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848695-25-0,MFCD15528939
Catalog No.:AA008FY8

848695-25-0 | BIIB021

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Purity
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Price(USD)
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1mg
≥98%
in stock  
$36.00   $25.00
- +
5mg
≥98%
in stock  
$72.00   $50.00
- +
50mg
98+%
in stock  
$89.00   $62.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA008FY8
Chemical Name:
BIIB021
CAS Number:
848695-25-0
Molecular Formula:
C14H15ClN6O
Molecular Weight:
318.7615
MDL Number:
MFCD15528939
SMILES:
COc1c(C)cnc(c1C)Cn1cnc2c1nc(N)nc2Cl
Properties
Computed Properties
 
Complexity:
388  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
22  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
3  
XLogP3:
1.9  

Literature

Title: Heat shock protein 90 inhibitors induce functional inhibition of human natural killer cells in a dose-dependent manner.

Journal: Immunopharmacology and immunotoxicology 20160101

Title: Correlation between chemotype-dependent binding conformations of HSP90α/β and isoform selectivity-Implications for the structure-based design of HSP90α/β selective inhibitors for treating neurodegenerative diseases.

Journal: Bioorganic & medicinal chemistry letters 20140101

Title: Identification of potent Yes1 kinase inhibitors using a library screening approach.

Journal: Bioorganic & medicinal chemistry letters 20130801

Title: EC144 is a potent inhibitor of the heat shock protein 90.

Journal: Journal of medicinal chemistry 20120913

Title: In vitro metabolism of BIIB021, an inhibitor of heat shock protein 90, in liver microsomes and hepatocytes of rats, dogs, and humans and recombinant human cytochrome P450 isoforms.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20120401

Title: ATPases as drug targets: insights from heat shock proteins 70 and 90.

Journal: Journal of medicinal chemistry 20101028

Title: BIIB021, a novel Hsp90 inhibitor, sensitizes head and neck squamous cell carcinoma to radiotherapy.

Journal: International journal of cancer 20100301

Title: BIIB021, a synthetic Hsp90 inhibitor, has broad application against tumors with acquired multidrug resistance.

Journal: International journal of cancer 20100301

Title: An investigation into the potential use of serum Hsp70 as a novel tumour biomarker for Hsp90 inhibitors.

Journal: Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 20100201

Title: Heat shock protein 90: inhibitors in clinical trials.

Journal: Journal of medicinal chemistry 20100114

Title: Heat shock protein 90 inhibitor BIIB021 (CNF2024) depletes NF-kappaB and sensitizes Hodgkin's lymphoma cells for natural killer cell-mediated cytotoxicity.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20090815

Title: BIIB021, an orally available, fully synthetic small-molecule inhibitor of the heat shock protein Hsp90.

Journal: Molecular cancer therapeutics 20090401

Title: Discovery and development of heat shock protein 90 inhibitors.

Journal: Bioorganic & medicinal chemistry 20090315

Title: Rationally designed high-affinity 2-amino-6-halopurine heat shock protein 90 inhibitors that exhibit potent antitumor activity.

Journal: Journal of medicinal chemistry 20070614

Title: Lundgren, Karen., et al. BIIB021, an orally available, fully synthetic small-molecule inhibitor of the heat shock protein Hsp90. Molecular Cancer Therapeutics (2009), 8(4), 921-929.

Title: B?ll B, et al. Heat shock protein 90 inhibitor BIIB021 (CNF2024) depletes NF-kappaB and sensitizes Hodgkin's lymphoma cells for natural killer cell-mediated cytotoxicity. Clin Cancer Res. 2009 Aug 15;15(16):5108-16.

Title: Yin X, et al. BIIB021, a novel Hsp90 inhibitor, sensitizes head and neck squamous cell carcinoma to radiotherapy. Int J Cancer. 2010 Mar 1;126(5):1216-25

Title: Zhang H, et al. BIIB021, a synthetic Hsp90 inhibitor, has broad application against tumors with acquired multidrug resistance. Int J Cancer. 2010 Mar 1;126(5):1226-34

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