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79-43-6,MFCD00004223
Catalog No.:AA003PAK

79-43-6 | Dichloroacetic acid

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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA003PAK
Chemical Name:
Dichloroacetic acid
CAS Number:
79-43-6
Molecular Formula:
C2H2Cl2O2
Molecular Weight:
128.9421
MDL Number:
MFCD00004223
SMILES:
ClC(C(=O)O)Cl
NSC Number:
2654
UN Number:
1764
Properties
Properties
 
BP:
194°C  
Form:
Liquid  
Storage:
2-8℃;  

Computed Properties
 
Complexity:
60.6  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
6  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
1  
XLogP3:
0.9  

Literature

Title: Metabolic Disruption Early in Life is Associated With Latent Carcinogenic Activity of Dichloroacetic Acid in Mice.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20171001

Title: Disinfection By-Product Exposures and the Risk of Specific Cardiac Birth Defects.

Journal: Environmental health perspectives 20170201

Title: Therapeutic applications of dichloroacetate and the role of glutathione transferase zeta-1.

Journal: Pharmacology & therapeutics 20170201

Title: Trichloroethylene and Its Oxidative Metabolites Enhance the Activated State and Th1 Cytokine Gene Expression in Jurkat Cells.

Journal: International journal of environmental research and public health 20150901

Title: Silencing gastrin-releasing peptide receptor suppresses key regulators of aerobic glycolysis in neuroblastoma cells.

Journal: Pediatric blood & cancer 20150401

Title: Dichloroacetate and cancer: new home for an orphan drug?

Journal: Biochimica et biophysica acta 20141201

Title: Long-term dietary exposure to low concentration of dichloroacetic acid promoted longevity and attenuated cellular and functional declines in aged Drosophila melanogaster.

Journal: Age (Dordrecht, Netherlands) 20140601

Title: Chloride and other anions inhibit dichloroacetate-induced inactivation of human liver GSTZ1 in a haplotype-dependent manner.

Journal: Chemico-biological interactions 20140525

Title: Metabolomics reveals trichloroacetate as a major contributor to trichloroethylene-induced metabolic alterations in mouse urine and serum.

Journal: Archives of toxicology 20131101

Title: Design, synthesis and biological evaluation of N-arylphenyl-2,2-dichloroacetamide analogues as anti-cancer agents.

Journal: Bioorganic & medicinal chemistry letters 20121201

Title: Influence of bacterial extracellular polymeric substances on the formation of carbonaceous and nitrogenous disinfection byproducts.

Journal: Environmental science & technology 20121016

Title: Application of hyperpolarized [1-¹³C]lactate for the in vivo investigation of cardiac metabolism.

Journal: NMR in biomedicine 20121001

Title: Unusual complex formation and chemical reaction of haloacetate anion on the exterior surface of cucurbit[6]uril in the gas phase.

Journal: Journal of the American Society for Mass Spectrometry 20121001

Title: Inactivation of the HIF-1α/PDK3 signaling axis drives melanoma toward mitochondrial oxidative metabolism and potentiates the therapeutic activity of pro-oxidants.

Journal: Cancer research 20121001

Title: Tormentic acid derivatives: synthesis and apoptotic activity.

Journal: European journal of medicinal chemistry 20121001

Title: Comparison of spheroids formed by rat glioma stem cells and neural stem cells reveals differences in glucose metabolism and promising therapeutic applications.

Journal: The Journal of biological chemistry 20120928

Title: Size-exclusion chromatography of poly(ethylene 2,6-naphthalate).

Journal: Journal of chromatography. A 20120921

Title: Prediction of death in the SMNΔ7 mouse model of spinal muscular atrophy: insight into disease stage and progression.

Journal: Journal of neuroscience methods 20120815

Title: Novel molecular mechanisms of antitumor action of dichloroacetate against T cell lymphoma: Implication of altered glucose metabolism, pH homeostasis and cell survival regulation.

Journal: Chemico-biological interactions 20120730

Title: Human polymorphisms in the glutathione transferase zeta 1/maleylacetoacetate isomerase gene influence the toxicokinetics of dichloroacetate.

Journal: Journal of clinical pharmacology 20120601

Title: Necrosis of cervical carcinoma by dichloroacetate released from electrospun polylactide mats.

Journal: Biomaterials 20120601

Title: Co-treatment of dichloroacetate, omeprazole and tamoxifen exhibited synergistically antiproliferative effect on malignant tumors: in vivo experiments and a case report.

Journal: Hepato-gastroenterology 20120601

Title: 2-Amino-4,6-dimeth-oxy-pyrimidin-1-ium 2,2-dichloro-acetate.

Journal: Acta crystallographica. Section E, Structure reports online 20120601

Title: Unilateral periventricular leukomalacia in association with pyruvate dehydrogenase deficiency.

Journal: Developmental medicine and child neurology 20120501

Title: Comparison of trihalomethanes in tap water and blood: a case study in the United States.

Journal: Environmental health perspectives 20120501

Title: The role of FOXO and PPAR transcription factors in diet-mediated inhibition of PDC activation and carbohydrate oxidation during exercise in humans and the role of pharmacological activation of PDC in overriding these changes.

Journal: Diabetes 20120501

Title: Effects of three modifiers of glycolysis on ATP, lactate, hypoxia, and growth in human tumor cell lines in vivo.

Journal: Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] 20120501

Title: Inorganic arsenic and basal cell carcinoma in areas of Hungary, Romania, and Slovakia: a case-control study.

Journal: Environmental health perspectives 20120501

Title: Stimulation of glucose oxidation protects against acute myocardial infarction and reperfusion injury.

Journal: Cardiovascular research 20120501

Title: Treatment for mitochondrial disorders.

Journal: The Cochrane database of systematic reviews 20120418

Title: Photocatalytic production of 1O2 and *OH mediated by silver oxidation during the photoinactivation of Escherichia coli with TiO2.

Journal: Journal of hazardous materials 20120415

Title: Dichloroacetate inhibits neuroblastoma growth by specifically acting against malignant undifferentiated cells.

Journal: International journal of cancer 20120401

Title: Toxicological evaluation of paper mill sewage sediment treated by indigenous dibenzofuran-degrading Pseudomonas sp.

Journal: Bioresource technology 20120401

Title: Mitochondrial genome-knockout cells demonstrate a dual mechanism of action for the electron transport complex I inhibitor mycothiazole.

Journal: Marine drugs 20120401

Title: Predicting the safety and efficacy of buffer therapy to raise tumour pHe: an integrative modelling study.

Journal: British journal of cancer 20120327

Title: Lung ¹⁸F-fluorodeoxyglucose positron emission tomography for diagnosis and monitoring of pulmonary arterial hypertension.

Journal: American journal of respiratory and critical care medicine 20120315

Title: Mitaplatin increases sensitivity of tumor cells to cisplatin by inducing mitochondrial dysfunction.

Journal: Molecular pharmaceutics 20120305

Title: Susceptibility to breast cancer and three polymorphisms of GSTZ1.

Journal: DNA and cell biology 20120301

Title: Vitamin E restriction in the diet enhances phagocytic activation by dichloroacetate and trichloroacetate in mice.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20120301

Title: The cycling of acetyl-coenzyme A through acetylcarnitine buffers cardiac substrate supply: a hyperpolarized 13C magnetic resonance study.

Journal: Circulation. Cardiovascular imaging 20120301

Title: One-flask synthesis of cyclic diguanosine monophosphate (c-di-GMP).

Journal: Current protocols in nucleic acid chemistry 20120301

Title: The effects of a low vitamin E diet on dichloroacetate- and trichloroacetate-induced oxidative stress in the livers of mice.

Journal: Journal of biochemical and molecular toxicology 20120301

Title: Multi-substituted N-phenyl-2, 2-dichloroacetamide analogues as anti-cancer drugs: design, synthesis and biological evaluation.

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20120301

Title: Beneficial effect of pyruvate therapy on Leigh syndrome due to a novel mutation in PDH E1α gene.

Journal: Brain & development 20120201

Title: Prenatal and postnatal expression of glutathione transferase ζ 1 in human liver and the roles of haplotype and subject age in determining activity with dichloroacetate.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20120201

Title: The role of low-level lactate production in airway inflammation in asthma.

Journal: American journal of physiology. Lung cellular and molecular physiology 20120201

Title: Dichloroacetic acid up-regulates hepatic glutathione synthesis via the induction of glutamate-cysteine ligase.

Journal: Biochemical pharmacology 20120201

Title: Formation of halogenated C-, N-DBPs from chlor(am)ination and UV irradiation of tyrosine in drinking water.

Journal: Environmental pollution (Barking, Essex : 1987) 20120201

Title: Flow cytometric evaluation of the effects of 3-bromopyruvate (3BP) and dichloracetate (DCA) on THP-1 cells: a multiparameter analysis.

Journal: Journal of bioenergetics and biomembranes 20120201

Title: Clinicopathologic Manifestations of Patients with Fordyce's Spots.

Journal: Annals of dermatology 20120201

Title: Cancer metabolism: current perspectives and future directions.

Journal: Cell death & disease 20120101

Title: Risk of stillbirth in the relation to water disinfection by-products: a population-based case-control study in Taiwan.

Journal: PloS one 20120101

Title: Correlation of diffusion and metabolic alterations in different clinical forms of multiple sclerosis.

Journal: PloS one 20120101

Title: Dichloroacetate induces different rates of cell death in cancer and noncancer cell lines in vitro.

Journal: Tumori 20120101

Title: Design and characterization of a silk-fibroin-based drug delivery platform using naproxen as a model drug.

Journal: Journal of drug delivery 20120101

Title: Synergistic effect of the combination of immobilized TiO2, UVA and ozone on the decomposition of dichloroacetic acid.

Journal: Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering 20120101

Title: Influence of dichloroacetate (DCA) on lactate production and oxygen consumption in neuroblastoma cells: is DCA a suitable drug for neuroblastoma therapy?

Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20120101

Title: Modulation of astrocytic mitochondrial function by dichloroacetate improves survival and motor performance in inherited amyotrophic lateral sclerosis.

Journal: PloS one 20120101

Title: Protection of rat cardiac myocytes by fructose-1,6-bisphosphate and 2,3-butanedione.

Journal: PloS one 20120101

Title: Defluorination of sodium fluoroacetate by bacteria from soil and plants in Brazil.

Journal: TheScientificWorldJournal 20120101

Title: PPARs: Interference with Warburg' Effect and Clinical Anticancer Trials.

Journal: PPAR research 20120101

Title: EMT and stem cell-like properties associated with HIF-2α are involved in arsenite-induced transformation of human bronchial epithelial cells.

Journal: PloS one 20120101

Title: Enzymatic synthesis of DNA strands containing α-L-LNA (α-L-configured locked nucleic acid) thymine nucleotides.

Journal: Artificial DNA, PNA & XNA 20120101

Title: Mitochondrial metabolism - neglected link of cancer transformation and treatment.

Journal: Prague medical report 20120101

Title: The reproducibility of 31-phosphorus MRS measures of muscle energetics at 3 Tesla in trained men.

Journal: PloS one 20120101

Title: Combination of sulindac and dichloroacetate kills cancer cells via oxidative damage.

Journal: PloS one 20120101

Title: Glucose is a pH-dependent motor for sperm beat frequency during early activation.

Journal: PloS one 20120101

Title: Dichloroacetate induces apoptosis of epithelial ovarian cancer cells through a mechanism involving modulation of oxidative stress.

Journal: Reproductive sciences (Thousand Oaks, Calif.) 20111201

Title: Exposure to trihalomethanes through different water uses and birth weight, small for gestational age, and preterm delivery in Spain.

Journal: Environmental health perspectives 20111201

Title: In vitro effects of an in silico-modelled 17β-estradiol derivative in combination with dichloroacetic acid on MCF-7 and MCF-12A cells.

Journal: Cell proliferation 20111201

Title: The influence of sodium dichloroacetate on the oxidative processes in sarcoma 37.

Journal: Experimental oncology 20111201

Title: Characteristic transformation of humic acid during photoelectrocatalysis process and its subsequent disinfection byproduct formation potential.

Journal: Water research 20111115

Title: Electromembrane extraction and HPLC analysis of haloacetic acids and aromatic acetic acids in wastewater.

Journal: Talanta 20111030

Title: Genome protective effect of metformin as revealed by reduced level of constitutive DNA damage signaling.

Journal: Aging 20111001

Title: Prospective power calculations for the Four Lab study of a multigenerational reproductive/developmental toxicity rodent bioassay using a complex mixture of disinfection by-products in the low-response region.

