Home Other Building Blocks 79516-67-9
79516-67-9,MFCD07787408
Catalog No.:AA01X49F

79516-67-9 | Levocabastine HCl

This product is typically in stock,please click "Inquire" below or
contact us at [email protected] for pricing and availability information.
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA01X49F
Chemical Name:
Levocabastine HCl
CAS Number:
79516-67-9
Molecular Formula:
C26H30ClFN2O2
Molecular Weight:
456.9800
MDL Number:
MFCD07787408
SMILES:
N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F.Cl
Properties
Computed Properties
 
Complexity:
681  
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
2  
Heavy Atom Count:
32  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
4  

Literature

Title: Spinal NTS2 receptor activation reverses signs of neuropathic pain.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20130901

Title: [Safety and efficacy of a new preservative-free levocabastine ophthalmic solution (Levofree®) using the conjunctival provocation test].

Journal: Journal francais d'ophtalmologie 20120901

Title: NTS1 and NTS2 mediate analgesia following neurotensin analog treatment in a mouse model for visceral pain.

Journal: Behavioural brain research 20120615

Title: Neurotensin decreases high affinity [3H]-ouabain binding to cerebral cortex membranes.

Journal: Regulatory peptides 20111210

Title: β-Lactotensin derived from bovine β-lactoglobulin exhibits anxiolytic-like activity as an agonist for neurotensin NTS(2) receptor via activation of dopamine D(1) receptor in mice.

Journal: Journal of neurochemistry 20111101

Title: Neurotensin inhibits background K+ channels and facilitates glutamatergic transmission in rat spinal cord dorsal horn.

Journal: The European journal of neuroscience 20111001

Title: A multicenter randomized double-blind 2-week comparison study of azelastine nasal spray 0.1% versus levocabastine nasal spray 0.05% in patients with moderate-to-severe allergic rhinitis.

Journal: ORL; journal for oto-rhino-laryngology and its related specialties 20110101

Title: In vivo investigations of neurotensin receptors in adipocytes, hepatocytes and enterocytes of rat.

Journal: Annals of agricultural and environmental medicine : AAEM 20110101

Title: Neurotensin is a regulator of insulin secretion in pancreatic beta-cells.

Journal: The international journal of biochemistry & cell biology 20101001

Title: Relation between cooling sheet effect and tear histamine concenration in allergic conjunctivitis.

Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20100701

Title: Treatment of allergic conjunctivitis: results of a 1-month, single-masked randomized study.

Journal: European journal of ophthalmology 20100101

Title: beta-Lactotensin derived from bovine beta-lactoglobulin suppresses food intake via the CRF system followed by the CGRP system in mice.

Journal: Peptides 20091201

Title: NT69L, a novel analgesic, shows synergy with morphine.

Journal: Brain research 20091019

Title: [Effect of intra nasally applied fluticasone propionate and levocabastine on the expression of aquaporin 5 in nasal mucosa of rat with experimental allergic rhinitis].

Journal: Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery 20091001

Title: The effect of levocabastine hydrochloride on human Tenon's capsule fibroblasts: inhibition of proliferation, suppression of DNA synthesis and induction of apoptosis.

Journal: Cutaneous and ocular toxicology 20090101

Title: Evidence for a role of NTS2 receptors in the modulation of tonic pain sensitivity.

Journal: Molecular pain 20090101

Title: [Intra-annual and seasonal allergic conjunctivitis treatment: comparison of two therapeutic protocols].

Journal: Journal francais d'ophtalmologie 20081201

Title: Contribution of alpha4beta1 integrin to the antiallergic effect of levocabastine.

Journal: Biochemical pharmacology 20080915

Title: The effect of a combined therapy with a histamine H1 antagonist and a chemical mediator release inhibitor on allergic conjunctivitis.

Journal: Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde 20080101

Title: The effect of levocabastine and furosemide pretreatment on hyperreactive response after nasal provocation with hypotonic aerosol in subjects with allergic rhinitis.

Journal: European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery 20071101

Title: Clinical and biological efficacy of preservative-free NAAGA eye-drops versus levocabastine eye-drops in vernal keratoconjunctivitis patients.

Journal: The British journal of ophthalmology 20070101

Title: Interactions between NTS2 neurotensin and opioid receptors on two nociceptive responses assessed on the hot plate test in mice.

Journal: Behavioural brain research 20061215

Title: Effect of antihistamine eye drops on the conjunctival provocation test with Japanese cedar pollen allergen.

Journal: Allergology international : official journal of the Japanese Society of Allergology 20061201

Title: The early efficacy of topical levocabastine in patients with allergic conjunctivitis.

Journal: Allergology international : official journal of the Japanese Society of Allergology 20060901

Title: Efficacy of levocabastine hydrochloride ophthalmic suspension in the conjunctival allergen challenge test in Japanese subjects with seasonal allergic conjunctivitis.

Journal: Allergology international : official journal of the Japanese Society of Allergology 20060601

Title: Potent spinal analgesia elicited through stimulation of NTS2 neurotensin receptors.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20050907

Title: Efficacy, cost-effectiveness, and tolerability of mometasone furoate, levocabastine, and disodium cromoglycate nasal sprays in the treatment of seasonal allergic rhinitis.

Journal: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20050901

Title: Identification and functional characterization of a 5-transmembrane domain variant isoform of the NTS2 neurotensin receptor in rat central nervous system.

Journal: The Journal of biological chemistry 20050318

Title: Increasing effect by simultaneous use of levocabastine and pemirolast on experimental allergic conjunctivitis in rats.

Journal: Biological & pharmaceutical bulletin 20050301

Title: [Comparison of three antiallergic eyedrops in a specific conjunctival provocation test: mequitazine, levocabastine and dexamethasone].

