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78660-92-1,MFCD00178257
Catalog No.:AA0058PC

78660-92-1 | 2-Biphenyl-4-yl-quinoline-4-carboxylic acid

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Purity
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500mg
>95%
2 weeks  
$592.00   $415.00
- +
1g
>95%
2 weeks  
$633.00   $443.00
- +
5g
>95%
2 weeks  
$1,143.00   $800.00
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10g
>95%
2 weeks  
$1,654.00   $1,158.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA0058PC
Chemical Name:
2-Biphenyl-4-yl-quinoline-4-carboxylic acid
CAS Number:
78660-92-1
Molecular Formula:
C22H15NO2
Molecular Weight:
325.3600
MDL Number:
MFCD00178257
SMILES:
OC(=O)c1cc(nc2c1cccc2)c1ccc(cc1)c1ccccc1
Properties
Computed Properties
 
Complexity:
451  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
25  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
3  
XLogP3:
5  

Downstream Synthesis Route

[1]Saudi,ManalN.S.;Rostom,SherifA.F.;Fahmy,HeshamT.Y.;ElAshmawy,IbrahimM.[ArchivderPharmazie,2003,vol.336,#3,p.165-174]

[2]Brownetal.[JournaloftheAmericanChemicalSociety,1946,vol.68,p.2705,2707]

[1]Steinkopf;v.Petersdorff[JustusLiebigsAnnalenderChemie,1940,vol.543,p.119,126]

78660-92-1   
2-(1,1′-biphenyl-4-yl)quinoline-4-carboxamide 

[1]White;Bergstrom[JournalofOrganicChemistry,1942,vol.7,p.497,503]

[2]Saudi,ManalN.S.;Rostom,SherifA.F.;Fahmy,HeshamT.Y.;ElAshmawy,IbrahimM.[ArchivderPharmazie,2003,vol.336,#3,p.165-174]

[1]Saudi,ManalN.S.;Rostom,SherifA.F.;Fahmy,HeshamT.Y.;ElAshmawy,IbrahimM.[ArchivderPharmazie,2003,vol.336,#3,p.165-174]

[2]Madak,JosephT.;Cuthbertson,ChristineR.;Miyata,Yoshinari;Tamura,Shuzo;Petrunak,ElyseM.;Stuckey,JeanneA.;Han,Yanyan;He,Miao;Sun,Duxin;Showalter,HollisD.;Neamati,Nouri[JournalofMedicinalChemistry,2018,vol.61,#12,p.5162-5186]

[3]Steinkopf;v.Petersdorff[JustusLiebigsAnnalenderChemie,1940,vol.543,p.119,126]White;Bergstrom[JournalofOrganicChemistry,1942,vol.7,p.497,503]

[4]Shi,Zhi-Bing;Zhang,Lei;Bin,Zheng-Yang;Cao,Xiang-Rong;Gong,Zhu-Nan;Li,Jian-Xin[Lettersindrugdesignanddiscovery,2013,vol.10,#5,p.420-426]

[5]Wang,Yedong;Wu,Yixin;Liu,Chang;Zhang,Jingli;Yan,Xiaoyu[Chemistry-AnAsianJournal,2022,vol.17,#18]

[1]Belen'kaya,R.S.;Boreko,E.I.;Zemtsova,M.N.;Kalinina,M.I.;Timofeeva,M.M.;etal.[PharmaceuticalChemistryJournal,1981,vol.15,#3,p.171-176][Khimiko-FarmatsevticheskiiZhurnal,1981,vol.15,#3,p.29-35]

Literature

Title: Synthesis of 2-(4-biphenylyl)quinoline-4-carboxylate and carboxamide analogs. New human neurokinin-3 (hNK-3) receptor antagonists.

Journal: Archiv der Pharmazie 20030601

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