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802904-66-1,MFCD26936340
Catalog No.:AA00G3O0

802904-66-1 | Azd1981

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Purity
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Price(USD)
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1mg
98+%
in stock  
$7.00   $5.00
- +
5mg
98+%
in stock  
$11.00   $8.00
- +
10mg
98+%
in stock  
$15.00   $11.00
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50mg
98+%
in stock  
$39.00   $28.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00G3O0
Chemical Name:
Azd1981
CAS Number:
802904-66-1
Molecular Formula:
C19H17ClN2O3S
Molecular Weight:
388.8679
MDL Number:
MFCD26936340
SMILES:
CC(=O)Nc1cccc2c1c(Sc1ccc(cc1)Cl)c(n2CC(=O)O)C
Properties
Computed Properties
 
Complexity:
527  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
26  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
5  
XLogP3:
4  

Downstream Synthesis Route

[1]CurrentPatentAssignee:ASTRAZENECAPLC-WO2011/4182,2011,A1Locationinpatent:Page/Pagecolumn34

[2]Sulur,Manjunatha;Sharma,Parhalad;Ramakrishnan,Ravi;Naidu,Ravi;Merifield,Eric;Gill,DuncanM.;Clarke,AdrianM.;Thomson,Colin;Butters,Michael;Bachu,Sreekanth;Benison,ColinH.;Dokka,Nagaraju;Fong,EmilyR.;Hose,DavidR.J.;Howell,GarethP.;Mobberley,SiobhanE.;Morton,SimonC.;Mullen,AlexanderK.;Rapai,Jayan;Tejas,Bharathi[OrganicProcessResearchandDevelopment,2012,vol.16,#11,p.1746-1753]

[3]CurrentPatentAssignee:ASTRAZENECAPLC;PHILIPKEEGEN-WO2006/75139,2006,A2Locationinpatent:Page/Pagecolumn8

[4]Locationinpatent:schemeortableLuker,Tim;Bonnert,Roger;Brough,Steve;Cook,AnthonyR.;Dickinson,MarkR.;Dougall,Iain;Logan,Chris;Mohammeda,RukhsanaT.;Paine,Stuart;Sanganee,HiteshJ.;Sargent,Carol;Schmidt,JerzyA.;Teague,Simon;Thom,Stephen[BioorganicandMedicinalChemistryLetters,2011,vol.21,#21,p.6288-6292]

[5]CurrentPatentAssignee:ASTRAZENECAPLC-WO2004/106302,2004,A1Locationinpatent:Page26-27

[1]CurrentPatentAssignee:ASTRAZENECAPLC;PHILIPKEEGEN-WO2006/75139,2006,A2Locationinpatent:Page/Pagecolumn12-13

[1]CurrentPatentAssignee:ASTRAZENECAPLC-WO2011/4182,2011,A1Locationinpatent:Page/Pagecolumn37

[1]CurrentPatentAssignee:ASTRAZENECAPLC-WO2011/4182,2011,A1Locationinpatent:Page/Pagecolumn41-42

[1]CurrentPatentAssignee:ASTRAZENECAPLC-WO2011/4182,2011,A1

[2]Sulur,Manjunatha;Sharma,Parhalad;Ramakrishnan,Ravi;Naidu,Ravi;Merifield,Eric;Gill,DuncanM.;Clarke,AdrianM.;Thomson,Colin;Butters,Michael;Bachu,Sreekanth;Benison,ColinH.;Dokka,Nagaraju;Fong,EmilyR.;Hose,DavidR.J.;Howell,GarethP.;Mobberley,SiobhanE.;Morton,SimonC.;Mullen,AlexanderK.;Rapai,Jayan;Tejas,Bharathi[OrganicProcessResearchandDevelopment,2012,vol.16,#11,p.1746-1753]

Literature

Title: Fevipiprant (QAW039), a Slowly Dissociating CRTh2 Antagonist with the Potential for Improved Clinical Efficacy.

Journal: Molecular pharmacology 20160501

Title: Lessons learned from the fate of AstraZeneca's drug pipeline: a five-dimensional framework.

Journal: Nature reviews. Drug discovery 20140601

Title: Substituted indole-1-acetic acids as potent and selective CRTh2 antagonists-discovery of AZD1981.

Journal: Bioorganic & medicinal chemistry letters 20111101

Title: Royer JF, et al. A novel antagonist of prostaglandin D2 blocks the locomotion of eosinophils and basophils. Eur J Clin Invest. 2008 Sep;38(9):663-71.

Title: Luker T, et al. Substituted indole-1-acetic acids as potent and selective CRTh2 antagonists-discovery of AZD1981. Bioorg Med Chem Lett. 2011 Nov 1;21(21):6288-92.

Title: Snell N, et al. Efficacy and safety of AZD1981, a CRTH2 receptor antagonist, in patients with moderate to severe COPD. Respir Med. 2013 Nov;107(11):1722-30.

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