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Home Amines 849550-05-6
849550-05-6,MFCD09832720
Catalog No.:AA00G3O4

849550-05-6 | 5-Chloro-6-[2,6-difluoro-4-[3-(methylamino)propoxy]phenyl]-N-((1S)-2,2,2-trifluoro-1-methylethyl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5mg
≥98%
in stock  
$133.00   $93.00
- +
10mg
≥98%
in stock  
$238.00   $166.00
- +
25mg
≥98%
in stock  
$426.00   $298.00
- +
50mg
≥98%
in stock  
$782.00   $547.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00G3O4
Chemical Name:
5-Chloro-6-[2,6-difluoro-4-[3-(methylamino)propoxy]phenyl]-N-((1S)-2,2,2-trifluoro-1-methylethyl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
CAS Number:
849550-05-6
Molecular Formula:
C18H18ClF5N6O
Molecular Weight:
464.8201
MDL Number:
MFCD09832720
SMILES:
CNCCCOc1cc(F)c(c(c1)F)c1c(Cl)nc2n(c1N[C@H](C(F)(F)F)C)ncn2
Properties
Computed Properties
 
Complexity:
566  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
31  
Hydrogen Bond Acceptor Count:
11  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
8  
XLogP3:
4.6  

Literature

Title: A phase I dose escalation study of TTI-237 in patients with advanced malignant solid tumors.

Journal: Investigational new drugs 20120201

Title: The microtubule-active antitumor compound TTI-237 has both paclitaxel-like and vincristine-like properties.

Journal: Cancer chemotherapy and pharmacology 20090901

Title: Cevipabulin (TTI-237): preclinical and clinical results for a novel antimicrotubule agent.

Journal: Methods and findings in experimental and clinical pharmacology 20090901

Title: TTI-237: a novel microtubule-active compound with in vivo antitumor activity.

Journal: Cancer research 20080401

Title: 2-cyanoaminopyrimidines as a class of antitumor agents that promote tubulin polymerization.

Journal: Bioorganic & medicinal chemistry letters 20070601

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Tags:849550-05-6 Molecular Formula|849550-05-6 MDL|849550-05-6 SMILES|849550-05-6 5-Chloro-6-[2,6-difluoro-4-[3-(methylamino)propoxy]phenyl]-N-((1S)-2,2,2-trifluoro-1-methylethyl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine