[1]CurrentPatentAssignee:KYORINHOLDINGS,INC.-EP195135,1992,B1
[1]CurrentPatentAssignee:ROCHEHOLDINGAG-US5329002,1994,A
[1]CurrentPatentAssignee:ROCHEHOLDINGAG-US5329002,1994,A
[1]Fasani,Elisa;Monti,Sandra;Manet,Ilse;Tilocca,Fedele;Pretali,Luca;Mella,Mariella;Albini,Angelo[OrganicLetters,2009,vol.11,#9,p.1875-1878]
[1]Fasani,Elisa;Monti,Sandra;Manet,Ilse;Tilocca,Fedele;Pretali,Luca;Mella,Mariella;Albini,Angelo[OrganicLetters,2009,vol.11,#9,p.1875-1878]
Title: Genital ulcer disease treatment for reducing sexual acquisition of HIV.
Journal: The Cochrane database of systematic reviews 20120815
Title: [A new pathogen of gibel carp Carassius auratus gibelio-Shewanella putrefaciens].
Journal: Wei sheng wu xue bao = Acta microbiologica Sinica 20120504
Title: Simultaneous determination of fluoroquinolones in foods of animal origin by a high performance liquid chromatography and a liquid chromatography tandem mass spectrometry with accelerated solvent extraction.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20120215
Title: Occurrence and fate of quinolone and fluoroquinolone antibiotics in a municipal sewage treatment plant.
Journal: Water research 20120201
Title: Interaction between gentamicin and mycophenolate mofetil in experimentally induced pyelonephritis.
Journal: Indian journal of nephrology 20120101
Title: Improved negative selection protocol for Plasmodium berghei in the rodent malarial model.
Journal: Malaria journal 20120101
Title: Mass spectrometic study of speciation in aluminium-fluoroquinolone solutions.
Journal: European journal of mass spectrometry (Chichester, England) 20120101
Title: Spectroscopic studies on the lanthanide sensitized luminescence and chemiluminescence properties of fluoroquinolone with different structure.
Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20111101
Title: Determination of quinolone residues in infant and young children powdered milk combining solid-phase extraction and ultra-performance liquid chromatography-tandem mass spectrometry.
Journal: Journal of chromatography. A 20111021
Title: Air- and heat-stable planar tri-p-quinodimethane with distinct biradical characteristics.
Journal: Journal of the American Chemical Society 20111019
Title: Photodegradation of fleroxacin injection: different products with different concentration levels.
Journal: AAPS PharmSciTech 20110901
Title: Gatifloxacin versus chloramphenicol for uncomplicated enteric fever: an open-label, randomised, controlled trial.
Journal: The Lancet. Infectious diseases 20110601
Title: Occurrence, distribution and seasonal variation of antibiotics in the Huangpu River, Shanghai, China.
Journal: Chemosphere 20110201
Title: Microwave-assisted extraction and in situ clean-up for the determination of fluoroquinolone antibiotics in chicken breast muscle by LC-MS/MS.
Journal: Journal of separation science 20110101
Title: Diffusion of ofloxacin in the endocarditis vegetation assessed with synchrotron radiation UV fluorescence microspectroscopy.
Journal: PloS one 20110101
Title: Preparation of high-affinity rabbit monoclonal antibodies for ciprofloxacin and development of an indirect competitive ELISA for residues in milk.
Journal: Journal of Zhejiang University. Science. B 20101001
Title: Determination of fluoroquinolone antibiotics in environmental water samples based on magnetic molecularly imprinted polymer extraction followed by liquid chromatography-tandem mass spectrometry.
Journal: Analytica chimica acta 20100303
Title: Comparative in vitro activity of Meropenem, Imipenem and Piperacillin/tazobactam against 1071 clinical isolates using 2 different methods: a French multicentre study.
Journal: BMC infectious diseases 20100101
Title: Biopsy proven acute interstitial nephritis after treatment with moxifloxacin.
Journal: BMC nephrology 20100101
Title: Cephalosporin Resistance in Neisseria gonorrhoeae.
Journal: Journal of global infectious diseases 20100101
Title: Multifocal aggressive squamous cell carcinomas induced by prolonged voriconazole therapy: a case report.
Journal: Case reports in medicine 20100101
Title: Synergistic antitumor effects of fleroxacin with 5-fluorouracil in vitro and in vivo for bladder cancer cell lines.
Journal: Urology 20091201
Title: Fluoroquinolone antibiotic determination in bovine, ovine and caprine milk using solid-phase extraction and high-performance liquid chromatography-fluorescence detection with ionic liquids as mobile phase additives.
