Home Amines 82186-77-4
82186-77-4,MFCD05662268
Catalog No.:AA0036I3

82186-77-4 | 2-(dibutylamino)-1-[(9Z)-2,7-dichloro-9-[(4-chlorophenyl)methylidene]-9H-fluoren-4-yl]ethan-1-ol

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1g
98%(HPLC)
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5g
98%(HPLC)
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25g
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100g
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA0036I3
Chemical Name:
2-(dibutylamino)-1-[(9Z)-2,7-dichloro-9-[(4-chlorophenyl)methylidene]-9H-fluoren-4-yl]ethan-1-ol
CAS Number:
82186-77-4
Molecular Formula:
C30H32Cl3NO
Molecular Weight:
528.9402
MDL Number:
MFCD05662268
SMILES:
CCCCN(CC(c1cc(Cl)cc2c1c1ccc(cc1/C/2=C/c1ccc(cc1)Cl)Cl)O)CCCC
Properties
Properties
 
BP:
642.5°C at 760 mmHg  
Form:
Solid  
MP:
129-131°C  
Solubility:
DMSO: ≥20mg/mL  
Storage:
Keep in dry area;Room Temperature;  

Computed Properties
 
Complexity:
671  
Covalently-Bonded Unit Count:
1  
Defined Bond Stereocenter Count:
1  
Heavy Atom Count:
35  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
10  
Undefined Atom Stereocenter Count:
1  
XLogP3:
8.7  

Literature

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Title: In vitro and in vivo combination of cepharanthine with anti-malarial drugs.

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Title: Ex vivo responses of Plasmodium falciparum clinical isolates to conventional and new antimalarial drugs in Niger.

Journal: Antimicrobial agents and chemotherapy 20130701

Title: Synthesis and antimalarial efficacy of two-carbon-linked, artemisinin-derived trioxane dimers in combination with known antimalarial drugs.

Journal: Journal of medicinal chemistry 20130328

Title: A SYBR Green 1-based in vitro test of susceptibility of Ghanaian Plasmodium falciparum clinical isolates to a panel of anti-malarial drugs.

Journal: Malaria journal 20130101

Title: Update on the in vivo tolerance and in vitro reduced susceptibility to the antimalarial lumefantrine.

Journal: The Journal of antimicrobial chemotherapy 20121001

Title: Why do Plasmodium malariae infections sometimes occur in spite of previous antimalarial medication?

Journal: Parasitology research 20120801

Title: Increased urinary frequency: an unusual presentation of Plasmodium falciparum malaria.

Journal: Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia 20120701

Title: Enhanced antimalarial activity of lumefantrine nanopowder prepared by wet-milling DYNO MILL technique.

Journal: Colloids and surfaces. B, Biointerfaces 20120615

Title: Gender differences in pharmacokinetics of lumefantrine and its metabolite desbutyl-lumefantrine in rats.

Journal: Biopharmaceutics & drug disposition 20120501

Title: Efficacy of artemether-lumefantrine in area of high malaria endemicity in India and its correlation with blood concentration of lumefantrine.

Journal: The American journal of tropical medicine and hygiene 20120301

Title: Successful oral therapy for severe falciparum malaria: the World Health Organization criteria revisited.

Journal: The American journal of tropical medicine and hygiene 20120301

Title: Determination of lumefantrine in small-volume human plasma by LC-MS/MS: using a deuterated lumefantrine to overcome matrix effect and ionization saturation.

Journal: Bioanalysis 20120101

Title: Falciparum--the masquerader.

Journal: JPMA. The Journal of the Pakistan Medical Association 20120101

Title: Genome wide adaptations of Plasmodium falciparum in response to lumefantrine selective drug pressure.

Journal: PloS one 20120101

Title: The effects of serum lipids on the in vitro activity of lumefantrine and atovaquone against Plasmodium falciparum.

Journal: Malaria journal 20120101

Title: In vitro sensitivity of Plasmodium falciparum from China-Myanmar border area to major ACT drugs and polymorphisms in potential target genes.

Journal: PloS one 20120101

Title: Prevalence of single nucleotide polymorphisms in the Plasmodium falciparum multidrug resistance gene (Pfmdr-1) in Korogwe District in Tanzania before and after introduction of artemisinin-based combination therapy.

Journal: The American journal of tropical medicine and hygiene 20111201

Title: In vitro activity of antiretroviral drugs against Plasmodium falciparum.