Journal: International journal of environmental research and public health 20111001

Title: Role of SLC5A8, a plasma membrane transporter and a tumor suppressor, in the antitumor activity of dichloroacetate.

Journal: Oncogene 20110922

Title: Comparative electrochemical treatments of two chlorinated aliphatic hydrocarbons. Time course of the main reaction by-products.

Journal: Journal of hazardous materials 20110915

Title: Why are there no proven therapies for genetic mitochondrial diseases?

Journal: Mitochondrion 20110901

Title: Functionalized polystyrene supports for solid-phase synthesis of glycyl-, alanyl-, and isoleucyl-RNA conjugates as hydrolysis-resistant mimics of peptidyl-tRNAs.

Journal: Bioorganic & medicinal chemistry 20110901

Title: Structures of a putative ζ-class glutathione S-transferase from the pathogenic fungus Coccidioides immitis.

Journal: Acta crystallographica. Section F, Structural biology and crystallization communications 20110901

Title: Bis-(chloro-acetato-κO)bis(trimethyl-silylmethyl)tin(IV).

Journal: Acta crystallographica. Section E, Structure reports online 20110901

Title: Use of oral dichloroacetate for palliation of leg pain arising from metastatic poorly differentiated carcinoma: a case report.

Journal: Journal of palliative medicine 20110801

Title: Removal of dichloroacetic acid from drinking water by using adsorptive ozonation.

Journal: Ecotoxicology (London, England) 20110701

Title: Haloacetic acids in swimming pools: swimmer and worker exposure.

Journal: Environmental science & technology 20110701

Title: [Chlorination byproducts formation potentials of typical nitrogenous organic compounds in water].

Journal: Huan jing ke xue= Huanjing kexue 20110701

Title: Inhibition of alanine aminotransferase in silico and in vivo promotes mitochondrial metabolism to impair malignant growth.

Journal: The Journal of biological chemistry 20110624

Title: Development and evaluation of a harmonized physiologically based pharmacokinetic (PBPK) model for perchloroethylene toxicokinetics in mice, rats, and humans.

Journal: Toxicology and applied pharmacology 20110615

Title: Role of pyruvate dehydrogenase inhibition in the development of hypertrophy in the hyperthyroid rat heart: a combined magnetic resonance imaging and hyperpolarized magnetic resonance spectroscopy study.

Journal: Circulation 20110607

Title: Butyrate elicits a metabolic switch in human colon cancer cells by targeting the pyruvate dehydrogenase complex.

Journal: International journal of cancer 20110601

Title: The effect of dichloroacetate on health- and lifespan in C. elegans.

Journal: Biogerontology 20110601

Title: Development of a dichloroacetic acid-hemoglobin conjugate as a potential targeted anti-cancer therapeutic.

Journal: Biotechnology and bioengineering 20110601

Title: Metabolism and brain cancer.

Journal: Clinics (Sao Paulo, Brazil) 20110601

Title: Effects of iron and manganese on the formation of HAAs upon chlorinating Chlorella vulgaris.

Journal: Journal of hazardous materials 20110515

Title: Effects of chlorinated acetates on the glutathione metabolism and on glycolysis of cultured astrocytes.

Journal: Neurotoxicity research 20110501

Title: Glutathione transferase zeta: discovery, polymorphic variants, catalysis, inactivation, and properties of Gstz1-/- mice.

Journal: Drug metabolism reviews 20110501

Title: Chronic and acute exposure of mouse hearts to fatty acids increases oxygen cost of excitation-contraction coupling.

Journal: American journal of physiology. Heart and circulatory physiology 20110501

Title: Formation and modeling of disinfection by-products in drinking water of six cities in China.

Journal: Journal of environmental monitoring : JEM 20110501

Title: Degradation of dichloroacetic acid in homogeneous aqueous media employing ozone and UVC radiation.

Journal: Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 20110302

Title: Dichloroacetate metabolically targeted therapy defeats cytotoxicity of standard anticancer drugs.

Journal: Cancer chemotherapy and pharmacology 20110301

Title: Anticancer drugs that target metabolism: Is dichloroacetate the new paradigm?

Journal: International journal of cancer 20110301

Title: High concentrations of dichloroacetate have minor effects on the vitality of the mammalian nerve fibers: an ex-vivo electrophysiological study.

Journal: Anti-cancer drugs 20110301

Title: Effects of environmental endocrine disruptors on pubertal development.

Journal: Journal of clinical research in pediatric endocrinology 20110301

Title: Pros and cons of analytical methods to quantify surrogate contaminants from the challenge test in recycled polyethylene terephthalate.

Journal: Analytica chimica acta 20110214

Title: Validation of the in vivo assessment of pyruvate dehydrogenase activity using hyperpolarised 13C MRS.

Journal: NMR in biomedicine 20110201

Title: The dichloroacetate dilemma: environmental hazard versus therapeutic goldmine--both or neither?

Journal: Environmental health perspectives 20110201

Title: Dichloroacetate shifts the metabolism from glycolysis to glucose oxidation and exhibits synergistic growth inhibition with cisplatin in HeLa cells.

Journal: International journal of oncology 20110201

Title: Influence of soluble microbial products (SMP) on wastewater disinfection byproducts: trihalomethanes and haloacetic acid species from the chlorination of SMP.

Journal: Environmental science and pollution research international 20110101

Title: A screening level fate model of organic contaminants from advanced water treatment in a potable water supply reservoir.

Journal: Water research 20110101

Title: Iron overload and diabetes risk: a shift from glucose to Fatty Acid oxidation and increased hepatic glucose production in a mouse model of hereditary hemochromatosis.

Journal: Diabetes 20110101

Title: Mitochondrion as a novel site of dichloroacetate biotransformation by glutathione transferase zeta 1.

Journal: The Journal of pharmacology and experimental therapeutics 20110101

Title: Metabolic-targeted therapy with dichloroacetate (DCA): a novel treatment strategy to improve the outcome of photodynamic therapy.

Journal: Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 20110101

Title: Developing new anti-cancer drugs.

Journal: Recent patents on anti-cancer drug discovery 20110101

Title: In vitro cytotoxicity of novel platinum-based drugs and dichloroacetate against lung carcinoid cell lines.

Journal: Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 20110101

Title: On-target inhibition of tumor fermentative glycolysis as visualized by hyperpolarized pyruvate.

Journal: Neoplasia (New York, N.Y.) 20110101

Title: Further optimization of detritylation in solid-phase oligodeoxyribonucleotide synthesis.

Journal: Nucleosides, nucleotides & nucleic acids 20110101

Title: Chronic CSE treatment induces the growth of normal oral keratinocytes via PDK2 upregulation, increased glycolysis and HIF1α stabilization.

Journal: PloS one 20110101

Title: Efficacy of fumaric acid esters in the R6/2 and YAC128 models of Huntington's disease.

Journal: PloS one 20110101

Title: Skeletal muscle metabolic gene expression is not affected by dichloroacetate-mediated modulation of substrate utilisation.

Journal: Annals of nutrition & metabolism 20110101

Title: Synergistic antitumor effect of dichloroacetate in combination with 5-fluorouracil in colorectal cancer.

Journal: Journal of biomedicine & biotechnology 20110101

Title: Stereocomplexes Formed From Select Oligomers of Polymer d-lactic Acid (PDLA) and l-lactate May Inhibit Growth of Cancer Cells and Help Diagnose Aggressive Cancers-Applications of the Warburg Effect.

Journal: Perspectives in medicinal chemistry 20110101

Title: Amyloid beta resistance in nerve cell lines is mediated by the Warburg effect.

Journal: PloS one 20110101

Title: Mitochondrial approaches to protect against cardiac ischemia and reperfusion injury.

Journal: Frontiers in physiology 20110101

Title: Mitochondrial changes in ageing Caenorhabditis elegans--what do we learn from superoxide dismutase knockouts?

Journal: PloS one 20110101

Title: The metabolic advantage of tumor cells.

Journal: Molecular cancer 20110101

Title: Bicarbonate and dichloroacetate: evaluating pH altering therapies in a mouse model for metastatic breast cancer.

Journal: BMC cancer 20110101

Title: Stage-related alterations in renal cell carcinoma--comprehensive quantitative analysis by 2D-DIGE and protein network analysis.

Journal: PloS one 20110101

Title: Exploiting mitochondrial dysfunction for effective elimination of imatinib-resistant leukemic cells.

Journal: PloS one 20110101

Title: Anticancer targets in the glycolytic metabolism of tumors: a comprehensive review.

Journal: Frontiers in pharmacology 20110101

Title: Probucol attenuates oxidative stress, energy starvation, and nitric acid production following transient forebrain ischemia in the rat hippocampus.

Journal: Oxidative medicine and cellular longevity 20110101

Title: Hepatocyte Lysosomal Membrane Stabilization by Olive Leaves against Chemically Induced Hepatocellular Neoplasia in Rats.

Journal: International journal of hepatology 20110101

Title: Bioremediation via Methanotrophy: Overview of Recent Findings and Suggestions for Future Research.

Journal: Frontiers in microbiology 20110101

Title: Resveratrol improves survival, hemodynamics and energetics in a rat model of hypertension leading to heart failure.

Journal: PloS one 20110101

Title: Screening for active small molecules in mitochondrial complex I deficient patient's fibroblasts, reveals AICAR as the most beneficial compound.

Journal: PloS one 20110101

Title: Formation of disinfection byproducts in typical Chinese drinking water.

Journal: Journal of environmental sciences (China) 20110101

Title: 8-Modified-2'-deoxyadenosine analogues induce delayed polymerization arrest during HIV-1 reverse transcription.

Journal: PloS one 20110101

Title: Targeting metabolism with arsenic trioxide and dichloroacetate in breast cancer cells.

Journal: Molecular cancer 20110101

Title: Ingestion exposure to nitrosamines in chlorinated drinking water.

Journal: Environmental health and toxicology 20110101

Title: The genetics of pulmonary arterial hypertension in the post-BMPR2 era.

Journal: Pulmonary circulation 20110101

Title: Arsenic exposure and the induction of human cancers.

Journal: Journal of toxicology 20110101

Title: Induction of human squamous cell-type carcinomas by arsenic.

Journal: Journal of skin cancer 20110101

Title: Biological roles and therapeutic potential of hydroxy-carboxylic Acid receptors.

Journal: Frontiers in endocrinology 20110101

Title: Glutathione s-transferases in pediatric cancer.

Journal: Frontiers in oncology 20110101

Title: Identification of radiolysis products of solid thiamphenicol.

Journal: Journal of pharmaceutical and biomedical analysis 20101201

Title: Sodium dichloroacetate selectively targets cells with defects in the mitochondrial ETC.

Journal: International journal of cancer 20101201

Title: Severe encephalopathy and polyneuropathy induced by dichloroacetate.

Journal: Journal of neurology 20101201

Title: Acid-base disorders in ICU patients.

Journal: Electrolyte & blood pressure : E & BP 20101201

Title: Sodium dichloroacetate (DCA) reduces apoptosis in colorectal tumor hypoxia.

Journal: Cancer letters 20101101

Title: Polymorphisms in GSTT1, GSTZ1, and CYP2E1, disinfection by-products, and risk of bladder cancer in Spain.

Journal: Environmental health perspectives 20101101

Title: Differential response to trichloroethylene-induced hepatosteatosis in wild-type and PPARalpha-humanized mice.

Journal: Environmental health perspectives 20101101

Title: Genotoxic effects in swimmers exposed to disinfection by-products in indoor swimming pools.

Journal: Environmental health perspectives 20101101

Title: Production of various disinfection byproducts in indoor swimming pool waters treated with different disinfection methods.

Journal: International journal of hygiene and environmental health 20101101

Title: The serum metabolite response to diet intervention with probiotic acidified milk in irritable bowel syndrome patients is indistinguishable from that of non-probiotic acidified milk by 1H NMR-based metabonomic analysis.

Journal: Nutrients 20101101

Title: Enhanced production and isotope enrichment of recombinant glycoproteins produced in cultured mammalian cells.

Journal: Journal of biomolecular NMR 20101001

Title: 5'-Bis-conjugation of oligonucleotides by amidative oxidation and click chemistry.

Journal: The Journal of organic chemistry 20101001

Title: Mitochondrial metabolic adaptation in right ventricular hypertrophy and failure.

Journal: Journal of molecular medicine (Berlin, Germany) 20101001

Title: Role of pyruvate dehydrogenase kinase 4 in regulation of blood glucose levels.

