Home Other Heterocycles 849928-22-9
849928-22-9,MFCD05861626
Catalog No.:AA008H6R

849928-22-9 | 4-Oxo-2-spiro(n-boc-piperidine-4-yl)-benzopyran

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250mg
98%
in stock  
$25.00   $18.00
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1g
98%
in stock  
$54.00   $38.00
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5g
98%
in stock  
$219.00   $153.00
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25g
98%
in stock  
$1,075.00   $753.00
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  • Technical Information
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  • Downstream Synthesis Route
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
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Technical Information
Catalog Number:
AA008H6R
Chemical Name:
4-Oxo-2-spiro(n-boc-piperidine-4-yl)-benzopyran
CAS Number:
849928-22-9
Molecular Formula:
C18H23NO4
Molecular Weight:
317.3795
MDL Number:
MFCD05861626
SMILES:
O=C(N1CCC2(CC1)CC(=O)c1c(O2)cccc1)OC(C)(C)C
Properties
Computed Properties
 
Complexity:
474  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
23  
Hydrogen Bond Acceptor Count:
4  
Rotatable Bond Count:
2  
XLogP3:
2.6  

Downstream Synthesis Route

[1]Chandrasekhar;Vijeender;VenkatramReddy[TetrahedronLetters,2005,vol.46,#41,p.6991-6993]

[2]CurrentPatentAssignee:SINOCHEMHOLDINGSCORPORATIONLTD-CN110872302,2020,ALocationinpatent:Paragraph0146-0149

[3]Uto,Yoshikazu;Ueno,Yuko;Kiyotsuka,Yohei;Miyazawa,Yuriko;Kurata,Hitoshi;Ogata,Tsuneaki;Yamada,Makiko;Deguchi,Tsuneo;Konishi,Masahiro;Takagi,Toshiyuki;Wakimoto,Satoko;Ohsumi,Jun[EuropeanJournalofMedicinalChemistry,2010,vol.45,#11,p.4788-4796]

[4]KalishaVali;Gundla,Rambabu;Singh,OmV.;Tamboli,Yasinalli;DiCesareManelli,Lorenzo;Ghelardini,Carla;Al-Tamimi,Abdul-MalekS.;Carta,Fabrizio;Angeli,Andrea;Supuran,ClaudiuT.[BioorganicChemistry,2019,vol.92]

[5]Guan,Aiying;Li,Zhinian;Liu,Changling;Yang,Jinlong;Zhang,Pengfei[JournalofAgriculturalandFoodChemistry,2020,vol.68,#24,p.6485-6492]

[6]Tantry,SubramanyamJ.;Degiacomi,Giulia;Sharma,Sreevalli;Jena,LalitKumar;Narayan,Ashwini;Guptha,Supreeth;Shanbhag,Gajanan;Menasinakai,Sreenivasaiah;Mallya,Meenakshi;Awasthy,Disha;Balakrishnan,Gayathri;Kaur,Parvinder;Bhattacharjee,Deepa;Narayan,Chandan;Reddy,Jitendar;NaveenKumar;Shandil,Radha;Boldrin,Francesca;Ventura,Marcello;Manganelli,Riccardo;Hartkoorn,RubenC.;Cole,StewartT.;Panda,Manoranjan;Markad,ShankarD.;Ramachandran,Vasanthi;Ghorpade,SandeepR.;Dinesh,Neela[BioorganicandMedicinalChemistryLetters,2015,vol.25,#16,p.3234-3245]

[7]Chaudhari,SachinS.;Kadam,AshokB.;Khairatkar-Joshi,Neelima;Mukhopadhyay,Indranil;Karnik,PallaviV.;Raghuram,Anupindi;Rao,ShobhaS.;Vaiyapuri,ThamilSelvan;Wale,DineshP.;Bhosale,VikramM.;Gudi,GirishS.;Sangana,RamchandraR.;Thomas,Abraham[BioorganicandMedicinalChemistry,2013,vol.21,#21,p.6542-6553]

[8]CurrentPatentAssignee:MERCK&COINC-WO2005/33073,2005,A2Locationinpatent:Page/Pagecolumn472

[9]CurrentPatentAssignee:MERCK&COINC-WO2005/33073,2005,A2Locationinpatent:Page/Pagecolumn236

[10]Huang,Tonghui;Sun,Jie;Wang,Qianqian;Gao,Jian;Liu,Yi[Molecules,2015,vol.20,#9,p.16221-16234]

[11]CurrentPatentAssignee:MERCK&COINC-WO2006/105442,2006,A2Locationinpatent:Page/Pagecolumn142;288288

[12]CurrentPatentAssignee:VERTEXPHARMACEUTICALS(OLD)-WO2012/112743,2012,A1Locationinpatent:Page/Pagecolumn67

[13]CurrentPatentAssignee:MERCK&COINC-WO2005/33073,2005,A2Locationinpatent:Page/Pagecolumn235-236

[14]CurrentPatentAssignee:MERCK&COINC-WO2006/105442,2006,A2Locationinpatent:Page/Pagecolumn142;287-288

[15]Locationinpatent:schemeortableShinde,Pundlik;Srivastava,SanjayK.;Odedara,Rajendra;Tuli,Davinder;Munshi,Siralee;Patel,Jitendra;Zambad,ShitalkumarP.;Sonawane,Rajesh;Gupta,RameshC.;Chauthaiwale,Vijay;Dutt,Chaitanya[BioorganicandMedicinalChemistryLetters,2009,vol.19,#3,p.949-953]