Journal: Journal of chromatography. A 20091023
Title: Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain.
Journal: Bioorganic & medicinal chemistry 20091001
Title: Application of ionic liquids in high performance reversed-phase chromatography.
Journal: International journal of molecular sciences 20090601
Title: Inter- and intramolecular photochemical reactions of fleroxacin.
Journal: Organic letters 20090507
Title: Enhanced separation of seven quinolones by capillary electrophoresis with silica nanoparticles as additive.
Journal: Talanta 20090315
Title: Urinary tract infections and reduced risk of bladder cancer in Los Angeles.
Journal: British journal of cancer 20090310
Title: Rapid determination of 19 quinolone residues in spiked fish and pig muscle by high-performance liquid chromatography (HPLC) tandem mass spectrometry.
Journal: Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment 20090301
Title: [Interaction of cucurbit[8]urils with ofloxacin, fleroxacin, gatifloxacin and sparfloxacin].
Journal: Guang pu xue yu guang pu fen xi = Guang pu 20090201
Title: Capillary electrophoresis with electrochemiluminescence detection for simultaneous determination of proline and fleroxacin in human urine.
Journal: Drug testing and analysis 20090201
Title: CE determination of quinolones in the presence of bovine serum albumin.
Journal: Journal of separation science 20090101
Title: Quantitative comparison of the convulsive activity of combinations of twelve fluoroquinolones with five nonsteroidal antiinflammatory agents.
Journal: Drug metabolism and pharmacokinetics 20090101
Title: [Simultaneous determination of 19 quinolone residues in honey using high performance liquid chromatography-tandem mass spectrometry].
Journal: Se pu = Chinese journal of chromatography 20090101
Title: A comparison of fluoroquinolones versus other antibiotics for treating enteric fever: meta-analysis.
Journal: BMJ (Clinical research ed.) 20090101
Title: Ionic liquids as mobile phase additives for the high-performance liquid chromatographic analysis of fluoroquinolone antibiotics in water samples.
Journal: Analytical and bioanalytical chemistry 20081201
Title: Drug resistance mechanism of the fish-pathogenic bacterium Lactococcus garvieae.
Journal: Journal of fish diseases 20080601
Title: [Simultaneous determination of sulfonamides and fluoroquinolones residues in chicken by high performance liquid chromatography-electrospray tandem mass spectrometry].
Journal: Se pu = Chinese journal of chromatography 20080501
Title: Utility of a single adjusting compartment: a novel methodology for whole body physiologically-based pharmacokinetic modelling.
Journal: Theoretical biology & medical modelling 20080101
Title: Solution equilibria between aluminum(III) ion and some fluoroquinolone family members. Spectroscopic and potentiometric study.
Journal: Chemical & pharmaceutical bulletin 20071201
Title: A rapid CE-potential gradient detection method for determination of quinolones.
Journal: Electrophoresis 20071101
Title: A flow injection chemiluminescence method for the determination of fluoroquinolone derivative using the reaction of luminol and hydrogen peroxide catalyzed by gold nanoparticles.
Journal: Talanta 20070515
Title: 1H and 19F NMR relaxation studies of fleroxacin with Micrococcus luteus.
Journal: Journal of pharmaceutical and biomedical analysis 20070411
Title: [Study on the ternary complex of FLRX, zinc(II) and BSA by the method of fluorescence].
Journal: Guang pu xue yu guang pu fen xi = Guang pu 20070401
Title: Interaction between fluoroquinolones and bovine serum albumin studied by affinity capillary electrophoresis.
Journal: Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20061201
Title: Moxifloxacin enhances antiproliferative and apoptotic effects of etoposide but inhibits its proinflammatory effects in THP-1 and Jurkat cells.
Journal: British journal of cancer 20061023
Title: Preparation of anti-pefloxacin antibody and development of an indirect competitive enzyme-linked immunosorbent assay for detection of pefloxacin residue in chicken liver.
Journal: Journal of agricultural and food chemistry 20060920
Title: [Clinical observation on shufei granule in improving right ventricular function of patients with chronic pulmonary heart disease].
Journal: Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20060801
Title: The use of microscopy and three-dimensional visualization to evaluate the structure of microbial biofilms cultivated in the Calgary Biofilm Device.
Journal: Biological procedures online 20060101
Title: Separation and determination of seven fluoroquinolones by pressurized capillary electrochromatography.
Journal: Journal of separation science 20051101
Title: [Determination of fleroxacin by photochemical fluorescence of zinc-fleroxacin complex].
