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82752-99-6,MFCD00935760
Catalog No.:AA0057ZV

82752-99-6 | 1-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}-3-ethyl-4-(2-phenoxyethyl)-4,5-dihydro-1H-1,2,4-triazol-5-one hydrochloride

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250mg
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1g
98%(HPLC)
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5g
98%(HPLC)
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$318.00   $223.00
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10g
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$477.00   $334.00
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25g
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100g
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  • Technical Information
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  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA0057ZV
Chemical Name:
1-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}-3-ethyl-4-(2-phenoxyethyl)-4,5-dihydro-1H-1,2,4-triazol-5-one hydrochloride
CAS Number:
82752-99-6
Molecular Formula:
C25H33Cl2N5O2
Molecular Weight:
506.4678
MDL Number:
MFCD00935760
SMILES:
CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl.Cl
Properties
Properties
 
BP:
599.6°C at 760 mmHg  
Form:
Solid  
MP:
186-188°C  
Solubility:
DMSO: ~11 mg/mL at 60 °C  
Storage:
Inert atmosphere;Room Temperature;  

Computed Properties
 
Complexity:
649  
Covalently-Bonded Unit Count:
2  
Heavy Atom Count:
34  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
10  

Literature

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Title: Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.

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Title: Triamcinolone acetonide induced secondary adrenal insufficiency related to impaired CYP3A4 metabolism by coadministration of nefazodone.

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Title: Utility of multivariate analysis in support of in vitro metabolite identification studies: retrospective analysis using the antidepressant drug nefazodone.

Journal: Xenobiotica; the fate of foreign compounds in biological systems 20100401

Title: Dyadic discord at baseline is associated with lack of remission in the acute treatment of chronic depression.

Journal: Psychological medicine 20100301

Title: Case report: delirium due to a diltiazem-fentanyl CYP3A4 drug interaction.

Journal: General hospital psychiatry 20100101

Title: Select comorbid personality disorders and the treatment of chronic depression with nefazodone, targeted psychotherapy, or their combination.

Journal: Journal of affective disorders 20091001

Title: Redistribution of slow wave activity of sleep during pharmacological treatment of depression with paroxetine but not with nefazodone.

Journal: Journal of sleep research 20090901

Title: Synergistic drug-cytokine induction of hepatocellular death as an in vitro approach for the study of inflammation-associated idiosyncratic drug hepatotoxicity.

Journal: Toxicology and applied pharmacology 20090615

Title: Patient preference as a moderator of outcome for chronic forms of major depressive disorder treated with nefazodone, cognitive behavioral analysis system of psychotherapy, or their combination.

Journal: The Journal of clinical psychiatry 20090301

Title: A preliminary trial: double-blind comparison of nefazodone, bupropion-SR, and placebo in the treatment of cannabis dependence.

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Title: Cellular imaging predictions of clinical drug-induced liver injury.

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Title: Can in vitro metabolism-dependent covalent binding data in liver microsomes distinguish hepatotoxic from nonhepatotoxic drugs? An analysis of 18 drugs with consideration of intrinsic clearance and daily dose.

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Title: Comparison of the bioactivation potential of the antidepressant and hepatotoxin nefazodone with aripiprazole, a structural analog and marketed drug.

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Title: In vitro assessment of mitochondrial dysfunction and cytotoxicity of nefazodone, trazodone, and buspirone.

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Title: Severity and duration of depression, not personality factors, predict short term outcome in the treatment of major depression.

Journal: Journal of affective disorders 20071201

Title: A meta-analysis of clinical trials comparing the serotonin (5HT)-2 receptor antagonists trazodone and nefazodone with selective serotonin reuptake inhibitors for the treatment of major depressive disorder.

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Title: Serzone semantics.

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Title: Coadministration of nefazodone and desipramine: a pharmacokinetic interaction study.

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Title: Dropouts versus completers among chronically depressed outpatients.

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Title: Complete profiling and characterization of in vitro nefazodone metabolites using two different tandem mass spectrometric platforms.

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Title: Inhibition of hepatobiliary transport as a predictive method for clinical hepatotoxicity of nefazodone.

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Title: Nefazodone for the treatment of postpartum depression.

