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82956-11-4,MFCD00941430
Catalog No.:AA003SMM

82956-11-4 | Nafamostat mesylate

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1mg
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$8.00   $6.00
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5mg
98%
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$16.00   $11.00
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10mg
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$23.00   $16.00
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50mg
95%
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$28.00   $19.00
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100mg
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$46.00   $32.00
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250mg
95%
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$69.00   $48.00
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1g
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$169.00   $118.00
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5g
98%
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$567.00   $397.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA003SMM
Chemical Name:
Nafamostat mesylate
CAS Number:
82956-11-4
Molecular Formula:
C21H25N5O8S2
Molecular Weight:
539.5819
MDL Number:
MFCD00941430
SMILES:
CS(=O)(=O)O.CS(=O)(=O)O.NC(=N)Nc1ccc(cc1)C(=O)Oc1ccc2c(c1)ccc(c2)C(=N)N
Properties
Properties
 
BP:
637.2°C at 760 mmHg  
Form:
Solid  
MP:
259-261°C  
Storage:
Keep in dry area;Room Temperature;  

Computed Properties
 
Complexity:
645  
Covalently-Bonded Unit Count:
3  
Heavy Atom Count:
36  
Hydrogen Bond Acceptor Count:
10  
Hydrogen Bond Donor Count:
6  
Rotatable Bond Count:
5  

Literature

Title: Nafamostat Mesilate as an Anticoagulant During Continuous Renal Replacement Therapy in Patients With High Bleeding Risk: A Randomized Clinical Trial.

Journal: Medicine 20151201

Title: Nafamostat mesilate attenuates neuronal damage in a rat model of transient focal cerebral ischemia through thrombin inhibition.

Journal: Scientific reports 20140101

Title: Nafamostat mesilate, a noncalcium compound, as an anticoagulant, induces calcium-dependent haemolysis when infused with packed erythrocytes.

Journal: Transfusion medicine (Oxford, England) 20120601

Title: [Could nafamostat or gabexate prevent the post endoscopic retrograde cholangiopancreatography pancreatitis?].

Journal: The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi 20120301

Title: Serine protease inhibition reduces post-ischemic granulocyte recruitment in mouse intestine.

Journal: The American journal of pathology 20120101

Title: The role of nafamostat mesylate in continuous renal replacement therapy among patients at high risk of bleeding.

Journal: Renal failure 20120101

Title: Protease activity increases in plasma, peritoneal fluid, and vital organs after hemorrhagic shock in rats.

Journal: PloS one 20120101

Title: Nafamostat mesylate, a serine protease inhibitor, demonstrates novel antimicrobial properties and effectiveness in Chlamydia-induced arthritis.

Journal: Arthritis research & therapy 20120101

Title: Breakdown of mucin as barrier to digestive enzymes in the ischemic rat small intestine.

Journal: PloS one 20120101

Title: Nafamostat mesilate, a potent tryptase inhibitor, modulates periodontitis in rats.

Journal: Clinical oral investigations 20111201

Title: Is high-dose nafamostat mesilate effective for the prevention of post-ERCP pancreatitis, especially in high-risk patients?

Journal: Pancreas 20111101

Title: The pharmacological profile of brain liver intestine Na+ channel: inhibition by diarylamidines and activation by fenamates.

Journal: Molecular pharmacology 20111101

Title: Nafamostat mesilate can prevent adhesion, invasion and peritoneal dissemination of pancreatic cancer thorough nuclear factor kappa-B inhibition.

Journal: Journal of hepato-biliary-pancreatic sciences 20110901

Title: Effect of various anticoagulant agents on large-volume leukocytapheresis using new Cellsorba CS-180S Filter.

Journal: Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy 20110801

Title: Combination treatment using adenovirus vector-mediated tumor necrosis factor-alpha gene transfer and a NF-κB inhibitor for pancreatic cancer in mice.

Journal: Cancer letters 20110701

Title: Use of nafamostat mesilate as an anticoagulant during extracorporeal membrane oxygenation.

Journal: Journal of Korean medical science 20110701

Title: Nafamostat mesilate as an anticoagulant during continuous veno-venous hemodialysis: a three-year retrospective cohort study.

Journal: The International journal of artificial organs 20110701

Title: RNA interference inhibits high mobility group box 1 by lipopolysaccharide-activated murine macrophage RAW 264.7 secretion.