Journal: Korean diabetes journal 20101001

Title: Counteranion-dependent mechanisms of intramolecular proton transfer in aprotic solution.

Journal: Physical chemistry chemical physics : PCCP 20100921

Title: Potential of the TCE-degrading endophyte Pseudomonas putida W619-TCE to improve plant growth and reduce TCE phytotoxicity and evapotranspiration in poplar cuttings.

Journal: Environmental pollution (Barking, Essex : 1987) 20100901

Title: Novel N-phenyl dichloroacetamide derivatives as anticancer reagents: design, synthesis and biological evaluation.

Journal: European journal of medicinal chemistry 20100901

Title: Electromigration diffusivity spectrometry: a way for simultaneous determination of diffusion coefficients from mixed samples.

Journal: Electrophoresis 20100901

Title: Platinized WO3 as an environmental photocatalyst that generates OH radicals under visible light.

Journal: Environmental science & technology 20100901

Title: Oncology's energetic pipeline.

Journal: Nature biotechnology 20100901

Title: Lactic acidemia in the pathogenesis of mice carrying mitochondrial DNA with a deletion.

Journal: Human molecular genetics 20100815

Title: Pyruvate suppresses PGC1alpha expression and substrate utilization despite increased respiratory chain content in C2C12 myotubes.

Journal: American journal of physiology. Cell physiology 20100801

Title: A simple and effective treatment for ectopic sebaceous glands on the areola.

Journal: Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] 20100801

Title: Determination of haloacetic acids in water using solid-phase extraction/microchip capillary electrophoresis with capacitively coupled contactless conductivity detection.

Journal: Electrophoresis 20100801

Title: Dichloroacetate (DCA) enhances tumor cell death in combination with oncolytic adenovirus armed with MDA-7/IL-24.

Journal: Molecular and cellular biochemistry 20100701

Title: Dichloroacetate- and trichloroacetate-induced oxidative stress in the hepatic tissues of mice after long-term exposure.

Journal: Journal of applied toxicology : JAT 20100701

Title: Electrochemically assisted photocatalytic degradation of 4-chlorophenol by ZnFe2O4-modified TiO2 nanotube array electrode under visible light irradiation.

Journal: Environmental science & technology 20100701

Title: Dichloroacetate induces apoptosis and cell-cycle arrest in colorectal cancer cells.

Journal: British journal of cancer 20100608

Title: Oxidative stress therapy for solid tumors - a proposal.

Journal: Medical hypotheses 20100601

Title: Novel strategy for treatment of pulmonary arterial hypertension: enhancement of apoptosis.

Journal: Lung 20100601

Title: Change of purpose.

Journal: Nature 20100520

Title: The reverse Warburg effect: glycolysis inhibitors prevent the tumor promoting effects of caveolin-1 deficient cancer associated fibroblasts.

Journal: Cell cycle (Georgetown, Tex.) 20100515

Title: Targeting cell metabolism in cancer patients.

Journal: Science translational medicine 20100512

Title: Metabolic modulation of glioblastoma with dichloroacetate.

Journal: Science translational medicine 20100512

Title: Practical strategies for suppressing hypoxia-inducible factor activity in cancer therapy.

Journal: Medical hypotheses 20100501

Title: Analysis of metabolic remodeling in compensated left ventricular hypertrophy and heart failure.

Journal: Circulation. Heart failure 20100501

Title: Physiologically based pharmacokinetic modeling of dibromoacetic acid in F344 rats.

Journal: Toxicology and applied pharmacology 20100415

Title: Selection of cancer cells with repressed mitochondria triggers colon cancer progression.

Journal: Carcinogenesis 20100401

Title: New therapies for pulmonary arterial hypertension: an update on current bench to bedside translation.

Journal: Expert opinion on investigational drugs 20100401

Title: Metabolic network topology reveals transcriptional regulatory signatures of type 2 diabetes.

Journal: PLoS computational biology 20100401

Title: Demand-induced ischemia in volume expanded isolated rat heart; the effect of dichloroacetate and trimetazidine.

Journal: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20100401

Title: Three-level topology switching in a molecular Möbius band.

Journal: Journal of the American Chemical Society 20100310

Title: Generation of disinfection by-products (DBPs) at two advanced water treatment plants.

Journal: Environmental monitoring and assessment 20100301

Title: Occurrence of haloacetic acids (HAAs) and trihalomethanes (THMs) in drinking water of Taiwan.

Journal: Environmental monitoring and assessment 20100301

Title: Treatment of mitochondrial electron transport chain disorders: a review of clinical trials over the past decade.

Journal: Molecular genetics and metabolism 20100301

Title: Emerging therapies for the treatment of pulmonary hypertension.

Journal: Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 20100301

Title: Expression and characterization of three new glutathione transferases, an epsilon (AcGSTE2-2), omega (AcGSTO1-1), and theta (AcGSTT1-1) from Anopheles cracens (Diptera: Culicidae), a major Thai malaria vector.

Journal: Journal of medical entomology 20100301

Title: The induction of tumor necrosis factor-alpha, superoxide anion, myeloperoxidase, and superoxide dismutase in the peritoneal lavage cells of mice after prolonged exposure to dichloroacetate and trichloroacetate.

Journal: Journal of biochemical and molecular toxicology 20100301

Title: [Determination of trihalomethanes and haloacetic acids in the sample holding time, and their stability in the extract].

Journal: Wei sheng yan jiu = Journal of hygiene research 20100301

Title: Effect of zinc on the transformation of haloacetic acids (HAAs) in drinking water.

Journal: Journal of hazardous materials 20100215

Title: Reversal of the glycolytic phenotype by dichloroacetate inhibits metastatic breast cancer cell growth in vitro and in vivo.

Journal: Breast cancer research and treatment 20100201

Title: Bis(2,2'-bipyrid-yl)(dichloro-acetato)copper(II) dichloro-acetate dihydrate.

Journal: Acta crystallographica. Section E, Structure reports online 20100201

Title: Formation of haloacetamides during chlorination of dissolved organic nitrogen aspartic acid.

Journal: Journal of hazardous materials 20100115

Title: The inhibition of pyruvate dehydrogenase kinase improves impaired cardiac function and electrical remodeling in two models of right ventricular hypertrophy: resuscitating the hibernating right ventricle.

Journal: Journal of molecular medicine (Berlin, Germany) 20100101

Title: Polymerase-endonuclease amplification reaction (PEAR) for large-scale enzymatic production of antisense oligonucleotides.

Journal: PloS one 20100101

Title: Gene expression in a Drosophila model of mitochondrial disease.

Journal: PloS one 20100101

Title: Cancer proliferation and therapy: the Warburg effect and quantum metabolism.

Journal: Theoretical biology & medical modelling 20100101

Title: Bacteria in cancer therapy: a novel experimental strategy.

Journal: Journal of biomedical science 20100101

Title: [Cytotoxicity of dichloroacetic acid in lymphocyte and expression of chemokine receptor CXCR2 and chemokine receptor CXCR3 mRNA].

Journal: Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases 20100101

Title: Synthesis and photocatalytic activity of boron-doped TiO(2) in aqueous suspensions under UV-A irradiation.

Journal: Water science and technology : a journal of the International Association on Water Pollution Research 20100101

Title: Degradation of a mixture of pollutants in water using the UV/H2O2 process.

Journal: Water science and technology : a journal of the International Association on Water Pollution Research 20100101

Title: Mammalian cell cytotoxicity and genotoxicity of the haloacetic acids, a major class of drinking water disinfection by-products.

Journal: Environmental and molecular mutagenesis 20100101

Title: Non-Hodgkin's Lymphoma Reversal with Dichloroacetate.

Journal: Journal of oncology 20100101

Title: The assessment of population exposure to chlorination by-products: a study on the influence of the water distribution system.

Journal: Environmental health : a global access science source 20100101

Title: Glucagon-like peptide-1 and the exenatide analogue AC3174 improve cardiac function, cardiac remodeling, and survival in rats with chronic heart failure.

Journal: Cardiovascular diabetology 20100101

Title: Enhanced ozonation of dichloroacetic acid in aqueous solution using nanometer ZnO powders.

Journal: Journal of environmental sciences (China) 20100101

Title: Development of a less toxic dichloroacetate analogue by docking and descriptor analysis.

Journal: Bioinformation 20100101

Title: Diaqua-hexa-μ(2)-dichloro-acetato-μ(3)-oxido-tetra-hydro-furan-diiron(III)manganese(II).

Journal: Acta crystallographica. Section E, Structure reports online 20100101

Title: In vitro cytotoxicity of combinations of dichloroacetate with anticancer platinum compounds.

Journal: Clinical pharmacology : advances and applications 20100101

Title: Pivotal role of the C-terminal DW-motif in mediating inhibition of pyruvate dehydrogenase kinase 2 by dichloroacetate.

Journal: The Journal of biological chemistry 20091204

Title: Hypoxia and the metabolic phenotype of prostate cancer cells.

Journal: Biochimica et biophysica acta 20091201

Title: Dichloroacetate treatment partially regresses established pulmonary hypertension in mice with SM22alpha-targeted overexpression of the serotonin transporter.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20091201

Title: Both substrate availability and utilisation contribute to the defence of core temperature in response to acute cold.

Journal: Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 20091201

Title: Pharmacologically increased tumor hypoxia can be measured by 18F-Fluoroazomycin arabinoside positron emission tomography and enhances tumor response to hypoxic cytotoxin PR-104.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20091201

Title: Effects of crystalline structures and surface functional groups on the adsorption of haloacetic acids by inorganic materials.

Journal: Journal of hazardous materials 20091115

Title: In vitro effects of dichloroacetate and CO2 on hypoxic HeLa cells.

Journal: Anticancer research 20091101

Title: A reexamination of the PPAR-alpha activation mode of action as a basis for assessing human cancer risks of environmental contaminants.

Journal: Environmental health perspectives 20091101

Title: Depressive episode with catatonic features in a case of mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS).

Journal: Journal of child neurology 20091001

Title: Quantitative mitochondrial phosphoproteomics using iTRAQ on an LTQ-Orbitrap with high energy collision dissociation.

Journal: Journal of proteome research 20091001

Title: Chlorination disinfection by-products in drinking water and congenital anomalies: review and meta-analyses.

Journal: Environmental health perspectives 20091001

Title: Aqua-tris(1H-benzimidazole-κN)(dichloro-acetato-κO)copper(II) dichloro-acetate dihydrate.

Journal: Acta crystallographica. Section E, Structure reports online 20091001

Title: Influence of dichloroacetate on pulmonary gas exchange and ventilation during incremental exercise in healthy humans.

Journal: Respiratory physiology & neurobiology 20090930

Title: Zero-valent aluminum for oxidative degradation of aqueous organic pollutants.

Journal: Environmental science & technology 20090915

Title: Kinetics and effects of dichloroacetic acid in rainbow trout.

Journal: Aquatic toxicology (Amsterdam, Netherlands) 20090914

Title: Dichloroacetate modulates the oxidative stress and inflammatory response to exercise in COPD.

Journal: Chest 20090901

Title: Peripheral neuropathy in rats exposed to dichloroacetate.

Journal: Journal of neuropathology and experimental neurology 20090901

Title: Liquid chromatography electrospray ionization tandem mass spectrometry analysis method for simultaneous detection of trichloroacetic acid, dichloroacetic acid, S-(1,2-dichlorovinyl)glutathione and S-(1,2-dichlorovinyl)-L-cysteine.

Journal: Toxicology 20090821

Title: From proton nuclear magnetic resonance spectra to pH. Assessment of 1H NMR pH indicator compound set for deuterium oxide solutions.

Journal: Analytica chimica acta 20090819

Title: Glycerol-induced folding of unstructured disulfide-deficient lysozyme into a native-like conformation.

Journal: Biopolymers 20090801

Title: Disinfection byproduct formation and fractionation behavior of natural organic matter surrogates.

Journal: Environmental science & technology 20090801

Title: Experimental and theoretical investigation of the catalytic ozonation on the surface of NiO-CuO nanoparticles.

Journal: Langmuir : the ACS journal of surfaces and colloids 20090721

Title: Reduction of protons assisted by a hexanuclear nickel thiolate metallacrown: protonation and electrocatalytic dihydrogen evolution.

Journal: Physical chemistry chemical physics : PCCP 20090721

Title: High rates of residual fatty acid oxidation during mild ischemia decrease cardiac work and efficiency.

