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[1]Ren,Xinkun;Yorke,JakeA.;Taylor,Emily;Zhang,Ting;Zhou,Weihong;Wong,LuetLok[Chemistry-AEuropeanJournal,2015,vol.21,#42,p.15039-15047]
Title: Effect of albumin on human liver microsomal and recombinant CYP1A2 activities: impact on in vitro-in vivo extrapolation of drug clearance.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20120501
Title: Comparison of five commonly-available, lidocaine-containing topical anesthetics and their effect on serum levels of lidocaine and its metabolite monoethylglycinexylidide (MEGX).
Journal: Aesthetic surgery journal 20120501
Title: Automated analysis of lidocaine and its metabolite in plasma by in-tube solid-phase microextraction coupled with LC-UV for pharmacokinetic study.
Journal: Journal of separation science 20120301
Title: Lignocaine plasma levels following topical gel application in laparoscopic and hysteroscopic procedures.
Journal: Anaesthesia and intensive care 20120301
Title: Can fractional lasers enhance transdermal absorption of topical lidocaine in an in vivo animal model?
Journal: Lasers in surgery and medicine 20120201
Title: Easy and fast LC-MS/MS determination of lidocaine and MEGX in plasma for therapeutic drug monitoring in neonates with seizures.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20120115
Title: Lidocaine metabolites inhibit glycine transporter 1: a novel mechanism for the analgesic action of systemic lidocaine?
Journal: Anesthesiology 20120101
Title: Dietary supplementation of female rats with elk velvet antler improves physical and neurological development of offspring.
Journal: Evidence-based complementary and alternative medicine : eCAM 20120101
Title: Toxicity of topical lidocaine applied to the breasts to reduce discomfort during screening mammography.
Journal: Journal of anaesthesiology, clinical pharmacology 20120101
Title: Formation of monoethylglycinexylidide (MEGX) in clinically healthy dogs.
Journal: Canadian journal of veterinary research = Revue canadienne de recherche veterinaire 20111001
Title: Use of lidocaine patch for percutaneous endoscopic lumbar discectomy.
Journal: The Korean journal of pain 20110601
Title: Local anesthetic inhibits hyperpolarization-activated cationic currents.
Journal: Molecular pharmacology 20110501
Title: Distribution of bupivacaine enantiomers and lidocaine and its metabolite in the placental intervillous space and in the different maternal and fetal compartments in term pregnant women.
Journal: Journal of clinical pharmacology 20110201
Title: Liposuction: Anaesthesia challenges.
Journal: Indian journal of anaesthesia 20110101
Title: Pharmacokinetics of lidocaine and its metabolite as a hepatic function marker in dogs.
Journal: Proceedings of the Western Pharmacology Society 20110101
Title: Biophysical characterization of recombinant proteins: a key to higher structural genomics success.
Journal: Journal of structural biology 20101001
Title: [Determination of lidocaine and its metabolites in human plasma by liquid chromatography in combination with tandem mass spectrometry].
Journal: Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20100701
Title: Lidocaine/monoethylglycinexylidide test, galactose elimination test, and sorbitol elimination test for metabolic assessment of liver cell bioreactors.
Journal: Artificial organs 20100601
Title: Is dopexamine superior to dopamine in the treatment of multiple trauma patients--a prospective, double-blind, randomised study.
Journal: Injury 20100501
Title: Effect of 4% topical lidocaine applied to the face on the serum levels of lidocaine and its metabolite, monoethylglycinexylidide.
Journal: Aesthetic surgery journal 20100101
Title: Cutaneous in vivo metabolism of topical lidocaine formulation in human skin.
Journal: Skin pharmacology and physiology 20090101
Title: Efficacy of lidocaine for pain control in subcutaneous infiltration during liposuction.
Journal: Aesthetic surgery journal 20090101
Title: Evaluation of quantitative liver function tests in HIV-positive patients under anti-retroviral therapy.
