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Home Carboxes 845256-59-9
845256-59-9,MFCD28016248
Catalog No.:AA008HSZ

845256-59-9 | Benzyl 3-fluoro-4-oxopiperidine-1-carboxylate

Pack Size
Purity
Availability
Price(USD)
Quantity
  
250mg
96%
in stock  
$15.00   $11.00
- +
1g
96%
in stock  
$25.00   $18.00
- +
5g
96%
in stock  
$102.00   $71.00
- +
25g
96%
in stock  
$497.00   $348.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA008HSZ
Chemical Name:
Benzyl 3-fluoro-4-oxopiperidine-1-carboxylate
CAS Number:
845256-59-9
Molecular Formula:
C13H14FNO3
Molecular Weight:
251.2536
MDL Number:
MFCD28016248
SMILES:
O=C1CCN(CC1F)C(=O)OCc1ccccc1
Properties
Computed Properties
 
Complexity:
315  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
18  
Hydrogen Bond Acceptor Count:
4  
Rotatable Bond Count:
3  
Undefined Atom Stereocenter Count:
1  
XLogP3:
1.6  

Downstream Synthesis Route
845256-59-9    74-89-5   
cis-3-fluoro-4-methylaminopiperidine-1-carboxylicacidbenzylester 

[1]CurrentPatentAssignee:MERCK&COINC-US2005/38074,2005,A1Locationinpatent:Page/Pagecolumn31

[2]CurrentPatentAssignee:ASTELLASPHARMAINC.-WO2012/66077,2012,A1Locationinpatent:Page/Pagecolumn22

[3]CurrentPatentAssignee:ASTELLASPHARMAINC.-WO2013/26587,2013,A1Locationinpatent:Page/Pagecolumn24

[4]CurrentPatentAssignee:MERCK&COINC-WO2006/101780,2006,A1Locationinpatent:Page/Pagecolumn75-76

845256-59-9    74-89-5   
cis-3-fluoro-4-methylaminopiperidine-1-carboxylicacidbenzylester 
 
cis-3-fluoro-4-methylaminopiperidine-1-carboxylicacidbenzylester 

[1]CurrentPatentAssignee:MERCK&COINC-US2005/38074,2005,A1Locationinpatent:Page/Pagecolumn30

[2]CurrentPatentAssignee:MERCK&COINC-WO2006/101780,2006,A1Locationinpatent:Page/Pagecolumn73

[1]Locationinpatent:schemeortableLiu,Jack;Chan,Johann;Bryant,CraigM.;Duspara,PetarA.;Lee,ErnestE.;Powell,David;Yang,Hua;Liu,Ziping;Walpole,Chris;Roberts,Edward;Batey,RobertA.[TetrahedronLetters,2012,vol.53,#24,p.2971-2975]

[2]CurrentPatentAssignee:MERCK&COINC-US2005/38074,2005,A1Locationinpatent:Page/Pagecolumn30

[3]CurrentPatentAssignee:MERCK&COINC-US2005/38074,2005,A1Locationinpatent:Page/Pagecolumn30;31

[4]CurrentPatentAssignee:MERCK&COINC-WO2005/102996,2005,A2Locationinpatent:Page/Pagecolumn28

[5]CurrentPatentAssignee:MERCK&COINC-WO2005/102996,2005,A2Locationinpatent:Page/Pagecolumn30

[6]Fujimoto,Tatsuhiko;Tomata,Yoshihide;Kunitomo,Jun;Hirozane,Mariko;Marui,Shogo[BioorganicandMedicinalChemistryLetters,2011,vol.21,#21,p.6409-6413]

[7]CurrentPatentAssignee:VTVTHERAPEUTICSINC.-WO2011/103091,2011,A1

[8]CurrentPatentAssignee:ASTELLASPHARMAINC.-WO2012/66077,2012,A1

[9]Liu,Jack;Chan,Johann;Bryant,CraigM.;Duspara,PetarA.;Lee,ErnestE.;Powell,David;Yang,Hua;Liu,Ziping;Walpole,Chris;Roberts,Edward;Batey,RobertA.[TetrahedronLetters,2012,vol.53,#24,p.2971-2975]

[10]Locationinpatent:bodytextWalpole,Chris;Liu,Ziping;Lee,ErnestE.;Yang,Hua;Zhou,Fei;MacKintosh,Nicole;Sjogren,Magnus;Taylor,David;Shen,Jinyu;Batey,RobertA.[TetrahedronLetters,2012,vol.53,#24,p.2942-2947]

[11]CurrentPatentAssignee:ASTELLASPHARMAINC.-WO2013/26587,2013,A1Locationinpatent:Page/Pagecolumn22-23