Journal: The Journal of surgical research 20110615

Title: Combination paclitaxel and inhibitor of nuclear factor κB activation improves therapeutic outcome for model mice with peritoneal dissemination of pancreatic cancer.

Journal: Pancreas 20110501

Title: Nafamostat mesilate attenuates Postreperfusion Syndrome during liver transplantation.

Journal: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20110501

Title: Nafamostat mesilate attenuates colonic inflammation and mast cell infiltration in the experimental colitis.

Journal: International immunopharmacology 20110401

Title: Nafamostat mesilate for prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis: a prospective, randomized, double-blind, controlled trial.

Journal: Pancreas 20110301

Title: [Synthetic protease inhibitors for the treatment of DIC].

Journal: Rinsho byori. The Japanese journal of clinical pathology 20110201

Title: Protease inhibitor nafamostat mesilate attenuates complement activation and improves function of xenografts in a discordant lung perfusion model.

Journal: Xenotransplantation 20110101

Title: Human eosinophils exert TNF-α and granzyme A-mediated tumoricidal activity toward colon carcinoma cells.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20101215

Title: The proteinase/proteinase-activated receptor-2/transient receptor potential vanilloid-1 cascade impacts pancreatic pain in mice.

Journal: Life sciences 20101120

Title: Anti-tumor effect by inhibition of NF-kappaB activation using nafamostat mesilate for pancreatic cancer in a mouse model.

Journal: Oncology reports 20101001

Title: The results of severe acute pancreatitis treatment with continuous regional arterial infusion of protease inhibitor and antibiotic: a randomized controlled study.

Journal: Pancreas 20100801

Title: Pretreatment with nafamostat mesilate, a kallikrein inhibitor, to decrease withdrawal response associated with rocuronium.

Journal: Journal of anesthesia 20100801

Title: Refractory chronic urticaria treated effectively with the protease inhibitors, nafamostat mesilate and camostat mesilate.

Journal: Acta dermato-venereologica 20100701

Title: Inhibition of intraluminal pancreatic enzymes with nafamostat mesilate improves clinical outcomes after hemorrhagic shock in swine.

Journal: The Journal of trauma 20100501

Title: Nafamostat mesilate is not appropriate as an anticoagulant during continuous renal replacement therapy in dogs.

Journal: The Journal of veterinary medical science 20100301

Title: Serine protease inhibitor attenuates intracerebral hemorrhage-induced brain injury and edema formation in rat.

Journal: Acta neurochirurgica. Supplement 20100101

Title: [Treatment of disseminated intravascular coagulation].

Journal: [Rinsho ketsueki] The Japanese journal of clinical hematology 20100101

Title: Anticoagulation in acute blood purification for acute renal failure in critical care.

Journal: Contributions to nephrology 20100101

Title: The modulation of TRPM7 currents by nafamostat mesilate depends directly upon extracellular concentrations of divalent cations.

Journal: Molecular brain 20100101

Title: Biological effect of anaphylatoxin C5a on the generation of anti-inflammatory substances in leukocyte adsorption.

Journal: Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy 20091201

Title: Effects of nafamostat mesilate on coagulopathy with chronic aortic dissection.

Journal: The Annals of thoracic surgery 20091001

Title: The complement inhibitor FUT-175 suppresses T cell autoreactivity in experimental autoimmune encephalomyelitis.

Journal: The American journal of pathology 20090801

Title: Combination chemotherapy of nafamostat mesilate with gemcitabine for pancreatic cancer targeting NF-kappaB activation.

Journal: Anticancer research 20090801

Title: Brugada-like electrocardiographic pattern due to hyperkalemia.

Journal: Clinical cardiology 20090701

Title: Effect of low-molecular weight trypsin inhibitor, nafamostat mesilate, on trypsin activity using the pancreatic acinar cells.

Journal: Pancreas 20090701

Title: Nafamostat mesylate in the prevention of post-ERCP pancreatitis and risk factors for post-ERCP pancreatitis.

Journal: Gastrointestinal endoscopy 20090401

Title: Refractory kaposiform hemangioendothelioma that expressed vascular endothelial growth factor receptor (VEGFR)-2 and VEGFR-3: a case report.

Journal: Journal of pediatric hematology/oncology 20090301

Title: Involvement of Tryptase and Proteinase-Activated Receptor-2 in Spontaneous Itch-Associated Response in Mice With Atopy-like Dermatitis.

