Title: Involvement of presynaptic voltage-dependent Kv3 channel in endothelin-1-induced inhibition of noradrenaline release from rat gastric sympathetic nerves.
Journal: European journal of pharmacology 20121105
Title: In vitro and in vivo efficacy of ether lipid edelfosine against Leishmania spp. and SbV-resistant parasites.
Journal: PLoS neglected tropical diseases 20120401
Title: Targeting SKCa channels in cancer: potential new therapeutic approaches.
Journal: Current medicinal chemistry 20120101
Title: Exogenous ether lipids predominantly target mitochondria.
Journal: PloS one 20120101
Title: Edelfosine disturbs the sphingomyelin-cholesterol model membrane system in a cholesterol-dependent way - the Langmuir monolayer study.
Journal: Colloids and surfaces. B, Biointerfaces 20111201
Title: Phosphoinositide phosphatase SHIP-1 regulates apoptosis induced by edelfosine, Fas ligation and DNA damage in mouse lymphoma cells.
Journal: The Biochemical journal 20111115
Title: New alkyl-lipid blockers of SK3 channels reduce cancer cell migration and occurrence of metastasis.
Journal: Current cancer drug targets 20111101
Title: Selenocyanates and diselenides: a new class of potent antileishmanial agents.
Journal: European journal of medicinal chemistry 20110801
Title: Impact of alkylphospholipids on the gene expression profile of HaCaT cells.
Journal: Pharmacogenetics and genomics 20110701
Title: Involvement of lipid rafts in the localization and dysfunction effect of the antitumor ether phospholipid edelfosine in mitochondria.
Journal: Cell death & disease 20110501
Title: The novel synthetic ether lipid inositol-C2-PAF inhibits phosphorylation of the tyrosine kinases Src and FAK independent of integrin activation in transformed skin cells.
Journal: Biochemical pharmacology 20110415
Title: Antitumoral alkylphospholipids induce cholesterol efflux from the plasma membrane in HepG2 cells.
Journal: The Journal of pharmacology and experimental therapeutics 20110301
Title: The SK3/K(Ca)2.3 potassium channel is a new cellular target for edelfosine.
Journal: British journal of pharmacology 20110101
Title: The relationship between the concentration of ganglioside GM1 and antitumor activity of edelfosine--the Langmuir monolayer study.
Journal: Colloids and surfaces. B, Biointerfaces 20101101
Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.
Journal: Bioorganic & medicinal chemistry letters 20101101
Title: Vitamin E prevents lipid raft modifications induced by an anti-cancer lysophospholipid and abolishes a Yap1-mediated stress response in yeast.
Journal: The Journal of biological chemistry 20100813
Title: Cell specific dopamine modulation of the transient potassium current in the pyloric network by the canonical D1 receptor signal transduction cascade.
Journal: Journal of neurophysiology 20100801
Title: Lipid raft-targeted therapy in multiple myeloma.
Journal: Oncogene 20100701
Title: Computational screening for membrane-directed inhibitors of mast cell activation.
Journal: European journal of medicinal chemistry 20100601
Title: Disruption of cellular cholesterol transport and homeostasis as a novel mechanism of action of membrane-targeted alkylphospholipid analogues.
Journal: British journal of pharmacology 20100501
Title: In vitro and In vivo selective antitumor activity of Edelfosine against mantle cell lymphoma and chronic lymphocytic leukemia involving lipid rafts.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20100401
Title: Effect of edelfosine on tumor and normal cells model membranes--a comparative study.
Journal: Colloids and surfaces. B, Biointerfaces 20100301
Title: Edelfosine-induced metabolic changes in cancer cells that precede the overproduction of reactive oxygen species and apoptosis.
Journal: BMC systems biology 20100101
Title: Targeting the PI3K/Akt cell survival pathway to induce cell death of HIV-1 infected macrophages with alkylphospholipid compounds.
Journal: PloS one 20100101
Title: Membrane rafts are involved in intracellular miconazole accumulation in yeast cells.
Journal: The Journal of biological chemistry 20091120
Title: Langmuir monolayer study toward combined antileishmanian therapy involving amphotericin B and edelfosine.
Journal: The journal of physical chemistry. B 20091029
Title: Study of the stress proteins secreted by Leishmania donovani after treatment with edelfosine, mitelfosine and ilmofosine, and morphological alterations analyzed by electronic microscopy.
Journal: Parasite (Paris, France) 20090901
Title: Novel anti-inflammatory action of edelfosine lacking toxicity with protective effect in experimental colitis.