Journal: Journal of molecular and cellular cardiology 20090701

Title: Pharmacokinetic analysis of trichloroethylene metabolism in male B6C3F1 mice: Formation and disposition of trichloroacetic acid, dichloroacetic acid, S-(1,2-dichlorovinyl)glutathione and S-(1,2-dichlorovinyl)-L-cysteine.

Journal: Toxicology and applied pharmacology 20090701

Title: Formation of chlorinated disinfection by-products in viticulture.

Journal: Environmental science and pollution research international 20090701

Title: Monitoring phosphorylation of the pyruvate dehydrogenase complex.

Journal: Analytical biochemistry 20090615

Title: Augmented cerebellar lactate in copper deficient rat pups originates from both blood and cerebellum.

Journal: Metabolic brain disease 20090601

Title: 1,3-Dihydr-oxy-2-(hydroxy-meth-yl)propan-2-aminium 2,2-dichloro-acetate.

Journal: Acta crystallographica. Section E, Structure reports online 20090601

Title: Evidence of autoimmune-related effects of trichloroethylene exposure from studies in mice and humans.

Journal: Environmental health perspectives 20090501

Title: Biodegradation of haloacetic acids by bacterial isolates and enrichment cultures from drinking water systems.

Journal: Environmental science & technology 20090501

Title: Phenylalanine-induced leucopenia in genetic and dichloroacetic acid generated deficiency of glutathione transferase Zeta.

Journal: Biochemical pharmacology 20090415

Title: Pyruvate dehydrogenase phosphatase 1 (PDP1) null mutation produces a lethal infantile phenotype.

Journal: Human genetics 20090401

Title: Treatment for Leigh syndrome by monitoring dichloroacetate concentration.

Journal: Pediatrics international : official journal of the Japan Pediatric Society 20090401

Title: Epigenetics and environmental chemicals.

Journal: Current opinion in pediatrics 20090401

Title: Substrate-enzyme competition attenuates upregulated anaplerotic flux through malic enzyme in hypertrophied rat heart and restores triacylglyceride content: attenuating upregulated anaplerosis in hypertrophy.

Journal: Circulation research 20090327

Title: Innate short-circuiting of mitochondrial metabolism in cardiac hypertrophy: identification of novel consequences of enhanced anaplerosis.

Journal: Circulation research 20090327

Title: Decomposition of two haloacetic acids in water using UV radiation, ozone and advanced oxidation processes.

Journal: Journal of hazardous materials 20090315

Title: Chloroform- and water-soluble sol-gel derived Eu+++/Y2O3 (red) and Tb+++/Y2O3 (green) nanophosphors: synthesis, characterization, and surface modification.

Journal: IEEE transactions on nanobioscience 20090301

Title: Central nervous system imaging in mitochondrial disorders.

Journal: The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques 20090301

Title: Biological Basis of Differential Susceptibility to Hepatocarcinogenesis among Mouse Strains.

Journal: Journal of toxicologic pathology 20090301

Title: N2'-->p3' phosphoramidate glycerol nucleic acid as a potential alternative genetic system.

Journal: Journal of the American Chemical Society 20090218

Title: Fate of THMs and HAAs in low TOC surface water.

Journal: Environmental research 20090201

Title: Mitochondrial mutations contribute to HIF1alpha accumulation via increased reactive oxygen species and up-regulated pyruvate dehydrogenease kinase 2 in head and neck squamous cell carcinoma.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20090115

Title: The kinetics and mechanism of the acid-catalysed detritylation of nucleotides in non-aqueous solution.

Journal: Organic & biomolecular chemistry 20090107

Title: Stimulation-induced increases of astrocytic oxidative metabolism in rats and humans investigated with 1-11C-acetate.

Journal: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20090101

Title: Evaluation of dichloroacetic acid for carcinogenicity in genetically modified Tg.AC hemizygous and p53 haploinsufficient mice.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20090101

Title: Therapeutic targets in pulmonary arterial hypertension.

Journal: Pharmacology & therapeutics 20090101

Title: Update on medication-induced peripheral neuropathy.

Journal: Current neurology and neuroscience reports 20090101

Title: Determination of ten haloacetic acids in drinking water using high-performance and ultra-performance liquid chromatography-tandem mass spectrometry.

Journal: Journal of chromatographic science 20090101

Title: The metabolic treatment of patients with coronary artery disease: effects on quality of life and effort angina.

Journal: Current pharmaceutical design 20090101

Title: Acetoacetate reduces growth and ATP concentration in cancer cell lines which over-express uncoupling protein 2.

Journal: Cancer cell international 20090101

Title: Dichloroacetate alleviates development of collagen II-induced arthritis in female DBA/1 mice.

Journal: Arthritis research & therapy 20090101

Title: Metabolism as means for hypoxia adaptation: metabolic profiling and flux balance analysis.

Journal: BMC systems biology 20090101

Title: Oxygen consumption can regulate the growth of tumors, a new perspective on the Warburg effect.

Journal: PloS one 20090101

Title: Interferon for the treatment of genital warts: a systematic review.

Journal: BMC infectious diseases 20090101

Title: PathBinder--text empirics and automatic extraction of biomolecular interactions.

Journal: BMC bioinformatics 20090101

Title: Trichloroethylene risk assessment: a review and commentary.

Journal: Critical reviews in toxicology 20090101

Title: A systematic review of the reporting of Data Monitoring Committees' roles, interim analysis and early termination in pediatric clinical trials.

Journal: BMC pediatrics 20090101

Title: Aqua-bis(dichloro-acetato-κO)(1,10-phenanthroline-κN,N')copper(II).

Journal: Acta crystallographica. Section E, Structure reports online 20090101

Title: Dichloroacetate-induced modulation of cellular antioxidant enzyme activities and glutathione level in the J774A.1 cells.

Journal: Journal of applied toxicology : JAT 20081101

Title: Visible light photo-oxidations in the presence of alpha-Bi(2)O(3).

Journal: Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 20081101

Title: Dichloroacetate (DCA) as a potential metabolic-targeting therapy for cancer.

Journal: British journal of cancer 20081007

Title: Differential effects of in vivo and in vitro lactate treatments on liver carbohydrate metabolism of rainbow trout.

Journal: Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 20081001

Title: Theoretical studies of different tautomers of anti cancer drug: dichloroacetate.

Journal: Pakistan journal of pharmaceutical sciences 20081001

Title: Trichloroethylene transformation by natural mineral pyrite: the deciding role of oxygen.

Journal: Environmental science & technology 20081001

Title: Pyruvate dehydrogenase kinase-4 structures reveal a metastable open conformation fostering robust core-free basal activity.

Journal: The Journal of biological chemistry 20080912

Title: Pyruvate dehydrogenase kinase 4: regulation by thiazolidinediones and implication in glyceroneogenesis in adipose tissue.

Journal: Diabetes 20080901

Title: The heme precursor delta-aminolevulinate blocks peripheral myelin formation.

Journal: Journal of neurochemistry 20080901

Title: Comparison of H2O2/UV and heterogeneous photocatalytic processes for the degradation of dichloroacetic acid in water.

Journal: Environmental science & technology 20080815

Title: Allosteric coupling in pyruvate dehydrogenase kinase 2.

Journal: Biochemistry 20080812

Title: Dichloroacetate (DCA) sensitizes both wild-type and over expressing Bcl-2 prostate cancer cells in vitro to radiation.

Journal: The Prostate 20080801

Title: Case: asymptomatic lesions on eyelids.

Journal: Geriatrics 20080801

Title: Characterization of Ser73 in Arabidopsis thaliana Glutathione S-transferase zeta class.

Journal: Journal of genetics and genomics = Yi chuan xue bao 20080801

Title: Analysis of in vivo mutation data can inform cancer risk assessment.

Journal: Regulatory toxicology and pharmacology : RTP 20080701

Title: ECVAM retrospective validation of in vitro micronucleus test (MNT).

Journal: Mutagenesis 20080701

Title: Domoic acid excretion in dungeness crabs, razor clams and mussels.

Journal: Marine environmental research 20080701

Title: Human health risk assessment of chlorinated disinfection by-products in drinking water using a probabilistic approach.

Journal: Water research 20080701

Title: Dichloroacetate stabilizes the intraoperative acid-base balance during liver transplantation.

Journal: Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 20080701

Title: A dynamic and chamber-specific mitochondrial remodeling in right ventricular hypertrophy can be therapeutically targeted.

Journal: The Journal of thoracic and cardiovascular surgery 20080701

Title: Metabolic agents in the management of diabetic coronary patients: a new era.

Journal: International journal of cardiology 20080623

Title: Metabolic agents in the management of diabetic coronary patients: a new era.

Journal: International journal of cardiology 20080623

Title: Role of glucose metabolism in the recovery of postischemic LV mechanical function: effects of insulin and other metabolic modulators.

Journal: American journal of physiology. Heart and circulatory physiology 20080601

Title: Dichloroacetate induces apoptosis in endometrial cancer cells.

Journal: Gynecologic oncology 20080601

Title: Oxidoreductase regulation of Kv currents in rat ventricle.

Journal: Journal of molecular and cellular cardiology 20080601

Title: Dichloroacetate enhances performance and reduces blood lactate during maximal cycle exercise in chronic obstructive pulmonary disease.

Journal: American journal of respiratory and critical care medicine 20080515

Title: Halogenated derivatives QSAR model using spectral moments to predict haloacetic acids (HAA) mutagenicity.

Journal: Bioorganic & medicinal chemistry 20080515

Title: Evaluation of long-term treatment of children with congenital lactic acidosis with dichloroacetate.

Journal: Pediatrics 20080501

Title: Haloacetic acid and trihalomethane formation from the chlorination and bromination of aliphatic beta-dicarbonyl acid model compounds.

Journal: Environmental science & technology 20080501

Title: A combined therapeutic approach for pyruvate dehydrogenase deficiency using self-complementary adeno-associated virus serotype-specific vectors and dichloroacetate.

Journal: Molecular genetics and metabolism 20080401

Title: Correlations between organic matter properties and DBP formation during chloramination.

Journal: Water research 20080401

Title: Glucose-insulin therapy, plasma substrate levels and cardiac recovery after cardiac ischemic events.

Journal: Cardiovascular drugs and therapy 20080401

Title: In situ derivatization/solid-phase microextraction coupled with gas chromatography/negative chemical ionization mass spectrometry for the determination of trichloroethylene metabolites in rat blood.

Journal: Rapid communications in mass spectrometry : RCM 20080401

Title: Involvement of lactate in glucose metabolism and glucosensing function in selected tissues of rainbow trout.

Journal: The Journal of experimental biology 20080401

Title: The formation and distribution of haloacetic acids in copper pipe during chlorination.

Journal: Journal of hazardous materials 20080321

Title: Quantitative evaluation of dichloroacetic acid kinetics in human--a physiologically based pharmacokinetic modeling investigation.

Journal: Toxicology 20080312

Title: Kinetics of chloral hydrate and its metabolites in male human volunteers.

Journal: Toxicology 20080312

Title: Difficulty of mode of action determination for trichloroethylene: An example of complex interactions of metabolites and other chemical exposures.

Journal: Environmental and molecular mutagenesis 20080301

Title: Age-dependent kinetics and metabolism of dichloroacetate: possible relevance to toxicity.

Journal: The Journal of pharmacology and experimental therapeutics 20080301

Title: Treatment of Fordyce spots with bichloracetic acid.

Journal: Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] 20080301

Title: RNA interference in mammalia cells by RNA-3'-PNA chimeras.

Journal: International journal of molecular sciences 20080301

Title: A refined radio-telemetry technique to monitor right ventricle or pulmonary artery pressures in rats: a useful tool in pulmonary hypertension research.

Journal: Pflugers Archiv : European journal of physiology 20080201

Title: Mitochondrial metabolism, redox signaling, and fusion: a mitochondria-ROS-HIF-1alpha-Kv1.5 O2-sensing pathway at the intersection of pulmonary hypertension and cancer.

Journal: American journal of physiology. Heart and circulatory physiology 20080201

Title: Dichloroacetate- and trichloroacetate-induced phagocytic activation and production of oxidative stress in the hepatic tissues of mice after acute exposure.

Journal: Journal of biochemical and molecular toxicology 20080201

Title: [Determination of five halogenated acetic acids in water using ion chromatography].

Journal: Se pu = Chinese journal of chromatography 20080101

Title: Water disinfection by-products and the risk of specific birth defects: a population-based cross-sectional study in Taiwan.

Journal: Environmental health : a global access science source 20080101

Title: Role of dichloroacetate in the treatment of genetic mitochondrial diseases.