Journal: Guang pu xue yu guang pu fen xi = Guang pu 20050901
Title: Structure-phototoxicity relationship in Balb/c mice treated with fluoroquinolone derivatives, followed by ultraviolet-A irradiation.
Journal: Toxicology letters 20050704
Title: Extrapolation of human pharmacokinetic parameters from rat, dog, and monkey data: Molecular properties associated with extrapolative success or failure.
Journal: Journal of pharmaceutical sciences 20050701
Title: Synthesis and antibacterial activity of 1-(2-fluorovinyl)-7-substituted-4-quinolone-3-carboxylic acid derivatives, conformationally restricted analogues of fleroxacin.
Journal: Journal of medicinal chemistry 20050505
Title: Susceptibility and resistance genes to fluoroquinolones in methicillin-resistant Staphylococcus aureus isolated in 2002.
Journal: International journal of antimicrobial agents 20050501
Title: [Ultraviolet spectral characteristics of charge-transfer reaction complex in micellar system and its application].
Journal: Guang pu xue yu guang pu fen xi = Guang pu 20050201
Title: Spectrofluorimetric study of the charge-transfer complexation of certain fluoroquinolones with 7,7,8,8-tetracyanoquinodimethane.
Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20050101
Title: Induced and photoinduced DNA damage by quinolones: ciprofloxacin, ofloxacin and nalidixic acid determined by comet assay.
Journal: Photochemistry and photobiology 20050101
Title: High-throughput metal susceptibility testing of microbial biofilms.
Journal: BMC microbiology 20050101
Title: A randomized clinical trial to compare fleroxacin-rifampicin with flucloxacillin or vancomycin for the treatment of staphylococcal infection.
Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20041101
Title: Mycobacterium tuberculosis DNA gyrase: interaction with quinolones and correlation with antimycobacterial drug activity.
Journal: Antimicrobial agents and chemotherapy 20040401
Title: Validation of an HPLC method for the determination of fleroxacin and its photo-degradation products in pharmaceutical forms.
Journal: Annali di chimica 20040101
Title: Fluorescence spectroscopy determination of fluoroquinolones by charge-transfer reaction.
Journal: Journal of pharmaceutical and biomedical analysis 20031124
Title: Alteration of constitutive apoptosis in neutrophils by quinolones.
Journal: Inflammation 20030601
Title: [Fluorescence spectrometric determination of fleroxacin by charge-transfer reaction].
Journal: Guang pu xue yu guang pu fen xi = Guang pu 20030401
Title: Inhibition by fluoroquinolones of K(+) currents in rat dissociated hippocampal neurons.
Journal: European journal of pharmacology 20030221
Title: Determination of fleroxacin in pure and tablet forms by liquid chromatography and derivative UV-spectrophotometry.
Journal: Journal of AOAC International 20030101
Title: Influence of sex on the pharmacokinetic interaction of fleroxacin and ciprofloxacin with caffeine.
Journal: Clinical pharmacokinetics 20030101
Title: [The history of the development and changes of quinolone antibacterial agents].
Journal: Yakushigaku zasshi 20030101
Title: [In vitro antibacterial activity of prulifloxacin, a new oral fluoroquinolone].
Journal: The Japanese journal of antibiotics 20021201
Title: Fleroxacin hydrochloride hydrate.
Journal: Acta crystallographica. Section C, Crystal structure communications 20021001
Title: Antimicrobial postexposure prophylaxis for anthrax: adverse events and adherence.
Journal: Emerging infectious diseases 20021001
Title: A pilot study of oral fleroxacin once daily compared with conventional therapy in patients with pyogenic liver abscess.
Journal: Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi 20020901
Title: [Drug interactions between nonsteroidal anti-inflammatory drug and pazufloxacin mesilate, a new quinolone antibacterial agent for intravenous use: convulsions in mice after intravenous or intracerebroventricular administration].
Journal: The Japanese journal of antibiotics 20020601
Title: In vitro photochemical clastogenicity of quinolone antibacterial agents studied by a chromosomal aberration test with light irradiation.
Journal: Mutation research 20020527
Title: Visible absorption spectra of the 4f electron transitions of neodymium, praseodymium, holmium and erbium complexes with fleroxacin and their analytical application.
Journal: Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20020501
Title: Protective effect of fleroxacin against the nephrotoxicity of isepamicin in rats.
Journal: Biological & pharmaceutical bulletin 20020401
Title: Ciprofloxacin induces apoptosis and inhibits proliferation of human colorectal carcinoma cells.
Journal: British journal of cancer 20020201
Title: Influence of CO(2) incubation on quinolone activity against Streptococcus pneumoniae and Haemophilus influenzae.