Journal: The Journal of pharmacology and experimental therapeutics 20090501
Title: Lipid raft connection between extrinsic and intrinsic apoptotic pathways.
Journal: Biochemical and biophysical research communications 20090320
Title: Phospholipase C-mediated regulation of transient receptor potential vanilloid 6 channels: implications in active intestinal Ca2+ transport.
Journal: Molecular pharmacology 20090301
Title: Involvement of raft aggregates enriched in Fas/CD95 death-inducing signaling complex in the antileukemic action of edelfosine in Jurkat cells.
Journal: PloS one 20090101
Title: Testing the hypothesis that amphiphilic antineoplastic lipid analogues act through reduction of membrane curvature elastic stress.
Journal: Journal of the Royal Society, Interface 20081106
Title: Serotonin increases GABA release in rat entorhinal cortex by inhibiting interneuron TASK-3 K+ channels.
Journal: Molecular and cellular neurosciences 20081001
Title: In vivo activity of perifosine against Leishmania amazonensis.
Journal: Acta tropica 20081001
Title: Edelfosine is incorporated into rafts and alters their organization.
Journal: The journal of physical chemistry. B 20080918
Title: Localization of Fas/CD95 into the lipid rafts on down-modulation of the phosphatidylinositol 3-kinase signaling pathway.
Journal: Molecular cancer research : MCR 20080401
Title: Lipid nanoparticles for alkyl lysophospholipid edelfosine encapsulation: development and in vitro characterization.
Journal: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20080201
Title: Alkylphospholipids inhibit capillary-like endothelial tube formation in vitro: antiangiogenic properties of a new class of antitumor agents.
Journal: Anti-cancer drugs 20080101
Title: The antitumor ether lipid edelfosine (ET-18-O-CH3) induces apoptosis in H-ras transformed human breast epithelial cells: by blocking ERK1/2 and p38 mitogen-activated protein kinases as potential targets.
Journal: Asia Pacific journal of clinical nutrition 20080101
Title: [Synthesis and cytotoxicity of novel phosphorusless analogues of edelfosine].
Journal: Bioorganicheskaia khimiia 20080101
Title: Lipid rafts and metabolic energy differentially determine uptake of anti-cancer alkylphospholipids in lymphoma versus carcinoma cells.
Journal: Biochemical pharmacology 20071115
Title: Roles of brain phosphatidylinositol-specific phospholipase C and diacylglycerol lipase in centrally administered histamine-induced adrenomedullary outflow in rats.
Journal: European journal of pharmacology 20071001
Title: Effect of alkyl-lysophospholipids on some aspects of the metabolism of Leishmania donovani.
Journal: The Journal of parasitology 20071001
Title: A new class of anticancer alkylphospholipids uses lipid rafts as membrane gateways to induce apoptosis in lymphoma cells.
Journal: Molecular cancer therapeutics 20070801
Title: Surface-active properties of the antitumour ether lipid 1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine (edelfosine).
Journal: Biochimica et biophysica acta 20070701
Title: Mitochondrial-derived ROS in edelfosine-induced apoptosis in yeasts and tumor cells.
Journal: Acta pharmacologica Sinica 20070601
Title: A novel ATP-binding cassette transporter from Leishmania is involved in transport of phosphatidylcholine analogues and resistance to alkyl-phospholipids.
Journal: Molecular microbiology 20070601
Title: Clustering of monosialyl-Gb5 initiates downstream signalling events leading to invasion of MCF-7 breast cancer cells.
Journal: The Biochemical journal 20070201
Title: Edelfosine protects precultured heart fragments against the invasion of malignant cells through altered sialylation.
Journal: Oncology reports 20070201
Title: Edelfosine and perifosine induce selective apoptosis in multiple myeloma by recruitment of death receptors and downstream signaling molecules into lipid rafts.
Journal: Blood 20070115
Title: Resistance to alkyl-lysophospholipid-induced apoptosis due to downregulated sphingomyelin synthase 1 expression with consequent sphingomyelin- and cholesterol-deficiency in lipid rafts.
Journal: The Biochemical journal 20070115
Title: Phospholipase C and myosin light chain kinase inhibition define a common step in actin regulation during cytokinesis.
Journal: BMC cell biology 20070101
Title: Involvement of phosphatidylinositol-phospholipase C in immune response to Salmonella lipopolysacharide in chicken macrophage cells (HD11).
Journal: International immunopharmacology 20061205
Title: Ultrastructural analysis of edelfosine-treated trypomastigotes and amastigotes of Trypanosoma cruzi.