Journal: Advanced drug delivery reviews 20080101

Title: Effect of streptozotocin-induced diabetes on myocardial blood flow reserve assessed by myocardial contrast echocardiography in rats.

Journal: Cardiovascular diabetology 20080101

Title: Evaluation of the role of peroxisome proliferator-activated receptor alpha (PPARalpha) in mouse liver tumor induction by trichloroethylene and metabolites.

Journal: Critical reviews in toxicology 20080101

Title: Gateways to clinical trials. July-August 2008.

Journal: Methods and findings in experimental and clinical pharmacology 20080101

Title: Metformin-associated lactic acidosis in an intensive care unit.

Journal: Critical care (London, England) 20080101

Title: Abstracts of papers presented at the 2008 pittsburgh conference.

Journal: Journal of automated methods & management in chemistry 20080101

Title: Total excision and V-Y plasty technique in the anal area condyloma acuminatum.

Journal: Indian journal of plastic surgery : official publication of the Association of Plastic Surgeons of India 20080101

Title: Don't take vitals, take a lactate.

Journal: Intensive care medicine 20071101

Title: Cytometric assessment of DNA damage by exogenous and endogenous oxidants reports aging-related processes.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20071101

Title: MALDI-linear ion trap microprobe MS/MS studies of the effects of dichloroacetate on lipid content of nerve tissue.

Journal: Analytical chemistry 20071101

Title: Wolff-Parkinson-White syndrome in Patients With MELAS.

Journal: Archives of neurology 20071101

Title: Formation and fate of haloacetic acids (HAAs) within the water treatment plant.

Journal: Water research 20071001

Title: A general, positive ion mode ESI-MS approach for the analysis of singly charged inorganic and organic anions using a dicationic reagent.

Journal: Analytical chemistry 20071001

Title: The ultrafast dynamics of hydrogen-bonded liquids: molecular structure-dependent occurrence of normal arrhenius or fractional Stokes-Einstein-Debye rotational diffusive relaxation.

Journal: The journal of physical chemistry. B 20070816

Title: Distinct structural mechanisms for inhibition of pyruvate dehydrogenase kinase isoforms by AZD7545, dichloroacetate, and radicicol.

Journal: Structure (London, England : 1993) 20070801

Title: The healthy men study: an evaluation of exposure to disinfection by-products in tap water and sperm quality.

Journal: Environmental health perspectives 20070801

Title: Amino acid residues responsible for the recognition of dichloroacetate by pyruvate dehydrogenase kinase 2.

Journal: FEBS letters 20070626

Title: Lactate interferes with ATP release from red blood cells.

Journal: American journal of physiology. Heart and circulatory physiology 20070601

Title: Functional diagnostics in mitochondrial diseases.

Journal: Bioscience reports 20070601

Title: The beneficial effects of dichloroacetate in acute limb ischemia.

Journal: Military medicine 20070601

Title: Trials and tribulations.

Journal: Nature reviews. Drug discovery 20070501

Title: Examination of NOM chlorination reactions by conventional and stop-flow differential absorbance spectroscopy.

Journal: Environmental science & technology 20070415

Title: Metabolic targeting as an anticancer strategy: dawn of a new era?

Journal: Science's STKE : signal transduction knowledge environment 20070410

Title: Toxicology and carcinogenesis studies of dibromoacetic acid (Cas No. 631-64-1) in F344/N rats and B6C3F1 mice (drinking water studies).

Journal: National Toxicology Program technical report series 20070401

Title: NTP report on the toxicology studies of dichloroacetic acid (CAS No. 79-43-6) in genetically modified (FVB Tg.AC hemizygous) mice (dermal and drinking water studies) and carcinogenicity studies of dichloroacetic acid in genetically modified [B6.129-Trp53(tm1Brd) (N5) haploinsufficient] mice (drinking water studies).

Journal: National Toxicology Program genetically modified model report 20070401

Title: Immuno- and hepato-toxicity of dichloroacetic acid in MRL(+/+) and B(6)C(3)F(1) mice.

Journal: Journal of immunotoxicology 20070401

Title: Cancer patients opt for unapproved drug.

Journal: Nature 20070329

Title: Insulin regulation of glutathione and contractile phenotype in diabetic rat ventricular myocytes.

Journal: American journal of physiology. Heart and circulatory physiology 20070301

Title: Modulation of the expression of peroxisome proliferators-activated receptors in human fibroblasts.

Journal: Fertility and sterility 20070301

Title: Myocardial lactate deprivation is associated with decreased cardiovascular performance, decreased myocardial energetics, and early death in endotoxic shock.

Journal: Intensive care medicine 20070301

Title: The use of Markov chain Monte Carlo uncertainty analysis to support a Public Health Goal for perchloroethylene.

Journal: Regulatory toxicology and pharmacology : RTP 20070201

Title: Malonyl coenzyme A affects insulin-stimulated glucose transport in myotubes.

Journal: Archives of physiology and biochemistry 20070201

Title: Dichloroacetic acid degradation employing hydrogen peroxide and UV radiation.

Journal: Chemosphere 20070101

Title: Reductive dehalogenation of haloacetic acids by hemoglobin-loaded carbon nanotube electrode.

Journal: Water research 20070101

Title: A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth.

Journal: Cancer cell 20070101

Title: Dichloroacetate causes reversible demyelination in vitro: potential mechanism for its neuropathic effect.

Journal: Journal of neurochemistry 20070101

Title: Modelling the kinetics of UV/H2O2 oxidation of dichloroacetic acid.

Journal: Water science and technology : a journal of the International Association on Water Pollution Research 20070101

Title: Effect of streptozotocin-induced diabetes on left ventricular function in adult rats: an in vivo Pinhole Gated SPECT study.

Journal: Cardiovascular diabetology 20070101

Title: Determination of haloacetic acids in hospital effluent after chlorination by ion chromatography.

Journal: Journal of environmental sciences (China) 20070101

Title: Occurrence, genotoxicity, and carcinogenicity of regulated and emerging disinfection by-products in drinking water: a review and roadmap for research.

Journal: Mutation research 20070101

Title: Abstracts of papers presented at the 2007 pittsburgh conference.

Journal: Journal of automated methods & management in chemistry 20070101

Title: The role of glucose metabolism and glucose-associated signalling in cancer.

Journal: Perspectives in medicinal chemistry 20070101

Title: The role of k+ channels in determining pulmonary vascular tone, oxygen sensing, cell proliferation, and apoptosis: implications in hypoxic pulmonary vasoconstriction and pulmonary arterial hypertension.

Journal: Microcirculation (New York, N.Y. : 1994) 20061201

Title: Human kinetics of orally and intravenously administered low-dose 1,2-(13)C-dichloroacetate.

Journal: Journal of clinical pharmacology 20061201

Title: [Study on rat's DNA damage of p53 induced by chlorinated acetic acids of drinking water disinfection by-products].

Journal: Wei sheng yan jiu = Journal of hygiene research 20061101

Title: Autoimmune response in MRL+/+ mice following treatment with dichloroacetyl chloride or dichloroacetic anhydride.

Journal: Toxicology and applied pharmacology 20061015

Title: Dichloroacetate causes toxic neuropathy in MELAS: a randomized, controlled clinical trial.

Journal: Neurology 20061010

Title: Short-term exposures to dihaloacetic acids produce dysmorphogenesis in mouse conceptuses in vitro.

Journal: Reproductive toxicology (Elmsford, N.Y.) 20061001

Title: Bayesian population analysis of a harmonized physiologically based pharmacokinetic model of trichloroethylene and its metabolites.

Journal: Regulatory toxicology and pharmacology : RTP 20061001

Title: Severe malaria: lessons learned from the management of critical illness in children.

Journal: Trends in parasitology 20061001

Title: New insights into the mechanism of methoxyflurane nephrotoxicity and implications for anesthetic development (part 2): Identification of nephrotoxic metabolites.

Journal: Anesthesiology 20061001

Title: A Korean female patient with thiamine-responsive pyruvate dehydrogenase complex deficiency due to a novel point mutation (Y161C)in the PDHA1 gene.

Journal: Journal of Korean medical science 20061001

Title: Tricarboxylic acid cycle intermediates accumulate at the onset of intense exercise in man but are not essential for the increase in muscle oxygen uptake.

Journal: Pflugers Archiv : European journal of physiology 20060901

Title: The key role of apoptosis in the pathogenesis and treatment of pulmonary hypertension.

Journal: European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 20060901

Title: Optimizing cardiac fatty acid and glucose metabolism as an approach to treating heart failure.

Journal: Seminars in cardiothoracic and vascular anesthesia 20060901

Title: Key scientific issues in the health risk assessment of trichloroethylene.

Journal: Environmental health perspectives 20060901

Title: Issues in the pharmacokinetics of trichloroethylene and its metabolites.

Journal: Environmental health perspectives 20060901

Title: Key issues in the modes of action and effects of trichloroethylene metabolites for liver and kidney tumorigenesis.

Journal: Environmental health perspectives 20060901

Title: Key issues in the role of peroxisome proliferator-activated receptor agonism and cell signaling in trichloroethylene toxicity.

Journal: Environmental health perspectives 20060901

Title: Volume expansion with albumin compared to gelofusine in children with severe malaria: results of a controlled trial.

Journal: PLoS clinical trials 20060901

Title: Modeling dichloroacetic acid formation from the reaction of monochloramine with natural organic matter.

Journal: Water research 20060801

Title: Application of cryopreserved human hepatocytes in trichloroethylene risk assessment: relative disposition of chloral hydrate to trichloroacetate and trichloroethanol.

Journal: Environmental health perspectives 20060801

Title: Effects of indoor drinking water handling on trihalomethanes and haloacetic acids.

Journal: Water research 20060801

Title: Trichloroethylene uptake by apple and peach trees and transfer to fruit.

Journal: Environmental science & technology 20060801

Title: [Impact of catalytic ozonation with ferric hydroxide on HAAs formation potential of a filtered surface water].

Journal: Huan jing ke xue= Huanjing kexue 20060801

Title: Dichloroacetate causes toxic neuropathy in MELAS: a randomized, controlled clinical trial.

Journal: Neurology 20060711

Title: Effect of short-term drinking water exposure to dichloroacetate on its pharmacokinetics and oral bioavailability in human volunteers: a stable isotope study.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20060701

Title: An evidence-based approach to the management of pulmonary arterial hypertension.

Journal: Current opinion in cardiology 20060701

Title: A GC-MS/MS method for the quantitative analysis of low levels of the tyrosine metabolites maleylacetone, succinylacetone, and the tyrosine metabolism inhibitor dichloroacetate in biological fluids and tissues.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20060606

Title: An abnormal mitochondrial-hypoxia inducible factor-1alpha-Kv channel pathway disrupts oxygen sensing and triggers pulmonary arterial hypertension in fawn hooded rats: similarities to human pulmonary arterial hypertension.

Journal: Circulation 20060606

Title: THM, HAA and CNCl formation from UV irradiation and chlor(am)ination of selected organic waters.

Journal: Water research 20060601

Title: Therapeutic potential of dichloroacetate for pyruvate dehydrogenase complex deficiency.

Journal: Mitochondrion 20060601

Title: Trichloroethylene exposure during cardiac valvuloseptal morphogenesis alters cushion formation and cardiac hemodynamics in the avian embryo.

Journal: Environmental health perspectives 20060601

Title: [Effect of preozonation on disinfection by-products formation potential of algae cells and extracellular organic matter].

Journal: Huan jing ke xue= Huanjing kexue 20060601

Title: Evaluation of dichloroacetate treatment in a murine model of hereditary tyrosinemia type 1.

Journal: Biochemical pharmacology 20060528

Title: Photocatalytic hydrogen generation in the presence of chloroacetic acids over Pt/TiO2.

Journal: Chemosphere 20060501

Title: Polymorphisms in the human glutathione transferase zeta promoter.

Journal: Pharmacogenetics and genomics 20060501

Title: Controlled clinical trial of dichloroacetate for treatment of congenital lactic acidosis in children.

Journal: Pediatrics 20060501

Title: [Expression of glutathione S-transferase zeta class genes in Saccharomyces cerevisiae].

Journal: Yi chuan = Hereditas 20060501

Title: [Determination of trace haloacetic acids in drinking water using ion chromatography coupled with solid phase extraction].

Journal: Se pu = Chinese journal of chromatography 20060501

Title: Dichloroacetate reduces tissue necrosis in a rat transverse rectus abdominis musculocutaneous flap model.

