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78-41-1,MFCD00865748
Catalog No.:AA0053GV

78-41-1 | Triparanol

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1mg
≥98%
in stock  
$135.00   $94.00
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5mg
≥98%
in stock  
$296.00   $207.00
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10mg
≥98%
in stock  
$510.00   $357.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA0053GV
Chemical Name:
Triparanol
CAS Number:
78-41-1
Molecular Formula:
C27H32ClNO2
Molecular Weight:
438.0015
MDL Number:
MFCD00865748
SMILES:
CCN(CCOc1ccc(cc1)C(c1ccc(cc1)C)(Cc1ccc(cc1)Cl)O)CC
NSC Number:
65345
Properties
Properties
 
Form:
Solid  
MP:
102.9-103.7℃  

Computed Properties
 
Complexity:
490  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
31  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
10  
Undefined Atom Stereocenter Count:
1  
XLogP3:
6.2  

Literature

Title: Triparanol suppresses human tumor growth in vitro and in vivo.

Journal: Biochemical and biophysical research communications 20120831

Title: Hedgehog and Notch signaling regulate self-renewal of undifferentiated pleomorphic sarcomas.

Journal: Cancer research 20120215

Title: Chance and serendipity in science: two examples from my own career.

Journal: The Journal of biological chemistry 20111104

Title: Statins: past and present.

Journal: Heart views : the official journal of the Gulf Heart Association 20110101

Title: A historical perspective on the discovery of statins.

Journal: Proceedings of the Japan Academy. Series B, Physical and biological sciences 20100511

Title: Different experimental approaches in modelling cataractogenesis: An overview of selenite-induced nuclear cataract in rats.

Journal: Interdisciplinary toxicology 20100301

Title: Chemical combinations elucidate pathway interactions and regulation relevant to Hepatitis C replication.

Journal: Molecular systems biology 20100101

Title: Age estimation in 25-45 yrs. old females by physical and radiological methods.

Journal: Journal of forensic dental sciences 20100101

Title: Inhibition of cholesterol biosynthesis disrupts lipid raft/caveolae and affects insulin receptor activation in 3T3-L1 preadipocytes.

Journal: Biochimica et biophysica acta 20090901

Title: Constitutive hedgehog signaling in chondrosarcoma up-regulates tumor cell proliferation.

Journal: The American journal of pathology 20060101

Title: Discovery of high-affinity ligands of sigma1 receptor, ERG2, and emopamil binding protein by pharmacophore modeling and virtual screening.

Journal: Journal of medicinal chemistry 20050728

Title: Dysregulation of hedgehog signalling predisposes to synovial chondromatosis.

Journal: The Journal of pathology 20050601

Title: Molecular mechanisms underlying limb anomalies associated with cholesterol deficiency during gestation: implications of Hedgehog signaling.

Journal: Human molecular genetics 20030515

Title: Limb malformations of rat fetuses exposed to a distal inhibitor of cholesterol biosynthesis.

Journal: Journal of lipid research 20020801

Title: Toxicologic lesions associated with two related inhibitors of oxidosqualene cyclase in the dog and mouse.

Journal: Toxicologic pathology 20010101

Title: Experimental myopathy induced by amphiphilic cationic compounds including several psychotropic drugs.

Journal: Neuroscience 19790101

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