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81-13-0,MFCD00065006
Catalog No.:AA0034QD

81-13-0 | (2R)-2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutanamide

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25g
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$8.00   $6.00
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500g
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  • Technical Information
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  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA0034QD
Chemical Name:
(2R)-2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutanamide
CAS Number:
81-13-0
Molecular Formula:
C9H19NO4
Molecular Weight:
205.2515
MDL Number:
MFCD00065006
SMILES:
OCCCNC(=O)[C@H](C(CO)(C)C)O
Properties
Properties
 
BP:
483.6°C at 760 mmHg  
Form:
Liquid  
Refractive Index:
1.495-1.502  
Stability:
Hygroscopic  
Storage:
Inert atmosphere;2-8℃;  

Computed Properties
 
Complexity:
182  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
14  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
6  
XLogP3:
-0.9  

Literature

Title: Insights into myalgic encephalomyelitis/chronic fatigue syndrome phenotypes through comprehensive metabolomics.

Journal: Scientific reports 20180101

Title: Effects of intravesical dexpanthenol use on lipid peroxidation and bladder histology in a chemical cystitis animal model.

Journal: Urology 20120501

Title: Allergic contact dermatitis caused by dexpanthenol: report of two cases.

Journal: Contact dermatitis 20120301

Title: Comparative trial of 5% dexpanthenol in water-in-oil formulation with 1% hydrocortisone ointment in the treatment of childhood atopic dermatitis: a pilot study.

Journal: Journal of drugs in dermatology : JDD 20120301

Title: Kinetics of physiological skin flora in a suction blister wound model on healthy subjects after treatment with water-filtered infrared-A radiation.

Journal: Skin pharmacology and physiology 20120101

Title: A randomized, prospective, double-blind study of the efficacy of dexpanthenol nasal spray on the postoperative treatment of patients with chronic rhinosinusitis after endoscopic sinus surgery.

Journal: Journal of the Medical Association of Thailand = Chotmaihet thangphaet 20120101

Title: Small-animal PET imaging of amyloid-beta plaques with [11C]PiB and its multi-modal validation in an APP/PS1 mouse model of Alzheimer's disease.

Journal: PloS one 20120101

Title: Systemic inflammatory effects of traumatic brain injury, femur fracture, and shock: an experimental murine polytrauma model.

Journal: Mediators of inflammation 20120101

Title: Dexpanthenol modulates gene expression in skin wound healing in vivo.

Journal: Skin pharmacology and physiology 20120101

Title: Nasal obstruction as a key symptom in allergic rhinitis: efficacy and safety of a medical device in children.

Journal: Otolaryngologia polska = The Polish otolaryngology 20120101

Title: Protective effects of dexpanthenol and y-27632 on stricture formation in a rat model of caustic esophageal injury.

Journal: The Journal of surgical research 20111201

Title: A novel cosmetic approach to treat thinning hair.

Journal: The British journal of dermatology 20111201

Title: Efficacy of topical hydrating and emollient lotion containing 10% urea ISDIN® plus dexpanthenol (Ureadin Rx 10) in the treatment of skin xerosis and pruritus in hemodialyzed patients: an open prospective pilot trial.

Journal: Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia 20111001

Title: Location and conformation of pantothenate and its derivatives in Mycobacterium tuberculosis pantothenate kinase: insights into enzyme action.

Journal: Acta crystallographica. Section D, Biological crystallography 20110901

Title: Ameliorating effects of dexpanthenol in cerebral ischaemia reperfusion induced injury in rat brain.

Journal: JPMA. The Journal of the Pakistan Medical Association 20110901

Title: Topical use of a silymarin-based preparation to prevent radiodermatitis : results of a prospective study in breast cancer patients.

Journal: Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] 20110801

Title: The influence of riboflavin and nicotinic acid on Shigella sonnei colony conversion.

Journal: Iranian journal of microbiology 20110301

Title: Corneal melting after collagen cross-linking for keratoconus: a case report.

Journal: Journal of medical case reports 20110101

Title: Use of topical povidone-iodine resulting in a iododerma.

Journal: Indian journal of dermatology 20110101

Title: Effect of ultrasound and dexpanthenol on collagen organization in tegumentary lesions.

Journal: Revista brasileira de fisioterapia (Sao Carlos (Sao Paulo, Brazil)) 20110101

Title: Skin moisturizing effects of panthenol-based formulations.

Journal: Journal of cosmetic science 20110101

Title: Comparing oil based ointment versus standard practice for the treatment of moderate burns in Greece: a trial based cost effectiveness evaluation.