Journal: Annals of plastic surgery 20060301

Title: Severe malaria: metabolic complications.

Journal: Current molecular medicine 20060301

Title: Determination of mono- and dichloroacetic acids in betaine media by liquid chromatography.

Journal: Talanta 20060215

Title: Trial of dichloroacetate in MELAS: toxicity overshadows the assessment of potential benefit.

Journal: Neurology 20060214

Title: Dichloroacetate causes toxic neuropathy in MELAS: a randomized, controlled clinical trial.

Journal: Neurology 20060214

Title: Pulmonary bronchiolar cytotoxicity and formation of dichloroacetyl lysine protein adducts in mice treated with trichloroethylene.

Journal: The Journal of pharmacology and experimental therapeutics 20060201

Title: Deficiency of glutathione transferase zeta causes oxidative stress and activation of antioxidant response pathways.

Journal: Molecular pharmacology 20060201

Title: Optical density and photonic efficiency of silica-supported TiO2 photocatalysts.

Journal: Water research 20060201

Title: Peripheral neuropathy in genetic mitochondrial diseases.

Journal: Pediatric neurology 20060201

Title: Treatment for mitochondrial disorders.

Journal: The Cochrane database of systematic reviews 20060125

Title: 9-(4-Bromophenyl)-9-fluorenyl as a safety-catch nitrogen protecting group.

Journal: The Journal of organic chemistry 20060120

Title: Regulatory roles of the N-terminal domain based on crystal structures of human pyruvate dehydrogenase kinase 2 containing physiological and synthetic ligands.

Journal: Biochemistry 20060117

Title: Inhibition and recovery of rat hepatic glutathione S-transferase zeta and alteration of tyrosine metabolism following dichloroacetate exposure and withdrawal.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20060101

Title: The effects of cyanobacterial exudates on bacterial growth and biodegradation of organic contaminants.

Journal: Microbial ecology 20060101

Title: Pulmonary arterial hypertension: new insights and new hope.

Journal: Respirology (Carlton, Vic.) 20060101

Title: A case of Melas (A3243G) on chronic dichloroacetate treatment.

Journal: European neurology 20060101

Title: Different net effect of TiO2 sintering temperature on the photocatalytic removal rates of 4-chlorophenol, 4-chlorobenzoic acid and dichloroacetic acid in water.

Journal: Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering 20060101

Title: Interaction between organic species in the formation of haloacetic acids following disinfection.

Journal: Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering 20060101

Title: Magnetic resonance spectroscopic investigation of mitochondrial fuel metabolism and energetics in cultured human fibroblasts: effects of pyruvate dehydrogenase complex deficiency and dichloroacetate.

Journal: Molecular genetics and metabolism 20060101

Title: Trichloroethylene, trichloroacetic acid, and dichloroacetic acid: do they affect eye development in the Sprague-Dawley rat?

Journal: International journal of toxicology 20060101

Title: [Analysis of haloacetic acids in drinking water by gas chromatography-mass spectrometry].

Journal: Se pu = Chinese journal of chromatography 20060101

Title: Modulation by ellagic acid of DCA-induced developmental toxicity in the zebrafish (Danio rerio).

Journal: Journal of biochemical and molecular toxicology 20060101

Title: Human malarial disease: a consequence of inflammatory cytokine release.

Journal: Malaria journal 20060101

Title: Visible light active platinum-ion-doped TiO2 photocatalyst.

Journal: The journal of physical chemistry. B 20051229

Title: Malaria and fluids--balancing acts.

Journal: Trends in parasitology 20051201

Title: Platelet mitochondrial evaluation during cytochrome c and dichloroacetate treatments of MELAS.

Journal: Mitochondrion 20051201

Title: Late pregnancy exposures to disinfection by-products and growth-related birth outcomes.

Journal: Environmental health perspectives 20051201

Title: Mitochondrial myopathies: diagnosis, exercise intolerance, and treatment options.

Journal: Medicine and science in sports and exercise 20051201

Title: Metabolic modulators for chronic cardiac ischemia.

Journal: Journal of cardiovascular pharmacology and therapeutics 20051201

Title: Comparison of haloacetic acids in the environment of the Northern and Southern Hemispheres.

Journal: Environmental science & technology 20051115

Title: Lung preservation solution substrate composition affects rat lung oxidative metabolism during hypothermic storage.

Journal: Respiratory physiology & neurobiology 20051012

Title: A review of analytical methods for the determination of trichloroethylene and its major metabolites chloral hydrate, trichloroacetic acid and dichloroacetic acid.

Journal: Biomedical chromatography : BMC 20051001

Title: DNA hypomethylation induced by drinking water disinfection by-products in mouse and rat kidney.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20051001

Title: The relevance of malaria pathophysiology to strategies of clinical management.

Journal: Current opinion in infectious diseases 20051001

Title: Trichloroacetaldehyde modified oligonucleotides.

Journal: Bioorganic & medicinal chemistry letters 20050915

Title: Fructose-1,6-bisphosphate enhances hypothermic preservation of cardiac myocytes.

Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20050901

Title: Lack of direct mitogenic activity of dichloroacetate and trichloroacetate in cultured rat hepatocytes.

Journal: Toxicology 20050801

Title: Pyruvate dehydrogenase phosphatase deficiency: identification of the first mutation in two brothers and restoration of activity by protein complementation.

Journal: The Journal of clinical endocrinology and metabolism 20050701

Title: The impacts of cyanobacteria on pulp-and-paper wastewater toxicity and biodegradation of wastewater contaminants.

Journal: Canadian journal of microbiology 20050701

Title: Photocatalytic reactivities of Nafion-coated TiO2 for the degradation of charged organic compounds under UV or visible light.

Journal: The journal of physical chemistry. B 20050616

Title: Myocardial metabolism and improved outcomes after high risk heart surgery.

Journal: Seminars in cardiothoracic and vascular anesthesia 20050601

Title: Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk).

Journal: Journal of medicinal chemistry 20050505

Title: Determination of dichloroacetic acid and trichloroacetic acid in drinking water by acidic methanol esterification and headspace gas chromatography.

Journal: Water research 20050501

Title: [Adsorption performance of haloacetic acids onto 5 GACs from water].

Journal: Huan jing ke xue= Huanjing kexue 20050501

Title: Impact of high glucose/high insulin and dichloroacetate treatment on carbohydrate oxidation and functional recovery after low-flow ischemia and reperfusion in the isolated perfused rat heart.

Journal: Circulation 20050426

Title: Photocatalytic reactivity of surface platinized TiO2: substrate specificity and the effect of Pt oxidation state.

Journal: The journal of physical chemistry. B 20050421

Title: Toxicokinetics and oral bioavailability of halogenated acetic acids mixtures in naïve and GSTzeta-depleted rats.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20050401

Title: Visible-light-induced photocatalytic degradation of 4-chlorophenol and phenolic compounds in aqueous suspension of pure titania: demonstrating the existence of a surface-complex-mediated path.

Journal: The journal of physical chemistry. B 20050324

Title: Hydrogen-deuterium (H/D) exchange mapping of Abeta 1-40 amyloid fibril secondary structure using nuclear magnetic resonance spectroscopy.

Journal: Biochemistry 20050322

Title: Redox regulation of Ito remodeling in diabetic rat heart.

Journal: American journal of physiology. Heart and circulatory physiology 20050301

Title: Characterization of the metabolic interaction between trihalomethanes and chloroacetic acids using rat liver microsomes.

Journal: Journal of toxicology and environmental health. Part A 20050227

Title: Haloacetic acids in drinking water and risk for stillbirth.

Journal: Occupational and environmental medicine 20050201

Title: Fatty acid oxidation inhibitors in the management of chronic complications of atherosclerosis.

Journal: Current atherosclerosis reports 20050201

Title: Modulation of the expression of vascular endothelial growth factor in human fibroblasts.

Journal: Fertility and sterility 20050201

Title: [Diisopropylamine dichloroacetate in the treatment of nonalcoholic fatty liver disease: a multicenter random double-blind controlled trial].

Journal: Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 20050201

Title: Chasing the 'ghost' of the acetyl group deficit.

Journal: Medicine and science in sports and exercise 20050101

Title: Severe falciparum malaria in Gabonese children: clinical and laboratory features.

Journal: Malaria journal 20050101

Title: Dichloroacetate-induced developmental toxicity and production of reactive oxygen species in zebrafish embryos.

Journal: Journal of biochemical and molecular toxicology 20050101

Title: Analysis of dichloroacetic acid in rat blood and tissues by hydrophilic interaction liquid chromatography with tandem mass spectrometry.

Journal: Rapid communications in mass spectrometry : RCM 20050101

Title: Characterization of the fluoroacetate detoxication enzymes of rat liver cytosol.

Journal: Xenobiotica; the fate of foreign compounds in biological systems 20050101

Title: Human glutathione transferase zeta.

Journal: Methods in enzymology 20050101

Title: Acetyl group availability influences phosphocreatine degradation even during intense muscle contraction.

Journal: The Journal of physiology 20041215

Title: Kinetics of haloacetic acid reactions with Fe(0).

Journal: Environmental science & technology 20041215

Title: A quantitative description of suicide inhibition of dichloroacetic acid in rats and mice.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20041201

Title: Behavior of trihalomethanes and haloacetic acids in a drinking water distribution system.

Journal: Water research 20041201

Title: Developmental toxicity of mixtures: the water disinfection by-products dichloro-, dibromo- and bromochloro acetic acid in rat embryo culture.

Journal: Reproductive toxicology (Elmsford, N.Y.) 20041101

Title: Effect of dibromoacetic acid on DNA methylation, glycogen accumulation, and peroxisome proliferation in mouse and rat liver.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20041101

Title: Muscle mechanoreceptor sensitivity in heart failure.

Journal: American journal of physiology. Heart and circulatory physiology 20041101

Title: Pyruvate dehydrogenase kinase isoform 2 activity limited and further inhibited by slowing down the rate of dissociation of ADP.

Journal: Biochemistry 20041026

Title: Role of the peroxisome proliferator-activated receptor alpha (PPARalpha) in responses to trichloroethylene and metabolites, trichloroacetate and dichloroacetate in mouse liver.

Journal: Toxicology 20041015

Title: Dichloroacetate prevents and reverses pulmonary hypertension by inducing pulmonary artery smooth muscle cell apoptosis.

Journal: Circulation research 20041015

Title: Dichloroacetate treatment for mitochondrial cytopathy: long-term effects in MELAS.

Journal: Brain & development 20041001

Title: Batch-test study on the dechlorination of 1,1,1-trichloroethane in contaminated aquifer material by zero-valent iron.

Journal: Journal of contaminant hydrology 20041001

Title: Assessment of volume depletion in children with malaria.

Journal: PLoS medicine 20041001

Title: Direct detection of trace haloacetates in drinking water using microbore ion chromatography. Improved detector sensitivity using a hydroxide gradient and a monolithic ion-exchange type suppressor.

Journal: Journal of chromatography. A 20040827

Title: Binding and kinetic mechanisms of the Zeta class glutathione transferase.

Journal: The Journal of biological chemistry 20040806

Title: Haloacetic acids in the aquatic environment. Part I: macrophyte toxicity.

Journal: Environmental pollution (Barking, Essex : 1987) 20040801

Title: Haloacetic acids in the aquatic environment. Part II: ecological risk assessment.

Journal: Environmental pollution (Barking, Essex : 1987) 20040801

Title: Mice deficient in glutathione transferase zeta/maleylacetoacetate isomerase exhibit a range of pathological changes and elevated expression of alpha, mu, and pi class glutathione transferases.

Journal: The American journal of pathology 20040801

Title: Mechanism of dichloroacetate-induced hypolactatemia in humans with or without cirrhosis.

Journal: Metabolism: clinical and experimental 20040801

Title: Ischemic heart disease: metabolic approaches to management.

Journal: Clinical cardiology 20040801

Title: Interactions in the tumor-promoting activity of carbon tetrachloride, trichloroacetate, and dichloroacetate in the liver of male B6C3F1 mice.

Journal: Toxicology 20040701

Title: Influence of DCA on pulmonary (.-)V(O2) kinetics during moderate-intensity cycle exercise.

Journal: Medicine and science in sports and exercise 20040701

Title: Determination of bromate and chlorinated haloacetic acids in bottled drinking water with chromatographic methods.

Journal: Chemosphere 20040601

Title: The effect of disinfection by-products and mutagenic activity on birth weight and gestational duration.