Journal: Antimicrobial agents and chemotherapy 20111101

Title: Pharmacokinetics of antimalarials in pregnancy: a systematic review.

Journal: Clinical pharmacokinetics 20111101

Title: Plasmodium species co-infection as a cause of treatment failure.

Journal: Travel medicine and infectious disease 20111101

Title: The pharmacogenetics of antimalaria artemisinin combination therapy.

Journal: Expert opinion on drug metabolism & toxicology 20111001

Title: Presumptive treatment to reduce imported malaria among refugees from east Africa resettling in the United States.

Journal: The American journal of tropical medicine and hygiene 20111001

Title: Synthesis of novel 6-phenyl-2,4-disubstituted pyrimidine-5-carbonitriles as potential antimicrobial agents.

Journal: European journal of medicinal chemistry 20110901

Title: Severe Plasmodium knowlesi malaria in a tertiary care hospital, Sabah, Malaysia.

Journal: Emerging infectious diseases 20110701

Title: Plasmodium knowlesi reinfection in human.

Journal: Emerging infectious diseases 20110701

Title: In vitro activity of Proveblue (methylene blue) on Plasmodium falciparum strains resistant to standard antimalarial drugs.

Journal: Antimicrobial agents and chemotherapy 20110501

Title: Identification and functional validation of the novel antimalarial resistance locus PF10_0355 in Plasmodium falciparum.

Journal: PLoS genetics 20110401

Title: Plasmodium berghei K173: selection of resistance to naphthoquine in a mouse model.

Journal: Experimental parasitology 20110201

Title: Liquid chromatography-tandem mass spectrometry for the simultaneous quantitation of artemether and lumefantrine in human plasma: application for a pharmacokinetic study.

Journal: Journal of pharmaceutical and biomedical analysis 20110105

Title: Measurement of lumefantrine and its metabolite in plasma by high performance liquid chromatography with ultraviolet detection.

Journal: Journal of pharmaceutical and biomedical analysis 20110105

Title: Automated erythrocytapheresis for severe falciparum malaria.

Journal: Internal medicine journal 20110101

Title: Stability-indicating HPLC-DAD/UV-ESI/MS impurity profiling of the anti-malarial drug lumefantrine.

Journal: Malaria journal 20110101

Title: Novel polymorphisms in Plasmodium falciparum ABC transporter genes are associated with major ACT antimalarial drug resistance.

Journal: PloS one 20110101

Title: Comparative study of the efficacy and tolerability of dihydroartemisinin-piperaquine-trimethoprim versus artemether-lumefantrine in the treatment of uncomplicated Plasmodium falciparum malaria in Cameroon, Ivory Coast and Senegal.

Journal: Malaria journal 20110101

Title: Intravenous pharmacokinetics, oral bioavailability, dose proportionality and in situ permeability of anti-malarial lumefantrine in rats.

Journal: Malaria journal 20110101

Title: Similar efficacy and safety of artemether-lumefantrine (Coartem®) in African infants and children with uncomplicated falciparum malaria across different body weight ranges.

Journal: Malaria journal 20110101

Title: Therapeutic efficacy and effect on gametocyte carriage of an artemisinin and a non-based combination treatment in children with uncomplicated P. falciparum malaria, living in an area with high-level chloroquine resistance.

Journal: Journal of tropical pediatrics 20101201

Title: Artemisinin-based combination therapies and their introduction in Japan.

Journal: Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20101201

Title: Association between the pfmdr1 gene and in vitro artemether and lumefantrine sensitivity in Thai isolates of Plasmodium falciparum.

Journal: The American journal of tropical medicine and hygiene 20101105

Title: Increased risk of early vomiting among infants and young children treated with dihydroartemisinin-piperaquine compared with artemether-lumefantrine for uncomplicated malaria.

Journal: The American journal of tropical medicine and hygiene 20101005

Title: Pharmacodynamic interaction between lumefantrine and desbutyl-benflumetol in Plasmodium falciparum in vitro.

Journal: Wiener klinische Wochenschrift 20101001

Title: Azithromycin combination therapy for the treatment of uncomplicated falciparum malaria in Bangladesh: an open-label randomized, controlled clinical trial.

Journal: The Journal of infectious diseases 20100815

Title: Dihydroartemisinin-piperaquine versus artemether-lumefantrine, in the treatment of uncomplicated Plasmodium falciparum malaria in central Sudan.