Journal: BMC complementary and alternative medicine 20110101

Title: Effect of contact lens material on cytotoxicity potential of multipurpose solutions using human corneal epithelial cells.

Journal: Molecular vision 20110101

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: [Simultaneous determination of pantothenic acid and D-panthenol in cosmetics by high performance liquid chromatography].

Journal: Se pu = Chinese journal of chromatography 20101101

Title: [Severe inflammation of the muzzle caused by a nose ring in a breeding bull].

Journal: Schweizer Archiv fur Tierheilkunde 20100901

Title: [Simulation of corneal epithelial injuries by mechanical and corrosive damage : Influence of fetal bovine serum and dexpanthenol on epithelial regeneration in a cell culture model].

Journal: Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft 20100601

Title: The nitric acid burn trauma of the skin.

Journal: Journal of plastic, reconstructive & aesthetic surgery : JPRAS 20100401

Title: Tissue extract from Eisenia foetida as a wound-healing agent.

Journal: European review for medical and pharmacological sciences 20100301

Title: [Glued eyelids by cyanoacrylate glue (superglue)].

Journal: Klinische Monatsblatter fur Augenheilkunde 20100201

Title: Enhancement of L-3-hydroxybutyryl-CoA dehydrogenase activity and circulating ketone body levels by pantethine. Relevance to dopaminergic injury.

Journal: BMC neuroscience 20100101

Title: Identifying essential genes in bacterial metabolic networks with machine learning methods.

Journal: BMC systems biology 20100101

Title: Conservative treatment of a patient with epidermolysis bullosa presenting as bart syndrome: a case report.

Journal: Case reports in medicine 20100101

Title: A management dilemma: infectious keratitis associated with soft contact lens use and dubious treatment compliance.

Journal: Case reports in medicine 20100101

Title: Physiology and pathophysiology of respiratory mucosa of the nose and the paranasal sinuses.

Journal: GMS current topics in otorhinolaryngology, head and neck surgery 20100101

Title: Calcium pantothenate modulates gene expression in proliferating human dermal fibroblasts.

Journal: Experimental dermatology 20091101

Title: [Survey of sensory perception and patients' subjective assessment of the application of nasal sprays - the nasal-spray-sensoric-scale].

Journal: Laryngo- rhino- otologie 20090901

Title: [Efficacy and patient benefit of treatment of irritated skin with ointments containing dexpanthenol: health services research (observational study) on self-medication in a pharmaceutical network].

Journal: Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete 20090501

Title: [Study of skin care in premature and newborn infants].

Journal: Kinderkrankenschwester : Organ der Sektion Kinderkrankenpflege 20090301

Title: Hippophae rhamnoides L. and dexpanthenol-bepanthene on blood flow after experimental skin burns in rats using 133Xe clearance technique.

Journal: Hellenic journal of nuclear medicine 20090101

Title: Comparison of primary human fibroblasts and keratinocytes with immortalized cell lines regarding their sensitivity to sodium dodecyl sulfate in a neutral red uptake cytotoxicity assay.

Journal: Arzneimittel-Forschung 20090101

Title: [Effects of panthenol and carnitine on aldehyde metabolic enzymes in rats with tetrachloromethane-induced liver injury].

Journal: Eksperimental'naia i klinicheskaia farmakologiia 20090101

Title: Corneal re-epithelialization following phototherapeutic keratectomy for recurrent corneal erosion as in vivo model of epithelial wound healing.

Journal: Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde 20090101

Title: [Evidence-based cosmetics: concepts and applications in photoaging of the skin and xerosis].

Journal: Wiener klinische Wochenschrift 20090101

Title: Vitiligo treatment with vitamins, minerals and polyphenol supplementation.

Journal: Indian journal of dermatology 20090101

Title: Water-filtered infrared-A (wIRA) in acute and chronic wounds.

Journal: GMS Krankenhaushygiene interdisziplinar 20090101

Title: Tracheostomy cannulas and voice prosthesis.

Journal: GMS current topics in otorhinolaryngology, head and neck surgery 20090101

Title: Oxymetazoline plus dexpanthenol in nasal congestion.

Journal: Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India 20081201

Title: Ointments as a source of meticillin-resistant Staphylococcus aureus spread.

Journal: The Journal of hospital infection 20081001

Title: Topical fentanyl in a randomized, double-blind study in patients with corneal damage.

Journal: The Clinical journal of pain 20081001

Title: Comparison on the efficacy of dexpanthenol in sea water and saline in postoperative endoscopic sinus surgery.

Journal: Journal of the Medical Association of Thailand = Chotmaihet thangphaet 20081001

Title: Miscellaneous.

