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84687-43-4,MFCD16036240
Catalog No.:AA004ZPM

84687-43-4 | Astragaloside iv

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100mg
≥ 98% (HPLC)
in stock  
$58.00   $40.00
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250mg
≥ 98% (HPLC)
in stock  
$86.00   $60.00
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1g
≥ 98% (HPLC)
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$150.00   $105.00
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5g
≥ 98% (HPLC)
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  • Literature
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  • Technical Information
  • Properties
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Technical Information
Catalog Number:
AA004ZPM
Chemical Name:
Astragaloside iv
CAS Number:
84687-43-4
Molecular Formula:
C41H68O14
Molecular Weight:
784.9702
MDL Number:
MFCD16036240
SMILES:
OC[C@H]1O[C@@H](O[C@@H]2CC3C4([C@@]5(C2C(C)(C)C(CC5)O[C@@H]2OC[C@H]([C@@H]([C@H]2O)O)O)C4)CC[C@]2([C@@]3(C)C[C@H]([C@@H]2[C@@]2(C)CC[C@H](O2)C(O)(C)C)O)C)[C@@H]([C@H]([C@@H]1O)O)O
Properties
Properties
 
Form:
Solid  
MP:
>278ºC (dec.)  
Storage:
Inert atmosphere;Room Temperature;  

Computed Properties
 
Complexity:
1460  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
21  
Heavy Atom Count:
55  
Hydrogen Bond Acceptor Count:
14  
Hydrogen Bond Donor Count:
9  
Rotatable Bond Count:
7  
XLogP3:
1.3  

Literature

Title: Astragaloside IV ameliorates acute pancreatitis in rats by inhibiting the activation of nuclear factor-κB.

Journal: International journal of molecular medicine 20150301

Title: Astragaloside IV attenuates Toll-like receptor 4 expression via NF-κB pathway under high glucose condition in mesenchymal stem cells.

Journal: European journal of pharmacology 20121205

Title: Chemical and biological assessment of Angelica herbal decoction: comparison of different preparations during historical applications.

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20120815

Title: Effects of astragaloside IV on eosinophil activation induced by house dust mite allergen.

Journal: Molecular medicine reports 20120701

Title: Astragaloside IV attenuates complement membranous attack complex induced podocyte injury through the MAPK pathway.

Journal: Phytotherapy research : PTR 20120601

Title: Astragaloside IV inhibits apoptotic cell death in the guinea pig cochlea exposed to impulse noise.

Journal: Acta oto-laryngologica 20120501

Title: Astragaloside IV prevents MPP⁺-induced SH-SY5Y cell death via the inhibition of Bax-mediated pathways and ROS production.

Journal: Molecular and cellular biochemistry 20120501

Title: Determination of astragalin and astragaloside content in Radix Astragali using high-performance liquid chromatography coupled with pulsed amperometric detection.

Journal: Journal of chromatography. A 20120406

Title: Synergistic protective effect of astragaloside IV-tetramethylpyrazine against cerebral ischemic-reperfusion injury induced by transient focal ischemia.

Journal: Journal of ethnopharmacology 20120306

Title: Topical astragaloside IV-releasing hydrogel improves healing of skin wounds in vivo.

Journal: Biological & pharmaceutical bulletin 20120101

Title: [Inhibitory effects of astragaloside IV on cytochrome P450 enzyme of rat liver microsomes].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20120101

Title: Astragaloside IV, a novel antioxidant, prevents glucose-induced podocyte apoptosis in vitro and in vivo.

Journal: PloS one 20120101

Title: Astragaloside IV alleviates hypoxia/reoxygenation-induced neonatal rat cardiomyocyte injury via the protein kinase a pathway.

Journal: Pharmacology 20120101

Title: Therapeutic effects of astragaloside IV on myocardial injuries: multi-target identification and network analysis.

Journal: PloS one 20120101

Title: Ultrasonic-assisted liquid-liquid extraction and HILIC-ELSD analysis of ginsenoside Rb(1), astragaloside IV and dulcitol in sugar-free 'Fufangfufangteng Heji'.

Journal: Journal of pharmaceutical and biomedical analysis 20111205

Title: [Immunoregulatory mechanisms of an optimal Chinese herbal monomer compound in mice with allergic rhinitis].