Journal: Journal of pharmacological sciences 20090301

Title: A phase I study of full-dose gemcitabine and regional arterial infusion of nafamostat mesilate for advanced pancreatic cancer.

Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20090201

Title: Mast cells reduce survival of myenteric neurons in culture.

Journal: Neuropharmacology 20090201

Title: The new strategy of liver transplantation from marginal donors using serine protease inhibitor.

Journal: Transplantation proceedings 20090101

Title: Utility of the new Japanese severity score and indications for special therapies in acute pancreatitis.

Journal: Journal of gastroenterology 20090101

Title: Successful treatment of Kasabach-Merritt syndrome with vincristine and diagnosis of the hemangioma using three-dimensional imaging.

Journal: Pediatric hematology and oncology 20090101

Title: Superior outcome of nafamostat mesilate as an anticoagulant in patients undergoing maintenance hemodialysis with intracerebral hemorrhage.

Journal: Renal failure 20090101

Title: Nafamostat prevents hypothermia and improves survival time after administration of lipopolysaccharide in a mouse surgical model.

Journal: Journal of anesthesia 20090101

Title: The mannose-binding lectin pathway is a significant contributor to reperfusion injury in the type 2 diabetic heart.

Journal: Diabetes & vascular disease research 20090101

Title: Complement inhibitor prevents disruption of sodium channel clusters in a rabbit model of Guillain-Barré syndrome.

Journal: Journal of neuroimmunology 20081215

Title: Structure of human prostasin, a target for the regulation of hypertension.

Journal: The Journal of biological chemistry 20081212

Title: An in vivo approach for globally estimating the drug flow between blood and tissue for nafamostat mesilate: the main hydrolysis site determination in human.

Journal: Biological & pharmaceutical bulletin 20081101

Title: Nafamostat mesilate, a potent serine protease inhibitor, inhibits airway eosinophilic inflammation and airway epithelial remodeling in a murine model of allergic asthma.

Journal: Journal of pharmacological sciences 20081101

Title: Management of uremic patients with heparin-induced thrombocytopenia requiring hemodialysis.

Journal: Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis 20081001

Title: Serine protease inhibitor nafamostat given before reperfusion reduces inflammatory myocardial injury by complement and neutrophil inhibition.

Journal: Journal of cardiovascular pharmacology 20080801

Title: A method for quantifying the unstable and highly polar drug nafamostat mesilate in human plasma with optimized solid-phase extraction and ESI-MS detection: more accurate evaluation for pharmacokinetic study.

Journal: Analytical and bioanalytical chemistry 20080601

Title: Tryptase activates TGFbeta in human airway smooth muscle cells via direct proteolysis.

Journal: Biochemical and biophysical research communications 20080530

Title: Effects of nafamostat mesilate on the prevention of cerulein-induced acute pancreatitis.

Journal: Pancreas 20080401

Title: Complement inhibition reduces injury in the type 2 diabetic heart following ischemia and reperfusion.

Journal: American journal of physiology. Heart and circulatory physiology 20080301

Title: Dramatic improvement of subcutaneous insulin resistance with nafamostat ointment treatment.

Journal: Diabetes care 20080301

Title: Characteristics of gabexate mesilate-induced cell injury in porcine aorta endothelial cells.

Journal: Journal of pharmacological sciences 20080301

Title: Effects of direct haemoperfusion through fibres immobilizing polymyxin B and nafamostat mesilate on endotoxaemia in conscious Guinea-pigs.

Journal: Clinical and experimental pharmacology & physiology 20080101

Title: Pancreaticoduodenectomy for bile duct carcinoma of a patient undergoing hemodialysis.

Journal: Hepato-gastroenterology 20080101

Title: A sudden onset of diabetic ketoacidosis and acute pancreatitis after introduction of mizoribine therapy in a patient with rheumatoid arthritis.

Journal: Modern rheumatology 20080101

Title: Antitumor effects of Nafamostat mesilate on head and neck squamous cell carcinoma.

Journal: Auris, nasus, larynx 20071201

Title: Nafamostat mesilate reversibly blocks acid-sensing ion channel currents.

Journal: Biochemical and biophysical research communications 20071109

Title: Continuous renal replacement therapy: a worldwide practice survey. The beginning and ending supportive therapy for the kidney (B.E.S.T. kidney) investigators.

