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80306-38-3,MFCD27978377
Catalog No.:AA00GA2G

80306-38-3 | AR7

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$46.00   $32.00
- +
5mg
98%
in stock  
$48.00   $34.00
- +
10mg
98%
in stock  
$80.00   $56.00
- +
25mg
98%
in stock  
$103.00   $72.00
- +
50mg
98%
in stock  
$135.00   $95.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00GA2G
Chemical Name:
AR7
CAS Number:
80306-38-3
Molecular Formula:
C15H12ClNO
Molecular Weight:
257.7149
MDL Number:
MFCD27978377
SMILES:
Cc1ccc(cc1)C1=Nc2c(OC1)cc(cc2)Cl
Properties
Computed Properties
 
Complexity:
323  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
18  
Hydrogen Bond Acceptor Count:
2  
Rotatable Bond Count:
1  
XLogP3:
4.1  

Downstream Synthesis Route

[1]Das,BhaskarC.;Madhukumar,AnkanahlliV.;Anguiano,Jaime;Mani,Sridhar[BioorganicandMedicinalChemistryLetters,2009,vol.19,#15,p.4204-4206]

[2]CurrentPatentAssignee:MONTEFIOREMEDICALCENTER-US2015/166492,2015,A1Locationinpatent:Paragraph0081;0082;0122

Literature

Title: Design, synthesis and biological evaluation of 2H-benzo[b][1,4] oxazine derivatives as hypoxia targeted compounds for cancer therapeutics.

Journal: Bioorganic & medicinal chemistry letters 20090801

Title: Philip Wing-Lok Ho, et al. Age-dependent accumulation of oligomeric SNCA/α-synuclein from impaired degradation in mutant LRRK2 knockin mouse model of Parkinson disease: role for therapeutic activation of chaperone-mediated autophagy (CMA). Autophagy. 2020 Feb;16(2):347-370.

Title: Mathieu Bourdenx, et al. Chaperone-mediated autophagy prevents collapse of the neuronal metastable proteome. Cell. 2021 May 13;184(10):2696-2714.e25.

Title: Anguiano J, et al. Chemical modulation of chaperone-mediated autophagy by retinoic acid derivatives. Nat Chem Biol. 2013 Jun;9(6):374-82.

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SDS
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