Journal: Annals of tropical medicine and parasitology 20100601

Title: Selection of known Plasmodium falciparum resistance-mediating polymorphisms by artemether-lumefantrine and amodiaquine-sulfadoxine-pyrimethamine but not dihydroartemisinin-piperaquine in Burkina Faso.

Journal: Antimicrobial agents and chemotherapy 20100501

Title: Pyronaridine-artesunate for uncomplicated falciparum malaria.

Journal: Lancet (London, England) 20100424

Title: Efficacy and safety of a fixed-dose oral combination of pyronaridine-artesunate compared with artemether-lumefantrine in children and adults with uncomplicated Plasmodium falciparum malaria: a randomised non-inferiority trial.

Journal: Lancet (London, England) 20100424

Title: The effect of food consumption on lumefantrine bioavailability in African children receiving artemether-lumefantrine crushed or dispersible tablets (Coartem) for acute uncomplicated Plasmodium falciparum malaria.

Journal: Tropical medicine & international health : TM & IH 20100401

Title: In vitro sensitivities of Plasmodium falciparum to different antimalarial drugs in Uganda.

Journal: Antimicrobial agents and chemotherapy 20100301

Title: A semi-automated method for counting fluorescent malaria oocysts increases the throughput of transmission blocking studies.

Journal: Malaria journal 20100101

Title: Incidence of malaria and efficacy of combination antimalarial therapies over 4 years in an urban cohort of Ugandan children.

Journal: PloS one 20100101

Title: Azithromycin plus artesunate versus artemether-lumefantrine for treatment of uncomplicated malaria in Tanzanian children: a randomized, controlled trial.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20091015

Title: Lopinavir/ritonavir affects pharmacokinetic exposure of artemether/lumefantrine in HIV-uninfected healthy volunteers.

Journal: Journal of acquired immune deficiency syndromes (1999) 20090801

Title: Artemisinin-based combination therapy for treating uncomplicated malaria.

Journal: The Cochrane database of systematic reviews 20090708

Title: Plasmodium berghei ANKA: selection of resistance to piperaquine and lumefantrine in a mouse model.

Journal: Experimental parasitology 20090701

Title: Comparison of sulfadoxine-pyrimethamine, unsupervised artemether-lumefantrine, and unsupervised artesunate-amodiaquine fixed-dose formulation for uncomplicated plasmodium falciparum malaria in Benin: a randomized effectiveness noninferiority trial.

Journal: The Journal of infectious diseases 20090701

Title: Mild increases in serum hepcidin and interleukin-6 concentrations impair iron incorporation in haemoglobin during an experimental human malaria infection.

Journal: British journal of haematology 20090601

Title: First artemisinin-based antimalarial combination approved for U.S. market.

Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20090515

Title: Treatment of severe sepsis with artemether-lumefantrine is associated with decreased mortality in Ugandan patients without malaria.

Journal: The American journal of tropical medicine and hygiene 20090501

Title: Determination of lumefantrine in rat plasma by liquid-liquid extraction using LC-MS/MS with electrospray ionization: assay development, validation and application to a pharmacokinetic study.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20090415

Title: A liquid chromatographic-tandem mass spectrometric method for determination of artemether and its metabolite dihydroartemisinin in human plasma.

Journal: Bioanalysis 20090401

Title: Antimalarial therapies in children from Papua New Guinea.

Journal: The New England journal of medicine 20090319

Title: Does artesunate prolong the electrocardiograph QT interval in patients with severe malaria?

Journal: The American journal of tropical medicine and hygiene 20090101

Title: Chlorproguanil-dapsone-artesunate versus artemether-lumefantrine: a randomized, double-blind phase III trial in African children and adolescents with uncomplicated Plasmodium falciparum malaria.

Journal: PloS one 20090101

Title: Dihydroartemisinin-piperaquine and artemether-lumefantrine for treating uncomplicated malaria in African children: a randomised, non-inferiority trial.

Journal: PloS one 20090101

Title: Cardiac complication after experimental human malaria infection: a case report.

Journal: Malaria journal 20090101

Title: A field-adapted sampling and HPLC quantification method for lumefantrine and its desbutyl metabolite in whole blood spotted on filter paper.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20081215

Title: A trial of combination antimalarial therapies in children from Papua New Guinea.

