846589-98-8,MFCD09833667
Catalog No.:AA00IKBN

846589-98-8 | 1H-3-Benzazepine, 8-chloro-2,3,4,5-tetrahydro-1-methyl-,hydrochloride, (1R)-

This product is typically in stock,please click "Inquire" below or
contact us at [email protected] for pricing and availability information.
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA00IKBN
Chemical Name:
1H-3-Benzazepine, 8-chloro-2,3,4,5-tetrahydro-1-methyl-,hydrochloride, (1R)-
CAS Number:
846589-98-8
Molecular Formula:
C11H15Cl2N
Molecular Weight:
232.1495
MDL Number:
MFCD09833667
SMILES:
Clc1ccc2c(c1)[C@@H](C)CNCC2.Cl
Properties
Computed Properties
 
Complexity:
172  
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
1  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
14  
Hydrogen Bond Acceptor Count:
1  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0  
Rotatable Bond Count:
0  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  

Literature

Title: Recent advancements in drug treatment of obesity.

Journal: Clinical medicine (London, England) 20121001

Title: Two new drugs approved for obesity.

Journal: South Dakota medicine : the journal of the South Dakota State Medical Association 20120901

Title: Insurers find small gains in weight control with Belviq.

Journal: Managed care (Langhorne, Pa.) 20120801

Title: Randomized placebo-controlled clinical trial of lorcaserin for weight loss in type 2 diabetes mellitus: the BLOOM-DM study.

Journal: Obesity (Silver Spring, Md.) 20120701

Title: The 5-HT2C receptor agonist lorcaserin reduces nicotine self-administration, discrimination, and reinstatement: relationship to feeding behavior and impulse control.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20120401

Title: Identification of human UDP-glucuronosyltransferases involved in N-carbamoyl glucuronidation of lorcaserin.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20120401

Title: Identification of human cytochrome P450 and flavin-containing monooxygenase enzymes involved in the metabolism of lorcaserin, a novel selective human 5-hydroxytryptamine 2C agonist.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20120401

Title: [The pharmacological treatment of obesity: past, present and future].

Journal: Orvosi hetilap 20120311

Title: What cost weight loss?

Journal: Circulation 20120306

Title: Serotonergic anti-obesity agents: past experience and future prospects.

Journal: Drugs 20111203

Title: Lorcaserin: an investigational serotonin 2C agonist for weight loss.

Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20111101

Title: Should the FDA approval process for weight-loss drugs be modified?

Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20111101

Title: A one-year randomized trial of lorcaserin for weight loss in obese and overweight adults: the BLOSSOM trial.

Journal: The Journal of clinical endocrinology and metabolism 20111001

Title: Lorcaserin, a 5-HT2C agonist, decreases nicotine self-administration in female rats.

Journal: The Journal of pharmacology and experimental therapeutics 20110901

Title: Evaluation of the abuse potential of lorcaserin, a serotonin 2C (5-HT2C) receptor agonist, in recreational polydrug users.

Journal: Clinical pharmacology and therapeutics 20110501

Title: Lorcaserin, a 5-HT(2C) receptor agonist, reduces body weight by decreasing energy intake without influencing energy expenditure.

Journal: The Journal of clinical endocrinology and metabolism 20110301

Title: Lorcaserin: drug profile and illustrative model of the regulatory challenges of weight-loss drug development.

Journal: Expert review of cardiovascular therapy 20110301

Title: The use of lorcaserin in the management of obesity: a critical appraisal.

Journal: Drug design, development and therapy 20110101

Title: Trial of lorcaserin for weight management.

Journal: The New England journal of medicine 20101216

Title: Trial of lorcaserin for weight management.

Journal: The New England journal of medicine 20101216

Title: Trial of lorcaserin for weight management.

Journal: The New England journal of medicine 20101216

Title: Lorcaserin--not a new weapon in the battle with appetite.

Journal: Nature reviews. Endocrinology 20101201

Title: Discovery and development of 5-HT(₂C) receptor agonists for obesity: is there light at the end of the tunnel?

Journal: Future medicinal chemistry 20101201

Title: Lorcaserin for the treatment of obesity.

Journal: Drugs of today (Barcelona, Spain : 1998) 20101201

Title: ACS chemical neuroscience molecule spotlight on Lorcaserin.

Journal: ACS chemical neuroscience 20101117

Title: Fat attack.

Journal: Scientific American 20100901

Title: Multicenter, placebo-controlled trial of lorcaserin for weight management.