Journal: Parasitology research 20061201
Title: PAR-1-dependent pp60src activation is dependent on protein kinase C and increased [Ca2+]: evidence that pp60src does not regulate PAR-1-dependent Ca2+ entry in human platelets.
Journal: Journal of thrombosis and haemostasis : JTH 20061201
Title: Phospholipase C isoforms are localized at the cleavage furrow during cytokinesis.
Journal: Journal of biochemistry 20061201
Title: Beta-1, 3-glucan modulates PKC signalling in Lymnaea stagnalis defence cells: a role for PKC in H2O2 production and downstream ERK activation.
Journal: The Journal of experimental biology 20061201
Title: Aspects of the cytological activity of edelfosine, miltefosine, and ilmofosine in Leishmania donovani.
Journal: The Journal of parasitology 20061001
Title: Angiotensin II regulates neuronal excitability via phosphatidylinositol 4,5-bisphosphate-dependent modulation of Kv7 (M-type) K+ channels.
Journal: The Journal of physiology 20060815
Title: Effects of the anti-neoplastic agent ET-18-OCH3 and some analogs on the biophysical properties of model membranes.
Journal: International journal of pharmaceutics 20060802
Title: Inositol triphosphate participates in an oestradiol nongenomic signalling pathway involved in accelerated oviductal transport in cycling rats.
Journal: The Journal of endocrinology 20060301
Title: Brown recluse spider (Loxosceles reclusa) venom phospholipase D (PLD) generates lysophosphatidic acid (LPA).
Journal: The Biochemical journal 20051015
Title: Ethanol triggers neural crest apoptosis through the selective activation of a pertussis toxin-sensitive G protein and a phospholipase Cbeta-dependent Ca2+ transient.
Journal: Alcoholism, clinical and experimental research 20050701
Title: Anti-proliferative synergy of lysophospholipid analogues and ketoconazole against Trypanosoma cruzi (Kinetoplastida: Trypanosomatidae): cellular and ultrastructural analysis.
Journal: The Journal of antimicrobial chemotherapy 20050501
Title: A comparative study of the effect of the antineoplastic ether lipid 1-O-octadecyl-2-O-methyl-glycero-3-phosphocholine and some homologous compounds on PKC alpha and PKC epsilon.
Journal: Biochimica et biophysica acta 20050221
Title: Purging of peripheral blood stem cell transplants in AML: a predictive model based on minimal residual disease burden.
Journal: Experimental hematology 20050101
Title: Leishmanicidal activity of edelfosine, miltefosine and ilmofosine.
Journal: Basic & clinical pharmacology & toxicology 20050101
Title: ET-18-OCH3 inhibits the phosphorylation and activation of p70 S6 kinase in MCF-7 cells.
Journal: Anticancer research 20050101
Title: ET-18-OCH3 (edelfosine): a selective antitumour lipid targeting apoptosis through intracellular activation of Fas/CD95 death receptor.
Journal: Current medicinal chemistry 20041201
Title: Effect of the lysophospholipid analogues edelfosine, ilmofosine and miltefosine against Leishmania amazonensis.
Journal: The Journal of antimicrobial chemotherapy 20041001
Title: Endogenous production and exogenous exposure to nitric oxide augment doxorubicin cytotoxicity for breast cancer cells but not cardiac myoblasts.
Journal: Nitric oxide : biology and chemistry 20040501
Title: Apical and basolateral ATP-induced anion secretion in polarized human airway epithelia.
Journal: American journal of respiratory cell and molecular biology 20040301
Title: Cell membranes and apoptosis: role of cardiolipin, phosphatidylcholine, and anticancer lipid analogues.
Journal: Biochemistry and cell biology = Biochimie et biologie cellulaire 20040201
Title: Functional cloning of the miltefosine transporter. A novel P-type phospholipid translocase from Leishmania involved in drug resistance.
Journal: The Journal of biological chemistry 20031212
Title: Fibroblast growth factors regulate prolactin transcription via an atypical Rac-dependent signaling pathway.
Journal: Molecular endocrinology (Baltimore, Md.) 20031001
Title: Lem3p is essential for the uptake and potency of alkylphosphocholine drugs, edelfosine and miltefosine.
Journal: The Journal of biological chemistry 20030919
Title: Activity, pharmacokinetics and tissue distribution of TLC ELL-12 (liposomal antitumor ether lipid) in rats with transplantable, s.c. methylnitrosourea-induced tumors.
Journal: Anti-cancer drugs 20030701
Title: Synaptic Drosophila UNC-13 is regulated by antagonistic G-protein pathways via a proteasome-dependent degradation mechanism.