Journal: Intensive care medicine 20070901

Title: Treatment strategy against infection: clinical outcome of continuous regional arterial infusion, enteral nutrition, and surgery in severe acute pancreatitis.

Journal: Journal of gastroenterology 20070801

Title: Cardiopulmonary bypass using nafamostat mesilate for patients with infective endocarditis and recent intracranial hemorrhage.

Journal: Interactive cardiovascular and thoracic surgery 20070601

Title: [Uremic pericarditis].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20070528

Title: Mechanisms of synthetic serine protease inhibitor (FUT-175)-mediated cell death.

Journal: Cancer 20070515

Title: Nafamostat mesilate inhibits high-mobility group box 1 by lipopolysaccharide stimulation in murine macrophage RAW 264.7.

Journal: Shock (Augusta, Ga.) 20070401

Title: Nafamostat is hydrolysed by human liver cytosolic long-chain acyl-CoA hydrolase.

Journal: Xenobiotica; the fate of foreign compounds in biological systems 20070301

Title: Low-volume continuous hemodiafiltration with nafamostat mesilate increases trypsin clearance without decreasing plasma trypsin concentration in severe acute pancreatitis.

Journal: ASAIO journal (American Society for Artificial Internal Organs : 1992) 20070101

Title: Nafamostat mesilate inhibits the expression of HMGB1 in lipopolysaccharide-induced acute lung injury.

Journal: Journal of anesthesia 20070101

Title: Aprotinin and nafamostat mesilate in liver surgery: effect on blood loss.

Journal: Digestive surgery 20070101

Title: Selection of anticoagulants for leukocytapheresis therapy in cases of active ulcerative colitis.

Journal: Blood purification 20070101

Title: Helicobacter pylori activates gastric epithelial cells to produce interleukin-8 via protease-activated receptor 2.

Journal: Digestion 20070101

Title: Protective effects of nafamostat mesilate on liver injury induced by lipopolysaccharide in rats: possible involvement of CD14 and TLR-4 downregulation on Kupffer cells.

Journal: Digestive diseases and sciences 20061101

Title: Anti-tryptase treatment using nafamostat mesilate has a therapeutic effect on experimental colitis.

Journal: Scandinavian journal of gastroenterology 20060801

Title: Serine protease inhibitors nafamostat mesilate and gabexate mesilate attenuate allergen-induced airway inflammation and eosinophilia in a murine model of asthma.

Journal: The Journal of allergy and clinical immunology 20060701

Title: [Prostasin].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20060701

Title: Properties of poly(lactic-co-glycolic acid) nanospheres containing protease inhibitors: camostat mesilate and nafamostat mesilate.

Journal: International journal of pharmaceutics 20060511

Title: Complement activation is involved in biological responses to leukocyte adsorptive apheresis.

Journal: Digestive diseases and sciences 20060501

Title: [Postoperative acute pulmonary thromboembolism treated with nafamostat mesilate].

Journal: Masui. The Japanese journal of anesthesiology 20060501

Title: Human complement-activating immunoglobulin (Ig)G3 antibodies are essential for porcine endothelial cell activation.

Journal: Xenotransplantation 20060501

Title: Nafamostat attenuated the impairment of fibrinolysis in animal sepsis model by suppressing the increase of plasminogen activator inhibitor type 1.

Journal: The Journal of trauma 20060401

Title: Involvement of human blood arylesterases and liver microsomal carboxylesterases in nafamostat hydrolysis.

Journal: Drug metabolism and pharmacokinetics 20060401

Title: Leukocytapheresis for ulcerative colitis: a comparative study of anticoagulant (nafamostat mesilate vs. dalteparin sodium) for reducing clinical complications.

Journal: Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy 20060201

Title: Potent pruritogenic action of tryptase mediated by PAR-2 receptor and its involvement in anti-pruritic effect of nafamostat mesilate in mice.

Journal: European journal of pharmacology 20060113

Title: Myeloperoxidase as a marker of hemodialysis biocompatibility and oxidative stress: the underestimated modifying effects of heparin.

Journal: American journal of kidney diseases : the official journal of the National Kidney Foundation 20060101

Title: [Quality of life in surgical treatment of pancreatic cancer].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20060101

Title: The role of a protease inhibitor against hepatectomy.

Journal: Hepato-gastroenterology 20060101

Title: Effects of nafamostat mesilate on ADP-induced platelet aggregation and disaggregation in hemodialysis patients.