Journal: The New England journal of medicine 20081211

Title: A randomised controlled trial of artemether-lumefantrine versus artesunate for uncomplicated plasmodium falciparum treatment in pregnancy.

Journal: PLoS medicine 20081201

Title: Simultaneous determination of artemether and lumefantrine in fixed dose combination tablets by HPLC with UV detection.

Journal: Journal of pharmaceutical and biomedical analysis 20081104

Title: A randomized trial of artesunate-mefloquine versus artemether-lumefantrine for treatment of uncomplicated Plasmodium falciparum malaria in Mali.

Journal: The American journal of tropical medicine and hygiene 20081101

Title: Comparison of HPLC, UV spectrophotometry and potentiometric titration methods for the determination of lumefantrine in pharmaceutical products.

Journal: Journal of pharmaceutical and biomedical analysis 20080910

Title: Adherence and efficacy of supervised versus non-supervised treatment with artemether/lumefantrine for the treatment of uncomplicated Plasmodium falciparum malaria in Bangladesh: a randomised controlled trial.

Journal: Transactions of the Royal Society of Tropical Medicine and Hygiene 20080901

Title: Effect of artemisinins and amino alcohol partner antimalarials on mammalian sarcoendoplasmic reticulum calcium adenosine triphosphatase activity.

Journal: Basic & clinical pharmacology & toxicology 20080901

Title: High efficacy of two artemisinin-based combinations (artemether-lumefantrine and artesunate plus amodiaquine) for acute uncomplicated malaria in Ibadan, Nigeria.

Journal: Tropical medicine & international health : TM & IH 20080501

Title: The use of artemether-lumefantrine by febrile children following national implementation of a revised drug policy in Kenya.

Journal: Tropical medicine & international health : TM & IH 20080401

Title: [Efficacy of dihydroartemisinin-piperaquine and artemether-lumefantrine in the treatment of uncomplicated falciparum malaria in Hainan, China].

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Title: An interactive model for the assessment of the economic costs and benefits of different rapid diagnostic tests for malaria.

Journal: Malaria journal 20080101

Title: From chloroquine to artemether-lumefantrine: the process of drug policy change in Zambia.

Journal: Malaria journal 20080101

Title: Why don't health workers prescribe ACT? A qualitative study of factors affecting the prescription of artemether-lumefantrine.

Journal: Malaria journal 20080101

Title: Artemether-lumefantrine versus dihydroartemisinin-piperaquine for treating uncomplicated malaria: a randomized trial to guide policy in Uganda.

Journal: PloS one 20080101

Title: Activities of artemether-lumefantrine and amodiaquine-sulfalene-pyrimethamine against sexual-stage parasites in falciparum malaria in children.

Journal: Chemotherapy 20080101

Title: An open label, randomised trial of artesunate+amodiaquine, artesunate+chlorproguanil-dapsone and artemether-lumefantrine for the treatment of uncomplicated malaria.

Journal: PloS one 20080101

Title: Different methodological approaches to the assessment of in vivo efficacy of three artemisinin-based combination antimalarial treatments for the treatment of uncomplicated falciparum malaria in African children.

Journal: Malaria journal 20080101

Title: Should countries implementing an artemisinin-based combination malaria treatment policy also introduce rapid diagnostic tests?

Journal: Malaria journal 20080101

Title: Ototoxicity of artemether/lumefantrine in the treatment of falciparum malaria: a randomized trial.

Journal: Malaria journal 20080101

Title: Malaria case-management under artemether-lumefantrine treatment policy in Uganda.

Journal: Malaria journal 20080101

Title: Overuse of artemisinin-combination therapy in Mto wa Mbu (river of mosquitoes), an area misinterpreted as high endemic for malaria.

Journal: Malaria journal 20080101

Title: Trends in antimalarial prescriptions in Australia 2002 to 2005.

Journal: Journal of travel medicine 20080101

Title: Malariological baseline survey and in vitro antimalarial drug resistance in Gulu district, Northern Uganda.

Journal: Wiener klinische Wochenschrift 20080101

Title: Interaction between lumefantrine and monodesbutyl-benflumetol in Plasmodium falciparum in vitro.

Journal: Wiener klinische Wochenschrift 20080101

Title: Community effectiveness of artemisinin-based combination therapy for malaria in rural southwestern Nigeria.