Journal: Journal of neurobiology 20030215
Title: Anti-cancer alkyl-lysophospholipids inhibit the phosphatidylinositol 3-kinase-Akt/PKB survival pathway.
Journal: Anti-cancer drugs 20030201
Title: Antiprotozoal activities of phospholipid analogues.
Journal: Molecular and biochemical parasitology 20030201
Title: Preferential inactivation of paediatric solid tumour cells by sequential exposure to Merocyanine 540-mediated photodynamic therapy and Edelfosine: implications for the ex vivo purging of autologous haematopoietic stem cell grafts.
Journal: Journal of photochemistry and photobiology. B, Biology 20030201
Title: Sensitivity of oocyte-expressed epithelial Na+ channel to glibenclamide.
Journal: Biochimica et biophysica acta 20030131
Title: Signaling events mediating activation of brain ethanolamine plasmalogen hydrolysis by ceramide.
Journal: European journal of biochemistry 20030101
Title: Alkylphospholipids reversibly open epithelial tight junctions.
Journal: Anticancer research 20030101
Title: Crystal structure of phospholipase A2 complex with the hydrolysis products of platelet activating factor: equilibrium binding of fatty acid and lysophospholipid-ether at the active site may be mutually exclusive.
Journal: Biochemistry 20021217
Title: Anti-tumor effect of Merocyanine 540-mediated photochemotherapy combined with Edelfosine: potential implications for the ex vivo purging of hematopoietic stem cell grafts from breast cancer patients.
Journal: Journal of photochemistry and photobiology. B, Biology 20021101
Title: Induction of cyclooxygenase-2 in Ras-transformed human mammary epithelial cells undergoing apoptosis.
Journal: Annals of the New York Academy of Sciences 20021101
Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.
Journal: The Journal of biological chemistry 20020419
Title: Perturbations in choline metabolism cause neural tube defects in mouse embryos in vitro.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20020401
Title: Ether phospholipids affect mast cell histamine release with relative potency similar to that with leukocyte membrane Ca2+-ATPase activity.
Journal: Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20020401
Title: Sensitivities of Leishmania species to hexadecylphosphocholine (miltefosine), ET-18-OCH(3) (edelfosine) and amphotericin B.
Journal: Acta tropica 20020201
Title: Requirement of Ca(2+) and PKCdelta for Janus kinase 2 activation by angiotensin II: involvement of PYK2.
Journal: Molecular endocrinology (Baltimore, Md.) 20020201
Title: Choline transport in Leishmania major promastigotes and its inhibition by choline and phosphocholine analogs.
Journal: Molecular and biochemical parasitology 20020101
Title: The antitumor ether lipid ET-18-OCH(3) induces apoptosis through translocation and capping of Fas/CD95 into membrane rafts in human leukemic cells.
Journal: Blood 20011215
Title: Regulation of eosinophil function by phosphatidylinositol-specific PLC and cytosolic PLA(2).
Journal: American journal of physiology. Lung cellular and molecular physiology 20011001
Title: Inhibitors of choline uptake and metabolism cause developmental abnormalities in neurulating mouse embryos.
Journal: Teratology 20010801
Title: Altered mitochondrial function and overgeneration of reactive oxygen species precede the induction of apoptosis by 1-O-octadecyl-2-methyl-rac-glycero-3-phosphocholine in p53-defective hepatocytes.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20010801
Title: Regulation of energy metabolism in macrophages during hypoxia. Roles of fructose 2,6-bisphosphate and ribose 1,5-bisphosphate.
Journal: The Journal of biological chemistry 20010727
Title: Alkyl-lysophospholipid 1-O-octadecyl-2-O-methyl- glycerophosphocholine induces invasion through episialin-mediated neutralization of E-cadherin in human mammary MCF-7 cells in vitro.
Journal: International journal of cancer 20010515
Title: Alkyl-lysophospholipids as anticancer agents and enhancers of radiation-induced apoptosis.
Journal: International journal of radiation oncology, biology, physics 20010201
Title: Protein kinase CbetaII activation by 1-beta-D-arabinofuranosylcytosine is antagonistic to stimulation of apoptosis and Bcl-2alpha down-regulation.
Journal: The Journal of biological chemistry 19970919
Title: Hexadecanoic and neuraminic acid incorporations in two rat colon carcinoma cell lipids: selective influence of 1-O-octadecyl 2-O-methyl-3-phosphocholine on glycerolipid and ganglioside biosynthesis.
Journal: Archives internationales de physiologie et de biochimie 19900801