[16]LeBourdonnec,Bertrand;Windh,RolfT.;Ajello,ChristopherW.;Leister,LaraK.;Gu,Minghua;Chu,Guo-Hua;Tuthill,PaulA.;Barker,WilliamM.;Koblish,Michael;Wiant,DanielD.;Graczyk,ThomasM.;Belanger,Serge;Cassel,JoelA.;Feschenko,MarinaS.;Brogdon,BerniceL.;Smith,StevenA.;Christ,DavidD.;Derelanko,MichaelJ.;Kutz,Steve;Little,PatrickJ.;DeHaven,RobertN.;DeHaven-Hudkins,DianeL.;Dolle,RolandE.[JournalofMedicinalChemistry,2008,vol.51,#19,p.5893-5896]

[17]Locationinpatent:experimentalpartBourdonnec,BertrandLe;Windh,RolfT.;Leister,LaraK.;Zhou,Q.Jean;Ajello,ChristopherW.;Gu,Minghua;Chu,Guo-Hua;Tuthill,PaulA.;Barker,WilliamM.;Koblish,Michael;Wiant,DanielD.;Graczyk,ThomasM.;Belanger,Serge;Cassel,JoelA.;Feschenko,MarinaS.;Brogdon,BerniceL.;Smith,StevenA.;Derelanko,MichaelJ.;Kutz,Steve;Little,PatrickJ.;Dehaven,RobertN.;DeHaven-Hudkins,DianeL.;Dolle,RolandE.[JournalofMedicinalChemistry,2009,vol.52,#18,p.5685-5702]

[18]Uto,Yoshikazu;Kiyotsuka,Yohei;Ueno,Yuko;Miyazawa,Yuriko;Kurata,Hitoshi;Ogata,Tsuneaki;Deguchi,Tsuneo;Yamada,Makiko;Watanabe,Nobuaki;Konishi,Masahiro;Kurikawa,Nobuya;Takagi,Toshiyuki;Wakimoto,Satoko;Kono,Keita;Ohsumi,Jun[BioorganicandMedicinalChemistryLetters,2010,vol.20,#2,p.746-754]

[19]Kazmierski,WieslawM.;Xia,Bing;Miller,John;DeLaRosa,Martha;Favre,David;Dunham,RichardM.;Washio,Yoshiaki;Zhu,Zhengrong;Wang,Feng;Mebrahtu,Makda;Deng,Hongfeng;Basilla,Jonathan;Wang,Liping;Evindar,Ghotas;Fan,Lijun;Olszewski,Alison;Prabhu,Ninad;Davie,Christopher;Messer,JeffreyA.;Samano,Vicente[JournalofMedicinalChemistry,2020,vol.63,#7,p.3552-3562]

[1]CurrentPatentAssignee:MERCK&COINC-WO2007/118151,2007,A2Locationinpatent:Page/Pagecolumn60;89

[1]CurrentPatentAssignee:PFIZERINC-WO2008/65508,2008,A1Locationinpatent:Page/Pagecolumn21

[1]CurrentPatentAssignee:PFIZERINC-WO2008/65508,2008,A1Locationinpatent:Page/Pagecolumn21

[2]Huang,Tonghui;Sun,Jie;Wang,Qianqian;Gao,Jian;Liu,Yi[Molecules,2015,vol.20,#9,p.16221-16234]

849928-22-9   
4-oxo-2-spiro(piperidin-4-yl)benzopyranhydrochloride 

[1]Tomassi,Stefano;Pfahler,Julian;Mautone,Nicola;Rovere,Annarita;Esposito,Chiara;Passeri,Daniela;Pellicciari,Roberto;Novellino,Ettore;Pannek,Martin;Steegborn,Clemens;Paiardini,Alessandro;Mai,Antonello;Rotili,Dante[ACSMedicinalChemistryLetters,2020,vol.11,#5,p.862-868]

[2]Locationinpatent:schemeortableShinde,Pundlik;Srivastava,SanjayK.;Odedara,Rajendra;Tuli,Davinder;Munshi,Siralee;Patel,Jitendra;Zambad,ShitalkumarP.;Sonawane,Rajesh;Gupta,RameshC.;Chauthaiwale,Vijay;Dutt,Chaitanya[BioorganicandMedicinalChemistryLetters,2009,vol.19,#3,p.949-953]

[3]Locationinpatent:schemeortableUto,Yoshikazu;Kiyotsuka,Yohei;Ueno,Yuko;Miyazawa,Yuriko;Kurata,Hitoshi;Ogata,Tsuneaki;Deguchi,Tsuneo;Yamada,Makiko;Watanabe,Nobuaki;Konishi,Masahiro;Kurikawa,Nobuya;Takagi,Toshiyuki;Wakimoto,Satoko;Kono,Keita;Ohsumi,Jun[BioorganicandMedicinalChemistryLetters,2010,vol.20,#2,p.746-754]

[4]CurrentPatentAssignee:MERCK&COINC-WO2011/11872,2011,A1Locationinpatent:Page/Pagecolumn54

[5]CurrentPatentAssignee:SINOCHEMHOLDINGSCORPORATIONLTD-CN110872302,2020,ALocationinpatent:Paragraph0146;0150-0152

[6]Guan,Aiying;Li,Zhinian;Liu,Changling;Yang,Jinlong;Zhang,Pengfei[JournalofAgriculturalandFoodChemistry,2020,vol.68,#24,p.6485-6492]

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Tags:849928-22-9 Molecular Formula|849928-22-9 MDL|849928-22-9 SMILES|849928-22-9 4-Oxo-2-spiro(n-boc-piperidine-4-yl)-benzopyran