Journal: International quarterly of community health education 20080101

Title: [Artemether-lumefantrine, treatment of child more than 5 years old uncomplicated malaria in Tsevie's hospital (Togo)].

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Title: Pharmacologic advances in the global control and treatment of malaria: combination therapy and resistance.

Journal: Clinical pharmacology and therapeutics 20071101

Title: Development and validation of an automated solid-phase extraction and liquid chromatographic method for determination of lumefantrine in capillary blood on sampling paper.

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Title: [Treatment of falciparum malaria with artemether-lumefantrine according to a 5-day schedule: results of a study in 21 patients and recommendations].

Journal: Nederlands tijdschrift voor geneeskunde 20071006

Title: Clinical efficacy of chloroquine versus artemether-lumefantrine for Plasmodium vivax treatment in Thailand.

Journal: The Korean journal of parasitology 20070601

Title: In vitro antimalarial drug susceptibility and pfcrt mutation among fresh Plasmodium falciparum isolates from the Lao PDR (Laos).

Journal: The American journal of tropical medicine and hygiene 20070201

Title: How much fat is necessary to optimize lumefantrine oral bioavailability?

Journal: Tropical medicine & international health : TM & IH 20070201

Title: Pharmacokinetic study of artemether-lumefantrine given once daily for the treatment of uncomplicated multidrug-resistant falciparum malaria.

Journal: Tropical medicine & international health : TM & IH 20070201

Title: [Surveillance of falciparum malaria susceptibility to antimalarial drugs and policy change in the Comoros].

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Title: Artemether/lumefantrine in the treatment of uncomplicated falciparum malaria.

Journal: Expert opinion on pharmacotherapy 20070101

Title: Efficacy and tolerability of four antimalarial combinations in the treatment of uncomplicated Plasmodium falciparum malaria in Senegal.

Journal: Malaria journal 20070101

Title: Synergistic interaction between monodesbutyl-benflumetol and retinol in Plasmodium falciparum.

Journal: Wiener klinische Wochenschrift 20070101

Title: Specific pharmacokinetic interaction between lumefantrine and monodesbutyl-benflumetol in Plasmodium falciparum.

Journal: Wiener klinische Wochenschrift 20070101

Title: In vitro interaction of dihydroartemisin and lumefantrine in clinical field isolates from Bangladesh.

Journal: Wiener klinische Wochenschrift 20070101

Title: Efficacy and safety of artemisinin-based antimalarial in the treatment of uncomplicated malaria in children in southern Tanzania.

Journal: Malaria journal 20070101

Title: The pharmacokinetics of artemether and lumefantrine in pregnant women with uncomplicated falciparum malaria.

Journal: European journal of clinical pharmacology 20061201

Title: Efficacy of artemether-lumefantrine for the treatment of uncomplicated falciparum malaria in northwest Cambodia.

Journal: Tropical medicine & international health : TM & IH 20061201

Title: HIV-1 immune suppression and antimalarial treatment outcome in Zambian adults with uncomplicated malaria.

Journal: The Journal of infectious diseases 20061001

Title: A randomized trial of artesunate-sulfamethoxypyrazine-pyrimethamine versus artemether-lumefantrine for the treatment of uncomplicated Plasmodium falciparum malaria in Mali.

Journal: The American journal of tropical medicine and hygiene 20061001

Title: Decreasing pfmdr1 copy number in plasmodium falciparum malaria heightens susceptibility to mefloquine, lumefantrine, halofantrine, quinine, and artemisinin.

Journal: The Journal of infectious diseases 20060815

Title: First Brazilian experience with the use of artemether-lumefantrine (Coartem) a fixed-dosed ACT combination.

Journal: The American journal of tropical medicine and hygiene 20060801

Title: The financial and clinical implications of adult malaria diagnosis using microscopy in Kenya.

Journal: Tropical medicine & international health : TM & IH 20060801

Title: Feasibility and acceptability of the use of artemether-lumefantrine in the home management of uncomplicated malaria in children 6-59 months old in Ghana.

Journal: Tropical medicine & international health : TM & IH 20060701

Title: High efficacy of two artemisinin-based combinations (artesunate + amodiaquine and artemether + lumefantrine) in Caala, Central Angola.

Journal: The American journal of tropical medicine and hygiene 20060701

Title: Molecular and pharmacological determinants of the therapeutic response to artemether-lumefantrine in multidrug-resistant Plasmodium falciparum malaria.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20060601

Title: A case-control auditory evaluation of patients treated with artemether-lumefantrine.