Journal: The New England journal of medicine 20100715

Title: Drug management of obesity--efficacy versus safety.

Journal: The New England journal of medicine 20100715

Title: Market watch: upcoming market catalysts in Q3 2010.

Journal: Nature reviews. Drug discovery 20100701

Title: Molecular Medicine - CHI's 17th International Tri-Conference: Mastering Medicinal Chemistry - CHI's Seventh Annual Conference.

Journal: IDrugs : the investigational drugs journal 20100401

Title: Pharmacologic therapies for obesity.

Journal: Gastroenterology clinics of North America 20100301

Title: Lorcaserin and adiposopathy: 5-HT2c agonism as a treatment for 'sick fat' and metabolic disease.

Journal: Expert review of cardiovascular therapy 20091101

Title: Characterizing the effects of 5-HT(2C) receptor ligands on motor activity and feeding behaviour in 5-HT(2C) receptor knockout mice.

Journal: Neuropharmacology 20090901

Title: Medicinal chemistry strategies in follow-on drug discovery.

Journal: Drug discovery today 20090501

Title: Lorcaserin (APD356), a selective 5-HT(2C) agonist, reduces body weight in obese men and women.

Journal: Obesity (Silver Spring, Md.) 20090301

Title: Agonists of the serotonin 5-HT2C receptor: preclinical and clinical progression in multiple diseases.

Journal: Current opinion in drug discovery & development 20080701

Title: Lorcaserin, a novel selective human 5-hydroxytryptamine2C agonist: in vitro and in vivo pharmacological characterization.

Journal: The Journal of pharmacology and experimental therapeutics 20080501

Title: Discovery and structure-activity relationship of (1R)-8-chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-benzazepine (Lorcaserin), a selective serotonin 5-HT2C receptor agonist for the treatment of obesity.

Journal: Journal of medicinal chemistry 20080124

Title: APD-356 (Arena).

Journal: Current opinion in investigational drugs (London, England : 2000) 20051001

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Additional Info:
SDS
Historical Records
Tags:846589-98-8 Molecular Formula|846589-98-8 MDL|846589-98-8 SMILES|846589-98-8 1H-3-Benzazepine, 8-chloro-2,3,4,5-tetrahydro-1-methyl-,hydrochloride, (1R)-
Catalog No.: AA00IKBN
846589-98-8,MFCD09833667
846589-98-8 | 1H-3-Benzazepine, 8-chloro-2,3,4,5-tetrahydro-1-methyl-,hydrochloride, (1R)-
This product is typically in stock,please click "Inquire" below or contact us at [email protected]for pricing and availability information.
Inquire
Technical Information
Catalog Number: AA00IKBN
Chemical Name: 1H-3-Benzazepine, 8-chloro-2,3,4,5-tetrahydro-1-methyl-,hydrochloride, (1R)-
CAS Number: 846589-98-8
Molecular Formula: C11H15Cl2N
Molecular Weight: 232.1495
MDL Number: MFCD09833667
SMILES: Clc1ccc2c(c1)[C@@H](C)CNCC2.Cl
Properties
Complexity: 172  
Covalently-Bonded Unit Count: 2  
Defined Atom Stereocenter Count: 1  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 14  
Hydrogen Bond Acceptor Count: 1  
Hydrogen Bond Donor Count: 2  
Isotope Atom Count: 0  
Rotatable Bond Count: 0  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
Literature fold

Title: Recent advancements in drug treatment of obesity.

Journal: Clinical medicine (London, England)20121001

Title: Two new drugs approved for obesity.

Journal: South Dakota medicine : the journal of the South Dakota State Medical Association20120901

Title: Insurers find small gains in weight control with Belviq.

Journal: Managed care (Langhorne, Pa.)20120801

Title: Randomized placebo-controlled clinical trial of lorcaserin for weight loss in type 2 diabetes mellitus: the BLOOM-DM study.

Journal: Obesity (Silver Spring, Md.)20120701

Title: The 5-HT2C receptor agonist lorcaserin reduces nicotine self-administration, discrimination, and reinstatement: relationship to feeding behavior and impulse control.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology20120401

Title: Identification of human UDP-glucuronosyltransferases involved in N-carbamoyl glucuronidation of lorcaserin.

Journal: Drug metabolism and disposition: the biological fate of chemicals20120401

Title: Identification of human cytochrome P450 and flavin-containing monooxygenase enzymes involved in the metabolism of lorcaserin, a novel selective human 5-hydroxytryptamine 2C agonist.

