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805239-56-9,MFCD09971112
Catalog No.:AA0059EV

805239-56-9 | PHTPP

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$27.00   $19.00
- +
5mg
98%
in stock  
$67.00   $47.00
- +
10mg
98%
in stock  
$100.00   $70.00
- +
25mg
98%
in stock  
$169.00   $118.00
- +
50mg
98%
in stock  
$286.00   $200.00
- +
100mg
98%
in stock  
$484.00   $339.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA0059EV
Chemical Name:
PHTPP
CAS Number:
805239-56-9
Molecular Formula:
C20H11F6N3O
Molecular Weight:
423.3113
MDL Number:
MFCD09971112
SMILES:
Oc1ccc(cc1)c1c(nn2c1nc(cc2C(F)(F)F)C(F)(F)F)c1ccccc1
Properties
Properties
 
Form:
Solid  
Storage:
Keep in dry area;2-8℃;  

Computed Properties
 
Complexity:
586  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
30  
Hydrogen Bond Acceptor Count:
9  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
2  
XLogP3:
5.1  

Literature

Title: Bisphenol AF as an activator of human estrogen receptor β1 (ERβ1) in breast cancer cell lines.

Journal: The Journal of toxicological sciences 20180101

Title: Arsenite and Cadmium Activate MAPK/ERK via Membrane Estrogen Receptors and G-Protein Coupled Estrogen Receptor Signaling in Human Lung Adenocarcinoma Cells.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20160701

Title: Bisphenol A at the reference level counteracts doxorubicin transcriptional effects on cancer related genes in HT29 cells.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20151201

Title: Rapid responses and mechanism of action for low-dose bisphenol S on ex vivo rat hearts and isolated myocytes: evidence of female-specific proarrhythmic effects.

Journal: Environmental health perspectives 20150601

Title: Methoxychlor and its metabolite HPTE inhibit cAMP production and expression of estrogen receptors α and β in the rat granulosa cell in vitro.

Journal: Reproductive toxicology (Elmsford, N.Y.) 20150101

Title: Selectivity of natural, synthetic and environmental estrogens for zebrafish estrogen receptors.

Journal: Toxicology and applied pharmacology 20141001

Title: Transgenic zebrafish reveal tissue-specific differences in estrogen signaling in response to environmental water samples.

Journal: Environmental health perspectives 20140401

Title: Mitochondrial p38β and manganese superoxide dismutase interaction mediated by estrogen in cardiomyocytes.

Journal: PloS one 20140101

Title: Estrogenic/antiestrogenic activities of a Epimedium koreanum extract and its major components: in vitro and in vivo studies.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20120801

Title: Neuroprotective role of estradiol against neuronal death induced by glucose deprivation in cultured rat hippocampal neurons.

Journal: Neuroendocrinology 20120101

Title: The antioxidant effect of carnosol in bovine aortic endothelial cells is mainly mediated via estrogen receptor α pathway.

Journal: Biological & pharmaceutical bulletin 20120101

Title: Progesterone and 17β-estradiol increase differentiation of mouse embryonic stem cells to motor neurons.

Journal: IUBMB life 20111001

Title: Efficacy of pharmacological estrogen receptor antagonists in blocking activation of zebrafish estrogen receptors.

Journal: General and comparative endocrinology 20110801

Title: P2Y2 receptor-mediated modulation of estrogen-induced proliferation of breast cancer cells.

Journal: Molecular and cellular endocrinology 20110516

Title: Mandibular and femoral growth alteration after sex hormone disruption in growing mice.

Journal: Orthodontics & craniofacial research 20110501

Title: Differential estrogenic effects of the persistent organochlorine pesticides dieldrin, endosulfan, and lindane in primary neuronal cultures.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20110401

Title: The effects of estrogen receptors α- and β-specific agonists and antagonists on cell proliferation and energy metabolism in human bone cell line.

Journal: Journal of cellular biochemistry 20110201

Title: Activation of ERα is necessary for estradiol's anorexigenic effect in female rats.

Journal: Hormones and behavior 20101101

Title: Neuroprotective effects of genistein in Mongolian gerbils: estrogen receptor-β involvement.

Journal: Journal of pharmacological sciences 20100101

Title: Estrogen receptor-alpha mediates the epidermal growth factor-stimulated prolactin expression and release in lactotrophs.

Journal: Endocrinology 20090201

Title: Bisphenol A at low nanomolar doses confers chemoresistance in estrogen receptor-alpha-positive and -negative breast cancer cells.

Journal: Environmental health perspectives 20090201

Title: Crucial role of estrogen receptor-alpha interaction with transcription coregulators in follicle-stimulating hormone and transforming growth factor beta1 up-regulation of steroidogenesis in rat ovarian granulosa cells.

Journal: Endocrinology 20080901

Title: Structure-guided optimization of estrogen receptor binding affinity and antagonist potency of pyrazolopyrimidines with basic side chains.

Journal: Journal of medicinal chemistry 20070125

Title: Pyrazolo[1,5-a]pyrimidines: estrogen receptor ligands possessing estrogen receptor beta antagonist activity.

Journal: Journal of medicinal chemistry 20041118

Title: Dennis R Compton, et al. Pyrazolo,5-apyrimidines: estrogen receptor ligands possessing estrogen receptor beta antagonist activity. J Med Chem. 2004 Nov 18;47(24):5872-93.

Title: Ogo Y, et al. IGF-1 gene expression is differentially regulated by estrogen receptors α and β in mouse endometrial stromal cells and ovarian granulosa cells. J Reprod Dev. 2014;60(3):216-23. Epub 2014 Mar 25.

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