Journal: Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20111201

Title: Astragaloside IV regulates expression of ATP-sensitive potassium channel subunits after ischemia-reperfusion in rat ventricular cardiomyocytes.

Journal: Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 20111201

Title: [Effects of astragaloside IV on the expressions of transforming growth factor-β1 and thymic stromal lymphopoietin in a murine model of asthma].

Journal: Zhonghua yi xue za zhi 20111129

Title: Astragaloside IV attenuates impulse noise-induced trauma in guinea pig.

Journal: Acta oto-laryngologica 20110801

Title: Astragaloside IV stimulates angiogenesis and increases hypoxia-inducible factor-1α accumulation via phosphatidylinositol 3-kinase/Akt pathway.

Journal: The Journal of pharmacology and experimental therapeutics 20110801

Title: Effect comparison of different formulation of Dang-Gui-Bu-Xu-Tang on myelosuppression mouse.

Journal: Asian Pacific journal of tropical medicine 20110701

Title: [Determination of astragaloside IV of eight area in Astragali Radix is by HPLC-ELSD internal standard method].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20110701

Title: Chuanxiongzine-astragaloside IV decreases IL-1β and Caspase-3 gene expressions in rat brain damaged by cerebral ischemia/reperfusion: a study of real-time quantitative PCR assay.

Journal: Sheng li xue bao : [Acta physiologica Sinica] 20110625

Title: Astragaloside IV protects against ischemia reperfusion in a murine model of orthotopic liver transplantation.

Journal: Transplantation proceedings 20110601

Title: [Effect of astragaloside against the oxidative damage on endothelial cells].

Journal: Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20110601

Title: Astragaloside IV improves metabolic syndrome and endothelium dysfunction in fructose-fed rats.

Journal: Molecules (Basel, Switzerland) 20110510

Title: The known immunologically active components of Astragalus account for only a small proportion of the immunological adjuvant activity when combined with conjugate vaccines.

Journal: Planta medica 20110501

Title: Astragaloside IV synergizes with ferulic acid to inhibit renal tubulointerstitial fibrosis in rats with obstructive nephropathy.

Journal: British journal of pharmacology 20110401

Title: [Simultaneous determination of five glycosides in Aidi injection by RP-HPLC-ELSD].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20110301

Title: The osteogenetic effect of astragaloside IV with centrifugating pressure on the OCT-1 cells.

Journal: Die Pharmazie 20110101

Title: [Protective effect of astragalosides on anoxia/reoxygenation injury of hippocampal neuron].

Journal: Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20101101

Title: Cigarette smoke enhances {beta}-defensin 2 expression in rat airways via nuclear factor-{kappa}B activation.

Journal: The European respiratory journal 20100901

Title: [Morphological investigation of the protective effect of astragaloside preconditioning against ischemia-reperfusion lung injury in rats].

Journal: Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20100801

Title: Effects of cycloartane saponins from hairy roots of Astragalus membranaceus Bge., on human tumor cell targets.

Journal: Fitoterapia 20100701

Title: Ligustilide suppresses the biological properties of Danggui Buxue Tang: a Chinese herbal decoction composed of radix astragali and radix angelica sinensis.

Journal: Planta medica 20100301

Title: [Study on preventative and curative effects of astragaloside (AST) on mice memory impairment and expression of amyloid precursor protein and beta secretase mRNA induced by dexamethasone].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20100301

Title: Effect of astragaloside IV on hepatic glucose-regulating enzymes in diabetic mice induced by a high-fat diet and streptozotocin.

Journal: Phytotherapy research : PTR 20100201

Title: Astragaloside IV improves homocysteine-induced acute phase endothelial dysfunction via antioxidation.

Journal: Biological & pharmaceutical bulletin 20100101

Title: Protective effect of astragaloside on focal cerebral ischemia/reperfusion injury in rats.

Journal: The American journal of Chinese medicine 20100101

Title: [Effects of Astragalus injection and its ingredients on proliferation and Akt phosphorylation of breast cancer cell lines].

Journal: Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20091201

Title: [Inhibitory effect on activated renin-angiotensin system by astragaloside IV in rats with pressure-overload induced cardiac hypertrophy].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20091201

Title: Neuroprotective effects of Astragaloside IV in 6-hydroxydopamine-treated primary nigral cell culture.