Journal: ASAIO journal (American Society for Artificial Internal Organs : 1992) 20060101

Title: Involvement of neutrophil recruitment and protease-activated receptor 2 activation in the induction of IL-18 in mice.

Journal: Journal of leukocyte biology 20051101

Title: Effect of intraportal infusion to improve small for size graft injury in living donor adult liver transplantation.

Journal: Transplant international : official journal of the European Society for Organ Transplantation 20050801

Title: Nafamostat mesilate induces production of interleukin-12 and -18 in human peripheral blood mononuclear cells.

Journal: Journal of pharmacological sciences 20050801

Title: Mast cell tryptase stimulates DLD-1 carcinoma through prostaglandin- and MAP kinase-dependent manners.

Journal: Journal of pharmacological sciences 20050801

Title: Small volume resuscitation with hypertonic saline is more effective in ameliorating trauma-hemorrhagic shock-induced lung injury, neutrophil activation and red blood cell dysfunction than pancreatitic protease inhibition.

Journal: The Journal of trauma 20050801

Title: Open heart surgery in a patient with paroxysmal nocturnal hemoglobinuria.

Journal: The Japanese journal of thoracic and cardiovascular surgery : official publication of the Japanese Association for Thoracic Surgery = Nihon Kyobu Geka Gakkai zasshi 20050601

Title: Rat experimental model of continuous regional arterial infusion of protease inhibitor and its effects on severe acute pancreatitis.

Journal: Pancreas 20050401

Title: Correlation between serum nafamostat mesilate and activated coagulation time during continuous hemodiafiltration.

Journal: Artificial organs 20050401

Title: Nafamostat preserves neutrophil deformability and reduces microaggregate formation during simulated extracorporeal circulation.

Journal: The Annals of thoracic surgery 20050401

Title: [A patient with Vibrio vulnificus meningoencephalitis].

Journal: Rinsho shinkeigaku = Clinical neurology 20050101

Title: A case of heparin-induced thrombocytopenia with sepsis and congestive heart failure--first autopsy report on Japan--.

Journal: Circulation journal : official journal of the Japanese Circulation Society 20041201

Title: A serine protease inhibitor, nafamostat mesilate, suppresses aldosterone secretions in vivo.

Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20041201

Title: Pancreatic proteases and inflammatory mediators in peritoneal fluid during splanchnic arterial occlusion and reperfusion.

Journal: Shock (Augusta, Ga.) 20041101

Title: [Treatment of acute pancreatitis with protease inhibitor, H2 receptor antagonist and somatostatin analogue].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20041101

Title: [Continuous regional arterial infusion of protease inhibitor and antibiotic for severe acute pancreatitis].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20041101

Title: [Role of pancreatic enzymes in gut injury secondary to trauma/hemorrhagic shock in rats].

Journal: Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA 20041001

Title: Continuous hemodiafiltration in pediatric critical care patients.

Journal: Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy 20041001

Title: Advanced glycation end products induce secretion of chemokines and apoptosis in human first trimester trophoblasts.

Journal: Human reproduction (Oxford, England) 20040901

Title: Intraoperative management of a congenital antithrombin deficient patient on chronic hemodialysis.

Journal: Thrombosis and haemostasis 20040701

Title: [Blood purification for patients with chronic renal failure accompanied by severe liver disease].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20040601

Title: [Treatment of uremic patients with high bleeding risk].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20040601

Title: [Heparin-induced thrombocytopenia in patients on hemodialysis].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20040601

Title: [Pregnancy and delivery in patients with hemodialysis].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20040601

Title: Effects of anti-inflammatory cytokine agent (FR167653) and serine protease inhibitor on warm ischemia-reperfusion injury of the liver graft.

Journal: Transplantation 20040527

Title: Efficacy of continuous regional arterial infusion of a protease inhibitor and antibiotic for severe acute pancreatitis in patients admitted to an intensive care unit.

Journal: Pancreas 20040501

Title: [Changes in coagulation, fibrinolysis and platelet functions during extracorporeal circulation].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20040501

Title: [How to use anticoagulants in hemodialysis therapy].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20040501

Title: [Anticoagulation for plasmapheresis].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20040501

Title: [Anticoagulant].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20040501

Title: [Fulminant myocarditis treated with percutaneous cardiopulmonary support and long-term complications: three case reports].

