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848591-90-2,MFCD20926358
Catalog No.:AA00GA2K

848591-90-2 | A 582941

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5mg
≥98%(HPLC)
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$268.00   $188.00
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10mg
≥98%(HPLC)
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$411.00   $288.00
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25mg
≥98%(HPLC)
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$834.00   $584.00
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50mg
≥98%(HPLC)
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$1,382.00   $968.00
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100mg
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00GA2K
Chemical Name:
A 582941
CAS Number:
848591-90-2
Molecular Formula:
C17H20N4
Molecular Weight:
280.3675
MDL Number:
MFCD20926358
SMILES:
CN1C[C@@H]2[C@H](C1)CN(C2)c1ccc(nn1)c1ccccc1
Properties
Computed Properties
 
Complexity:
341  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
2  
Heavy Atom Count:
21  
Hydrogen Bond Acceptor Count:
4  
Rotatable Bond Count:
2  
XLogP3:
2.1  

Literature

Title: Differential immediate and sustained memory enhancing effects of alpha7 nicotinic receptor agonists and allosteric modulators in rats.

Journal: PloS one 20110101

Title: Repeated administration of alpha7 nicotinic acetylcholine receptor (nAChR) agonists, but not positive allosteric modulators, increases alpha7 nAChR levels in the brain.

Journal: Journal of neurochemistry 20100801

Title: Structure-activity relationships of N-substituted ligands for the alpha7 nicotinic acetylcholine receptor.

Journal: Bioorganic & medicinal chemistry letters 20100101

Title: In vivo evaluation of alpha7 nicotinic acetylcholine receptor agonists [11C]A-582941 and [11C]A-844606 in mice and conscious monkeys.

Journal: PloS one 20100101

Title: Role of channel activation in cognitive enhancement mediated by alpha7 nicotinic acetylcholine receptors.

Journal: British journal of pharmacology 20091101

Title: Octahydropyrrolo[3,4-c]pyrrole: a diamine scaffold for construction of either alpha4beta2 or alpha7-selective nicotinic acetylcholine receptor (nAChR) ligands. Substitutions that switch subtype selectivity.

Journal: Journal of medicinal chemistry 20090723

Title: Selective alpha7 nicotinic acetylcholine receptor activation regulates glycogen synthase kinase3beta and decreases tau phosphorylation in vivo.

Journal: Brain research 20090410

Title: Alpha7 nicotinic acetylcholine receptor activation ameliorates scopolamine-induced behavioural changes in a modified continuous Y-maze task in mice.

Journal: European journal of pharmacology 20090105

Title: The selective alpha7 nicotinic acetylcholine receptor agonist A-582941 activates immediate early genes in limbic regions of the forebrain: Differential effects in the juvenile and adult rat.

Journal: Neuroscience 20080623

Title: Preclinical characterization of A-582941: a novel alpha7 neuronal nicotinic receptor agonist with broad spectrum cognition-enhancing properties.

Journal: CNS neuroscience & therapeutics 20080101

Title: Profile of nicotinic acetylcholine receptor agonists ABT-594 and A-582941, with differential subtype selectivity, on delayed matching accuracy by young monkeys.

Journal: Biochemical pharmacology 20071015

Title: Broad-spectrum efficacy across cognitive domains by alpha7 nicotinic acetylcholine receptor agonism correlates with activation of ERK1/2 and CREB phosphorylation pathways.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20070926

Title: Anderson DJ, et, al. HA-585539 [(1S,4S)-2,2-dimethyl-5-(6-phenylpyridazin-3-yl)-5-aza-2-azoniabicyclo.2.1heptane, a novel high-affinity alpha7 neuronal nicotinic receptor agonist: radioligand binding characterization to rat and human brain. J Pharmacol Exp Ther. 2008 Jan; 324(1): 179-87.

Title: Tietje KR, et, al. Preclinical characterization of A-582941: a novel alpha7 neuronal nicotinic receptor agonist with broad spectrum cognition-enhancing properties. CNS Neurosci Ther. Spring 2008; 14(1): 65-82.

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Tags:848591-90-2 Molecular Formula|848591-90-2 MDL|848591-90-2 SMILES|848591-90-2 A 582941