title: Estrogen receptor-alpha-interacting cytokeratins potentiate the antiestrogenic activity of fulvestrant.
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Title: Association between CYP2D6 *10 genotype and survival of breast cancer patients receiving tamoxifen treatment.
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Title: A phase II trial of Afimoxifene (4-hydroxytamoxifen gel) for cyclical mastalgia in premenopausal women.
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Title: Regulation of intracellular calcium release and PP1alpha in a mechanism for 4-hydroxytamoxifen-induced cytotoxicity.
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Title: Glucuronidation of active tamoxifen metabolites by the human UDP glucuronosyltransferases.
Journal: Drug metabolism and disposition: the biological fate of chemicals20071101
Title: Target specific virtual screening: optimization of an estrogen receptor screening platform.
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Title: Tamoxifen induction of CCAAT enhancer-binding protein alpha is required for tamoxifen-induced apoptosis.
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Title: Synergistic cytotoxicity between tamoxifen and the plant toxin persin in human breast cancer cells is dependent on Bim expression and mediated by modulation of ceramide metabolism.
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Title: Changes in expression of steroid receptors, their downstream target genes and their associated co-regulators during the sequential acquisition of tamoxifen resistance in vitro.
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Title: Downregulation of retinoblastoma protein is involved in the enhanced cytotoxicity of 4-hydroxytamoxifen plus mifepristone combination therapy versus antiestrogen monotherapy of human breast cancer.
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Title: Effects of estradiol and 4-hydroxytamoxifen on the conformation, thermal stability, and DNA recognition of estrogen receptor beta.
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Journal: Genes, chromosomes & cancer20060801
Title: Endoxifen, a secondary metabolite of tamoxifen, and 4-OH-tamoxifen induce similar changes in global gene expression patterns in MCF-7 breast cancer cells.
Journal: The Journal of pharmacology and experimental therapeutics20060801
Title: Downregulation of the PI3K/Akt survival pathway in cells with deregulated expression of c-Myc.
Journal: Apoptosis : an international journal on programmed cell death20060801
Title: Comparison of effects of 4-hydroxy tamoxifen and trilostane on oestrogen-regulated gene expression in MCF-7 cells: up-regulation of oestrogen receptor beta.
Journal: The Journal of steroid biochemistry and molecular biology20060801
Title: [Inhibitory effect of carbamazepine on proliferation of estrogen-dependent breast cancer cells].
Journal: Ai zheng = Aizheng = Chinese journal of cancer20060801
Title: Control of transcription factor activity and osteoblast differentiation in mammalian cells using an evolved small-molecule-dependent intein.
Journal: Journal of the American Chemical Society20060712
Title: Frequency distribution of phenol sulfotransferase 1A1 activity in platelet cells from healthy Japanese subjects.
Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences20060701
Title: Three-dimensional models of non-steroidal ligands: a comparative molecular field analysis.
Journal: Steroids20060601
Title: Functional screen for genes responsible for tamoxifen resistance in human breast cancer cells.
Journal: Molecular cancer research : MCR20060601
Title: N-terminal region of CCAAT/enhancer-binding protein epsilon is critical for cell cycle arrest, apoptosis, and functional maturation during myeloid differentiation.
Journal: The Journal of biological chemistry20060519
Title: Activation of Akt signaling is sufficient to maintain pluripotency in mouse and primate embryonic stem cells.
Journal: Oncogene20060504
Title: Characterization of melanocyte-specific inducible Cre recombinase transgenic mice.
Journal: Genesis (New York, N.Y. : 2000)20060501
Title: Enhanced bioavailability of tamoxifen after oral administration of tamoxifen with quercetin in rats.
Journal: International journal of pharmaceutics20060426
Title: An inducible mouse model of melanoma expressing a defined tumor antigen.
Journal: Cancer research20060315
Title: Estrogen and tamoxifen induce cytoskeletal remodeling and migration in endometrial cancer cells.
Journal: Endocrinology20060301
Title: Sulfation of raloxifene and 4-hydroxytamoxifen by human cytosolic sulfotransferases.
Journal: Drug metabolism and disposition: the biological fate of chemicals20060301
Title: Antiestrogenically active 2-benzyl-1,1-diarylbut-2-enes: synthesis, structure-activity relationships and molecular modeling study for flexible estrogen receptor antagonists.
Journal: Medicinal chemistry (Shariqah (United Arab Emirates))20060301
Title: Different effects of estradiol and various antiestrogens on TNF-alpha-induced changes of biochemical markers for growth and invasion of human breast cancer cells.
Journal: Life sciences20060223
Title: Structure-guided synthesis of tamoxifen analogs with improved selectivity for the orphan ERRgamma.
Journal: Bioorganic & medicinal chemistry letters20060215
Title: Targeting cyclin D1, a downstream effector of INI1/hSNF5, in rhabdoid tumors.
Journal: Oncogene20060202
Title: Local Cre-mediated gene recombination in vascular smooth muscle cells in mice.
Journal: Transgenic research20060201
Title: [Effects of exogenous ER beta expression on the cell growth properties of MCF-7 breast cancer cell line].
Journal: Zhonghua zhong liu za zhi [Chinese journal of oncology]20060201
Title: Ductal access for prevention and therapy of mammary tumors.
Journal: Cancer research20060115
Title: Tamoxifen-regulated adenoviral E1A chimeras for the control of tumor selective oncolytic adenovirus replication in vitro and in vivo.