Journal: European journal of medical research 20090101
Title: Pharmacokinetics of lidocaine and its metabolite in peridural anesthesia administered to pregnant women with gestational diabetes mellitus.
Journal: European journal of clinical pharmacology 20081201
Title: Pharmacokinetics of lidocaine following the application of 5% lidocaine patches to cats.
Journal: Journal of veterinary pharmacology and therapeutics 20080801
Title: Reporting a fatality during tumescent liposuction.
Journal: Forensic science international 20080610
Title: Serum concentrations of lidocaine and its metabolites after prolonged infusion in healthy horses.
Journal: Equine veterinary journal 20080601
Title: [Determination of monoethylglycinexylidide concentration in serum using solid phase extraction and capillary gas chromatography-mass spectrometry].
Journal: Se pu = Chinese journal of chromatography 20080501
Title: Prognostic value of the monoethylglycinexylidide (MEGX)-test prior to liver resection.
Journal: Hepato-gastroenterology 20080101
Title: Effect of erythromycin and rifampicin on monoethylglycinexylidide test.
Journal: Indian journal of pharmacology 20080101
Title: [Liver function test to predict hepatic failure after liver resection--expensive and without clinical relevance?].
Journal: Zentralblatt fur Chirurgie 20070801
Title: Determination of lidocaine and its two N-desethylated metabolites in dog and horse plasma by high-performance liquid chromatography combined with electrospray ionization tandem mass spectrometry.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070601
Title: Pharmacokinetics of tilidine and naloxone in patients with severe hepatic impairment.
Journal: Arzneimittel-Forschung 20070101
Title: Monoethylglycinexylidide (MEGX) as a liver function test in cirrhosis.
Journal: Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology 20070101
Title: Measuring hepatic functional reserve using MEGX: still a mirage!
Journal: Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology 20070101
Title: Prognostic value of the monoethylglycinexylidide test in alcoholic cirrhosis.
Journal: Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association 20070101
Title: Differential effect of chronic renal failure on the pharmacokinetics of lidocaine in patients receiving and not receiving hemodialysis.
Journal: Clinical pharmacology and therapeutics 20061201
Title: Lidocaine metabolism in isolated perfused liver from streptozotocin-induced diabetic rats.
Journal: The Journal of pharmacy and pharmacology 20060801
Title: Effect of fluvoxamine and erythromycin on the pharmacokinetics of oral lidocaine.
Journal: Basic & clinical pharmacology & toxicology 20060801
Title: Prognostic value of quantitative liver function tests in viral cirrhosis: a prospective study.
Journal: European journal of gastroenterology & hepatology 20060701
Title: [Evaluation of the liver reserve using lidocaine test on experimental liver injuries in rats].
Journal: Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 20060601
Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.
Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501
Title: Splanchnic organ injury during coronary surgery with or without cardiopulmonary bypass: a randomized, controlled trial.
Journal: The Annals of thoracic surgery 20060101
Title: Safety of occluded 4% liposomal lidocaine cream.
Journal: Journal of drugs in dermatology : JDD 20060101
Title: Double-compartment cell culture apparatus: construction and biochemical evaluation for bioartificial liver support.
Journal: Cell transplantation 20060101
Title: Assessment of liver function in children with acute lymphoblastic leukemia in remission.
Journal: Annales Academiae Medicae Stetinensis 20060101
Title: Effect of ciprofloxin on the pharmacokinetics of intravenous lidocaine.
Journal: European journal of anaesthesiology 20051001
Title: Pharmacokinetics of lidocaine and its active metabolite, monoethylglycinexylidide, after intravenous administration of lidocaine to awake and isoflurane-anesthetized cats.
Journal: American journal of veterinary research 20050701
Title: The effect of mild and moderate hepatic impairment on the pharmacokinetics of valdecoxib, a selective COX-2 inhibitor.
Journal: European journal of clinical pharmacology 20050601
Title: Blockade of spinal nitric oxide synthase on blood pressure variability and hepatic microcirculation.