Journal: Journal of cardiology 20040401

Title: Inhibition of enteral enzymes by enteroclysis with nafamostat mesilate reduces neutrophil activation and transfusion requirements after hemorrhagic shock.

Journal: The Journal of trauma 20040301

Title: Transporter-mediated renal handling of nafamostat mesilate.

Journal: Journal of pharmaceutical sciences 20040201

Title: Effects of nafamostat mesilate and minimal-dose aprotinin on blood-foreign surface interactions in cardiopulmonary bypass.

Journal: The Annals of thoracic surgery 20040201

Title: Detection of specific IgE antibodies to nafamostat mesilate as an indication of possible adverse effects of leukocytapheresis using nafamostat mesilate as anticoagulant.

Journal: Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy 20040201

Title: IL-15 levels in patients with acute hepatic failure.

Journal: Research communications in molecular pathology and pharmacology 20040101

Title: Pharmacokinetics of nafamostat mesilate during continuous hemodiafiltration with a polyacrylonitrile membrane.

Journal: Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy 20031001

Title: Nafamostat mesilate suppresses NF-kappaB activation and NO overproduction in LPS-treated macrophages.

Journal: International immunopharmacology 20030901

Title: Involvement of proteinase-activated receptor-2 in mast cell tryptase-induced barrier dysfunction in bovine aortic endothelial cells.

Journal: Cellular signalling 20030801

Title: Nafamostat mesilate is an extremely potent inhibitor of human tryptase.

Journal: Journal of pharmacological sciences 20030801

Title: Combined treatment with nafamostat mesilate and aspirin prevents heparin-induced thrombocytopenia in a hemodialysis patient.

Journal: Clinical nephrology 20030601

Title: Successful adult ABO-incompatible liver transplantation: therapeutic strategy for thrombotic microangiopathy is the key to success.

Journal: Transplantation 20030515

Title: Serine proteases are involved in the pathogenesis of trauma-hemorrhagic shock-induced gut and lung injury.

Journal: Shock (Augusta, Ga.) 20030501

Title: Influence of heparin dosage on hemostasis under combined use of Nafamostat mesilate during deep hypothermic circulatory arrest.

Journal: The Japanese journal of thoracic and cardiovascular surgery : official publication of the Japanese Association for Thoracic Surgery = Nihon Kyobu Geka Gakkai zasshi 20030501

Title: Changes in blood viscosity with synthetic protease inhibitors.

Journal: Journal of pharmacological sciences 20030401

Title: A potent tryptase inhibitor nafamostat mesilate dramatically suppressed pulmonary dysfunction induced in rats by a radiographic contrast medium.

Journal: British journal of pharmacology 20030301

Title: Inhibition of prostasin secretion by serine protease inhibitors in the kidney.

Journal: Journal of the American Society of Nephrology : JASN 20030101

Title: In vitro relationship between the blood nafamostat concentration and activated coagulation time.

Journal: Canadian journal of anaesthesia = Journal canadien d'anesthesie 20030101

Title: Severe abdominal pain associated with allergic reaction to nafamostat mesilate in a chronic hemodialysis patient.

Journal: Internal medicine (Tokyo, Japan) 20021001

Title: Extracorporeal membrane oxygenation with nafamostat mesilate as an anticoagulant for massive pulmonary hemorrhage after living-donor lobar lung transplantation.

Journal: The Journal of thoracic and cardiovascular surgery 20020901

Title: [A case with severe acute pancreatitis treated by regional arterial infusion of nafamostat mesilate and imipenem via both celiac artery and superior mesenteric artery].

Journal: Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology 20020901

Title: Two-dimensional analysis of myocardial protein expression following myocardial ischemia and reperfusion in rabbits.

Journal: Proteomics 20020801

Title: [Management of intraoperative anticoagulantless CHD with EVAL-dialyzer in four patients on maintenance hemodialysis].

Journal: Masui. The Japanese journal of anesthesiology 20020301

Title: Case of a bleeding pseudoaneurysm of the middle colic artery complicating acute pancreatitis.

Journal: Hepato-gastroenterology 20020101

Title: Inhibition of natural killer cytotoxicity in vitro by clinical grade serine protease inhibitors.

Journal: Haematologia 20020101

Title: Induction of IkappaB-kinase by cholecystokinin is mediated by trypsinogen activation in rat pancreatic lobules.