Journal: Archives of women's mental health 20050501

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Journal: Journal of psychiatry & neuroscience : JPN 20050101

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Title: Effect of the antidepressant nefazodone on the density of cells expressing mu-opioid receptors in discrete brain areas processing sensory and affective dimensions of pain.

Journal: Psychopharmacology 20041101

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Journal: The Journal of clinical psychiatry 20041001

Title: Preventive migraine therapy: what is new.

Journal: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 20041001

Title: A placebo-controlled study of nefazodone for the treatment of chronic posttraumatic stress disorder: a preliminary study.

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Journal: Praxis 20040505

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Title: Nefazodone treatment of comorbid alcohol dependence and major depression.

Journal: Alcoholism, clinical and experimental research 20040301

Title: Comparative CYP3A4 inhibitory effects of venlafaxine, fluoxetine, sertraline, and nefazodone in healthy volunteers.

Journal: Journal of clinical psychopharmacology 20040201

Title: The serotonin-dopamine interaction is critical for fast-onset action of antidepressant treatment: in vivo studies in an animal model of depression.

Journal: Progress in neuro-psychopharmacology & biological psychiatry 20040101

Title: Nefazodone-associated torsade de pointes.

Journal: International journal of cardiology 20040101

Title: A preliminary open study of the tolerability and effectiveness of nefazodone in major depressive disorder: comparing patients who recently discontinued an SSRI with those on no recent antidepressant treatment.

Journal: Depression and anxiety 20040101

Title: Mirtazapine is associated with less anxiolytic use among elderly depressed patients in long-term care facilities.

Journal: Journal of the American Medical Directors Association 20040101

Title: Comparative toxicity of citalopram and the newer antidepressants after overdose.

Journal: Journal of toxicology. Clinical toxicology 20040101

Title: Comparison of nefazodone and sertraline for the treatment of posttraumatic stress disorder.

Journal: Depression and anxiety 20040101

Title: Therapeutic drug monitoring of non-tricyclic antidepressant drugs.

Journal: Clinical chemistry and laboratory medicine 20040101

Title: Therapeutic alliance in depression treatment: controlling for prior change and patient characteristics.

Journal: Journal of consulting and clinical psychology 20031201

Title: Therapeutic reactance as a predictor of outcome in the treatment of chronic depression.

Journal: Journal of consulting and clinical psychology 20031201

Title: Nefazodone inhibits methylprednisolone disposition and enhances its adrenal-suppressant effect.

Journal: Journal of clinical psychopharmacology 20031201

Title: Discontinuation symptoms associated with nefazodone.

Journal: Journal of psychopharmacology (Oxford, England) 20031201

Title: Nefazodone (Serzone) withdrawn because of hepatotoxicity.

Journal: CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 20031125

Title: Pharmacokinetic and pharmacodynamic interactions of oral midazolam with ketoconazole, fluoxetine, fluvoxamine, and nefazodone.

Journal: Journal of clinical pharmacology 20031101

Title: An open-label study of nefazodone treatment of major depression in patients with congestive heart failure.

Journal: Canadian journal of psychiatry. Revue canadienne de psychiatrie 20031101

Title: Dyskinetopsia during light adaptation associated with nefazodone treatment.

Journal: Eye (London, England) 20031101

Title: Randomized, placebo-controlled trial of nefazodone maintenance treatment in preventing recurrence in chronic depression.

Journal: Biological psychiatry 20031015

Title: Does nefazodone improve both depression and Parkinson disease? A pilot randomized trial.

Journal: Journal of clinical psychopharmacology 20031001

Title: Rhabdomyolysis associated with simvastatin-nefazodone therapy.

Journal: Southern medical journal 20031001

Title: Correlation of subjective and objective sleep measurements at different stages of the treatment of depression.

Journal: Psychiatry research 20030930

Title: A comparison of antidepressant response in younger and older women.

Journal: Journal of clinical psychopharmacology 20030801

Title: Disorders of motion and depth.

Journal: Neurologic clinics 20030801

Title: Early onset, nefazodone-induced fulminant hepatic failure.

Journal: The American journal of gastroenterology 20030701

Title: Conditioned taste aversion: modulation by 5-HT receptor activity and corticosterone.

Journal: European journal of pharmacology 20030620

Title: Efficacy of nefazodone in the treatment of neuroleptic induced extrapyramidal side effects: a double-blind randomised parallel group placebo-controlled trial.

Journal: Human psychopharmacology 20030601

Title: Open-label nefazodone in patients with a major depressive episode and alcohol dependence.

Journal: Progress in neuro-psychopharmacology & biological psychiatry 20030601

Title: Hepatic injury and pancreatitis during treatment with serotonin reuptake inhibitors: data from the World Health Organization (WHO) database of adverse drug reactions.

Journal: International clinical psychopharmacology 20030501

Title: Central and peripheral vision loss associated with nefazodone usage.

Journal: Documenta ophthalmologica. Advances in ophthalmology 20030501

Title: Patient's therapeutic skill acquisition and response to psychotherapy, alone or in combination with medication.

Journal: Psychological medicine 20030501

Title: Nefazodone in the rat: mimicry and antagonism of [-]-DOM-induced stimulus control.

Journal: Pharmacology, biochemistry, and behavior 20030501

Title: Withdrawing drugs: nefazodone, the start of the latest saga.

Journal: Lancet (London, England) 20030412

Title: The effect of nefazodone on subjective and objective sleep quality in posttraumatic stress disorder.

Journal: The Journal of clinical psychiatry 20030401

Title: The effects of psychotherapy, nefazodone, and their combination on subjective assessment of disturbed sleep in chronic depression.

Journal: Sleep 20030315

Title: Electroanalytical characteristics of piribedil and its differential pulse and square wave voltammetric determination in pharmaceuticals and human serum.

Journal: Journal of pharmaceutical and biomedical analysis 20030310

Title: Assessment of the contributions of CYP3A4 and CYP3A5 in the metabolism of the antipsychotic agent haloperidol to its potentially neurotoxic pyridinium metabolite and effect of antidepressants on the bioactivation pathway.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20030301

Title: Cortical myoclonus during lithium exposure.

Journal: Archives of neurology 20030301

Title: A multicentre prospective controlled study to determine the safety of trazodone and nefazodone use during pregnancy.

Journal: Canadian journal of psychiatry. Revue canadienne de psychiatrie 20030301

Title: Nefazodone decreases anxiety during marijuana withdrawal in humans.

Journal: Psychopharmacology 20030101

Title: Enhanced resolution triple-quadrupole mass spectrometry for fast quantitative bioanalysis using liquid chromatography/tandem mass spectrometry: investigations of parameters that affect ruggedness.

Journal: Rapid communications in mass spectrometry : RCM 20030101

Title: [Drug safety. Notes about surveillance].

Journal: Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria 20030101

Title: Nefazodone poisoning: toxicokinetics and toxicodynamics using continuous data collection.

Journal: Journal of toxicology. Clinical toxicology 20030101

Title: Antidepressant-related erectile dysfunction: management via avoidance, switching antidepressants, antidotes, and adaptation.

Journal: The Journal of clinical psychiatry 20030101

Title: Piperazine-derived designer drug 1-(3-chlorophenyl)piperazine (mCPP): GC-MS studies on its metabolism and its toxicological detection in rat urine including analytical differentiation from its precursor drugs trazodone and nefazodone.

Journal: Journal of analytical toxicology 20030101

Title: A strategy for metabolite identification using triple-quadrupole mass spectrometry with enhanced resolution and accurate mass capability.

Journal: Rapid communications in mass spectrometry : RCM 20030101

Title: Effects of classic and newer antidepressants on the oxidation pathways of caffeine in rat liver. In vitro study.

Journal: Polish journal of pharmacology 20030101

Title: Continuation treatment of chronic depression: a comparison of nefazodone, cognitive behavioral analysis system of psychotherapy, and their combination.

Journal: Psychopharmacology bulletin 20030101

Title: An open pilot study of nefazodone in depression with anger attacks: relationship between clinical response and receptor binding.

Journal: Psychiatry research 20021230

Title: Three- to four-year follow-up to an open trial of nefazodone for combat-related posttraumatic stress disorder.

Journal: Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists 20021201

Title: Effects of smoked marijuana in healthy and HIV + marijuana smokers.

Journal: Journal of clinical pharmacology 20021101

Title: Nefazodone treatment of pathological gambling: a prospective open-label controlled trial.

Journal: The Journal of clinical psychiatry 20021101

Title: Effects of nefazodone on voluntary ethanol consumption induced by isolation stress in young and aged rats.