Journal: Gene therapy20060101
Title: Viral-mediated temporally controlled dopamine production in a rat model of Parkinson disease.
Journal: Molecular therapy : the journal of the American Society of Gene Therapy20060101
Title: Targeted mutation of key residues at the start of helix 12 in the hERalpha ligand-binding domain identifies the role of hydrogen-bonding and hydrophobic interactions in the activity of the protein.
Journal: The Journal of steroid biochemistry and molecular biology20060101
Title: Induction of PPARbeta and prostacyclin (PGI2) synthesis by Raf signaling: failure of PGI2 to activate PPARbeta.
Journal: The FEBS journal20060101
Title: Additive growth inhibitory effects of ibandronate and antiestrogens in estrogen receptor-positive breast cancer cell lines.
Journal: Breast cancer research : BCR20060101
Title: Conditional regulation of a ROCK-estrogen receptor fusion protein.
Journal: Methods in enzymology20060101
Title: AIB1 gene amplification and the instability of polyQ encoding sequence in breast cancer cell lines.
Journal: BMC cancer20060101
Title: Tamoxifen-based probes for the study of estrogen receptor-mediated transcription.
Journal: Ernst Schering Research Foundation workshop20060101
Title: Keratinocyte growth factor (KGF) induces tamoxifen (Tam) resistance in human breast cancer MCF-7 cells.
Journal: Anticancer research20060101
Title: A role for plakophilin-1 in the initiation of desmosome assembly.
Journal: Journal of cellular biochemistry20051001
Title: Analogs of GnRH-I and GnRH-II inhibit epidermal growth factor-induced signal transduction and resensitize resistant human breast cancer cells to 4OH-tamoxifen.
Journal: European journal of endocrinology20051001
Title: Activity of estradiol and selective estrogen receptor modulators in the mouse N20.1 oligodendrocyte/astrocytes cell line.
Journal: Neuro endocrinology letters20051001
Title: PKB/Akt induces transcription of enzymes involved in cholesterol and fatty acid biosynthesis via activation of SREBP.
Journal: Oncogene20050929
Title: Light activated recombination.
Journal: Journal of the American Chemical Society20050928
Title: Diffusion-time distribution analysis reveals characteristic ligand-dependent interaction patterns of nuclear receptors in living cells.
Journal: Biochemistry20050906
Title: HIV-1 Nef regulates the release of superoxide anions from human macrophages.
Journal: The Biochemical journal20050901
Title: Modulating the strength of cadherin adhesion: evidence for a novel adhesion complex.
Journal: Journal of cell science20050901
Title: Chronic activation of protein kinase Bbeta/Akt2 leads to multinucleation and cell fusion in human epithelial kidney cells: events associated with tumorigenesis.
Journal: Oncogene20050818
Title: Involvement of HP1alpha protein in irreversible transcriptional inactivation by antiestrogens in breast cancer cells.
Journal: FEBS letters20050815
Title: Stem cell depletion through epidermal deletion of Rac1.
Journal: Science (New York, N.Y.)20050805
Title: Regulatory and necrotic volume increase in boar spermatozoa.
Journal: Journal of cellular physiology20050801
Title: Modulation of mitochondrial Ca(2+) uptake by estrogen receptor agonists and antagonists.
Journal: British journal of pharmacology20050801
Title: Selenium disrupts estrogen receptor (alpha) signaling and potentiates tamoxifen antagonism in endometrial cancer cells and tamoxifen-resistant breast cancer cells.
Journal: Molecular cancer therapeutics20050801
Title: Identification and quantification of tamoxifen and four metabolites in serum by liquid chromatography-tandem mass spectrometry.
Journal: Journal of chromatography. A20050729
Title: A novel method for generation of signature networks as biomarkers from complex high throughput data.
Journal: Toxicology letters20050728
Title: Temporal dissection of p53 function in vitro and in vivo.
Journal: Nature genetics20050701
Title: Beta-catenin and Hedgehog signal strength can specify number and location of hair follicles in adult epidermis without recruitment of bulge stem cells.
Journal: Developmental cell20050701
Title: Inactivation of Myc in murine two-hit B lymphomas causes dormancy with elevated levels of interleukin 10 receptor and CD20: implications for adjuvant therapies.
Journal: Cancer research20050615
Title: Estrogen receptor alpha and beta heterodimers exert unique effects on estrogen- and tamoxifen-dependent gene expression in human U2OS osteosarcoma cells.
Journal: Molecular endocrinology (Baltimore, Md.)20050601
Title: Dose-dependent effects of 4-hydroxytamoxifen, the active metabolite of tamoxifen, on estrogen receptor-alpha expression in the rat uterus.
Journal: Anti-cancer drugs20050601
Title: Ectopic expression of c-Myc in the skin affects the hair growth cycle and causes an enlargement of the sebaceous gland.
Journal: The British journal of dermatology20050601
Title: Estradiol activates group I and II metabotropic glutamate receptor signaling, leading to opposing influences on cAMP response element-binding protein.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience20050518
Title: Endoxifen (4-hydroxy-N-desmethyl-tamoxifen) has anti-estrogenic effects in breast cancer cells with potency similar to 4-hydroxy-tamoxifen.
Journal: Cancer chemotherapy and pharmacology20050501
Title: Neoadjuvant percutaneous 4-hydroxytamoxifen decreases breast tumoral cell proliferation: a prospective controlled randomized study comparing three doses of 4-hydroxytamoxifen gel to oral tamoxifen.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology20050501
Title: Protein farnesyltransferase in embryogenesis, adult homeostasis, and tumor development.