Journal: Digestion 20020101

Title: [A case of pancreatic ascites due to rupture of pancreatic pseudocyst successfully treated with continuous arterial infusion of nafamostat mesilate].

Journal: Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology 20011101

Title: Can nafamostat mesilate be used for temporary management of hemodialysis in a patient with heparin-induced thrombocytopenia (HIT)?

Journal: Thrombosis and haemostasis 20011001

Title: [Molecular specificity of nafamostat mesilate (FUT), a drug used for the treatments of DIC and acute pancreatitis and as an anticoagulant--the pharmacodynamics and pharmacological action].

Journal: Gan to kagaku ryoho. Cancer & chemotherapy 20010901

Title: Granulomatous tubulointerstitial nephritis induced by all-trans retinoic acid.

Journal: Anti-cancer drugs 20010901

Title: Regional effects of nafamostat, a novel potent protease and complement inhibitor, on severe necrotizing pancreatitis.

Journal: Surgery 20010801

Title: [Anti-bleeding effect of nafamostat mesilate for the surgery of thoracic ascending aorta].

Journal: Kyobu geka. The Japanese journal of thoracic surgery 20010801

Title: Successful treatment of severe acute pancreatitis by the combination therapy of continuous arterial infusion of a protease inhibitor and continuous hemofiltration.

Journal: Journal of gastroenterology and hepatology 20010801

Title: Broad-spectrum and selective serine protease inhibitors prevent expression of platelet-derived growth factor-BB and cerebral vasospasm after subarachnoid hemorrhage: vasospasm caused by cisternal injection of recombinant platelet-derived growth factor-BB.

Journal: Stroke 20010701

Title: The efficacy of nafamostat mesilate on the performance of a hybrid-artificial liver using a polyurethane foam/porcine hepatocyte spheroid culture system in human plasma.

Journal: The International journal of artificial organs 20010101

Title: Attenuation of hepatic ischemia and reperfusion injury by serine protease inhibitor, FUT-175, in dogs.

Journal: Transplantation proceedings 20010101

Title: Site-specific therapeutic effects of protease inhibitors: effect of route of administration in experimental pancreatitis.

Journal: Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 20010101

Title: Continuous regional application of protease inhibitor in the treatment of acute pancreatitis. An experimental study using closed duodenal obstruction model in dogs.

Journal: Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 20010101

Title: Benefit of continuous regional arterial infusion of protease inhibitor and antibiotic in the management of acute necrotizing pancreatitis.

Journal: Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 20010101

Title: A potential mechanism of propofol-induced pain on injection based on studies using nafamostat mesilate.

Journal: British journal of anaesthesia 19990901

Title: Nafamostat mesilate, a kallikrein inhibitor, prevents pain on injection with propofol.

Journal: British journal of anaesthesia 19981201

Title: Mechanisms of the hyperkalaemia caused by nafamostat mesilate: effects of its two metabolites on Na+ and K+ transport properties in the rabbit cortical collecting duct.

Journal: British journal of pharmacology 19940101

Title: Successful treatment of levodopa-induced neuroleptic malignant syndrome (NMS) and disseminated intravascular coagulation (DIC) in a patient with Parkinson's disease.

Journal: Internal medicine (Tokyo, Japan) 19921101

Title: [Successful treatment of levodopa-induced neuroleptic malignant syndrome (NMS) with disseminated intravascular coagulation (DIC) in a patient with Parkinson's disease].

Journal: Rinsho shinkeigaku = Clinical neurology 19910101

Title: Ikehara S, et al. Effect of FUT-175, a new synthetic protease inhibitor, on the development of lupus nephritis in (NZB x NZW) F1 mice. Immunology. 1985 Aug;55(4):595-600.

Title: Homma S, et al. Nafamostat mesilate, a serine protease inhibitor, suppresses interferon-gamma-induced up-regulation of programmed cell death ligand 1 in human cancer cells. Int Immunopharmacol. 2018 Jan;54:39-45.

Title: Pak K, et al. Effectiveness of FUT-175, protease inhibitor, as an anticoagulant to hemodialysis. Hinyokika Kiyo. 1988 Jun;34(6):1077-81.

Title: Markus Hoffmann, et al. Nafamostat Mesylate Blocks Activation of SARS-CoV-2: New Treatment Option for COVID-19. Antimicrob Agents Chemother. 2020 Jun; 64(6): e00754-20.

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