Journal: Indian journal of pharmacology 20081001

Title: Simultaneous determination of some water-soluble vitamins and preservatives in multivitamin syrup by validated stability-indicating high-performance liquid chromatography method.

Journal: Journal of chromatography. A 20080822

Title: Safety and efficacy of a new honey ointment on diabetic foot ulcers: a prospective pilot study.

Journal: Journal of wound care 20080301

Title: Skin protection creams in medical settings: successful or evil?

Journal: Journal of occupational medicine and toxicology (London, England) 20080101

Title: targetTB: a target identification pipeline for Mycobacterium tuberculosis through an interactome, reactome and genome-scale structural analysis.

Journal: BMC systems biology 20080101

Title: Antioxidant systems and oxidative stress in the testes.

Journal: Oxidative medicine and cellular longevity 20080101

Title: Natural advances in eczema care.

Journal: Cutis 20071201

Title: Lactobacillus supplementation for diarrhoea related to chemotherapy of colorectal cancer: a randomised study.

Journal: British journal of cancer 20071022

Title: How pantothenol intervenes in Coenzyme-A biosynthesis of Mycobacterium tuberculosis.

Journal: Biochemical and biophysical research communications 20071005

Title: [Can dexpanthenol prevent peritoneal adhesion formation? An experimental study].

Journal: Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES 20071001

Title: Hamamelis in children with skin disorders and skin injuries: results of an observational study.

Journal: European journal of pediatrics 20070901

Title: Feedback inhibition of pantothenate kinase regulates pantothenol uptake by the malaria parasite.

Journal: The Journal of biological chemistry 20070831

Title: Wound-healing activity of St. John's Wort (Hypericum perforatum L.) on chicken embryonic fibroblasts.

Journal: Journal of ethnopharmacology 20070420

Title: [Can dexpanthenol prevent peritoneal adhesion formation? An experimental study].

Journal: Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES 20070401

Title: The protective effect of dexpanthenol on testicular atrophy at 60th day following experimental testicular torsion.

Journal: Pediatric surgery international 20070301

Title: Development and validation of reversed phase high performance liquid chromatography method for determination of dexpanthenol in pharmaceutical formulations.

Journal: Journal of pharmaceutical and biomedical analysis 20070219

Title: Dexpanthenol attenuates lipid peroxidation and testicular damage at experimental ischemia and reperfusion injury.

Journal: Pediatric surgery international 20070201

Title: Dexpanthenol pastille and benzydamine hydrochloride spray for the prevention of post-operative sore throat.

Journal: Acta anaesthesiologica Scandinavica 20070201

Title: [Clinical evaluation of the efficacy and tolerability of the ''NoAll Bimbi Pasta Trattante'' barrier cream in napkin dermatitis].

Journal: Minerva pediatrica 20070201

Title: Efficacy of Tonimer gel spray on postoperative nasal care after endonasal surgery.

Journal: ORL; journal for oto-rhino-laryngology and its related specialties 20070101

Title: Therapy of acute wounds with water-filtered infrared-A (wIRA).

Journal: GMS Krankenhaushygiene interdisziplinar 20070101

Title: Allergic contact dermatitis to panthenol and cocamidopropyl PG dimonium chloride phosphate in a facial hydrating lotion.

Journal: Contact dermatitis 20061201

Title: Comparison of dexpanthenol and zinc oxide ointment with ointment base in the treatment of irritant diaper dermatitis from diarrhea: a multicenter study.

Journal: Journal of the Medical Association of Thailand = Chotmaihet thangphaet 20061001

Title: Effects of gentiopicroside, sweroside and swertiamarine, secoiridoids from gentian (Gentiana lutea ssp. symphyandra), on cultured chicken embryonic fibroblasts.

Journal: Planta medica 20060301

Title: Development of a w/o/w emulsion for chemical peeling applications containing glycolic acid.

Journal: Journal of cosmetic science 20060101

Title: Anaphylaxis after dexpanthenol exposure by multivitamin tablets.

Journal: Clinical and experimental dermatology 20051101

Title: [Guidelines for treatment and prevention of diaper rash].

Journal: Kinderkrankenschwester : Organ der Sektion Kinderkrankenpflege 20051101

Title: Effects of dexpanthenol with or without Aloe vera extract on radiation-induced oral mucositis: preclinical studies.

Journal: International journal of radiation biology 20050301

Title: [Conservative and surgical treatment of neurotrophic keratopathy].

Journal: Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft 20050101

Title: Prevention of and therapies for nipple pain: a systematic review.

Journal: Journal of obstetric, gynecologic, and neonatal nursing : JOGNN 20050101

Title: Conservative procedures in skin reconstitution.

