Home Other Building Blocks 78574-94-4
78574-94-4,MFCD24849201
Catalog No.:AA00G233

78574-94-4 | Cycloastragenol

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100mg
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$102.00   $72.00
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250mg
≥ 99% (HPLC)
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$164.00   $115.00
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1g
≥ 99% (HPLC)
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5g
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00G233
Chemical Name:
Cycloastragenol
CAS Number:
78574-94-4
Molecular Formula:
C30H50O5
Molecular Weight:
490.7150
MDL Number:
MFCD24849201
SMILES:
O[C@H]1C[C@@]2([C@]([C@H]1[C@@]1(C)CC[C@H](O1)C(O)(C)C)(C)CC[C@@]13[C@H]2C[C@H](O)[C@@H]2[C@]3(C1)CC[C@@H](C2(C)C)O)C
Properties
Computed Properties
 
Complexity:
916  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
12  
Heavy Atom Count:
35  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
2  
XLogP3:
4.4  

Downstream Synthesis Route

[1]Patent:US2010/292197,2010,A1.Locationinpatent:Page/Pagecolumn14

[2]Patent:US9248088,2016,B2.Locationinpatent:Page/Pagecolumn21

[3]ChemicalandPharmaceuticalBulletin,1983,vol.31,p.698-708

[4]ChemistryofNaturalCompounds,2004,vol.40,p.40-44

[5]ChemistryofNaturalCompounds,1998,vol.34,p.672-675

[6]ChemistryofNaturalCompounds,1998,vol.34,p.672-675

[7]ChemistryofNaturalCompounds,2009,vol.45,p.595-596

[8]AdvancedSynthesisandCatalysis,2012,vol.354,p.527-539

[9]Patent:CN109942663,2019,A.Locationinpatent:Paragraph0024-0066

Literature

Title: In vitro intestinal absorption and first-pass intestinal and hepatic metabolism of cycloastragenol, a potent small molecule telomerase activator.

Journal: Drug metabolism and pharmacokinetics 20100101

Title: Yu Y, et al. Cycloastragenol: An exciting novel candidate for age-associated diseases. Exp Ther Med. 2018;16(3):2175-2182.

Title: Li M, et al. Cycloastragenol upregulates SIRT1 expression, attenuates apoptosis and suppresses neuroinflammation after brain ischemia. Acta Pharmacol Sin. 2020;41(8):1025-1032.

Title: Yu Y, et al. Cycloastragenol prevents age-related bone loss: Evidence in d-galactose-treated and aged rats. Biomed Pharmacother. 2020;128:110304.

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SDS
Tags:78574-94-4 Molecular Formula|78574-94-4 MDL|78574-94-4 SMILES|78574-94-4 Cycloastragenol |Heterocyclic_Building_Blocks