Journal: Cancer cell20050401
Title: Tamoxifen pharmacogenetics moves closer to reality.
Journal: Journal of the National Cancer Institute20050316
Title: 4-Hydroxytamoxifen inhibits proliferation of multiple myeloma cells in vitro through down-regulation of c-Myc, up-regulation of p27Kip1, and modulation of Bcl-2 family members.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research20050315
Title: Resveratrol and estradiol rapidly activate MAPK signaling through estrogen receptors alpha and beta in endothelial cells.
Journal: The Journal of biological chemistry20050304
Title: The Src kinase pathway promotes tamoxifen agonist action in Ishikawa endometrial cells through phosphorylation-dependent stabilization of estrogen receptor (alpha) promoter interaction and elevated steroid receptor coactivator 1 activity.
Journal: Molecular endocrinology (Baltimore, Md.)20050301
Title: Select forms of tumor cell apoptosis induce dendritic cell maturation.
Journal: Journal of leukocyte biology20050301
Title: Effects of prolonged tamoxifen treatment on receptor expression and apoptosis of ovarian cancer cells.
Journal: Gynecologic oncology20050301
Title: Role of the proteasome in the regulation of estrogen receptor alpha turnover and function in MCF-7 breast carcinoma cells.
Journal: The Journal of steroid biochemistry and molecular biology20050301
Title: Reversible switching of immunoglobulin hypermutation machinery in a chicken B cell line.
Journal: Biochemical and biophysical research communications20050204
Title: Functional analysis of the effect of forced activation of STAT3 on M1 mouse leukemia cells.
Journal: International journal of molecular medicine20050201
Title: Innovative drug delivery nanosystems improve the anti-tumor activity in vitro and in vivo of anti-estrogens in human breast cancer and multiple myeloma.
Journal: The Journal of steroid biochemistry and molecular biology20050201
Title: A novel pesticide-induced conformational state of the oestrogen receptor ligand-binding domain, detected by conformation-specific peptide binding.
Journal: FEBS letters20050117
Title: Polymorphisms in cytochrome P4503A5 (CYP3A5) may be associated with race and tumor characteristics, but not metabolism and side effects of tamoxifen in breast cancer patients.
Journal: Cancer letters20050110
Title: The effects of progesterone, medroxyprogesterone acetate, and norethisterone on growth factor- and estradiol-treated human cancerous and noncancerous breast cells.
Journal: Menopause (New York, N.Y.)20050101
Title: Use of dong quai (Angelica sinensis) to treat peri- or postmenopausal symptoms in women with breast cancer: is it appropriate?
Journal: Menopause (New York, N.Y.)20050101
Title: 4-OH tamoxifen does not interfere with bicalutamide inhibitory effects on human prostatic cancer cells in vitro.
Journal: Anticancer research20050101
Title: Excretion of hydroxylated metabolites of tamoxifen in human bile and urine.
Journal: Anticancer research20050101
Title: Oligomerization is required for HIV-1 Nef-induced activation of the Src family protein-tyrosine kinase, Hck.
Journal: Biochemistry20041221
Title: Antiestrogen binding site and estrogen receptor mediate uptake and distribution of 4-hydroxytamoxifen-targeted doxorubicin-formaldehyde conjugate in breast cancer cells.
Journal: Journal of medicinal chemistry20041216
Title: Specific deletion of focal adhesion kinase suppresses tumor formation and blocks malignant progression.
Journal: Genes & development20041215
Title: Conditional ROCK activation in vivo induces tumor cell dissemination and angiogenesis.
Journal: Cancer research20041215
Title: Induction of apoptosis in human prostate stromal cells by 4-hydroxytamoxifen: an alternative therapy for benign prostate hyperplasia.
Journal: World journal of urology20041201
Title: Transgenic mice expressing a ligand-inducible cre recombinase in osteoblasts and odontoblasts: a new tool to examine physiology and disease of postnatal bone and tooth.
Journal: The American journal of pathology20041201
Title: All trans-retinoic acid acts synergistically with hydroxytamoxifen and transforming-growth factor beta to stimulate apoptosis in MCF-7 breast cancer cells.
Journal: The Journal of endocrinology20041101
Title: SRA coactivation of estrogen receptor-alpha is phosphorylation-independent, and enhances 4-hydroxytamoxifen agonist activity.
Journal: Biochemical and biophysical research communications20041008
Title: Interactions of tamoxifen, N-desmethyltamoxifen and 4-hydroxytamoxifen with P-glycoprotein and CYP3A.
Journal: Biopharmaceutics & drug disposition20041001
Title: Liposomal 4-hydroxy-tamoxifen: effect on cellular uptake and resulting cytotoxicity in drug resistant breast cancer cells in vitro.
Journal: Breast cancer research and treatment20041001
Title: c-Myc interacts with hypoxia to induce angiogenesis in vivo by a vascular endothelial growth factor-dependent mechanism.
Journal: Cancer research20040915
Title: Mek1 alters epidermal growth and differentiation.
Journal: Cancer research20040901
Title: Transient activation of FOXN1 in keratinocytes induces a transcriptional programme that promotes terminal differentiation: contrasting roles of FOXN1 and Akt.