Journal: Diagnostic microbiology and infectious disease 20020101
Title: High-performance liquid chromatographic assay of fleroxacin in human serum using fluorescence detection.
Journal: Talanta 20010913
Title: Natural antibiotic susceptibility of recently established coryneform bacteria.
Journal: European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 20010501
Title: Ultrastructure of Achilles tendon from rats after treatment with fleroxacin.
Journal: Archives of toxicology 20010401
Title: Effects of fluoroquinolones on the locomotor activity in rats.
Journal: Archives of toxicology 20010301
Title: Spectrophotometric and HPLC determination of fleroxacin in tablets.
Journal: Die Pharmazie 20010201
Title: Quinolones alter defense reactions mediated by macrophages.
Journal: International immunopharmacology 20010201
Title: Fleroxacin uptake in ischaemic limb tissue.
Journal: Acta microbiologica et immunologica Hungarica 20010101
Title: History of quinolones and their side effects.
Journal: Chemotherapy 20010101
Title: Prediction of quinolone activity against Mycobacterium avium by molecular topology and virtual computational screening.
Journal: Antimicrobial agents and chemotherapy 20001001
Title: Anti-toxoplasma activities of 24 quinolones and fluoroquinolones in vitro: prediction of activity by molecular topology and virtual computational techniques.
Journal: Antimicrobial agents and chemotherapy 20001001
Title: [Encephalopathy induced by fleroxacin in a patient with Machado-Joseph disease].
Journal: Rinsho shinkeigaku = Clinical neurology 19980901
Title: Atypical pneumonia in the Nordic countries: aetiology and clinical results of a trial comparing fleroxacin and doxycycline. Nordic Atypical Pneumonia Study Group.
Journal: The Journal of antimicrobial chemotherapy 19970401
Title: Fleroxacin 400 mg once daily versus ofloxacin 400 mg twice daily in skin and soft tissue infections.
Journal: Chemotherapy 19970101
Title: [In vitro anti-MAC activities of new quinolones in focus (2)].
Journal: Kekkaku : [Tuberculosis] 19960901
Title: Trovafloxacin is active against Toxoplasma gondii.
Journal: Antimicrobial agents and chemotherapy 19960801
Title: Two cases of fleroxacin-induced insomnia.
Journal: International clinical psychopharmacology 19940101
Title: In-vitro activities of quinolones against mycobacteria.
Journal: The Journal of antimicrobial chemotherapy 19931201
Title: Activity of topoisomerase inhibitors against Pneumocystis carinii in vitro and in an inoculated mouse model.
Journal: Antimicrobial agents and chemotherapy 19930701
Title: Comparative in vitro and in vivo activity of fleroxacin and ofloxacin against various mycobacteria.
Journal: Tubercle 19910901
Title: Fluoronaphthyridines and -quinolones as antibacterial agents. 3. Synthesis and structure-activity relationships of new 1-(1,1-dimethyl-2-fluoroethyl), 1-[1-methyl-1-(fluoromethyl)-2-fluoroethyl], and 1-[1,1-(difluoromethyl)-2-fluoroethyl] substituted derivatives.
Journal: Journal of medicinal chemistry 19910101
Title: Central nervous system toxicity of quinolones: human and animal findings.
Journal: The Journal of antimicrobial chemotherapy 19901001
Title: The antimicrobial activity of Fleroxacin RO 23-6240, a third generation fluoroquinolone derivative, tested in vitro.
Journal: Journal of hygiene, epidemiology, microbiology, and immunology 19900101
Title: Adverse reactions in a dose-ranging study with a new long-acting fluoroquinolone, fleroxacin.
Journal: Antimicrobial agents and chemotherapy 19891001
Title: Comparative in-vitro activity of fleroxacin and other 6-fluoroquinolones against mycobacteria.
Journal: The Journal of antimicrobial chemotherapy 19881001
Title: Activity of ciprofloxacin and other fluorinated quinolones against mycobacteria.
Journal: The American journal of medicine 19870427
Title: Weidekamm, E., et al., Single- and multiple-dose pharmacokinetics of fleroxacin, a trifluorinated quinolone, in humans. Antimicrob Agents Chemother, 1987. 31(12): p. 1909-14.
Title: MacDonald, K.S., et al., Evaluation of fleroxacin (RO 23-6240) as single-oral-dose therapy of culture-proven chancroid in Nairobi, Kenya. Antimicrob Agents Chemother, 1989. 33(5): p. 612-4.
Title: Rubinstein, E., History of quinolones and their side effects. Chemotherapy, 2001. 47 Suppl 3: p. 3-8; discussion 44-8.