Home Amines 851-68-3
851-68-3,MFCD00869255
Catalog No.:AA00GAJC

851-68-3 | 2-methoxy-N,N,beta-trimethyl-10H-phenothiazine-10-propylamine

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5mg
99%
1 week  
$177.00   $124.00
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10mg
99%
1 week  
$257.00   $180.00
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25mg
99%
1 week  
$447.00   $313.00
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50mg
99%
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$685.00   $480.00
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100mg
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$1,082.00   $758.00
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  • Technical Information
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00GAJC
Chemical Name:
2-methoxy-N,N,beta-trimethyl-10H-phenothiazine-10-propylamine
CAS Number:
851-68-3
Molecular Formula:
C19H24N2OS
Molecular Weight:
328.4717
MDL Number:
MFCD00869255
SMILES:
COc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1
NSC Number:
226516
Properties
Computed Properties
 
Complexity:
378  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
23  
Hydrogen Bond Acceptor Count:
4  
Rotatable Bond Count:
5  
Undefined Atom Stereocenter Count:
1  
XLogP3:
4.7  

Literature

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Journal: Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 20121001

Title: Simultaneous determination of 25 common pharmaceuticals in whole blood using ultra-performance liquid chromatography-tandem mass spectrometry.

Journal: Journal of analytical toxicology 20120901

Title: A case of possible glossitis in a patient with non small cell carcinoma of the lung secondary to levomepromazine.

Journal: Palliative medicine 20120901

Title: Levomepromazine for schizophrenia.

Journal: Schizophrenia bulletin 20120301

Title: Recurrent delusional ideas due to left caudate head infarction, without dementia.

Journal: Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society 20120301

Title: A stability indicating assay for a combination of morphine sulphate with levomepromazine hydrochloride used in palliative care.

Journal: Journal of clinical pharmacy and therapeutics 20120201

Title: Additional use of methotrimeprazine for treating refractory agitation in pediatric patients.

Journal: Intensive care medicine 20120101

Title: Levomepromazine-induced retrograde ejaculation.

Journal: The Journal of neuropsychiatry and clinical neurosciences 20120101

Title: Symptom management using methotrimeprazine: expanding the definition of respite sedation.

Journal: Journal of palliative care 20120101

Title: Quantitative determination of phenothiazine derivatives in human plasma using monolithic silica solid-phase extraction tips and gas chromatography-mass spectrometry.

Journal: Journal of chromatography. A 20110506

Title: Is levomepromazine stable over time?

Journal: Palliative medicine 20110401

Title: Characterisation of zuclopenthixol metabolism by in vitro and therapeutic drug monitoring studies.

Journal: Acta psychiatrica Scandinavica 20101201

Title: Methotrimeprazine-induced corneal deposits and cataract revealed by urine drug profiling test.

Journal: Journal of Korean medical science 20101101

Title: Levomepromazine for schizophrenia.

Journal: The Cochrane database of systematic reviews 20101006

Title: Prescription persistence and safety of antipsychotic medication: a national registry-based 3-year follow-up.

Journal: European journal of clinical pharmacology 20100901

Title: The differential diagnoses of parkinsonism: findings from a cohort of 1528 patients and a 10 years comparison in tertiary movement disorders clinics.

Journal: Clinical neurology and neurosurgery 20100601

Title: Neuroleptic malignant syndrome following levomepromazine discontinuation.

Journal: The Journal of neuropsychiatry and clinical neurosciences 20100101

Title: O-demethylation of codeine to morphine inhibited by low-dose levomepromazine.

Journal: European journal of clinical pharmacology 20090801

Title: Protective role of selenium supplementation against cardiac lesions induced by the combination of levomepromazine and risperidone in the rabbit.

Journal: Human & experimental toxicology 20090801

Title: Levomepromazine-induced lupus?

Journal: Journal of pain and symptom management 20090601

Title: A case of stuttering during treatment with levomepromazine.

Journal: Psychopharmacology bulletin 20090101

Title: An open-label study of levopromazine (methotrimeprazine) as an add-on therapy in fibromyalgia management.

Journal: Clinical and experimental rheumatology 20090101

Title: An application of UV-derivative spectrophotometry and bivariate calibration algorithm for study of photostability of levomepromazine hydrochloride.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20081215

Title: Activation syndrome caused by paroxetine in a cancer patient.

Journal: Palliative & supportive care 20080601

Title: [Atypical antipsychotics in elderly patients with dementia].

Journal: Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke 20080501

Title: High-throughput screening assay for D-amino acid oxidase.

Journal: Analytical biochemistry 20080315

Title: Role of selenium in heart lesions produced by neuroleptics in the rabbit.

Journal: Journal of applied toxicology : JAT 20080301

Title: Comparative study between target-controlled-infusion and continuous-infusion anesthesia in dogs treated with methotrimeprazine and treated with propofol and remifentanil.

Journal: Acta cirurgica brasileira 20080101

Title: Akathisia and an unusual symptomatic treatment: a case report.

Journal: Palliative medicine 20071201

Title: Akathisia and an unusual symptomatic treatment.

Journal: Palliative medicine 20071201

Title: Quetiapine and drug interactions: evidence from a routine therapeutic drug monitoring service.

Journal: The Journal of clinical psychiatry 20071001

Title: Possible levomepromazine-clozapine interaction: two case reports.

Journal: Progress in neuro-psychopharmacology & biological psychiatry 20070330

Title: A fatal case of amoxapine poisoning under the influence of chronic use of psychotropic drugs.

Journal: Legal medicine (Tokyo, Japan) 20070301

Title: Simultaneous determination of the antipsychotic drugs levomepromazine and clozapine and their main metabolites in human plasma by a HPLC-UV method with solid-phase extraction.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070201

Title: Continuous infusion in adult females dogs submitted to ovariohysterectomy with midazolam-xylazine and/or medetomidine pre-treated with methotrimeprazine and buprenorphine.

Journal: Acta cirurgica brasileira 20070101

Title: Neuroleptic drugs in the human brain: clinical impact of persistence and region-specific distribution.

Journal: European archives of psychiatry and clinical neuroscience 20060801

Title: Levomepromazine versus chlorpromazine in treatment-resistant schizophrenia: a double-blind randomized trial.

Journal: Journal of psychiatry & neuroscience : JPN 20060701

Title: [Trazodone for the treatment of behavioral and psychological symptoms of dementia (BPSD) in Alzheimer's disease: a retrospective study focused on the aggression and negativism in caregiving situations].

Journal: No to shinkei = Brain and nerve 20060601

Title: [Neuroleptic malignant syndrome].

Journal: Annales francaises d'anesthesie et de reanimation 20060501

Title: Region specific distribution of levomepromazine in the human brain.

Journal: Journal of neural transmission (Vienna, Austria : 1996) 20060301

Title: Parametric evaluation of methotrimeprazine-midazolam-ketamine and methotrimeprazine-midazolam-ketamine-xylazine combination in dogs.

Journal: Acta cirurgica brasileira 20060101

Title: Neuroleptic malignant syndrome associated with risperidone in a male with early-onset schizophrenia.

Journal: Journal of child and adolescent psychopharmacology 20051201

Title: False-positive results in the detection of methadone in urines of patients treated with psychotropic substances.

Journal: Clinical chemistry 20051101

Title: An open study of methotrimeprazine in the management of nausea and vomiting in patients with advanced cancer.

Journal: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20050901

Title: A case of transient myopia in a patient with multiple myeloma secondary to levomepromazine.

Journal: Palliative medicine 20050401

Title: Little effects of low dosage of levomepromazine on plasma risperidone levels.

Journal: Pharmacopsychiatry 20050301

Title: [Methadone and sleep apnea syndrome].

Journal: Canadian journal of psychiatry. Revue canadienne de psychiatrie 20050301

Title: Low-dose levomepromazine in refractory emesis in advanced cancer patients: an open-label study.

Journal: Palliative medicine 20050101

Title: [Levomepromazine-induced peripheral edema].

Journal: Annales de dermatologie et de venereologie 20050101

Title: [The algimetry evaluation by thermic and pressoric nociceptive stimulus in dogs pre treated with methotrimeprazine, midazolam and ketamine with or without butorphanol or buprenorphine].

Journal: Acta cirurgica brasileira 20050101

Title: The use of levomepromazine in Hyperemesis Gravidarum resistant to drug therapy--a case series.