Journal: Journal francais d'ophtalmologie 20050301

Title: Effect of ketotifen fumarate, olopatadine, and levocabastine on ocular active anaphylaxis in the guinea pig and ocular immediate hypersensitivity in the albino rat.

Journal: Ocular immunology and inflammation 20050201

Title: Comparison of allergen immunotherapy and drug treatment in seasonal rhinoconjunctivitis: a 3-years study.

Journal: European annals of allergy and clinical immunology 20050201

Title: Low-affinity neurotensin receptor (NTS2) signaling: internalization-dependent activation of extracellular signal-regulated kinases 1/2.

Journal: Molecular pharmacology 20041201

Title: Comparative efficacy of olopatadine 0.1% ophthalmic solution versus levocabastine 0.05% ophthalmic suspension using the conjunctival allergen challenge model.

Journal: Current medical research and opinion 20041201

Title: Randomised double masked trial comparing the efficacy and tolerance of 0.05% mequitazine eye drops versus 0.05% levocabastine and placebo in allergic conjunctivitis induced by a conjunctival provocation test with Dermatophagoides pteronyssinus.

Journal: The British journal of ophthalmology 20040301

Title: Efficacy and tolerability of ophthalmic epinastine: a randomized, double-masked, parallel-group, active- and vehicle-controlled environmental trial in patients with seasonal allergic conjunctivitis.

Journal: Clinical therapeutics 20040101

Title: Beta-lactotensin and neurotensin rapidly reduce serum cholesterol via NT2 receptor.

Journal: Peptides 20031201

Title: Efficacy and safety of ketotifen eye drops in the treatment of seasonal allergic conjunctivitis.

Journal: The British journal of ophthalmology 20031001

Title: Regulation of DARPP-32 Thr75 phosphorylation by neurotensin in neostriatal neurons: involvement of glutamate signalling.

Journal: The European journal of neuroscience 20030901

Title: [In vitro effects of antiallergic eyedrops on complement activation induced by particulate matter].

Journal: Journal francais d'ophtalmologie 20030401

Title: Topical azelastine in perennial allergic conjunctivitis.

Journal: Current medical research and opinion 20030101

Title: Intranasal corticosteroids versus topical H1 receptor antagonists for the treatment of allergic rhinitis: a systematic review with meta-analysis.

Journal: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20021101

Title: Pharmacology and functional properties of NTS2 neurotensin receptors in cerebellar granule cells.

Journal: The Journal of biological chemistry 20020927

Title: Neurotensin causes tyrosine phosphorylation of focal adhesion kinase in lung cancer cells.

Journal: European journal of pharmacology 20020510

Title: Neurotensin regulates DARPP-32 thr34 phosphorylation in neostriatal neurons by activation of dopamine D1-type receptors.

Journal: Journal of neurochemistry 20020401

Title: [Pharmacological and clinical properties of levocabastine hydrochloride (eye drop and nasal spray), a selective H1 antagonist].

Journal: Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20020301

Title: [Ocular injuries due to allergic mechanism].

Journal: Oftalmologia (Bucharest, Romania : 1990) 20020101

Title: Agonism, inverse agonism, and neutral antagonism at the constitutively active human neurotensin receptor 2.

Journal: Molecular pharmacology 20011201

Title: Nedocromil sodium and levocabastine reduce the symptoms of conjunctival allergen challenge by different mechanisms.

Journal: The Journal of allergy and clinical immunology 20010901

Title: Characterization and autoradiographic localization of neurotensin binding sites in human sigmoid colon.

Journal: The Journal of pharmacology and experimental therapeutics 20010601

Title: Clinical evaluation of twice-daily emedastine 0.05% eye drops (Emadine eye drops) versus levocabastine 0.05% eye drops in patients with allergic conjunctivitis.

Journal: American journal of ophthalmology 20010601

Title: Involvement of the neurotensin receptor subtype NTR3 in the growth effect of neurotensin on cancer cell lines.

Journal: International journal of cancer 20010515

Title: Localization of neurotensin NTS2 receptors in rat brain, using.

Journal: Neuroreport 20010417

Title: [The curative effect of livostin spray on treating allergic rhinitis of children].

Journal: Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology 20010401

Title: Cost effectiveness of emedastine versus levocabastine in the treatment of allergic conjunctivitis in 7 European countries.

Journal: PharmacoEconomics 20010101

Title: Comparative efficacy and safety of azelastine and levocabastine nasal sprays in patients with seasonal allergic rhinitis.

Journal: Arzneimittel-Forschung 20010101

Title: Comparison of lodoxamide 0.1% ophthalmic solution and levocabastine 0.05% ophthalmic suspension in vernal keratoconjunctivitis.

Journal: European journal of ophthalmology 20010101

Title: Stable expression of the mouse levocabastine-sensitive neurotensin receptor in HEK 293 cell line: binding properties, photoaffinity labeling, and internalization mechanism.

Journal: Biochemical and biophysical research communications 19980213

Title: Structure, functional expression, and cerebral localization of the levocabastine-sensitive neurotensin/neuromedin N receptor from mouse brain.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 19960915

Title: Molecular cloning of a levocabastine-sensitive neurotensin binding site.

Journal: FEBS letters 19960520

Title: Selective effect of levocabastine on histamine receptor and histamine release from human leukocytes and guinea pig isolated tissue.

Journal: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 19960401

Title: Evidence for a displaceable non-specific [3H]neurotensin binding site in rat brain.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 19860801

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Related Products of 79516-67-9
Tags:79516-67-9 Molecular Formula|79516-67-9 MDL|79516-67-9 SMILES|79516-67-9 Levocabastine HCl