Journal: Journal of cell science20040815
Title: Structural basis for the deactivation of the estrogen-related receptor gamma by diethylstilbestrol or 4-hydroxytamoxifen and determinants of selectivity.
Journal: The Journal of biological chemistry20040806
Title: A genetic, non-transcriptional assay for nuclear receptor ligand binding in yeast.
Journal: Gene20040804
Title: Ambiguity of estrogen receptor antagonists: good guys don't always wear white hats... or do they?
Journal: Experimental neurology20040801
Title: Impact of the selective estrogen receptor modulator, tamoxifen, on neuronal outgrowth and survival following toxic insults associated with aging and Alzheimer's disease.
Journal: Experimental neurology20040801
Title: Mifepristone induces growth arrest, caspase activation, and apoptosis of estrogen receptor-expressing, antiestrogen-resistant breast cancer cells.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research20040801
Title: Antiestrogens induce growth inhibition by sequential activation of p38 mitogen-activated protein kinase and transforming growth factor-beta pathways in human breast cancer cells.
Journal: Molecular endocrinology (Baltimore, Md.)20040701
Title: Roles for c-Myc in self-renewal of hematopoietic stem cells.
Journal: The Journal of biological chemistry20040611
Title: BRG1/BRM and prohibitin are required for growth suppression by estrogen antagonists.
Journal: The EMBO journal20040602
Title: Re: Active tamoxifen metabolite plasma concentrations after coadministration of tamoxifen and the selective serotonin reuptake inhibitor paroxetine.
Journal: Journal of the National Cancer Institute20040602
Title: Human epidermal growth factor receptor 2 status modulates subcellular localization of and interaction with estrogen receptor alpha in breast cancer cells.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research20040601
Title: Association of tamoxifen (TAM) and TAM metabolite concentrations with self-reported side effects of TAM in women with breast cancer.
Journal: Breast cancer research and treatment20040501
Title: ERK1/2 and p38 cooperate to induce a p21CIP1-dependent G1 cell cycle arrest.
Journal: Oncogene20040422
Title: Recruitment of distinct chromatin-modifying complexes by tamoxifen-complexed estrogen receptor at natural target gene promoters in vivo.
Journal: The Journal of biological chemistry20040409
Title: Ability of the activated PI3K/Akt oncoproteins to synergize with MEK1 and induce cell cycle progression and abrogate the cytokine-dependence of hematopoietic cells.
Journal: Cell cycle (Georgetown, Tex.)20040401
Title: Re-expression of estrogen receptor alpha using a tetracycline-regulated gene expression system induced estrogen-mediated growth inhibition of the MDA-MB-231 breast cancer cell line.
Journal: Biochemistry and cell biology = Biochimie et biologie cellulaire20040401
Title: Histone deacetylase inhibition and estrogen receptor alpha levels modulate the transcriptional activity of partial antiestrogens.
Journal: Journal of molecular endocrinology20040401
Title: Tamoxifen and metabolite concentrations in serum and breast cancer tissue during three dose regimens in a randomized preoperative trial.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research20040401
Title: Bystander elimination of antigen loss variants in established tumors.
Journal: Nature medicine20040301
Title: Recovering the true targets of specific ligands by virtual screening of the protein data bank.
Journal: Proteins20040301
Title: Interplay between estrogen response element sequence and ligands controls in vivo binding of estrogen receptor to regulated genes.
Journal: The Journal of biological chemistry20040206
Title: Identification of estrogen-responsive genes by complementary deoxyribonucleic acid microarray and characterization of a novel early estrogen-induced gene: EEIG1.
Journal: Molecular endocrinology (Baltimore, Md.)20040201
Title: Estrogen receptor-alpha interaction with the CREB binding protein coactivator is regulated by the cellular environment.
Journal: Journal of molecular endocrinology20040201
Title: Large interindividual variability in the in vitro formation of tamoxifen metabolites related to the development of genotoxicity.
Journal: British journal of clinical pharmacology20040101
Title: Differential recruitment of coregulator proteins steroid receptor coactivator-1 and silencing mediator for retinoid and thyroid receptors to the estrogen receptor-estrogen response element by beta-estradiol and 4-hydroxytamoxifen in human breast cancer.
Journal: The Journal of clinical endocrinology and metabolism20040101
Title: Functional role of connexin43 gap junction channels in adult mouse heart assessed by inducible gene deletion.
Journal: Journal of molecular and cellular cardiology20040101
Title: Lentivectors for regulated and reversible cutaneous gene delivery.
Journal: Molecular therapy : the journal of the American Society of Gene Therapy20040101
Title: Biotransformation of tamoxifen in a human endometrial explant culture model.
Journal: Chemico-biological interactions20031215
Title: A hot flash on tamoxifen metabolism.
Journal: Journal of the National Cancer Institute20031203
Title: Active tamoxifen metabolite plasma concentrations after coadministration of tamoxifen and the selective serotonin reuptake inhibitor paroxetine.
Journal: Journal of the National Cancer Institute20031203
Title: 4-Hydroxytamoxifen attenuates methamphetamine-induced nigrostriatal dopaminergic toxicity in intact and gonadetomized mice.
Journal: Journal of neurochemistry20031201
Title: The selective estrogen receptor modulator 4-hydroxy tamoxifen induces G1 arrest and apoptosis of multiple myeloma cell lines.
Journal: Annals of the New York Academy of Sciences20031201
Title: Simple and efficient production of (Z)-4-hydroxytamoxifen, a potent estrogen receptor modulator.
