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84283-08-9,MFCD01863374
Catalog No.:AA004TFS

84283-08-9 | N-(2'-Deoxyguanosin-8-yl)-4-Aminobiphenyl

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  • Technical Information
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Technical Information
Catalog Number:
AA004TFS
Chemical Name:
N-(2'-Deoxyguanosin-8-yl)-4-Aminobiphenyl
CAS Number:
84283-08-9
Molecular Formula:
C22H22N6O4
Molecular Weight:
434.4479
MDL Number:
MFCD01863374
SMILES:
OC[C@H]1O[C@H](C[C@@H]1O)n1c(Nc2ccc(cc2)c2ccccc2)nc2c1[nH]c(N)nc2=O
Properties
Properties
 
MP:
>193°C (dec.)  
Storage:
-20 ℃;  

Computed Properties
 
Complexity:
709  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
3  
Heavy Atom Count:
32  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
5  
Rotatable Bond Count:
5  
XLogP3:
1.7  

Literature

Title: Identification of an unintended consequence of Nrf2-directed cytoprotection against a key tobacco carcinogen plus a counteracting chemopreventive intervention.

Journal: Cancer research 20110601

Title: White blood cell DNA adducts in a cohort of asthmatic children exposed to environmental tobacco smoke.

Journal: International archives of occupational and environmental health 20110101

Title: Identification of carcinogen DNA adducts in human saliva by linear quadrupole ion trap/multistage tandem mass spectrometry.

Journal: Chemical research in toxicology 20100719

Title: Formation and repair of tobacco carcinogen-derived bulky DNA adducts.

Journal: Journal of nucleic acids 20100101

Title: Differences between human slow N-acetyltransferase 2 alleles in levels of 4-aminobiphenyl-induced DNA adducts and mutations.

Journal: Mutation research 20091201

Title: Hydroxyl-specific fluorescence labeling of ABP-deoxyguanosine, PhIP-deoxyguanosine, and AFB1-formamidopyrimidine with BODIPY-FL.

Journal: Analytical biochemistry 20061215

Title: Quantification of N-(deoxyguanosin-8-yl)-4-aminobiphenyl adducts in human lymphoblastoid TK6 cells dosed with N-hydroxy-4-acetylaminobiphenyl and their relationship to mutation, toxicity, and gene expression profiling.

Journal: Analytical chemistry 20060915

Title: Detection and quantification of N-(deoxyguanosin-8-yl)-4-aminobiphenyl adducts in human pancreas tissue using capillary liquid chromatography-microelectrospray mass spectrometry.

Journal: Chemical research in toxicology 20050401

Title: Synthesis, characterization, and 32P-postlabeling of N-(deoxyguanosin)-4-aminobiphenyl 3'-phosphate adducts.

Journal: Chemical research in toxicology 20040601

Title: Identification of new DNA adducts in human bladder epithelia exposed to the proximate metabolite of 4-aminobiphenyl using 32P-postlabeling method.

Journal: Chemico-biological interactions 20020220

Title: Human urinary bladder epithelial cells lacking wild-type p53 function are deficient in the repair of 4-aminobiphenyl-DNA adducts in genomic DNA.

Journal: Mutation research 20020129

Title: Identification of N-(deoxyguanosin-8-yl)-4-azobiphenyl by (32)P-postlabeling analyses of DNA in human uroepithelial cells exposed to proximate metabolites of the environmental carcinogen 4-aminobiphenyl.

Journal: Environmental and molecular mutagenesis 20020101

Title: Synthesis and characterization of nucleoside derivatives, n-(benzoyl)-n-(deoxyguanosin-8-yl)4-aminobiphenyl and n-(2'-deoxyguanosin-8-yl)4-aminobiphenyl via alpha-phenyl-n-(4-biphenyl)nitrone.

Journal: Nucleosides, nucleotides & nucleic acids 20020101

Title: Role of TP53 in repair of N-(deoxyguanosin-8-yl)-4-aminobiphenyl adducts in human transitional cell carcinoma of the urinary bladder.

Journal: Carcinogenesis 20010101

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Tags:84283-08-9 Molecular Formula|84283-08-9 MDL|84283-08-9 SMILES|84283-08-9 N-(2'-Deoxyguanosin-8-yl)-4-Aminobiphenyl