Journal: Pharmacology, biochemistry, and behavior 20021001

Title: Nefazodone alters NPY immunostaining in rat arcuate-paraventricular projection without changes in food intake and body weight.

Journal: Nutritional neuroscience 20021001

Title: Nefazodone and cyp450 3a4 interactions with cyclosporine and tacrolimus1.

Journal: Transplantation 20020915

Title: Rhabdomyolysis with simvastatin and nefazodone.

Journal: The American journal of psychiatry 20020901

Title: Reversible penile priapism associated with nefazodone.

Journal: Journal of the American Geriatrics Society 20020901

Title: [Pharmacological justification for the use of new antidepressant drugs].

Journal: Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20020901

Title: Long-term side effects of newer-generation antidepressants: SSRIS, venlafaxine, nefazodone, bupropion, and mirtazapine.

Journal: Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists 20020901

Title: Differential effects of amitriptyline, nefazodone and paroxetine on performance and brain indices of visual selective attention and working memory.

Journal: Psychopharmacology 20020801

Title: Sexual function and satisfaction in the treatment of chronic major depression with nefazodone, psychotherapy, and their combination.

Journal: The Journal of clinical psychiatry 20020801

Title: Nefazodone and liver damage.

Journal: The Harvard mental health letter 20020801

Title: [Acute liver failure in nefazodone therapy? A case report].

Journal: Der Nervenarzt 20020701

Title: Randomised controlled study of sleep after nefazodone or paroxetine treatment in out-patients with depression.

Journal: The British journal of psychiatry : the journal of mental science 20020601

Title: Differential effects of nefazodone and cognitive behavioral analysis system of psychotherapy on insomnia associated with chronic forms of major depression.

Journal: The Journal of clinical psychiatry 20020601

Title: Loratadine/nefazodone interaction.

Journal: Clinical pharmacology and therapeutics 20020501

Title: Hepatic adverse reactions associated with nefazodone.

Journal: Canadian journal of psychiatry. Revue canadienne de psychiatrie 20020501

Title: Symptomatic and syndromal anxiety in chronic forms of major depression: effect of nefazodone, cognitive behavioral analysis system of psychotherapy, and their combination.

Journal: The Journal of clinical psychiatry 20020501

Title: Nefazodone treatment of dysthymic disorder an open, long-term, prospective pilot study.

Journal: Progress in neuro-psychopharmacology & biological psychiatry 20020501

Title: Human CYP3A4 and the metabolism of nefazodone and hydroxynefazodone by human liver microsomes and heterologously expressed enzymes.

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20020401

Title: Serzone. Beware of dangerous liver problems.

Journal: Nursing 20020401

Title: From the Food and Drug Administration.

Journal: JAMA 20020306

Title: Nefazodone may increase anxiety in panic disorder.

Journal: Journal of clinical psychopharmacology 20020201

Title: Hepatotoxicity associated with the new antidepressants.

Journal: The Journal of clinical psychiatry 20020201

Title: Does psychosocial functioning improve independent of depressive symptoms? A comparison of nefazodone, psychotherapy, and their combination.

Journal: Biological psychiatry 20020115

Title: Increased premenstrual dosing of nefazodone relieves premenstrual magnification of depression.

Journal: Depression and anxiety 20020101

Title: Pharmacology of antidepressants: focus on nefazodone.

Journal: The Journal of clinical psychiatry 20020101

Title: Clinical use of nefazodone in major depression: a 6-year perspective.

Journal: The Journal of clinical psychiatry 20020101

Title: Overview of psychiatric disorders and the role of newer antidepressants.

Journal: The Journal of clinical psychiatry 20020101

Title: Six-year perspectives on the safety and tolerability of nefazodone.

Journal: The Journal of clinical psychiatry 20020101

Title: Antidepressant dosing and switching guidelines: focus on nefazodone.

Journal: The Journal of clinical psychiatry 20020101

Title: Cost savings with nefazodone in treating depression.

Journal: The Journal of clinical psychiatry 20020101

Title: Nefazodone in the treatment of elderly patients with depressive disorders: a prospective, observational study.

Journal: CNS drugs 20020101

Title: An open-label clinical trial of nefazodone in hypochondriasis.