Journal: The Journal of organic chemistry20031128
Title: The antiepidermal growth factor receptor agent gefitinib (ZD1839/Iressa) improves antihormone response and prevents development of resistance in breast cancer in vitro.
Journal: Endocrinology20031101
Title: Tamoxifen might influence the affinity of LPL for heparin-sepharose.
Journal: Clinica chimica acta; international journal of clinical chemistry20031101
Title: Pharmacologic activation of p53 elicits Bax-dependent apoptosis in the absence of transcription.
Journal: Cancer cell20031101
Title: Various phosphorylation pathways, depending on agonist and antagonist binding to endogenous estrogen receptor alpha (ERalpha), differentially affect ERalpha extractability, proteasome-mediated stability, and transcriptional activity in human breast cancer cells.
Journal: Molecular endocrinology (Baltimore, Md.)20031001
Title: Stable transfection of an estrogen receptor beta cDNA isoform into MDA-MB-231 breast cancer cells.
Journal: The Journal of steroid biochemistry and molecular biology20031001
Title: Structure activity relationship studies on C2 side chain substituted 1,1-bis(4-methoxyphenyl)-2-phenylalkenes and 1,1,2-tris(4-methoxyphenyl)alkenes.
Journal: The Journal of steroid biochemistry and molecular biology20031001
Title: MafA has strong cell transforming ability but is a weak transactivator.
Journal: Oncogene20030911
Title: Alpha-hydroxylation of tamoxifen and toremifene by human and rat cytochrome P450 3A subfamily enzymes.
Journal: Chemical research in toxicology20030901
Title: Estrogen-mediated down-regulation of E-cadherin in breast cancer cells.
Journal: Cancer research20030901
Title: Induction of antiproliferation and apoptosis in estrogen receptor negative MDA-231 human breast cancer cells by mifepristone and 4-hydroxytamoxifen combination therapy: a role for TGFbeta1.
Journal: International journal of oncology20030801
Title: Oestrogens and selective oestrogen receptor (ER) modulators regulate EGF receptor gene expression through human ER alpha and beta subtypes via an Sp1 site.
Journal: Oncogene20030731
Title: Mutation of Leu-536 in human estrogen receptor-alpha alters the coupling between ligand binding, transcription activation, and receptor conformation.
Journal: The Journal of biological chemistry20030718
Title: Full activation of estrogen receptor alpha activation function-1 induces proliferation of breast cancer cells.
Journal: The Journal of biological chemistry20030718
Title: Antiestrogens are pro-apoptotic in normal human breast epithelial cells.
Journal: International journal of cancer20030710
Title: Potentiation of human estrogen receptor alpha-mediated gene expression by steroid receptor coactivator-1 (SRC-1) in Saccharomyces cerevisiae.
Journal: The Journal of steroid biochemistry and molecular biology20030701
Title: Identification of estrogen receptor beta expression in Chinese hamster ovary (CHO) cells and comparison of estrogen-responsive gene transcription in cells adapted to serum-free media.
Journal: The Journal of steroid biochemistry and molecular biology20030701
Title: A triple mutant of the Drosophila ERR confers ligand-induced suppression of activity.
Journal: Biochemistry20030603
Title: c-Myc induces cytochrome c release in Rat1 fibroblasts by increasing outer mitochondrial membrane permeability in a Bid-dependent manner.
Journal: Cell death and differentiation20030501
Title: Isoform-selective interactions between estrogen receptors and steroid receptor coactivators promoted by estradiol and ErbB-2 signaling in living cells.
Journal: Molecular endocrinology (Baltimore, Md.)20030401
Title: Estrogenic activity in white and red wine extracts.
Journal: Journal of agricultural and food chemistry20030326
Title: 4-ethoxymethylphenol: a novel phytoestrogen that acts as an agonist for human estrogen receptors.
Journal: The Journal of steroid biochemistry and molecular biology20030301
Title: The phosphatidylinositol 3-kinase inhibitor LY294002 binds the estrogen receptor and inhibits 17beta-estradiol-induced transcriptional activity of an estrogen sensitive reporter gene.
Journal: Molecular and cellular endocrinology20030227
Title: Tamoxifen functions as a molecular agonist inducing cell cycle-associated genes in breast cancer cells.
Journal: Molecular cancer research : MCR20030201
Title: Tamoxifen administration and metabolism in nude mice and nude rats.
Journal: The Journal of steroid biochemistry and molecular biology20030201
Title: Inducible activation of Ras and Raf in adult epidermis.
Journal: Cancer research20030115
Title: Nongenomic activity and subsequent c-fos induction by estrogen receptor ligands are not sufficient to promote deoxyribonucleic acid synthesis in human endometrial adenocarcinoma cells.
Journal: Endocrinology20030101
Title: Selective estrogen receptor modulators regulate phasic activation of hippocampal CA1 pyramidal cells by estrogen.
Journal: Endocrinology20030101
Title: 17 beta-estradiol- and 4-hydroxytamoxifen-induced transactivation in breast, endometrial and liver cancer cells is dependent on ER-subtype, cell and promoter context.
Journal: The Journal of steroid biochemistry and molecular biology20030101
Title: mRNA expression of the type I growth factor receptors in the human breast cancer cells MCF-7: regulation by estradiol and tamoxifen.
Journal: Anticancer research20030101
Title: Novel fluorescence based receptor binding assay method for receptors lacking ligand conjugates with preserved affinity: study on estrogen receptor alpha.