Journal: The American journal of tropical medicine and hygiene 20060601

Title: Efficacy and safety of the six-dose regimen of artemether-lumefantrine in pediatrics with uncomplicated Plasmodium falciparum malaria: a pooled analysis of individual patient data.

Journal: The American journal of tropical medicine and hygiene 20060601

Title: Examples of tropical disease control in the humanitarian medical programmes of MSF and Merlin.

Journal: Transactions of the Royal Society of Tropical Medicine and Hygiene 20060401

Title: Operational response to malaria epidemics: are rapid diagnostic tests cost-effective?

Journal: Tropical medicine & international health : TM & IH 20060401

Title: [Malaria: a medical and economic problem].

Journal: Presse medicale (Paris, France : 1983) 20060401

Title: Effects of weight, age, and time on artemether-lumefantrine associated ototoxicity and evidence of irreversibility.

Journal: Travel medicine and infectious disease 20060301

Title: A case-control auditory evaluation of patients treated with artemether-lumefantrine.

Journal: The American journal of tropical medicine and hygiene 20060201

Title: Successful treatment of Plasmodium falciparum malaria with a six-dose regimen of artemether-lumefantrine versus quinine-doxycycline in the Western Amazon region of Brazil.

Journal: The American journal of tropical medicine and hygiene 20060101

Title: The efficacies of artesunate-sulfadoxine-pyrimethamine and artemether-lumefantrine in the treatment of uncomplicated, Plasmodium falciparum malaria, in an area of low transmission in central Sudan.

Journal: Annals of tropical medicine and parasitology 20060101

Title: Artemether-lumefantrine versus artesunate plus amodiaquine for treating uncomplicated childhood malaria in Nigeria: randomized controlled trial.

Journal: Malaria journal 20060101

Title: Supervised versus unsupervised antimalarial treatment with six-dose artemether-lumefantrine: pharmacokinetic and dosage-related findings from a clinical trial in Uganda.

Journal: Malaria journal 20060101

Title: From chloroquine to artemisinin-based combination therapy: the Sudanese experience.

Journal: Malaria journal 20060101

Title: Safety and efficacy of lumefantrine-artemether (Coartem) for the treatment of uncomplicated Plasmodium falciparum malaria in Zambian adults.

Journal: Malaria journal 20060101

Title: Assessment of the therapeutic efficacy of a paediatric formulation of artemether-lumefantrine (Coartesiane) for the treatment of uncomplicated Plasmodium falciparum in children in Zambia.

Journal: Malaria journal 20060101

Title: Malaria treatment failures after artemisinin-based therapy in three expatriates: could improved manufacturer information help to decrease the risk of treatment failure?

Journal: Malaria journal 20060101

Title: Efficacy of three artemisinin combination therapies for the treatment of uncomplicated Plasmodium falciparum malaria in the Republic of Congo.

Journal: Malaria journal 20060101

Title: The cost of uncomplicated childhood fevers to Kenyan households: implications for reaching international access targets.

Journal: BMC public health 20060101

Title: Artemisinin-based combinations.

Journal: Current opinion in infectious diseases 20051201

Title: Effect of artemether-lumefantrine policy and improved vector control on malaria burden in KwaZulu-Natal, South Africa.

Journal: PLoS medicine 20051101

Title: Efficacy of artesunate plus amodiaquine versus that of artemether-lumefantrine for the treatment of uncomplicated childhood Plasmodium falciparum malaria in Zanzibar, Tanzania.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20051015

Title: Efficacy of chloroquine + sulfadoxine--pyrimethamine, mefloquine + artesunate and artemether + lumefantrine combination therapies to treat Plasmodium falciparum malaria in the Chittagong Hill Tracts, Bangladesh.

Journal: Transactions of the Royal Society of Tropical Medicine and Hygiene 20051001

Title: Coartem (artemether-lumefantrine) in Africa: the beginning of the end?

Journal: The Journal of infectious diseases 20051001

Title: High throughput assay for the determination of lumefantrine in plasma.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050805

Title: Safety and efficacy of artemether-lumefantrine in the treatment of uncomplicated falciparum malaria in Ethiopia.

Journal: East African medical journal 20050801

Title: Malaria: uncomplicated, caused by Plasmodium falciparum.