Journal: Psychosomatics 20020101

Title: Combination therapy in the treatment of major depressive disorder complicated by fibromyalgia and menopause.

Journal: Psychosomatics 20020101

Title: Nefazodone in psychotic unipolar and bipolar depression: a retrospective chart analysis and open prospective study on its efficacy and safety versus combined treatment with amitriptyline and haloperidol.

Journal: Neuropsychobiology 20020101

Title: QTc prolongation and drugs.

Journal: Clinical pharmacology and therapeutics 20011201

Title: A probable interaction between a very low-dose oral contraceptive and the antidepressant nefazodone: a case report.

Journal: Journal of clinical psychopharmacology 20011201

Title: LC determination and purity evaluation of nefazodone HCl in bulk drug and pharmaceutical formulations.

Journal: Journal of pharmaceutical and biomedical analysis 20011101

Title: Possible interaction of zopiclone and nefazodone.

Journal: The Annals of pharmacotherapy 20011101

Title: An open-label, 12-week clinical and sleep EEG study of nefazodone in chronic combat-related posttraumatic stress disorder.

Journal: The Journal of clinical psychiatry 20011001

Title: A randomized, double-blind controlled comparison of nefazodone and paroxetine in the treatment of depression: safety, tolerability and efficacy in continuation phase treatment.

Journal: Journal of psychopharmacology (Oxford, England) 20010901

Title: Treatment of somatization disorder with nefazodone: a prospective, open-label study.

Journal: Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists 20010901

Title: Opposite effects of nefazodone in two human models of anxiety.

Journal: Psychopharmacology 20010801

Title: Nefazodone may inhibit the metabolism of carbamazepine: three case reports.

Journal: European psychiatry : the journal of the Association of European Psychiatrists 20010801

Title: Bupropion and drug-induced parkinsonism.

Journal: Canadian journal of psychiatry. Revue canadienne de psychiatrie 20010801

Title: P-glycoprotein interactions of nefazodone and trazodone in cell culture.

Journal: Journal of clinical pharmacology 20010701

Title: Remission of SSRI-induced akathisia after switch to nefazodone.

Journal: The Journal of clinical psychiatry 20010701

Title: Open trial of nefazodone for combat veterans with posttraumatic stress disorder.

Journal: Journal of traumatic stress 20010701

Title: Antidepressants and ejaculation: a double-blind, randomized, placebo-controlled, fixed-dose study with paroxetine, sertraline, and nefazodone.

Journal: Journal of clinical psychopharmacology 20010601

Title: The 'dalhousie serotonin cocktail' for treatment-resistant major depressive disorder.

Journal: Journal of psychopharmacology (Oxford, England) 20010601

Title: [The antidepressant nefazodone. Healthy sleep fosters compliance].

Journal: MMW Fortschritte der Medizin 20010528

Title: Nefazodone for chronic daily headache prophylaxis: an open-label study.

Journal: Headache 20010501

Title: Increase in plasma levels of clozapine and norclozapine after administration of nefazodone.

Journal: The Journal of clinical psychiatry 20010501

Title: Compounds with affinity for serotonergic receptors in the treatment of premenstrual dysphoria: a comparison of buspirone, nefazodone and placebo.

Journal: Psychopharmacology 20010501

Title: Effects of nefazodone on body weight: a pooled analysis of selective serotonin reuptake inhibitor- and imipramine-controlled trials.

Journal: The Journal of clinical psychiatry 20010401

Title: Quantitation of itraconazole in rat heparinized plasma by liquid chromatography-mass spectrometry.

Journal: Journal of chromatography. B, Biomedical sciences and applications 20010305

Title: Loratadine and terfenadine interaction with nefazodone: Both antihistamines are associated with QTc prolongation.

Journal: Clinical pharmacology and therapeutics 20010301

Title: Intermittent, luteal phase nefazodone treatment of premenstrual dysphoric disorder.

Journal: Journal of psychopharmacology (Oxford, England) 20010301

Title: Which depressed patients respond to nefazodone and when?

Journal: The Journal of clinical psychiatry 20010301

Title: Autonomic neurocardiac function in patients with major depression and effects of antidepressive treatment with nefazodone.