Journal: Biopolymers20030101
Title: How cancers escape their oncogene habit.
Journal: Cell cycle (Georgetown, Tex.)20030101
Title: Molecular mechanisms of the metabolite 4-hydroxytamoxifen of the anticancer drug tamoxifen: use of a model microorganism.
Journal: Toxicology in vitro : an international journal published in association with BIBRA20030101
Title: Comparison of the changes in adenine nucleotides of rat liver mitochondria induced by tamoxifen and 4-hydroxytamoxifen.
Journal: Toxicology in vitro : an international journal published in association with BIBRA20030101
Title: Synthesis and estrogen receptor affinity of a 4-hydroxytamoxifen-labeled ligand for diagnostic imaging.
Journal: Bioorganic & medicinal chemistry20021201
Title: Controlling gene expression in the urothelium using transgenic mice with inducible bladder specific Cre-lox recombination.
Journal: The Journal of urology20021201
Title: Estrogen receptor expression and estrogen receptor-independent cytotoxic effects of tamoxifen on malignant rhabdoid tumor cells in vitro.
Journal: Japanese journal of cancer research : Gann20021201
Title: Determination of estrogenic activity in landfill leachate by simplified yeast two-hybrid assay.
Journal: Journal of environmental monitoring : JEM20021201
Title: How does glucose evoke electrical activity in the pancreatic beta-cell?
Journal: Diabetes & metabolism20021201
Title: Delta MEKK3:ER* activation induces a p38 alpha/beta 2-dependent cell cycle arrest at the G2 checkpoint.
Journal: Oncogene20021121
Title: An estrogen-responsive element-targeted histone deacetylase enzyme has an antiestrogen activity that differs from that of hydroxytamoxifen.
Journal: Cancer research20021115
Title: Long-term and tight control of gene expression in mouse skeletal muscle by a new hybrid human transcription factor.
Journal: Molecular therapy : the journal of the American Society of Gene Therapy20021101
Title: Identification of human CYP forms involved in the activation of tamoxifen and irreversible binding to DNA.
Journal: Carcinogenesis20021101
Title: Effect of 4-hydroxytamoxifen isomers on growth and ultrastructural aspects of normal human breast epithelial (HBE) cells in culture.
Journal: The Journal of steroid biochemistry and molecular biology20021101
Title: 4-Hydroxytamoxifen induces slight uncoupling of mitochondrial oxidative phosphorylation system in relation to the deleterious effects of tamoxifen.
Journal: Toxicology20021015
Title: Two antiestrogens affect differently chromatin remodeling of trefoil factor 1 (pS2) gene and the fate of estrogen receptor in MCF7 cells.
Journal: Biochimica et biophysica acta20021011
Title: Strain differences in tamoxifen sensitivity of Sprague-Dawley and Fischer 344 rats.
Journal: Anti-cancer drugs20021001
Title: Study of a glucose-activated anion-selective channel in rat pancreatic beta-cells.
Journal: Pflugers Archiv : European journal of physiology20021001
Title: STAT3 down-regulates the expression of cyclin D during liver development.
Journal: The Journal of biological chemistry20020927
Title: New oncolytic adenoviruses with hypoxia- and estrogen receptor-regulated replication.
Journal: Human gene therapy20020920
Title: Transcriptional activation of estrogen receptor ERalpha and ERbeta by polycyclic musks is cell type dependent.
Journal: Toxicology and applied pharmacology20020815
Title: Metabolism of tamoxifen by recombinant human cytochrome P450 enzymes: formation of the 4-hydroxy, 4'-hydroxy and N-desmethyl metabolites and isomerization of trans-4-hydroxytamoxifen.
Journal: Drug metabolism and disposition: the biological fate of chemicals20020801
Title: Persistent suppression of hepatic CYP2A1 expression and serum triiodothyronine levels by tamoxifen in intact female rats: dose-response analysis and comparison with 4-hydroxytamoxifen, fulvestrant (ICI 182,780), and 17beta-estradiol-3-benzoate.
Journal: The Journal of pharmacology and experimental therapeutics20020801
Title: The influence of CYP2B6, CYP2C9 and CYP2D6 genotypes on the formation of the potent antioestrogen Z-4-hydroxy-tamoxifen in human liver.
Journal: British journal of clinical pharmacology20020801
Title: Phosphorylation of human estrogen receptor alpha at serine 118 by two distinct signal transduction pathways revealed by phosphorylation-specific antisera.
Journal: Oncogene20020725
Title: DNA adducts formed from 4-hydroxytamoxifen are more mutagenic than those formed by alpha-acetoxytamoxifen in a shuttle vector target gene replicated in human Ad293 cells.
Journal: Biochemistry20020716
Title: Signaling through estrogen receptors modulates telomerase activity in human prostate cancer.
Journal: The Journal of clinical investigation20020715
Title: Reversion of B cell commitment upon loss of Pax5 expression.
Journal: Science (New York, N.Y.)20020705
Title: Synthesis of (Z)-4-hydroxytamoxifen and (Z)-2-[4-[1-(p-hydroxyphenyl)-2-phenyl]-1butenyl]phenoxyacetic acid.
Journal: The Journal of organic chemistry20020628
Title: Estrogen receptor-mediated effects of tamoxifen on human endometrial cancer cells.
