Catalog No.:AA003A34

811803-05-1 | Apatinib

Name: Name:Apatinib
Brand: AABLOCKS
SKU: AA003A34
Rating: 90 (10 reviews)

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Technical Information
Properties
Literature
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Technical Information
Properties
Literature

Technical Information

Catalog Number:

AA003A34

Chemical Name:

Apatinib

CAS Number:

811803-05-1

Molecular Formula:

C24H23N5O

Molecular Weight:

397.4723

MDL Number:

MFCD21648511

SMILES:

N#CC1(CCCC1)c1ccc(cc1)NC(=O)c1cccnc1NCc1ccncc1

Properties

Computed Properties

Complexity:

608

Covalently-Bonded Unit Count:

Heavy Atom Count:

Hydrogen Bond Acceptor Count:

Hydrogen Bond Donor Count:

Rotatable Bond Count:

XLogP3:

4.1

Literature

Title: Simultaneous determination of apatinib and its four major metabolites in human plasma using liquid chromatography-tandem mass spectrometry and its application to a pharmacokinetic study.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20120501

Title: YN968D1 is a novel and selective inhibitor of vascular endothelial growth factor receptor-2 tyrosine kinase with potent activity in vitro and in vivo.

Journal: Cancer science 20110701

Title: Apatinib (YN968D1) reverses multidrug resistance by inhibiting the efflux function of multiple ATP-binding cassette transporters.

Journal: Cancer research 20101015

Title: Safety and pharmacokinetics of novel selective vascular endothelial growth factor receptor-2 inhibitor YN968D1 in patients with advanced malignancies.

Journal: BMC cancer 20100101

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