Journal: Environmental health perspectives 20040601

Title: Effects of dichloroacetate and ubiquinone infusions on glycolysis activity and thermal sensitivity during sepsis.

Journal: The Journal of laboratory and clinical medicine 20040601

Title: Effects of superoxide dismutase and polyclonal tumor necrosis factor-alpha antibodies on chloroacetate-induced cellular death and superoxide anion production by J774.A1 macrophages.

Journal: Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20040601

Title: Experimental cancer studies of chlorinated by-products.

Journal: Toxicology 20040520

Title: Induction of peroxisome proliferation in cultured hepatocytes by a series of halogenated acetates.

Journal: Toxicology 20040503

Title: Formation of haloacetic acids during monochloramination.

Journal: Water research 20040501

Title: Glutathione transferase zeta-catalyzed bioactivation of dichloroacetic acid: reaction of glyoxylate with amino acid nucleophiles.

Journal: Chemical research in toxicology 20040501

Title: Dichloroacetate therapy attenuates the blood lactate response to submaximal exercise in patients with defects in mitochondrial energy metabolism.

Journal: The Journal of clinical endocrinology and metabolism 20040401

Title: Regulation of expression of tissue plasminogen activator and plasminogen activator inhibitor-1 by dichloroacetic acid in human fibroblasts from normal peritoneum and adhesions.

Journal: American journal of obstetrics and gynecology 20040401

Title: Accurate determination of low pK values by (1)H NMR titration.

Journal: Talanta 20040310

Title: Dichloroacetate does not speed phase-II pulmonary VO2 kinetics following the onset of heavy intensity cycle exercise.

Journal: Pflugers Archiv : European journal of physiology 20040301

Title: [Treatment for mitochondrial diseases].

Journal: No to hattatsu = Brain and development 20040301

Title: Hypomethylation of DNA and the insulin-like growth factor-II gene in dichloroacetic and trichloroacetic acid-promoted mouse liver tumors.

Journal: Toxicology 20040301

Title: [Heart disease and diabetes: from pathophysiology to therapeutic options].

Journal: Italian heart journal : official journal of the Italian Federation of Cardiology 20040301

Title: [Investigation of bromate, haloacetic acids and perchlorate in Beijing's drinking water].

Journal: Huan jing ke xue= Huanjing kexue 20040301

Title: Prevention by methionine of dichloroacetic acid-induced liver cancer and DNA hypomethylation in mice.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20040201

Title: Mitochondrial complex I mutations in Caenorhabditis elegans produce cytochrome c oxidase deficiency, oxidative stress and vitamin-responsive lactic acidosis.

Journal: Human molecular genetics 20040201

Title: Therapeutic effect and [123I]IMP SPECT findings of sodium dichloroacetate in a patient with MELAS.

Journal: Neurology 20040127

Title: Regulation of matrix metalloproteinase-1 and tissue inhibitor of matrix metalloproteinase-1 by dichloroacetic acid in human fibroblasts from normal peritoneum and adhesions.

Journal: Fertility and sterility 20040101

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20040101

Title: DBP levels in chlorinated drinking water: effect of humic substances.

Journal: Environmental monitoring and assessment 20040101

Title: Mechanistic implications of the effect of TiO2 accessibility in TiO2-SiO2 coatings upon chlorinated organics photocatalytic removal in water.

Journal: Water science and technology : a journal of the International Association on Water Pollution Research 20040101

Title: Evaluation of the combined solar TiO2/photo-Fenton process using multivariate analysis.

Journal: Water science and technology : a journal of the International Association on Water Pollution Research 20040101

Title: Textile wastewater treatment and reuse by solar catalysis: results from a pilot plant in Tunisia.

Journal: Water science and technology : a journal of the International Association on Water Pollution Research 20040101

Title: Elevated blood lactate is not a primary cause of anorexia in tumor-bearing rats.

Journal: Nutrition and cancer 20040101

Title: POSaM: a fast, flexible, open-source, inkjet oligonucleotide synthesizer and microarrayer.

Journal: Genome biology 20040101

Title: Bench-to-bedside review: treating acid-base abnormalities in the intensive care unit - the role of buffers.

Journal: Critical care (London, England) 20040101

Title: Chronic treatment of mitochondrial disease patients with dichloroacetate.

Journal: Molecular genetics and metabolism 20040101

Title: Therapy of cutaneous human Papillomavirus infections.

Journal: Dermatologic therapy 20040101

Title: Some drinking-water disinfectants and contaminants, including arsenic.

Journal: IARC monographs on the evaluation of carcinogenic risks to humans 20040101

Title: Some drinking-water disinfectants and contaminants, including arsenic. Monographs on chloramine, chloral and chloral hydrate, dichloroacetic acid, trichloroacetic acid and 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone.

Journal: IARC monographs on the evaluation of carcinogenic risks to humans 20040101

Title: Evaluation of the influence of chloroacetic acids on the pharmacokinetics of trihalomethanes in the rat.

Journal: Journal of toxicology and environmental health. Part A 20031212

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20031201

Title: Pharmacologic or genetic ablation of maleylacetoacetate isomerase increases levels of toxic tyrosine catabolites in rodents.

Journal: Biochemical pharmacology 20031115

Title: Lactate as a modulator of hypoxia-induced hyperventilation.

Journal: Respiratory physiology & neurobiology 20031016

Title: Improvement of thermal hydrolysis rate of dichloroacetic acid using alcohol.

Journal: Chemosphere 20031001

Title: Pyruvate and acetate metabolism in termite mitochondria.

Journal: Journal of insect physiology 20031001

Title: The effects of dichloroacetate in a rabbit model of acute hind-limb ischemia and reperfusion.

Journal: Journal of the American College of Surgeons 20031001

Title: Effects of dichloroacetate on VO2 and intramuscular 31P metabolite kinetics during high-intensity exercise in humans.

Journal: Journal of applied physiology (Bethesda, Md. : 1985) 20030901

Title: Low-frequency modes of peptides and globular proteins in solution observed by ultrafast OHD-RIKES spectroscopy.

Journal: Biophysical journal 20030901

Title: Evidence for rapid 'metabolic switching' through lipoprotein lipase occupation of endothelial-binding sites.

Journal: Journal of molecular and cellular cardiology 20030901

Title: Multinuclear NMR investigations on the metabolic recovery of the isolated perfused mouse liver after cold preservation.

Journal: Biochimie 20030901

Title: Design and synthesis of novel pyridoxine 5'-phosphonates as potential antiischemic agents.

Journal: Journal of medicinal chemistry 20030814

Title: Beneficial effects of trimetazidine in ex vivo working ischemic hearts are due to a stimulation of glucose oxidation secondary to inhibition of long-chain 3-ketoacyl coenzyme a thiolase.

Journal: Circulation research 20030808

Title: Perturbation of maleylacetoacetic acid metabolism in rats with dichloroacetic Acid-induced glutathione transferase zeta deficiency.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20030701

Title: Formation of chloroacetic acids from soil, humic acid and phenolic moieties.

Journal: Chemosphere 20030701

Title: Differential modulation of glucose, lactate, and pyruvate oxidation by insulin and dichloroacetate in the rat heart.

Journal: American journal of physiology. Heart and circulatory physiology 20030701

Title: Efficacy of dichloroacetate as a lactate-lowering drug.

Journal: Journal of clinical pharmacology 20030701

Title: Airborne haloacetic acids.

Journal: Environmental science & technology 20030701

Title: Impairment of glucose metabolism and energy transfer in the rat heart.

Journal: Molecular and cellular biochemistry 20030701

Title: Determination of chloroacetates in atmospheric particulate matter.

Journal: Environmental science & technology 20030601

Title: The induction of oxidative stress and cellular death by the drinking water disinfection by-products, dichloroacetate and trichloroacetate in J774.A1 cells.

Journal: Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20030601

Title: Vacancy ion-exclusion chromatography of haloacetic acids on a weakly acidic cation-exchange resin.

Journal: Journal of chromatography. A 20030516

Title: Differential effect of DCA treatment on the pyruvate dehydrogenase complex in patients with severe PDHC deficiency.

Journal: Pediatric research 20030501

Title: Field level evaluation and risk assessment of the toxicity of dichloroacetic acid to the aquatic macrophytes Lemna gibba, Myriophyllum spicatum, and Myriophyllum sibiricum.

Journal: Ecotoxicology and environmental safety 20030501

Title: Regulation of transforming growth factor-beta, type III collagen, and fibronectin by dichloroacetic acid in human fibroblasts from normal peritoneum and adhesions.

Journal: Fertility and sterility 20030501

Title: Population kinetics, efficacy, and safety of dichloroacetate for lactic acidosis due to severe malaria in children.

Journal: Journal of clinical pharmacology 20030401

Title: Chloroacetic acids in European soils and vegetation.

Journal: Journal of environmental monitoring : JEM 20030401

Title: [Dichloroacetate treatment for adult patients with mitochondrial disease].

Journal: Rinsho shinkeigaku = Clinical neurology 20030401

Title: Identification of trichloroethylene and its metabolites in human seminal fluid of workers exposed to trichloroethylene.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20030301

Title: Pyruvate-dependent preconditioning and cardioprotection in murine myocardium.

Journal: Clinical and experimental pharmacology & physiology 20030301

Title: Physicochemical characterization of phosphinic pseudopeptides by capillary zone electrophoresis in highly acidic background electrolytes.

Journal: Electrophoresis 20030301

Title: Altered gene expression in mouse livers after dichloroacetic acid exposure.

Journal: Mutation research 20030301

Title: Dichloroacetate accelerates the fall in intracellular PO2 at onset of contractions in Xenopus single muscle fibers.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20030201

Title: Measurement of 13C/12C of chloroacetic acids by gas chromatography/combustion/isotope ratio mass spectrometry.

Journal: Chemosphere 20030201

Title: Synthesis and immunogenic properties of phosphopeptides related to the human insulin receptor.

Journal: The journal of peptide research : official journal of the American Peptide Society 20030101

Title: A 2-year dose-response study of lesion sequences during hepatocellular carcinogenesis in the male B6C3F(1) mouse given the drinking water chemical dichloroacetic acid.

Journal: Environmental health perspectives 20030101

Title: [Adverse effects of dichloroacetate in a girl with mitochondrial disorder].

Journal: No to hattatsu = Brain and development 20030101

Title: Dichloroacetate increases skeletal muscle pyruvate dehydrogenase activity during acute limb ischemia.

Journal: Vascular and endovascular surgery 20030101

Title: The NO - K+ channel axis in pulmonary arterial hypertension. Activation by experimental oral therapies.

Journal: Advances in experimental medicine and biology 20030101

Title: Cloning and in vitro and in vivo expression of plant glutathione S-transferase zeta class genes.

Journal: Journal of bioscience and bioengineering 20030101

Title: Nephrotoxicity of chlorofluoroacetic acid in rats.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20021201

Title: Metabolic regulation of collagen I in fibroblasts isolated from normal peritoneum and adhesions by dichloroacetic acid.

Journal: American journal of obstetrics and gynecology 20021201

Title: Brief increase in carbohydrate oxidation after reperfusion reverses myocardial stunning in conscious pigs.

Journal: Circulation 20021126

Title: Stearoyl-CoA desaturase 1 (Scd1) gene overexpression is associated with genetic predisposition to hepatocarcinogenesis in mice and rats.

Journal: Carcinogenesis 20021101

Title: Mass spectral characterization of dichloroacetic acid-modified human glutathione transferase zeta.

Journal: Chemical research in toxicology 20021101

Title: The use of partial fatty acid oxidation inhibitors for metabolic therapy of angina pectoris and heart failure.

Journal: Herz 20021101

Title: Time-resolved optical Kerr-effect spectroscopy of low-frequency dynamics in Di-L-alanine, poly-L-alanine, and lysozyme in solution.

Journal: Journal of the American Chemical Society 20021016

Title: The acetyl group deficit at the onset of contraction in ischaemic canine skeletal muscle.

Journal: The Journal of physiology 20021015

Title: [Acute complications due to diabetes mellitus: Lactic acidosis].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20021001

Title: Is lactate a mediator of hypoxia-induced anapyrexia?

Journal: Pflugers Archiv : European journal of physiology 20020901

Title: Dichloroacetate stimulates glycogen accumulation in primary hepatocytes through an insulin-independent mechanism.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20020801

Title: Low-dose pharmacokinetics and oral bioavailability of dichloroacetate in naive and GST-zeta-depleted rats.

Journal: Environmental health perspectives 20020801

Title: Synthesis of optically active homocysteine from methionine and its use in preparing four stereoisomers of cystathionine.