Journal: Journal of affective disorders 20010201

Title: Incidence of sexual dysfunction associated with antidepressant agents: a prospective multicenter study of 1022 outpatients. Spanish Working Group for the Study of Psychotropic-Related Sexual Dysfunction.

Journal: The Journal of clinical psychiatry 20010101

Title: The effects of antidepressants on sexual functioning in depressed patients: a review.

Journal: The Journal of clinical psychiatry 20010101

Title: Clinical significance of monitoring early symptom change to predict outcome.

Journal: The Journal of clinical psychiatry 20010101

Title: Reemergence of sexual dysfunction in patients with major depressive disorder: double-blind comparison of nefazodone and sertraline.

Journal: The Journal of clinical psychiatry 20010101

Title: Response to nefazodone in a depressed patient with end-stage renal disease.

Journal: General hospital psychiatry 20010101

Title: Acute and maintenance treatment of chronic depression.

Journal: The Journal of clinical psychiatry 20010101

Title: Open trial of nefazodone among Hispanics with major depression: efficacy, tolerability, and adherence issues.

Journal: Depression and anxiety 20010101

Title: Increased throughput in quantitative bioanalysis using parallel-column liquid chromatography with mass spectrometric detection.

Journal: Rapid communications in mass spectrometry : RCM 20010101

Title: Long-term treatment of recurrent and chronic depression.

Journal: The Journal of clinical psychiatry 20010101

Title: Pharmacokinetically induced benzodiazepine withdrawal.

Journal: Psychopharmacology bulletin 20010101

Title: [Acute liver failure ascribed to nefazodone: importance of 'postmarketing surveillance' for recently introduced drugs].

Journal: Nederlands tijdschrift voor geneeskunde 20001007

Title: Nefazodone-induced acute liver failure.

Journal: The American journal of gastroenterology 20000601

Title: Reversible nefazodone-induced liver failure.

Journal: Digestive diseases and sciences 20000501

Title: Nefazodone, meta-chlorophenylpiperazine, and their metabolites in vitro: cytochromes mediating transformation, and P450-3A4 inhibitory actions.

Journal: Psychopharmacology 19990701

Title: Nefazodone-induced liver failure: report of three cases.

Journal: Annals of internal medicine 19990216

Title: Interaction between tacrolimus and nefazodone in a stable renal transplant recipient.

Journal: Pharmacotherapy 19980101

Title: Neurotransmitter receptor and transporter binding profile of antidepressants and their metabolites.

Journal: The Journal of pharmacology and experimental therapeutics 19971201

Title: A comparison of nefazodone and fluoxetine on mood and on objective, subjective, and clinician-rated measures of sleep in depressed patients: a double-blind, 8-week clinical trial.

Journal: The Journal of clinical psychiatry 19970501

Title: Nefazodone. A review of its pharmacology and clinical efficacy in the management of major depression.

Journal: Drugs 19970401

Title: Serotonin syndrome associated with nefazodone and paroxetine.

Journal: Annals of emergency medicine 19970201

Title: Myositis and rhabdomyolysis associated with concurrent use of simvastatin and nefazodone.

Journal: JAMA 19970101

Title: Probable nefazodone-induced mania in a patient with unreported bipolar disorder.

Journal: Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists 19961201

Title: Nefazodone relief of alprazolam interdose dysphoria: a potential therapeutic benefit of 3A3/4 inhibition.

Journal: The Journal of clinical psychiatry 19960701

Title: The safety profile of nefazodone.

Journal: The Journal of clinical psychiatry 19960101

Title: Binding of antidepressants to human brain receptors: focus on newer generation compounds.

Journal: Psychopharmacology 19940501

Title: Pullar IA, et al. LY367265, an inhibitor of the 5-hydroxytryptamine transporter and 5-hydroxytryptamine(2A) receptor antagonist: a comparison with the antidepressant, nefazodone. Eur J Pharmacol. 2000;407(1-2):39-46.

Title: Ellingrod VL, et al. Nefazodone: a new antidepressant. Am J Health Syst Pharm. 1995;52(24):2799-2812.

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Tags:82752-99-6 Molecular Formula|82752-99-6 MDL|82752-99-6 SMILES|82752-99-6 1-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}-3-ethyl-4-(2-phenoxyethyl)-4,5-dihydro-1H-1,2,4-triazol-5-one hydrochloride |Heterocyclic_Building_Blocks