+1 858-523-8231
Login | Register
AA Blocks, Building Blocks, Catalysts, Inhibitors
Login | Register
Home Carboxes 802906-73-6
802906-73-6,MFCD25976719
Catalog No.:AA00G3LA

802906-73-6 | 2-Chloro-4-((1-(4-fluorophenyl)-2,5-dimethyl-1h-imidazol-4-yl)ethynyl)pyridine

Pack Size
Purity
Availability
Price(USD)
Quantity
  
2mg
98%
in stock  
$116.00   $82.00
- +
5mg
98%
in stock  
$204.00   $143.00
- +
25mg
98%
in stock  
$497.00   $348.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00G3LA
Chemical Name:
2-Chloro-4-((1-(4-fluorophenyl)-2,5-dimethyl-1h-imidazol-4-yl)ethynyl)pyridine
CAS Number:
802906-73-6
Molecular Formula:
C18H13ClFN3
Molecular Weight:
325.7673
MDL Number:
MFCD25976719
SMILES:
Fc1ccc(cc1)n1c(C)nc(c1C)C#Cc1ccnc(c1)Cl
Properties
Computed Properties
 
Complexity:
465  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
23  
Hydrogen Bond Acceptor Count:
3  
Rotatable Bond Count:
3  
XLogP3:
4.5  

Downstream Synthesis Route

[1]CurrentPatentAssignee:ROCHEHOLDINGAG-WO2005/118568,2005,A1Locationinpatent:Page/Pagecolumn22-23

[1]CurrentPatentAssignee:ROCHEHOLDINGAG-WO2005/118568,2005,A1Locationinpatent:Page/Pagecolumn24

[1]CurrentPatentAssignee:ROCHEHOLDINGAG-WO2008/74697,2008,A1Locationinpatent:Page/Pagecolumn18

[2]CurrentPatentAssignee:NOEMAPHARMA-WO2022/23519,2022,A1Locationinpatent:Paragraph00120

[3]CurrentPatentAssignee:NOEMAPHARMA-WO2022/23519,2022,A1Locationinpatent:Paragraph00120

3-chloro-2-(2-chloropyridin-4-yl)-3-1-(4-fluorophenyl)-2,5-dimethyl-1H-imidazol-4-ylpropenal 
  802906-73-6 

[1]Jaeschke,Georg;Kolczewski,Sabine;Spooren,Will;Vieira,Eric;Bitter-Stoll,Nadia;Boissin,Patrick;Borroni,Edilio;Büttelmann,Bernd;Ceccarelli,Simona;Clemann,Nicole;David,Beatrice;Funk,Christoph;Guba,Wolfgang;Harrison,Anthony;Hartung,Thomas;Honer,Michael;Huwyler,Jörg;Kuratli,Martin;Niederhauser,Urs;Pähler,Axel;Peters,Jens-Uwe;Petersen,Ann;Prinssen,Eric;Ricci,Antonio;Rueher,Daniel;Rueher,Marianne;Schneider,Manfred;Spurr,Paul;Stoll,Theodor;Tännler,Daniel;Wichmann,Jürgen;Porter,RichardH.;Wettstein,JosephG.;Lindemann,Lothar[JournalofMedicinalChemistry,2015,vol.58,#3,p.1358-1371]

Literature

Title: Metabotropic glutamate receptor 5 negative allosteric modulators: discovery of 2-chloro-4-[1-(4-fluorophenyl)-2,5-dimethyl-1H-imidazol-4-ylethynyl]pyridine (basimglurant, RO4917523), a promising novel medicine for psychiatric diseases.

Journal: Journal of medicinal chemistry 20150212

Title: CTEP: a novel, potent, long-acting, and orally bioavailable metabotropic glutamate receptor 5 inhibitor.

Journal: The Journal of pharmacology and experimental therapeutics 20111101

Title: Lindemann L, et al. Pharmacology of basimglurant (RO4917523, RG7090), a unique metabotropic glutamate receptor 5 negative allosteric modulator in clinical development for depression. J Pharmacol Exp Ther. 2015 Apr;353(1):213-33.

Title: Jaeschke G, et al. Metabotropic glutamate receptor 5 negative allosteric modulators: discovery of 2-chloro-4--(4-fluorophenyl)-2,5-dimethyl-1H-imidazol-4-ylethynylpyridine (basimglurant, RO4917523), a promising novel medicine for psychiatric diseases.

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Related Products of 802906-73-6
1235492-75-7

1235492-75-7

 1268338-83-5

1268338-83-5

 1268338-83-5

1268338-83-5
Building Blocks
More >
Tags:802906-73-6 Molecular Formula|802906-73-6 MDL|802906-73-6 SMILES|802906-73-6 2-Chloro-4-((1-(4-fluorophenyl)-2,5-dimethyl-1h-imidazol-4-yl)ethynyl)pyridine