[12]CurrentPatentAssignee:GLAXOSMITHKLINEPLC-WO2013/177253,2013,A2

[13]CurrentPatentAssignee:GLAXOSMITHKLINEPLC-WO2014/8223,2014,A2

[14]CurrentPatentAssignee:BRISTOL-MYERSSQUIBBCO-WO2014/78609,2014,A1

[15]CurrentPatentAssignee:MERCK&COINC-WO2014/194519,2014,A1

[16]CurrentPatentAssignee:MERCK&COINC-WO2014/197345,2014,A2

[17]CurrentPatentAssignee:BRISTOL-MYERSSQUIBBCO-US9133163,2015,B2

[18]CurrentPatentAssignee:MERCK&COINC-WO2016/127358,2016,A1

[19]CurrentPatentAssignee:MERCK&COINC-US2017/183342,2017,A1CurrentPatentAssignee:MERCK&COINC-WO2018/118734,2018,A1CurrentPatentAssignee:MERCK&COINC;WUXIAPPTECCO.,LTD.-WO2018/118736,2018,A1

[20]Shi,Jun;Gu,Zhengxiang;Jurica,ElizabethAnne;Wu,Ximao;Haque,LaurenE.;Williams,KristinN.;Hernandez,AndresS.;Hong,Zhenqiu;Gao,Qi;Dabros,Marta;Davulcu,AkinH.;Mathur,Arvind;Rampulla,RichardA.;Gupta,ArunKumar;Jayaram,Ramya;Apedo,Atsu;Moore,DouglasB.;Liu,Heng;Kunselman,LoriK.;Brady,EdwardJ.;Wilkes,JasonJ.;Zinker,BradleyA.;Cai,Hong;Shu,Yue-Zhong;Sun,Qin;Dierks,ElizabethA.;Foster,KimberlyA.;Xu,Carrie;Wang,Tao;Panemangalore,Reshma;Cvijic,MaryEllen;Xie,Chunshan;Cao,GaryG.;Zhou,Min;Krupinski,John;Whaley,JeanM.;Robl,JeffreyA.;Ewing,WilliamR.;Ellsworth,BruceAlan[JournalofMedicinalChemistry,2018,vol.61,#3,p.681-694]

[21]CurrentPatentAssignee:MERCK&COINC-WO2006/113471,2006,A2

[22]CurrentPatentAssignee:MERCK&COINC-WO2006/101780,2006,A1

[1]CurrentPatentAssignee:MERCK&COINC-WO2005/102996,2005,A2Locationinpatent:Page/Pagecolumn31

845256-59-9    74-89-5   
(+/-)-cis-benzyl3-fluoro-4-(methylamino)piperidine-1-carboxylate 
 
(+/-)-trans-benzyl3-fluoro-4-(methylamino)piperidine-1-carboxylate 

[1]Locationinpatent:experimentalpartCox,ChristopherD.;Coleman,PaulJ.;Breslin,MichaelJ.;Whitman,DavidB.;Garbaccio,RobertM.;Fraley,MarkE.;Buser,CarolynA.;Walsh,EileenS.;Hamilton,Kelly;Schaber,MichaelD.;Lobell,RobertB.;Tao,Weikang;Davide,JosephP.;Diehl,RonaldE.;Abrams,MarcT.;South,VickiJ.;Huber,HansE.;Torrent,Maricel;Prueksaritanont,Thomayant;Li,Chunze;Slaughter,DonaldE.;Mahan,Elizabeth;Fernandez-Metzler,Carmen;Yan,Youwei;Kuo,LawrenceC.;Kohl,NancyE.;Hartman,GeorgeD.[JournalofMedicinalChemistry,2008,vol.51,#14,p.4239-4252]

[2]Locationinpatent:experimentalpartCox,ChristopherD.;Coleman,PaulJ.;Breslin,MichaelJ.;Whitman,DavidB.;Garbaccio,RobertM.;Fraley,MarkE.;Buser,CarolynA.;Walsh,EileenS.;Hamilton,Kelly;Schaber,MichaelD.;Lobell,RobertB.;Tao,Weikang;Davide,JosephP.;Diehl,RonaldE.;Abrams,MarcT.;South,VickiJ.;Huber,HansE.;Torrent,Maricel;Prueksaritanont,Thomayant;Li,Chunze;Slaughter,DonaldE.;Mahan,Elizabeth;Fernandez-Metzler,Carmen;Yan,Youwei;Kuo,LawrenceC.;Kohl,NancyE.;Hartman,GeorgeD.[JournalofMedicinalChemistry,2008,vol.51,#14,p.4239-4252]

[3]CurrentPatentAssignee:MERCK&COINC-WO2005/102996,2005,A2Locationinpatent:Page/Pagecolumn29

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