Journal: Chemical & pharmaceutical bulletin 20020801

Title: Skeletal muscle metabolism is unaffected by DCA infusion and hyperoxia after onset of intense aerobic exercise.

Journal: American journal of physiology. Endocrinology and metabolism 20020701

Title: Bromochloroacetic acid exerts qualitative effects on rat sperm: implications for a novel biomarker.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20020701

Title: Manipulations in glycogen metabolism and the failure to influence infarct size in the ischaemic rabbit heart.

Journal: European journal of anaesthesiology 20020701

Title: Kinetics of the biotransformation of maleylacetone and chlorofluoroacetic acid by polymorphic variants of human glutathione transferase zeta (hGSTZ1-1).

Journal: Chemical research in toxicology 20020701

Title: Contribution of dichloroacetate and trichloroacetate to liver tumor induction in mice by trichloroethylene.

Journal: Toxicology and applied pharmacology 20020701

Title: Solar photodegradation of dichloroacetic acid and 2,4-dichlorophenol using an enhanced photo-Fenton process.

Journal: Chemosphere 20020701

Title: Dichloroacetate therapy in Leigh syndrome with a mitochondrial T8993C mutation.

Journal: Pediatric neurology 20020701

Title: Glutathione and K(+) channel remodeling in postinfarction rat heart.

Journal: American journal of physiology. Heart and circulatory physiology 20020601

Title: Immunohistochemical localization and activity of glutathione transferase zeta (GSTZ1-1) in rat tissues.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20020601

Title: Dichloroacetate toxicokinetics and disruption of tyrosine catabolism in B6C3F1 mice: dose-response relationships and age as a modifying factor.

Journal: Toxicology 20020501

Title: Alkylation and inactivation of human glutathione transferase zeta (hGSTZ1-1) by maleylacetone and fumarylacetone.

Journal: Chemical research in toxicology 20020501

Title: Distribution of haloacetic acids in the water columns of the Laurentian Great Lakes and Lake Malawi.

Journal: Environmental science & technology 20020501

Title: New large solar photocatalytic plant: set-up and preliminary results.

Journal: Chemosphere 20020401

Title: [Drug therapy for mitochondrial diseases].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20020401

Title: An acetyl group deficit limits mitochondrial ATP production at the onset of exercise.

Journal: Biochemical Society transactions 20020401

Title: Genetic polymorphisms in assessing interindividual variability in delivered dose.

Journal: Regulatory toxicology and pharmacology : RTP 20020401

Title: Glucose-stimulated insulin secretion does not require activation of pyruvate dehydrogenase: impact of adenovirus-mediated overexpression of PDH kinase and PDH phosphate phosphatase in pancreatic islets.

Journal: Biochemical and biophysical research communications 20020308

Title: Pyruvate dehydrogenase and the regulation of glucose oxidation in hypertrophied rat hearts.

Journal: Cardiovascular research 20020301

Title: High levels of fatty acids delay the recovery of intracellular pH and cardiac efficiency in post-ischemic hearts by inhibiting glucose oxidation.

Journal: Journal of the American College of Cardiology 20020220

Title: Measurement of interstitial lactate during hypoxia-induced dilatation in isolated pressurised porcine coronary arteries.

Journal: The Journal of physiology 20020215

Title: Monochloramine loss in the presence of humic acid.

Journal: Journal of environmental monitoring : JEM 20020201

Title: Degradation pathways of trichloroethylene and 1,1,1-trichloroethane by Mycobacterium sp. TA27.

Journal: Bioscience, biotechnology, and biochemistry 20020201

Title: Dichloroacetate, a metabolic modulator, prevents and reverses chronic hypoxic pulmonary hypertension in rats: role of increased expression and activity of voltage-gated potassium channels.

Journal: Circulation 20020115

Title: Enhanced pyruvate dehydrogenase activity does not affect muscle O2 uptake at onset of intense exercise in humans.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20020101

Title: Oxygen uptake on-kinetics in dog gastrocnemius in situ following activation of pyruvate dehydrogenase by dichloroacetate.

Journal: The Journal of physiology 20020101

Title: Renal manifestations of congenital lactic acidosis.

Journal: American journal of kidney diseases : the official journal of the National Kidney Foundation 20020101

Title: Mouse models of Huntington's disease.

Journal: Trends in pharmacological sciences 20020101

Title: Analysis of the cytotoxicity and mutagenicity of drinking water disinfection by-products in Salmonella typhimurium.

Journal: Teratogenesis, carcinogenesis, and mutagenesis 20020101

Title: Mammalian cell cytotoxicity and genotoxicity analysis of drinking water disinfection by-products.

Journal: Environmental and molecular mutagenesis 20020101

Title: Trichloroethylene oxidative metabolism in plants: the trichloroethanol pathway.

Journal: Phytochemistry 20011201

Title: GSTZ1d: a new allele of glutathione transferase zeta and maleylacetoacetate isomerase.

Journal: Pharmacogenetics 20011101

Title: Dichloroacetate reduces diaphragmatic lactate formation but impairs respiratory performance.

Journal: American journal of respiratory and critical care medicine 20011101

Title: Effect of chloroform on dichloroacetic acid and trichloroacetic acid-induced hypomethylation and expression of the c-myc gene and on their promotion of liver and kidney tumors in mice.

Journal: Carcinogenesis 20010901

Title: Stereospecific toxicokinetics of bromochloro- and chlorofluoroacetate: effect of GST-zeta depletion.

Journal: Toxicology and applied pharmacology 20010901

Title: Changes of activity inducing chromosomal aberrations and transformations of chlorinated humic acid.

Journal: Water research 20010801

Title: Detection of early gene expression changes by differential display in the livers of mice exposed to dichloroacetic acid.

Journal: Carcinogenesis 20010801

Title: Nerve conduction changes in patients with mitochondrial diseases treated with dichloroacetate.

Journal: Muscle & nerve 20010701

Title: Dichloroacetate exerts therapeutic effects in transgenic mouse models of Huntington's disease.

Journal: Annals of neurology 20010701

Title: Hepatic and renal toxicities associated with perchloroethylene.

Journal: Pharmacological reviews 20010601

Title: Pyruvate/dichloroacetate supply during reperfusion accelerates recovery of cardiac energetics and improves mechanical function following cardioplegic arrest.

Journal: European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 20010601

Title: Oxygen supply and oxidative phosphorylation limitation in rat myocardium in situ.

Journal: American journal of physiology. Heart and circulatory physiology 20010501

Title: Postischemic Na(+)-K(+)-ATPase reactivation is delayed in the absence of glycolytic ATP in isolated rat hearts.

Journal: American journal of physiology. Heart and circulatory physiology 20010501

Title: Potential for creatine and other therapies targeting cellular energy dysfunction in neurological disorders.

Journal: Annals of neurology 20010501

Title: Exercise intolerance in mitochondrial myopathy is not related to lactic acidosis.

Journal: Annals of neurology 20010501

Title: Dichloroacetate improves cardiac efficiency after ischemia independent of changes in mitochondrial proton leak.

Journal: American journal of physiology. Heart and circulatory physiology 20010401

Title: Direct imaging of dehydrogenase activity within living cells using enzyme-dependent fluorescence recovery after photobleaching (ED-FRAP).

Journal: Biophysical journal 20010401

Title: Identification of novel glutathione transferases and polymorphic variants by expressed sequence tag database analysis.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20010401

Title: Haloacetates in fog and rain.

Journal: Environmental science & technology 20010401

Title: Dichloroacetate: population pharmacokinetics with a pharmacodynamic sequential link model.

Journal: Journal of clinical pharmacology 20010301

Title: Study on the cytochrome P-450- and glutathione-dependent biotransformation of trichloroethylene in humans.

Journal: International archives of occupational and environmental health 20010301

Title: Photocatalytic degradation of gaseous perchloroethylene: products and pathway.

Journal: Chemosphere 20010201

Title: Dichloroacetate treatment for severe refractory metabolic acidosis during neonatal sepsis.

Journal: The Pediatric infectious disease journal 20010201

Title: Lactic acidosis update for critical care clinicians.

Journal: Journal of the American Society of Nephrology : JASN 20010201

Title: Diffusion-weighted image and MR spectroscopic analysis of a case of MELAS with repeated attacks.

Journal: Yonsei medical journal 20010201

Title: The fate and persistence of trifluoroacetic and chloroacetic acids in pond waters.

Journal: Chemosphere 20010101

Title: Effects of dichloroacetate (DCA) on serum insulin levels and insulin-controlled signaling proteins in livers of male B6C3F1 mice.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20010101

Title: The effect of dichloroacetic acid and trichloroacetic acid on DNA methylation and cell proliferation in B6C3F1 mice.

Journal: Journal of biochemical and molecular toxicology 20010101

Title: Differential effects of dihalogenated and trihalogenated acetates in the liver of B6C3F1 mice.

Journal: Journal of applied toxicology : JAT 20010101

Title: Lack of IL-6 production during exercise in patients with mitochondrial myopathy.

Journal: European journal of applied physiology 20010101

Title: [Benign infantile mitochondrial myopathy].

Journal: Ryoikibetsu shokogun shirizu 20010101

Title: Novel mutations in a boy with dihydrolipoamide dehydrogenase deficiency.

Journal: Medical science monitor : international medical journal of experimental and clinical research 20010101

Title: Solar detoxification of wastewater in a novel aerated cascade photoreactor (ACP).

Journal: Water science and technology : a journal of the International Association on Water Pollution Research 20010101

Title: Use of structure-activity relationships for probing biochemical mechanisms: glutathione transferase zeta conjugation of haloacids.

Journal: Advances in experimental medicine and biology 20010101

Title: Trichloroethylene, trichloroacetic acid, and dichloroacetic acid: do they affect fetal rat heart development?

Journal: International journal of toxicology 20010101

Title: Gene transfer and metabolic modulators as new therapies for pulmonary hypertension. Increasing expression and activity of potassium channels in rat and human models.

Journal: Advances in experimental medicine and biology 20010101

Title: Role of metabolically active drugs in the management of ischemic heart disease.

Journal: American journal of cardiovascular drugs : drugs, devices, and other interventions 20010101

Title: Effect of trichloroethylene and its metabolites, dichloroacetic acid and trichloroacetic acid, on the methylation and expression of c-Jun and c-Myc protooncogenes in mouse liver: prevention by methionine.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20000401

Title: Discovery of a functional polymorphism in human glutathione transferase zeta by expressed sequence tag database analysis.

Journal: Pharmacogenetics 20000201

Title: The effect of the trichloroethylene metabolites trichloroacetate and dichloroacetate on peroxisome proliferation and DNA synthesis in cultured human hepatocytes.

Journal: Cell biology and toxicology 20000101

Title: Expression of PPAR(alpha) in human hepatocytes and activation by trichloroacetate and dichloroacetate.

Journal: Research communications in molecular pathology and pharmacology 20000101

Title: trans-Activation of PPARalpha and PPARgamma by structurally diverse environmental chemicals.

Journal: Toxicology and applied pharmacology 19991201

Title: Inhibition of glutathione S-transferase zeta and tyrosine metabolism by dichloroacetate: a potential unifying mechanism for its altered biotransformation and toxicity.

Journal: Biochemical and biophysical research communications 19990907

Title: Activation of peroxisome proliferator-activated receptors by chlorinated hydrocarbons and endogenous steroids.

Journal: Environmental health perspectives 19980801

Title: Loss of heterozygosity on chromosome 6 in dichloroacetic acid and trichloroacetic acid-induced liver tumors in female B6C3F1 mice.

Journal: Cancer letters 19961129

Title: Effects of chemical pretreatment on posttraumatic cortical edema in the rat.

Journal: The American journal of emergency medicine 19960101

Title: ras proto-oncogene activation in dichloroacetic acid-, trichloroethylene- and tetrachloroethylene-induced liver tumors in B6C3F1 mice.

Journal: Carcinogenesis 19941001

Title: The carcinogenicity of trichloroethylene and its metabolites, trichloroacetic acid and dichloroacetic acid, in mouse liver.

Journal: Toxicology and applied pharmacology 19870915

Title: Toxic effects of chlorinated and brominated alkanoic acids on Pseudomonas putida PP3: selection at high frequencies of mutations in genes encoding dehalogenases.

Journal: Applied and environmental microbiology 19850601

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Tags:79-43-6 Molecular Formula|79-43-6 MDL|79-43-6 SMILES|79-43-6 Dichloroacetic acid