Journal: Neurochemistry international 20091101

Title: Astragalosides isolated from the root of astragalus radix inhibit the formation of advanced glycation end products.

Journal: Journal of agricultural and food chemistry 20090909

Title: Protective effects of astragaloside IV on porcine-serum-induced hepatic fibrosis in rats and in vitro effects on hepatic stellate cells.

Journal: Journal of ethnopharmacology 20090421

Title: Astragaloside IV attenuates hypoxia-induced cardiomyocyte damage in rats by upregulating superoxide dismutase-1 levels.

Journal: Clinical and experimental pharmacology & physiology 20090401

Title: [Study on the determination method of the astragaloside IV in health food].

Journal: Wei sheng yan jiu = Journal of hygiene research 20090301

Title: Anti-hepatitis B virus activities of astragaloside IV isolated from radix Astragali.

Journal: Biological & pharmaceutical bulletin 20090101

Title: Astragaloside IV improves high glucose-induced podocyte adhesion dysfunction via alpha3beta1 integrin upregulation and integrin-linked kinase inhibition.

Journal: Biochemical pharmacology 20080915

Title: Astragaloside IV inhibits proliferation and promotes apoptosis in rat vascular smooth muscle cells under high glucose concentration in vitro.

Journal: Planta medica 20080801

Title: Inhibitory effects of astragaloside IV on ovalbumin-induced chronic experimental asthma.

Journal: Canadian journal of physiology and pharmacology 20080701

Title: [Study on absorption kinetics of astragaloside IV in rats intestines].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080701

Title: Simultaneous determination of calycosin-7-O-beta-D-glucoside, ononin, astragaloside IV, astragaloside I and ferulic acid in rat plasma after oral administration of Danggui Buxue Tang extract for their pharmacokinetic studies by liquid chromatography-mass spectrometry.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20080401

Title: Aqueous extract of Astragali Radix induces human natriuresis through enhancement of renal response to atrial natriuretic peptide.

Journal: Journal of ethnopharmacology 20080328

Title: Astragaloside IV inhibits spontaneous synaptic transmission and synchronized Ca2+ oscillations on hippocampal neurons.

Journal: Acta pharmacologica Sinica 20080101

Title: Astragaloside IV improved intracellular calcium handling in hypoxia-reoxygenated cardiomyocytes via the sarcoplasmic reticulum Ca-ATPase.

Journal: Pharmacology 20080101

Title: [Effects of AST and ASI on metabolism of free radical in senescent rats treated by HC].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20071201

Title: [Investigation on one-pot extraction of active ingredient group from Yupingfeng powder by HPLC].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20070901

Title: Modification of alterations in cardiac function and sarcoplasmic reticulum by astragaloside IV in myocardial injury in vivo.

Journal: European journal of pharmacology 20070730

Title: [Protective effects of Astragaloside and Quercetin on rat myocardial cells after hypoxia].

Journal: Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns 20070601

Title: Mechanisms underlying vasorelaxant action of astragaloside IV in isolated rat aortic rings.

Journal: Clinical and experimental pharmacology & physiology 20070101

Title: [Anti-apoptosis effect of astragaloside on adriamycin induced rat's cardiotoxicity].

Journal: Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20061101

Title: [The effect of icariin and astragalosid I on the proliferation and differentiation of bone marrow stromal cells].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20061001

Title: Astragaloside IV improved barrier dysfunction induced by acute high glucose in human umbilical vein endothelial cells.

Journal: Life sciences 20060815

Title: Simultaneous analysis of seven astragalosides in Radix Astragali and related preparations by liquid chromatography coupled with electrospray ionization time-of-flight mass spectrometry.

Journal: Journal of separation science 20060801

Title: [Determination of three constituents in Radix Astragali by HPLC-MS].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20060801

Title: Astragaloside IV dilates aortic vessels from normal and spontaneously hypertensive rats through endothelium-dependent and endothelium-independent ways.

Journal: Planta medica 20060601

Title: Inhibitory effects of astragaloside IV on diabetic peripheral neuropathy in rats.