Journal: GMS current topics in otorhinolaryngology, head and neck surgery 20050101

Title: [Siccaprotect eye drop--results of treatment in clinical practice].

Journal: Ceska a slovenska oftalmologie : casopis Ceske oftalmologicke spolecnosti a Slovenske oftalmologicke spolecnosti 20041101

Title: [Bilateral keratitis in lagophthalmos and lower lid ectropion].

Journal: Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft 20040901

Title: Pantothenic acid and pantothenol increase biosynthesis of glutathione by boosting cell energetics.

Journal: FEBS letters 20040702

Title: Allergic and non-allergic periorbital dermatitis: patch test results of the Information Network of the Departments of Dermatology during a 5-year period.

Journal: Contact dermatitis 20040701

Title: [Dexpanthenol nasal spray in comparison to dexpanthenol nasal ointment. A prospective, randomised, open, cross-over study to compare nasal mucociliary clearance].

Journal: HNO 20040701

Title: Clear hydro-gel, compared to ointment, provides improved eye comfort after brief surgery.

Journal: Canadian journal of anaesthesia = Journal canadien d'anesthesie 20040201

Title: Evaluation of protective and therapeutic effects of dexpanthenol on nasal decongestants and preservatives: results of cytotoxic studies in vitro.

Journal: American journal of rhinology 20040101

Title: Investigation of some topical formulations containing dexpanthenol.

Journal: Acta poloniae pharmaceutica 20040101

Title: Efficacy of dexpanthenol in skin protection against irritation: a double-blind, placebo-controlled study.

Journal: Contact dermatitis 20030801

Title: [Advance in therapy of acute rhinitis--comparison of efficacy and safety of xylometazoline in combination xylometazoline-dexpanthenol in patients with acute rhinitis].

Journal: Laryngo- rhino- otologie 20030401

Title: [The protective effect of dexpanthenol in nasal sprays. First results of cytotoxic and ciliary-toxic studies in vitro].

Journal: Laryngo- rhino- otologie 20030301

Title: [Febrile respiratory infection and erythema in a 25-year-old man].

Journal: Deutsche medizinische Wochenschrift (1946) 20030207

Title: [Ogilvie's syndrome: a rare cause of the acute abdomen].

Journal: Zeitschrift fur Gastroenterologie 20030201

Title: [Clinical evaluation of provitamin B5 drops and gel for postoperative treatment of corneal and conjuctival injuries].

Journal: Klinika oczna 20030101

Title: [Gel with provitamin B5 applied during tests with the Goldmann triple-mirror].

Journal: Klinika oczna 20030101

Title: Dexpanthenol enhances skin barrier repair and reduces inflammation after sodium lauryl sulphate-induced irritation.

Journal: The Journal of dermatological treatment 20021201

Title: Intravenous nutrient therapy: the 'Myers' cocktail'.

Journal: Alternative medicine review : a journal of clinical therapeutic 20021001

Title: Topical corticosteroid therapy for acute radiation dermatitis: a prospective, randomized, double-blind study.

Journal: The British journal of dermatology 20020601

Title: Intraindividual comparison of two different skin care conceptions in patients undergoing radiotherapy of the head-and-neck region. Creme or powder?

Journal: Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] 20020601

Title: Topical estrogens combined with argon plasma coagulation in the management of epistaxis in hereditary hemorrhagic telangiectasia.

Journal: The Annals of otology, rhinology, and laryngology 20020301

Title: Colorimetric and fluorimetric methods for determination of panthenol in cosmetic and pharmaceutical formulation.

Journal: Journal of pharmaceutical and biomedical analysis 20020201

Title: Collagenase treatment of sore nipples.

Journal: International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics 20020101

Title: Topical use of dexpanthenol in skin disorders.

Journal: American journal of clinical dermatology 20020101

Title: Dexpanthenol cream significantly improves mucocutaneous side effects associated with isotretinoin therapy.

Journal: Pediatric dermatology 20020101

Title: [Closure of the wound defect by transferred flap of skin].

Journal: Klinichna khirurhiia 20020101

Title: [Other drugs administered with TPN solution].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20010501

Title: [Skin care in deep radiotherapy].

Journal: Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete 20010201

Title: Effect of urea and pantothenol on the permeation of progesterone through excised rat skin from polymer matrix systems.

Journal: Drug development and industrial pharmacy 20010101

Title: Oguz A, et al. Topical N-acetylcysteine improves wound healing comparable to dexpanthenol: an experimental study. Int Surg. 2015 Apr;100(4):656-61.

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Tags:81-13-0 Molecular Formula|81-13-0 MDL|81-13-0 SMILES|81-13-0 (2R)-2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutanamide