Home Other Building Blocks 81226-60-0
81226-60-0,MFCD00953632
Catalog No.:AA00GA2J

81226-60-0 | L 741626

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5mg
≥98%
in stock  
$98.00   $68.00
- +
10mg
≥98%
in stock  
$166.00   $116.00
- +
25mg
≥98%
in stock  
$383.00   $268.00
- +
50mg
97%
in stock  
$675.00   $473.00
- +
100mg
97%
in stock  
$1,047.00   $733.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00GA2J
Chemical Name:
L 741626
CAS Number:
81226-60-0
Molecular Formula:
C20H21ClN2O
Molecular Weight:
340.8465
MDL Number:
MFCD00953632
SMILES:
Clc1ccc(cc1)C1(O)CCN(CC1)Cc1c[nH]c2c1cccc2
Properties
Computed Properties
 
Complexity:
416  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
24  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
3  
XLogP3:
3.7  

Literature

Title: Dopamine D2-Receptor Antagonists Down-Regulate CYP1A1/2 and CYP1B1 in the Rat Liver.

Journal: PloS one 20150101

Title: Discovery, optimization, and characterization of novel D2 dopamine receptor selective antagonists.

Journal: Journal of medicinal chemistry 20140424

Title: The role of the dopamine D2 receptor in descending control of pain induced by motor cortex stimulation in the neuropathic rat.

Journal: Brain research bulletin 20121101

Title: Dopaminergic modulation of low-Mg²⁺-induced epileptiform activity in the intact hippocampus of the newborn mouse in vitro.

Journal: Journal of neuroscience research 20121001

Title: D₂-dopaminergic receptor-linked pathways: critical regulators of CYP3A, CYP2C, and CYP2D.

Journal: Molecular pharmacology 20121001

Title: Selective blockade of dopamine D3 receptors enhances while D2 receptor antagonism impairs social novelty discrimination and novel object recognition in rats: a key role for the prefrontal cortex.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20120201

Title: Disparate effects of pramipexole on locomotor activity and sensorimotor gating in Sprague-Dawley rats.

Journal: Pharmacology, biochemistry, and behavior 20111001

Title: Signaling pathways leading to phosphorylation of Akt and GSK-3β by activation of cloned human and rat cerebral D₂and D₃ receptors.

Journal: Molecular pharmacology 20110101

Title: p-Hydroxyamphetamine causes prepulse inhibition disruptions in mice: contribution of dopamine neurotransmission.

Journal: Behavioural brain research 20101225

Title: Dopamine D3 and D2 receptor mechanisms in the abuse-related behavioral effects of cocaine: studies with preferential antagonists in squirrel monkeys.

Journal: The Journal of pharmacology and experimental therapeutics 20100801

Title: Synthesis and characterization of selective dopamine D2 receptor antagonists. 2. Azaindole, benzofuran, and benzothiophene analogs of L-741,626.

Journal: Bioorganic & medicinal chemistry 20100715

Title: Dopamine D3 receptors mediate the discriminative stimulus effects of quinpirole in free-feeding rats.

Journal: The Journal of pharmacology and experimental therapeutics 20100101

Title: D2 dopamine receptor subtype-mediated hyperactivity and amphetamine responses in a model of ADHD.

Journal: Neurobiology of disease 20100101

Title: Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

Journal: Nature chemical biology 20091001

Title: NCS-1 in the dentate gyrus promotes exploration, synaptic plasticity, and rapid acquisition of spatial memory.

Journal: Neuron 20090910

Title: Amphetamine decreases behavioral inhibition by stimulation of dopamine D2, but not D3, receptors.

Journal: Behavioural pharmacology 20090901

Title: Bifeprunox and aripiprazole suppress in vivo VTA dopaminergic neuronal activity via D2 and not D3 dopamine autoreceptor activation.

Journal: Neuroscience letters 20090821

Title: Using prepulse inhibition to detect functional D3 receptor antagonism: effects of WC10 and WC44.

Journal: Pharmacology, biochemistry, and behavior 20090801

Title: Modulation of AMPA currents by D(1)-like but not D(2)-like receptors in spinal motoneurons.

Journal: Neuroscience 20090218

Title: Synthesis and evaluation of ligands for D2-like receptors: the role of common pharmacophoric groups.

Journal: Bioorganic & medicinal chemistry 20090215

Title: Blockade of dopamine D(3) receptors in frontal cortex, but not in sub-cortical structures, enhances social recognition in rats: similar actions of D(1) receptor agonists, but not of D(2) antagonists.