Journal: Acta anaesthesiologica Taiwanica : official journal of the Taiwan Society of Anesthesiologists 20050601
Title: The effect of erythromycin and fluvoxamine on the pharmacokinetics of intravenous lidocaine.
Journal: Anesthesia and analgesia 20050501
Title: Analysis of lidocaine and its major metabolite, monoethylglycinexylidide, in elk velvet antler by liquid chromatography with UV detection and confirmation by electrospray ionization tandem mass spectrometry.
Journal: Journal of agricultural and food chemistry 20050406
Title: Monoethylglycinexylidide and lidocaine determination in porcine microsomal preparations.
Journal: Journal of pharmaceutical and biomedical analysis 20050401
Title: A study of the in vitro interaction between lidocaine and premedications using human liver microsomes.
Journal: Journal of clinical pharmacy and therapeutics 20050401
Title: Assessment of the hemodynamic effects of lidocaine administered IV in isoflurane-anesthetized cats.
Journal: American journal of veterinary research 20050401
Title: Assessment of hepatic reserve for indication of hepatic resection: how I do it.
Journal: Journal of hepato-biliary-pancreatic surgery 20050101
Title: Pharmacokinetics and transplacental transfer of lidocaine and its metabolite for perineal analgesic assistance to pregnant women.
Journal: European journal of clinical pharmacology 20041001
Title: Effect of lidocaine on the minimum alveolar concentration of isoflurane in dogs.
Journal: Veterinary anaesthesia and analgesia 20041001
Title: Effect of itraconazole on the pharmacokinetics of inhaled lidocaine.
Journal: Basic & clinical pharmacology & toxicology 20040901
Title: Pharmacokinetics and safety of lidocaine and monoethylglycinexylidide in liposuction: a microdialysis study.
Journal: Plastic and reconstructive surgery 20040801
Title: Splanchnic oxygen transport, hepatic function and gastrointestinal barrier after normothermic cardiopulmonary bypass.
Journal: Acta anaesthesiologica Scandinavica 20040701
Title: Liquid chromatographic method for the determination of lidocaine and monoethylglycine xylidide in human serum containing various concentrations of bilirubin for the assessment of liver function.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20040605
Title: Use of lidocaine metabolism to test liver function during the long-term follow-up of liver transplant recipients.
Journal: Clinical transplantation 20040601
Title: Experimental study of the evaluation of liver function on the opposite side during portacaval anastomosis and ligation of the left portal branch.
Journal: The journal of medical investigation : JMI 20040201
Title: Cytochrome P450 1A2 is a major determinant of lidocaine metabolism in vivo: effects of liver function.
Journal: Clinical pharmacology and therapeutics 20040101
Title: N-acetylcysteine decreases lactate signal intensities in liver tissue and improves liver function in septic shock patients, as shown by magnetic resonance spectroscopy: extended case report.
Journal: Critical care (London, England) 20040101
Title: Clinical review: influence of vasoactive and other therapies on intestinal and hepatic circulations in patients with septic shock.
Journal: Critical care (London, England) 20040101
Title: Development of a protocol for cryopreservation of hepatocytes for use in bioartificial liver systems.
Journal: Annals of clinical and laboratory science 20040101
Title: Utility of nonaqueous capillary electrophoresis for the determination of lidocaine and its metabolites in human plasma: a comparison of ultraviolet and mass spectrometric detection.
Journal: Rapid communications in mass spectrometry : RCM 20040101
Title: Tissue distribution of lidocaine in critical care patients after intubation.
Journal: Forensic science international 20031126
Title: Relationship between thrombopoietin serum levels and liver function in patients with chronic liver disease related to hepatitis C virus infection.
Journal: The American journal of gastroenterology 20031101
Title: The P-glycoprotein inhibitor quinidine decreases the threshold for bupivacaine-induced, but not lidocaine-induced, convulsions in rats.