Journal: Clinical evidence 20050601

Title: Towards a proteomic definition of CoArtem action in Plasmodium falciparum malaria.

Journal: Proteomics 20050501

Title: Antimalarial drugs: QT prolongation and cardiac arrhythmias.

Journal: Expert opinion on drug safety 20050501

Title: Development and validation of a bioanalytical method using automated solid-phase extraction and LC-UV for the simultaneous determination of lumefantrine and its desbutyl metabolite in plasma.

Journal: Journal of pharmaceutical and biomedical analysis 20050429

Title: Supervised versus unsupervised intake of six-dose artemether-lumefantrine for treatment of acute, uncomplicated Plasmodium falciparum malaria in Mbarara, Uganda: a randomised trial.

Journal: Lancet (London, England) 20050401

Title: Amodiaquine alone, amodiaquine+sulfadoxine-pyrimethamine, amodiaquine+artesunate, and artemether-lumefantrine for outpatient treatment of malaria in Tanzanian children: a four-arm randomised effectiveness trial.

Journal: Lancet (London, England) 20050401

Title: In vivo selection of Plasmodium falciparum pfmdr1 86N coding alleles by artemether-lumefantrine (Coartem).

Journal: The Journal of infectious diseases 20050315

Title: A randomized trial of artemether-lumefantrine versus mefloquine-artesunate for the treatment of uncomplicated multi-drug resistant Plasmodium falciparum on the western border of Thailand.

Journal: Malaria journal 20050101

Title: Therapeutic efficacy of artemether-lumefantrine and artesunate-mefloquine for treatment of uncomplicated Plasmodium falciparum malaria in Luang Namtha Province, Lao People's Democratic Republic.

Journal: Tropical medicine & international health : TM & IH 20041101

Title: Adherence to a six-dose regimen of artemether-lumefantrine for treatment of uncomplicated Plasmodium falciparum malaria in Uganda.

Journal: The American journal of tropical medicine and hygiene 20041101

Title: Randomized comparison of chloroquine plus sulfadoxine-pyrimethamine versus artesunate plus mefloquine versus artemether-lumefantrine in the treatment of uncomplicated falciparum malaria in the Lao People's Democratic Republic.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20041015

Title: Adherence to a combination of artemether and lumefantrine (Coartem) in Kajo Keji, southern Sudan.

Journal: Annals of tropical medicine and parasitology 20040901

Title: Artemisinin-based combination therapy reduces expenditure on malaria treatment in KwaZulu Natal, South Africa.

Journal: Tropical medicine & international health : TM & IH 20040901

Title: Efficacy of artemether-lumefantrine treatment in patients with acute uncomplicated Falciparum malaria in Mayotte, a French collectivity of the Comoros Archipelago.

Journal: Parasite (Paris, France) 20040901

Title: [Malaria: prophylaxis, treatment, stand-by medication. A single mosquito bite suffices].

Journal: MMW Fortschritte der Medizin 20040617

Title: [Efficacy of therapeutic combinations with artemisinin derivatives in the treatment of non complicated malaria in Burundi].

Journal: Tropical medicine & international health : TM & IH 20040601

Title: Coartemether (artemether and lumefantrine): an oral antimalarial drug.

Journal: Expert review of anti-infective therapy 20040401

Title: Artemether-lumefantrine for uncomplicated malaria: a systematic review.

Journal: Tropical medicine & international health : TM & IH 20040201

Title: In vitro sensitivity of Plasmodium falciparum to lumefantrine in north-western Thailand.

Journal: Wiener klinische Wochenschrift 20040101

Title: Comparative study on the in vitro activity of lumefantrine and desbutyl-benflumetol in fresh isolates of Plasmodium vivax from Thailand.

Journal: Wiener klinische Wochenschrift 20040101

Title: New antimalarial drugs.

Journal: Angewandte Chemie (International ed. in English) 20031110

Title: Monitoring the therapeutic efficacy of antimalarials against uncomplicated falciparum malaria in Thailand.

Journal: The Southeast Asian journal of tropical medicine and public health 20030901

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Tags:82186-77-4 Molecular Formula|82186-77-4 MDL|82186-77-4 SMILES|82186-77-4 2-(dibutylamino)-1-[(9Z)-2,7-dichloro-9-[(4-chlorophenyl)methylidene]-9H-fluoren-4-yl]ethan-1-ol