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20090101

Title: Heritable strain differences in sensitivity to the startle gating-disruptive effects of D2 but not D3 receptor stimulation.

Journal: Behavioural pharmacology 20081201

Title: Structure-activity relationships for a novel series of dopamine D2-like receptor ligands based on N-substituted 3-aryl-8-azabicyclo[3.2.1]octan-3-ol.

Journal: Journal of medicinal chemistry 20081009

Title: The dopamine agonism on ADP-stimulated platelets is mediated through D2-like but not D1-like dopamine receptors.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20081001

Title: Aripiprazole inhibits marble-burying behavior via 5-hydroxytryptamine (5-HT)1A receptor-independent mechanisms.

Journal: European journal of pharmacology 20080911

Title: Food restriction alters N'-propyl-4,5,6,7-tetrahydrobenzothiazole-2,6-diamine dihydrochloride (pramipexole)-induced yawning, hypothermia, and locomotor activity in rats: evidence for sensitization of dopamine D2 receptor-mediated effects.

Journal: The Journal of pharmacology and experimental therapeutics 20080501

Title: Analogues of the dopamine D2 receptor antagonist L741,626: Binding, function, and SAR.

Journal: Bioorganic & medicinal chemistry letters 20070201

Title: Antiparkinsonian effects of the novel D3/D2 dopamine receptor agonist, S32504, in MPTP-lesioned marmosets: Mediation by D2, not D3, dopamine receptors.

Journal: Movement disorders : official journal of the Movement Disorder Society 20061201

Title: Actions at sites other than D(3) receptors mediate the effects of BP897 on l-DOPA-induced hyperactivity in monoamine-depleted rats.

Journal: Experimental neurology 20061101

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Fyn is required for haloperidol-induced catalepsy in mice.

Journal: The Journal of biological chemistry 20060317

Title: D2 autoreceptor inhibition reveals oxygen-glucose deprivation-induced release of dopamine in guinea-pig cochlea.

Journal: Neuroscience 20050101

Title: Molecular modeling of the three-dimensional structure of dopamine 3 (D3) subtype receptor: discovery of novel and potent D3 ligands through a hybrid pharmacophore- and structure-based database searching approach.

Journal: Journal of medicinal chemistry 20031009

Title: Pharmacological and functional characterisation of dopamine D4 receptors in the rat retina.

Journal: Neuropharmacology 20030601

Title: Evidence for regulation of body temperature in rats by dopamine D2 receptor and possible influence of D1 but not D3 and D4 receptors.

Journal: Neuropharmacology 20030601

Title: Fully automated radioligand binding filtration assay for membrane-bound receptors.

Journal: BioTechniques 20021001

Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

Journal: The Journal of biological chemistry 20020419

Title: S33084, a novel, potent, selective, and competitive antagonist at dopamine D(3)-receptors: I. Receptorial, electrophysiological and neurochemical profile compared with GR218,231 and L741,626.

Journal: The Journal of pharmacology and experimental therapeutics 20000601

Title: Discriminative stimulus properties of the dopamine D3 receptor agonists, PD128,907 and 7-OH-DPAT: a comparative characterization with novel ligands at D3 versus D2 receptors.

Journal: Neuropharmacology 20000214

Title: 3-((4-(4-Chlorophenyl)piperazin-1-yl)-methyl)-1H-pyrrolo-2,3-b-pyridine: an antagonist with high affinity and selectivity for the human dopamine D4 receptor.

Journal: Journal of medicinal chemistry 19960510

Title: Lewitus GM, et al. Microglial TNF-α Suppresses Cocaine-Induced Plasticity and Behavioral Sensitization. Neuron. 2016 May 4;90(3):483-91.

Title: Grundt P, et al. Analogues of the dopamine D2 receptor antagonist L741,626: Binding, function, and SAR. Bioorg Med Chem Lett. 2007 Feb 1;17(3):745-9.

Title: Koffarnus MN, et al. The discriminative stimulus effects of dopamine D2- and D3-preferring agonists in rats. Psychopharmacology (Berl). 2009 Apr;203(2):317-27.

Title: Kulagowski JJ, et al. 3-((4-(4-Chlorophenyl)piperazin-1-yl)-methyl)-1H-pyrrolo-2,3-b-pyridine: an antagonist with high affinity and selectivity for the human dopamine D4 receptor. J Med Chem. 1996 May 10;39(10):1941-2.

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Related Products of 81226-60-0
Tags:81226-60-0 Molecular Formula|81226-60-0 MDL|81226-60-0 SMILES|81226-60-0 L 741626