Journal: Canadian journal of anaesthesia = Journal canadien d'anesthesie 20031001
Title: Influence of prolonged cardiopulmonary bypass times on splanchnic perfusion and markers of splanchnic organ function.
Journal: The Annals of thoracic surgery 20030501
Title: Helicobacter pylori infection is associated with greater impairment of cytochrome P-450 liver metabolic activity in anti-HCV positive cirrhotic patients.
Journal: Digestive diseases and sciences 20030401
Title: Distributions of ethanol and intubation-related lidocaine in the brain of a trauma patient who was brain dead for about 5 days.
Journal: Legal medicine (Tokyo, Japan) 20030301
Title: Functional significance of hepatic arterial flow reserve in patients with cirrhosis.
Journal: Hepatology (Baltimore, Md.) 20030201
Title: Modulation of pro-apoptotic (Bax) and anti-apoptotic (Bcl-2) gene expression in isolated porcine hepatocytes perfused within a radial-flow bioreactor after low-temperature storing.
Journal: The International journal of artificial organs 20030201
Title: Validity and clinical utility of the aspartate aminotransferase-alanine aminotransferase ratio in assessing disease severity and prognosis in patients with hepatitis C virus-related chronic liver disease.
Journal: Archives of internal medicine 20030127
Title: MELD scoring system is useful for predicting prognosis in patients with liver cirrhosis and is correlated with residual liver function: a European study.
Journal: Gut 20030101
Title: Effect of the CYP3A4 inhibitor erythromycin on the pharmacokinetics of lignocaine and its pharmacologically active metabolites in subjects with normal and impaired liver function.
Journal: British journal of clinical pharmacology 20030101
Title: Free lidocaine concentrations during continuous epidural anesthesia in geriatric patients.
Journal: Regional anesthesia and pain medicine 20030101
Title: Operative risk by the lidocaine test (MEGX) in resected patients for HCC on cirrhosis.
Journal: Hepato-gastroenterology 20030101
Title: Effect of experimental diabetes on pharmacokinetic parameters of lidocaine and MEGX in rats.
Journal: Polish journal of pharmacology 20030101
Title: Propofol inhibits lidocaine metabolism in human and rat liver microsomes.
Journal: Journal of anesthesia 20030101
Title: MEGX disposition in critically-ill trauma patients: subsequent assessments during the first week following trauma.
Journal: Fundamental & clinical pharmacology 20021201
Title: Chromatographic determination of free lidocaine and its active metabolites in plasma from patients under epidural anesthesia.
Journal: International journal of clinical pharmacology and therapeutics 20021101
Title: Cultivation of porcine hepatocytes in polyurethane nonwovens as part of a biohybrid liver support system.
Journal: The International journal of artificial organs 20021001
Title: Effect of dopamine-induced changes in splanchnic blood flow on MEGX production from lidocaine in septic and cardiac surgery patients.
Journal: Shock (Augusta, Ga.) 20020701
Title: Involvement of liver carboxylesterases in the in vitro metabolism of lidocaine.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20020601
Title: Systemic absorption of topical lidocaine in normal volunteers, patients with post-herpetic neuralgia, and patients with acute herpes zoster.
Journal: Journal of pharmaceutical sciences 20020501
Title: Risk of hepatic failure after transcatheter arterial chemoembolization for hepatocellular carcinoma: predictive value of the monoethylglycinexylidide test.
Journal: The American journal of gastroenterology 20020501
Title: Deferoxamine and hespan complex as a resuscitative adjuvant in hemorrhagic shock rat model.
Journal: Shock (Augusta, Ga.) 20020401
Title: Endotoxic shock alters the pharmacokinetics of lidocaine and monoethylglycinexylidide.
Journal: Shock (Augusta, Ga.) 20020301
Title: Biochemical function of the donor liver in living related liver transplantation.
Journal: Transplantation proceedings 20020301
Title: Correlation between midazolam and lignocaine pharmacokinetics and MEGX formation in healthy volunteers.
