Home Other Building Blocks 783348-36-7
783348-36-7,MFCD17392835
Catalog No.:AA00G3MD

783348-36-7 | MLN-120B

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25mg
98+%
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$143.00   $100.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00G3MD
Chemical Name:
MLN-120B
CAS Number:
783348-36-7
Molecular Formula:
C19H15ClN4O2
Molecular Weight:
366.8010
MDL Number:
MFCD17392835
SMILES:
COc1c(Cl)cc2c(c1NC(=O)c1cccnc1C)[nH]c1c2ccnc1
Properties
Computed Properties
 
Complexity:
522  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
26  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
3  
XLogP3:
3.1  

Literature

Title: Identification of potent Yes1 kinase inhibitors using a library screening approach.

Journal: Bioorganic & medicinal chemistry letters 20130801

Title: Comprehensive analysis of kinase inhibitor selectivity.

Journal: Nature biotechnology 20111030

Title: Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry.

Journal: Chemistry & biology 20101124

Title: Activation of NF-kappaB signaling by inhibitor of NF-kappaB kinase beta increases aggressiveness of ovarian cancer.

Journal: Cancer research 20100515

Title: Inhibition of IKK-beta: a new development in the mechanism of the anti-obesity effects of PTP1B inhibitors SA18 and SA32.

Journal: Bioorganic & medicinal chemistry letters 20100201

Title: Nitric oxide inhibits IFN regulatory factor 1 and nuclear factor-kappaB pathways in rhinovirus-infected epithelial cells.

Journal: The Journal of allergy and clinical immunology 20090901

Title: Repression of inflammatory gene expression in human pulmonary epithelial cells by small-molecule IkappaB kinase inhibitors.

Journal: The Journal of pharmacology and experimental therapeutics 20070501

Title: Use of molecular imaging to quantify response to IKK-2 inhibitor treatment in murine arthritis.

Journal: Arthritis and rheumatism 20070101

Title: IKKbeta inhibition protects against bone and cartilage destruction in a rat model of rheumatoid arthritis.

Journal: Arthritis and rheumatism 20061001

Title: Validation of the anti-inflammatory properties of small-molecule IkappaB Kinase (IKK)-2 inhibitors by comparison with adenoviral-mediated delivery of dominant-negative IKK1 and IKK2 in human airways smooth muscle.

Journal: Molecular pharmacology 20060801

Title: Rapid TNFR1-dependent lymphocyte depletion in vivo with a selective chemical inhibitor of IKKbeta.

Journal: Blood 20060601

Title: A selective small molecule IkappaB Kinase beta inhibitor blocks nuclear factor kappaB-mediated inflammatory responses in human fibroblast-like synoviocytes, chondrocytes, and mast cells.

Journal: The Journal of pharmacology and experimental therapeutics 20060601

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