Journal: Drug metabolism and disposition: the biological fate of chemicals20120401

Title: [The pharmacological treatment of obesity: past, present and future].

Journal: Orvosi hetilap20120311

Title: What cost weight loss?

Journal: Circulation20120306

Title: Serotonergic anti-obesity agents: past experience and future prospects.

Journal: Drugs20111203

Title: Lorcaserin: an investigational serotonin 2C agonist for weight loss.

Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists20111101

Title: Should the FDA approval process for weight-loss drugs be modified?

Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists20111101

Title: A one-year randomized trial of lorcaserin for weight loss in obese and overweight adults: the BLOSSOM trial.

Journal: The Journal of clinical endocrinology and metabolism20111001

Title: Lorcaserin, a 5-HT2C agonist, decreases nicotine self-administration in female rats.

Journal: The Journal of pharmacology and experimental therapeutics20110901

Title: Evaluation of the abuse potential of lorcaserin, a serotonin 2C (5-HT2C) receptor agonist, in recreational polydrug users.

Journal: Clinical pharmacology and therapeutics20110501

Title: Lorcaserin, a 5-HT(2C) receptor agonist, reduces body weight by decreasing energy intake without influencing energy expenditure.

Journal: The Journal of clinical endocrinology and metabolism20110301

Title: Lorcaserin: drug profile and illustrative model of the regulatory challenges of weight-loss drug development.

Journal: Expert review of cardiovascular therapy20110301

Title: The use of lorcaserin in the management of obesity: a critical appraisal.

Journal: Drug design, development and therapy20110101

Title: Trial of lorcaserin for weight management.

Journal: The New England journal of medicine20101216

Title: Trial of lorcaserin for weight management.

Journal: The New England journal of medicine20101216

Title: Trial of lorcaserin for weight management.

Journal: The New England journal of medicine20101216

Title: Lorcaserin--not a new weapon in the battle with appetite.

Journal: Nature reviews. Endocrinology20101201

Title: Discovery and development of 5-HT(₂C) receptor agonists for obesity: is there light at the end of the tunnel?

Journal: Future medicinal chemistry20101201

Title: Lorcaserin for the treatment of obesity.

Journal: Drugs of today (Barcelona, Spain : 1998)20101201

Title: ACS chemical neuroscience molecule spotlight on Lorcaserin.

Journal: ACS chemical neuroscience20101117

Title: Fat attack.

Journal: Scientific American20100901

Title: Multicenter, placebo-controlled trial of lorcaserin for weight management.

Journal: The New England journal of medicine20100715

Title: Drug management of obesity--efficacy versus safety.

Journal: The New England journal of medicine20100715

Title: Market watch: upcoming market catalysts in Q3 2010.

Journal: Nature reviews. Drug discovery20100701

Title: Molecular Medicine - CHI's 17th International Tri-Conference: Mastering Medicinal Chemistry - CHI's Seventh Annual Conference.

Journal: IDrugs : the investigational drugs journal20100401

Title: Pharmacologic therapies for obesity.

Journal: Gastroenterology clinics of North America20100301

Title: Lorcaserin and adiposopathy: 5-HT2c agonism as a treatment for 'sick fat' and metabolic disease.

Journal: Expert review of cardiovascular therapy20091101

Title: Characterizing the effects of 5-HT(2C) receptor ligands on motor activity and feeding behaviour in 5-HT(2C) receptor knockout mice.

Journal: Neuropharmacology20090901

Title: Medicinal chemistry strategies in follow-on drug discovery.

Journal: Drug discovery today20090501

Title: Lorcaserin (APD356), a selective 5-HT(2C) agonist, reduces body weight in obese men and women.

Journal: Obesity (Silver Spring, Md.)20090301

Title: Agonists of the serotonin 5-HT2C receptor: preclinical and clinical progression in multiple diseases.

Journal: Current opinion in drug discovery & development20080701

Title: Lorcaserin, a novel selective human 5-hydroxytryptamine2C agonist: in vitro and in vivo pharmacological characterization.

Journal: The Journal of pharmacology and experimental therapeutics20080501

Title: Discovery and structure-activity relationship of (1R)-8-chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-benzazepine (Lorcaserin), a selective serotonin 5-HT2C receptor agonist for the treatment of obesity.

Journal: Journal of medicinal chemistry20080124

Title: APD-356 (Arena).

Journal: Current opinion in investigational drugs (London, England : 2000)20051001

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