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7761-45-7,MFCD00866407
Catalog No.:AA00G4VW

7761-45-7 | Metoprine

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5mg
95%
1 week  
$120.00   $84.00
- +
10mg
95%
1 week  
$159.00   $112.00
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25mg
95%
1 week  
$239.00   $168.00
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50mg
95%
1 week  
$358.00   $251.00
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100mg
95%
1 week  
$511.00   $358.00
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500mg
95%
1 week  
$1,101.00   $771.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00G4VW
Chemical Name:
Metoprine
CAS Number:
7761-45-7
Molecular Formula:
C11H10Cl2N4
Molecular Weight:
269.1299
MDL Number:
MFCD00866407
SMILES:
Nc1nc(C)c(c(n1)N)c1ccc(c(c1)Cl)Cl
Properties
Computed Properties
 
Complexity:
266  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
17  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
1  
XLogP3:
2.8  

Literature

Title: Metoprine induced behavioral modifications and brain regional histamine increase in WAG/Rij and Wistar rats.

Journal: Epilepsy research 20120801

Title: Design, synthesis, and docking studies of novel benzopyrone derivatives as H(1)-antihistaminic agents.

Journal: Bioorganic & medicinal chemistry 20081001

Title: [New chemical constituents from Radix Polygoni Multiflori after processing].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20071201

Title: Histaminergic modulation of acoustically induced running behavior in rats.

Journal: Brain research 20070507

Title: Histaminergic involvement in neuropathic pain produced by partial ligation of the sciatic nerve in rats.

Journal: Regional anesthesia and pain medicine 20070101

Title: Mutant Gly482 and Thr482 ABCG2 mediate high-level resistance to lipophilic antifolates.

Journal: Cancer chemotherapy and pharmacology 20061201

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Reduction in brain infarction by augmentation of central histaminergic activity in rats.

Journal: Brain research 20051220

Title: Structural basis for inhibition of histamine N-methyltransferase by diverse drugs.

Journal: Journal of molecular biology 20051021

Title: The role of peripherally acting histamine in metoprine-induced reversal of haemorrhagic hypotension in rats--skeletal muscle microcirculatory studies.

Journal: Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20050401

Title: Role of histaminergic neurons in development of epileptic seizures in EL mice.

Journal: Brain research. Molecular brain research 20041206

Title: Involvement of arginine vasopressin in endogenous central histamine-induced reversal of critical haemorrhagic hypotension in rats.

Journal: Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20040701

Title: Cardiac and regional haemodynamic effects of histamine N-methyltransferase inhibitor metoprine in haemorrhage-shocked rats.

Journal: Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20040701

Title: Involvement of the sympathetic nervous system in the reversal of critical haemorrhagic hypotension by endogenous central histamine in rats.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20040401

Title: Accumulation of 5-phosphoribosyl-1-pyrophosphate in human CCRF-CEM leukaemia cells treated with antifolates.

Journal: The international journal of biochemistry & cell biology 20040301

Title: Involvement of the renin-angiotensin system in endogenous central histamine-induced reversal of critical haemorrhagic hypotension in rats.

Journal: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20040301

Title: Involvement of proopiomenalocortin-derived peptides in endogenous central histamine-induced reversal of critical haemorrhagic hypotension in rats.

Journal: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20040301

Title: Inhibition of histamine catabolism suppresses fat intake but not the intake of carbohydrates and protein.

Journal: Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20020401

Title: Mouse light/dark box test reveals anxiogenic-like effects by activation of histamine H1 receptors.

Journal: Pharmacology, biochemistry, and behavior 20020101

Title: Effect of clobenpropit on regional cerebral blood flow in rat hippocampus.

Journal: Acta pharmacologica Sinica 20010401

Title: Antiamnesic effect of metoprine and of selective histamine H(1) receptor agonists in a modified mouse passive avoidance test.

Journal: Neuroscience letters 20000707

Title: Inhibition of dihydrofolate reductases from Toxoplasma gondii, Pneumocystis carinii, and rat liver by rotationally restricted analogues of pyrimethamine and metoprine.

Journal: Drug design and discovery 19990701

Title: Nonclassical 2,4-diamino-5-aryl-6-ethylpyrimidine antifolates: activity as inhibitors of dihydrofolate reductase from Pneumocystis carinii and Toxoplasma gondii and as antitumor agents.

Journal: Journal of medicinal chemistry 19970912

Title: Inhibitory H3 receptors on sympathetic nerves of the pithed rat: activation by endogenous histamine and operation in spontaneously hypertensive rats.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 19970201

Title: High-affinity inhibitors of dihydrofolate reductase: antimicrobial and anticancer activities of 7,8-dialkyl-1,3-diaminopyrrolo[3,2-f]quinazolines with small molecular size.

Journal: Journal of medicinal chemistry 19960216

Title: Metoprine, an inhibitor of histamine N-methyltransferase but not catechol-O-methyltransferase, suppresses feeding in sated and in food deprived rats.

Journal: Methods and findings in experimental and clinical pharmacology 19950101

Title: Identification of highly potent and selective inhibitors of Toxoplasma gondii dihydrofolate reductase.

Journal: Antimicrobial agents and chemotherapy 19930901

Title: Pneumocystis carinii dihydrofolate reductase used to screen potential antipneumocystis drugs.

Journal: Antimicrobial agents and chemotherapy 19910701

Title: Phase I trial of metoprine in patients with advanced cancer.

Journal: Cancer treatment reports 19800101

Title: Junichi Kitanaka, et al. Brain Histamine N-Methyltransferase As a Possible Target of Treatment for Methamphetamine Overdose. Drug Target Insights. 2016 Mar 2;10:1-7.

Title: Zhong Chen, et al. Effects of brain histamine on memory deficit induced by nucleus basalis-lesion in rats. Acta Pharmacol Sin. 2002 Jan;23(1):66-70.

Title: John R Horton, et al. Structural basis for inhibition of histamine N-methyltransferase by diverse drugs. J Mol Biol. 2005 Oct 21;353(2):334-344.

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