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81136-42-7,MFCD01950152
Catalog No.:AA005GAP

81136-42-7 | 4-Chloro-6-ethylthieno[2,3-d]pyrimidine

Pack Size
Purity
Availability
Price(USD)
Quantity
  
250mg
95%
in stock  
$244.00   $171.00
- +
1g
95%
in stock  
$446.00   $312.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA005GAP
Chemical Name:
4-Chloro-6-ethylthieno[2,3-d]pyrimidine
CAS Number:
81136-42-7
Molecular Formula:
C8H7ClN2S
Molecular Weight:
198.6726
MDL Number:
MFCD01950152
SMILES:
CCc1sc2c(c1)c(Cl)ncn2
Properties
Properties
 
BP:
311.1°C at 760 mmHg  
Form:
Solid  
MP:
56-57°C  
Storage:
Keep in dry area;2-8℃;  

Computed Properties
 
Complexity:
167  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
12  
Hydrogen Bond Acceptor Count:
3  
Rotatable Bond Count:
1  
XLogP3:
3.3  

Downstream Synthesis Route

[1]CurrentPatentAssignee:C.H.BoehringerSohnAG&Co.KG-WO2006/136402,2006,A1Locationinpatent:Page/Pagecolumn80

[2]Locationinpatent:schemeortableKortum,StevenW.;Lachance,RhondaM.;Schweitzer,BarbaraA.;Yalamanchili,Gopichand;Rahman,Hayat;Ennis,MichaelD.;Huff,RitaM.;TenBrink,RuthE.[BioorganicandMedicinalChemistryLetters,2009,vol.19,#20,p.5919-5923]

[3]Phoujdar,ManishaS.;Kathiravan,MuthuK.;Bariwal,JitenderB.;Shah,AnamikK.;Jain,KishorS.[TetrahedronLetters,2008,vol.49,#7,p.1269-1273]

[4]Ostrynska,OlgaV.;Balanda,AnatoliyO.;Bdzhola,VolodymyrG.;Golub,AndriyG.;Kotey,IgorM.;Kukharenko,OlexanderP.;Gryshchenko,AndriiA.;Briukhovetska,NadiiaV.;Yarmoluk,SergiyM.[EuropeanJournalofMedicinalChemistry,2016,vol.115,p.148-160]

[5]Ram;Pandey;Vlietinck[JournalofHeterocyclicChemistry,1981,vol.18,#7,p.1277-1280]

[6]Locationinpatent:schemeortableHoriuchi,Takao;Chiba,Jun;Uoto,Kouichi;Soga,Tsunehiko[BioorganicandMedicinalChemistryLetters,2009,vol.19,#2,p.305-308]

ethylacetaten-hexane 
  18593-51-6    81136-42-7 

[1]CurrentPatentAssignee:ABBVIEINC-US6232320,2001,B1

90924-12-2    81136-42-7   
6-ethyl-4-(3-phenylisoxazol-5-yl)-methoxy-thieno2,3-dpyrimidine 

[1]Lettersindrugdesignanddiscovery,2018,vol.15,p.463-474

81136-42-7    438565-33-4   
6-ethyl-4-3-(2-chlorophenyl)-isoxazol-5-yl-methoxy}-thieno2,3-dpyrimidine 

[1]Yong,Jianping;Lu,Canzhong;Wu,Xiaoyuan[Lettersindrugdesignanddiscovery,2018,vol.15,#5,p.463-474]

81136-42-7    206055-90-5   
6-ethyl-4-3-(4-chlorophenyl)-isoxazol-5-yl-methoxy}-thieno2,3-dpyrimidine 

[1]Yong,Jianping;Lu,Canzhong;Wu,Xiaoyuan[Lettersindrugdesignanddiscovery,2018,vol.15,#5,p.463-474]

Literature

Title: Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia.

Journal: Nature chemical biology 20120129

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