Journal: Molecular and cellular endocrinology20020628
Title: Differential interactions of estrogens and antiestrogens at the 17 beta-hydroxyl or counterpart hydroxyl with histidine 524 of the human estrogen receptor alpha.
Journal: Biochemistry20020625
Title: Estrogens prevent calcium-induced release of cytochrome c from heart mitochondria.
Journal: FEBS letters20020619
Title: Tamoxifen enhancement of TNF-alpha induced MnSOD expression: modulation of NF-kappaB dimerization.
Journal: Oncogene20020516
Title: Reverse geometrical selectivity in glucuronidation and sulfation of cis- and trans-4-hydroxytamoxifens by human liver UDP-glucuronosyltransferases and sulfotransferases.
Journal: Biochemical pharmacology20020515
Title: AML1 stimulates G1 to S progression via its transactivation domain.
Journal: Oncogene20020509
Title: Suppression of Myc-induced apoptosis in beta cells exposes multiple oncogenic properties of Myc and triggers carcinogenic progression.
Journal: Cell20020503
Title: Induction of cytochrome P450 3A4 in primary human hepatocytes and activation of the human pregnane X receptor by tamoxifen and 4-hydroxytamoxifen.
Journal: Drug metabolism and disposition: the biological fate of chemicals20020501
Title: Dietary genistein negates the inhibitory effect of tamoxifen on growth of estrogen-dependent human breast cancer (MCF-7) cells implanted in athymic mice.
Journal: Cancer research20020501
Title: Ovarian hormones do not attenuate methamphetamine-induced dopaminergic neurotoxicity in mice gonadectomized at 4 weeks postpartum.
Journal: Neuroendocrinology20020501
Title: Estrogenic activity of the phytoestrogens naringenin, 6-(1,1-dimethylallyl)naringenin and 8-prenylnaringenin.
Journal: Planta medica20020501
Title: DNA repair pathway stimulated by the forkhead transcription factor FOXO3a through the Gadd45 protein.
Journal: Science (New York, N.Y.)20020419
Title: Mutations targeted to a predicted helix in the extreme carboxyl-terminal region of the human estrogen receptor-alpha alter its response to estradiol and 4-hydroxytamoxifen.
Journal: The Journal of biological chemistry20020412
Title: Structure-function relationships of the raloxifene-estrogen receptor-alpha complex for regulating transforming growth factor-alpha expression in breast cancer cells.
Journal: The Journal of biological chemistry20020315
Title: The agonist activity of tamoxifen is inhibited by the short heterodimer partner orphan nuclear receptor in human endometrial cancer cells.
Journal: Endocrinology20020301
Title: Structural and functional evidence for ligand-independent transcriptional activation by the estrogen-related receptor 3.
Journal: Molecular cell20020201
Title: Determination of tamoxifen and metabolites in mouse fetal tissue using nonaqueous capillary electrophoresis.
Journal: Electrophoresis20020201
Title: Regulation of focal adhesion targeting and inhibitory functions of the FAK related protein FRNK using a novel estrogen receptor 'switch'.
Journal: Cell motility and the cytoskeleton20020201
Title: Repression of in vivo growth of Myc/Ras transformed tumor cells by Mad1.
Journal: Oncogene20020117
Title: Inhibition of glucose-induced electrical activity by 4-hydroxytamoxifen in rat pancreatic beta-cells.
Journal: Cellular signalling20020101
Title: AR and ER interaction with a p21-activated kinase (PAK6).
Journal: Molecular endocrinology (Baltimore, Md.)20020101
Title: The influence of tamoxifen on the secretion of transforming growth factor-beta2 (TGF-beta2) in glioblastomas: in vitro and in vivo findings.
Journal: Anticancer research20020101
Title: Regulation of Fas ligand expression by estrogen in normal ovary.
Journal: Journal of the Society for Gynecologic Investigation20020101
Title: NAD(P)H: quinone oxidoreductase enhances proliferation inhibition by 4-hydroxytamoxifen.
Journal: Anticancer research20020101
Title: In vitro regulation of vascular endothelial growth factor by estrogens and antiestrogens in estrogen-receptor positive breast cancer.
Journal: Breast cancer (Tokyo, Japan)20020101
Title: 4-Hydroxytamoxifen sulfation metabolism.
Journal: Journal of biochemical and molecular toxicology20020101
Title: c-Myc overcomes cell cycle inhibition by CBFbeta-SMMHC, a myeloid leukemia oncoprotein.
Journal: Cancer biology & therapy20020101
Title: Inducible activation of c-Myc in adult myocardium in vivo provokes cardiac myocyte hypertrophy and reactivation of DNA synthesis.
Journal: Circulation research20011207
Title: Hydroxytamoxifen interaction with human erythrocyte membrane and induction of permeabilization and subsequent hemolysis.
Journal: Toxicology in vitro : an international journal published in association with BIBRA20011201
Title: Identification of novel oestrogen receptor target genes in human ZR75-1 breast cancer cells by expression profiling.
Journal: Journal of molecular endocrinology20011201
Title: Estrogen response element binding induces alterations in estrogen receptor-alpha conformation as revealed by susceptibility to partial proteolysis.
Journal: Journal of molecular endocrinology20011201
Title: Synthesis and reactivity of potential toxic metabolites of tamoxifen analogues: droloxifene and toremifene o-quinones.
Journal: Chemical research in toxicology20011201
Title: Effects of the new selective estrogen receptor modulator LY353381.HCl (Arzoxifene) on human endometrial cancer growth in athymic mice.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research20011201
Title: (Xeno)estrogen sensitivity of smooth muscle BK channels conferred by the regulatory beta1 subunit: a study of beta1 knockout mice.
Journal: The Journal of biological chemistry20011130
Title: Synergism between ERalpha transactivation function 1 (AF-1) and AF-2 mediated by steroid receptor coactivator protein-1: requirement for the AF-1 alpha-helical core and for a direct interaction between the N- and C-terminal domains.
Journal: Molecular endocrinology (Baltimore, Md.)20011101
Title: 4-Hydroxytamoxifen is an isoform-specific inhibitor of orphan estrogen-receptor-related (ERR) nuclear receptors beta and gamma.
Journal: Endocrinology20011001
Title: c-myc box II mutations in Burkitt's lymphoma-derived alleles reduce cell-transformation activity and lower response to broad apoptotic stimuli.
Journal: Oncogene20010920
Title: 4-Hydroxytamoxifen binds to and deactivates the estrogen-related receptor gamma.
Journal: Proceedings of the National Academy of Sciences of the United States of America20010717
Title: Interactions of synthetic estrogens with human estrogen receptors.
Journal: The Journal of endocrinology20010701
Title: Differential activation of wild-type and variant forms of estrogen receptor alpha by synthetic and natural estrogenic compounds using a promoter containing three estrogen-responsive elements.
Journal: The Journal of steroid biochemistry and molecular biology20010701
Title: Estrogen receptor alpha mediated induction of the transforming growth factor alpha gene by estradiol and 4-hydroxytamoxifen in MDA-MB-231 breast cancer cells.
Journal: The Journal of steroid biochemistry and molecular biology20010701
Title: Increase in the stability and helical content of estrogen receptor alpha in the presence of the estrogen response element: analysis by circular dichroism spectroscopy.
Journal: Biochemistry20010605
Title: Flexible alignment of small molecules.
Journal: Journal of medicinal chemistry20010510
Title: Increased formation of micronuclei after hormonal stimulation of cell proliferation in human breast cancer cells.
Journal: Mutagenesis20010501
Title: Silencing and reactivation of the selective estrogen receptor modulator-estrogen receptor alpha complex.
Journal: Cancer research20010501
Title: Effects of anti-oestrogens and beta-estradiol on calcium uptake by cardiac sarcoplasmic reticulum.
Journal: British journal of pharmacology20010401
Title: Synergistic activation of the serotonin-1A receptor by nuclear factor-kappa B and estrogen.
Journal: Molecular endocrinology (Baltimore, Md.)20010401
Title: Estrogen and antiestrogen actions on transforming growth factorbeta (TGFbeta) in normal human breast epithelial (HBE) cells.
Journal: Molecular and cellular endocrinology20010328
Title: 4-hydroxytamoxifen trans-represses nuclear factor-kappa B activity in human osteoblastic U2-OS cells through estrogen receptor (ER)alpha, and not through ER beta.
Journal: Endocrinology20010301
Title: 4-Hydroxytamoxifen differentially exerts estrogenic and antiestrogenic effects on discrete subpopulations of human breast cancer cells.
Journal: Endocrine20010301
Title: Tamoxifen but not 4-hydroxytamoxifen initiates apoptosis in p53(-) normal human mammary epithelial cells by inducing mitochondrial depolarization.
Journal: The Journal of biological chemistry20010216
Title: Molecular mechanism of action at estrogen receptor alpha of a new clinically relevant antiestrogen (GW7604) related to tamoxifen.
Journal: Endocrinology20010201
Title: Effects of tamoxifen metabolites on fertility of male rat.
Journal: Contraception20010201
Title: FRAP reveals that mobility of oestrogen receptor-alpha is ligand- and proteasome-dependent.
Journal: Nature cell biology20010101
Title: Determination of 4-hydroxytamoxifen in mouse plasma in the pg/mL range by gradient capillary liquid chromatography/tandem mass spectrometry.
Journal: Rapid communications in mass spectrometry : RCM20010101
Title: Assaying the estrogenicity of phytoestrogens in cells of different estrogen sensitive tissues.
Journal: Toxicology in vitro : an international journal published in association with BIBRA20010101
Title: Modulation of soluble CD44 concentrations by hormone and anti-hormone treatment in gynecological tumor cell lines.
Journal: Oncology reports20010101
Title: Estrogenic activity of naturally occurring anthocyanidins.
Journal: Nutrition and cancer20010101
Title: Activation of a uterine insulin-like growth factor I signaling pathway by clinical and environmental estrogens: requirement of estrogen receptor-alpha.
Journal: Endocrinology20000901
Title: Comparative analyses of mechanistic differences among antiestrogens.
Journal: Endocrinology19991201
Title: The anti-estrogen hydroxytamoxifen is a potent antagonist in a novel yeast system.
Journal: Biological chemistry19991101
Title: Regulation of parathyroid hormone-related protein expression in MCF-7 breast carcinoma cells by estrogen and antiestrogens.
Journal: Biochemical and biophysical research communications19981029
Title: Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta.
Journal: Endocrinology19970301
Title: Studies of tamoxifen as a promoter of hepatocarcinogenesis in female Fischer F344 rats.
Journal: Breast cancer research and treatment19940101
Title: Differential regulation of growth and invasiveness of MCF-7 breast cancer cells by antiestrogens.
Journal: Cancer research19881201