Journal: British journal of clinical pharmacology 20020201
Title: [Fatal intoxication after accidental ingestion of viscous 2% lidocaine in a young child].
Journal: Acta clinica Belgica 20020101
Title: Monitoring of liver metabolic function during interferon-alpha therapy and its relationship to treatment outcome in chronic hepatitis C patients.
Journal: Hepato-gastroenterology 20020101
Title: Induction of olfactory mucosal and liver metabolism of lidocaine by 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Journal: Journal of biochemical and molecular toxicology 20020101
Title: Epinephrine does not reduce the plasma concentration of lidocaine during continuous epidural infusion in children.
Journal: Canadian journal of anaesthesia = Journal canadien d'anesthesie 20020101
Title: Lidocaine elimination in patients with liver cirrhosis.
Journal: Acta poloniae pharmaceutica 20020101
Title: Comparison of MEGX (monoethylglycinexylidide) and antipyrine tests in patients with liver cirrhosis.
Journal: European journal of drug metabolism and pharmacokinetics 20020101
Title: Pharmacokinetics of lidocaine delivered from a transmucosal patch in children.
Journal: Anesthesia progress 20020101
Title: Impairment of cytochrome P-450-dependent liver activity in cirrhotic patients with Helicobacter pylori infection.
Journal: Alimentary pharmacology & therapeutics 20011201
Title: Plasma lidocaine concentrations during continuous thoracic epidural anesthesia after clonidine premedication in children.
Journal: Anesthesia and analgesia 20011101
Title: Does age affect liver function and the hepatic acute phase response after major abdominal surgery?
Journal: Intensive care medicine 20011101
Title: Rapid and sensitive liquid chromatography-tandem mass spectrometry method for determination of monoethylglycinexylidide.
Journal: Clinical chemistry 20011001
Title: Long-term expression of highly differentiated functions by isolated porcine hepatocytes perfused in a radial-flow bioreactor.
Journal: Artificial organs 20010901
Title: Enoximone in contrast to dobutamine improves hepatosplanchnic function in fluid-optimized septic shock patients.
Journal: Critical care medicine 20010801
Title: Culture of porcine hepatocytes: the dogma of exogenous matrix revisited.
Journal: Artificial organs 20010701
Title: A preliminary evaluation of the discriminative power of the monoethylglycinexylidide formation test after intravenous and oral administration of lidocaine.
Journal: Transplantation proceedings 20010601
Title: Influence of prophylactic use of pentoxifylline on postoperative organ function in elderly cardiac surgery patients.
Journal: Critical care medicine 20010501
Title: The MEGX test: a tool for the real-time assessment of hepatic function.
Journal: Therapeutic drug monitoring 20010401
Title: Long-term follow up of chronic hepatitis C patients after alpha-interferon treatment: a functional study.
Journal: Journal of gastroenterology and hepatology 20010401
Title: Assessment of hepatic function in cystic fibrosis by lidocaine metabolism.
Journal: Journal of pediatric gastroenterology and nutrition 20010401
Title: The effects of norepinephrine and prostaglandin E1 on pharmacokinetics of lidocaine in isolated perfused rat liver.
Journal: Life sciences 20010323
Title: Reassessment of monoethylglycinexylidide as preoperative liver function test in a rat model of liver cirrhosis and man.
Journal: Clinical and experimental medicine 20010301
Title: Could local anesthesia while breast-feeding be harmful to infants?
Journal: Journal of pediatric gastroenterology and nutrition 20010201
Title: An in vivo rat model for assessment of extrahepatic metabolism.
Journal: Journal of pharmacological and toxicological methods 20010101
Title: Prolonged seizures associated with the use of viscous lidocaine.
Journal: The Journal of pediatrics 19820901
Title: The acute antiarrhythmic and toxic effects in mice and dogs of 2-ethylamino-2',6-'acetoxylidine (L-86), a metabolite of lidocaine.
Journal: The Journal of pharmacology and experimental therapeutics 19711201