Journal: Canadian journal of physiology and pharmacology 20060601

Title: [Study on fingerprints of astragalosides injection by HPLC-ELSD].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20060501

Title: Chemical and biological assessment of a chinese herbal decoction containing Radix Astragali and Radix Angelicae Sinensis: Determination of drug ratio in having optimized properties.

Journal: Journal of agricultural and food chemistry 20060405

Title: Sensitive and selective liquid chromatography-electrospray ionisation-mass spectrometry analysis of astragaloside-IV in rat plasma.

Journal: Journal of pharmaceutical and biomedical analysis 20060224

Title: Effects of astragaloside IV on pathogenesis of metabolic syndrome in vitro.

Journal: Acta pharmacologica Sinica 20060201

Title: Astragaloside IV from Astragalus membranaceus shows cardioprotection during myocardial ischemia in vivo and in vitro.

Journal: Planta medica 20060101

Title: Absorption enhancement study of astragaloside IV based on its transport mechanism in caco-2 cells.

Journal: European journal of drug metabolism and pharmacokinetics 20060101

Title: Quantitation of astragaloside IV in rat plasma by liquid chromatography-tandem mass spectrometry.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050925

Title: Gastroprotective effect of Astragaloside IV: role of prostaglandins, sulfhydryls and nitric oxide.

Journal: The Journal of pharmacy and pharmacology 20050801

Title: [Study on new extraction technology of astragaloside IV].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20050801

Title: Separation of compounds interacting with liposome membrane in combined prescription of traditional Chinese medicines with immobilized liposome chromatography.

Journal: Journal of pharmaceutical and biomedical analysis 20050615

Title: Leishmanicidal cycloartane-type triterpene glycosides from Astragalus oleifolius.

Journal: Phytochemistry 20050501

Title: Effect of astragalosides on intracellular calcium overload in cultured cardiac myocytes of neonatal rats.

Journal: The American journal of Chinese medicine 20050101

Title: [Studies on chromatography fingerprint of huangqi by HPLC].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20041101

Title: [Effect of astrgaloside IV on the long-term consequences of renal ischemia-reperfusion injury in rat].

Journal: Zhonghua yi xue za zhi 20040902

Title: Astragaloside IV protects against ischemic brain injury in a murine model of transient focal ischemia.

Journal: Neuroscience letters 20040617

Title: Antiinflammatory activity of astragaloside IV is mediated by inhibition of NF-kappaB activation and adhesion molecule expression.

Journal: Thrombosis and haemostasis 20031101

Title: Determination of serum astragaloside in rats fed with Buyanghuanwu dicoction using solidphase extraction, chemical derivatization and fluorospectrophotometry.

Journal: Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA 20030401

Title: Effects of astragaloside IV on myocardial calcium transport and cardiac function in ischemic rats.

Journal: Acta pharmacologica Sinica 20021001

Title: Determination of astragaloside IV in Radix astragali (Astragalus membranaceus var. monghulicus) using high-performance liquid chromatography with evaporative light-scattering detection.

Journal: Journal of chromatographic science 20011101

Title: Antinociceptive effect of astragalosides and its mechanism of action.

Journal: Acta pharmacologica Sinica 20010901

Title: Li M, et al. Astragaloside IV attenuates cognitive impairments induced by transient cerebral ischemia and reperfusion in mice via anti-inflammatory mechanisms. Neurosci Lett. 2016 Dec 20. pii: S0304-3940(16)30994-

Title: He CS, et al. Astragaloside IV Enhances Cisplatin Chemosensitivity in Non-Small Cell Lung Cancer Cells Through Inhibition of B7-H3. Cell Physiol Biochem. 2016;40(5):1221-1229. Epub 2016 Dec 14.

Title: Liu L, et al. [Protective effect of astragaloside IV against acute liver failure in experimental mice Zhonghua Gan Zang Bing Za Zhi. 2016 Oct 20;24(10):772-777

Title: Jiang K, et al. Astragaloside IV inhibits breast cancer cell invasion by suppressing Vav3 mediated Rac1/MAPK signaling. Int Immunopharmacol. 2016 Dec 5;42:195-20

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Tags:84687-43-4 Molecular Formula|84687-43-4 MDL|84687-43-4 SMILES|84687-43-4 Astragaloside iv