Journal: Reproductive toxicology (Elmsford, N.Y.) 20050101

Title: Interactions between neuroleptics and CYP2C6 in rat liver--in vitro and ex vivo study.

Journal: Pharmacological reports : PR 20050101

Title: Focus on levomepromazine.

Journal: Current medical research and opinion 20041201

Title: Intentional overdose of Large Animal Immobilon.

Journal: European journal of emergency medicine : official journal of the European Society for Emergency Medicine 20041001

Title: Combined therapy with low-potency neuroleptic levomepromazine as an adjunct to haloperidol for agitated patients with acute exacerbation of schizophrenia.

Journal: European psychiatry : the journal of the Association of European Psychiatrists 20040901

Title: Approval by MREC of a modified patient information and consent form. does this set a precedent for trials in palliative care?

Journal: Palliative medicine 20040701

Title: Levomepromazine helps to reduce sleep problems in patients with PTSD.

Journal: European psychiatry : the journal of the Association of European Psychiatrists 20040601

Title: Olanzapine excretion into breast milk: a case report.

Journal: Journal of clinical psychopharmacology 20040201

Title: Effects of levomepromazine and different desflurane concentrations upon electrocardiographic variables in dogs.

Journal: Veterinary anaesthesia and analgesia 20040101

Title: [Effect of a levopromazine-thymalin combination on the development of toxic edema and swelling in the brain].

Journal: Eksperimental'naia i klinicheskaia farmakologiia 20040101

Title: High-dose levomepromazine (methotrimeprazine) to control nausea in carcinoid syndrome.

Journal: Journal of palliative care 20040101

Title: [Hair analysis as a document of oxcarbazepine therapy in fatal levomepromazine poisoning].

Journal: Przeglad lekarski 20040101

Title: Pulmonary embolism possibly associated with olanzapine treatment.

Journal: BMJ (Clinical research ed.) 20031213

Title: Use of Immobilon in deer.

Journal: The Veterinary record 20031206

Title: Antipsychotic-induced paroxysmal perceptual alteration.

Journal: The American journal of psychiatry 20031201

Title: Enantioseparation of phenothiazines in cyclodextrin-modified capillary zone electrophoresis: reversal of migration order.

Journal: Electrophoresis 20030901

Title: Simultaneous determination of levomepromazine, midazolam and their major metabolites in human plasma by reversed-phase liquid chromatography.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20030705

Title: Photochemistry and in vitro phototoxicity studies of levomepromazine (methotrimeprazine), a phototoxic neuroleptic drug.

Journal: Die Pharmazie 20030501

Title: Sedative use in the last week of life and the implications for end-of-life decision making.

Journal: Archives of internal medicine 20030210

Title: Acute-phase treatment in general hospitals: clinical psychopharmacologic evaluation in first-episode schizophrenia patients.

Journal: General hospital psychiatry 20030101

Title: Fatal acute topiramate toxicity.

Journal: Journal of analytical toxicology 20030101

Title: Subcutaneous levomepromazine rescue (SLR) for high grade delayed chemotherapy-induced emesis (DCIE).

Journal: Anticancer research 20030101

Title: [Reversible cardiomyopathy induced by psychotropic drugs: case report and literature overview].

Journal: Annales de cardiologie et d'angeiologie 20021201

Title: Neuroleptic malignant syndrome complicated by massive intestinal bleeding in a patient with chronic renal failure.

Journal: Progress in neuro-psychopharmacology & biological psychiatry 20021001

Title: Delayed-onset nocturnal akathisia due to risperidone and levomepromazine: a case report.

Journal: European psychiatry : the journal of the Association of European Psychiatrists 20020901

Title: Spectrophotometric determination of the phosphatidylcholine liposomes/water partition coefficients and the protonation equilibrium constants of phenothiazine derivatives.

Journal: Cellular & molecular biology letters 20020101

Title: [Neutropenia in a patient treated with clozapine in combination with other psychotropic drugs].

Journal: L'Encephale 20020101

Title: Use, storage and supply of schedule 2 drugs.

Journal: The Veterinary record 20010804

Title: Severe hyponatremia in a patient treated with levomepromazine and carbamazepine.

Journal: Internal medicine (Tokyo, Japan) 20010501

Title: The effects of atropine and methotrimeprazine on the epinephrine-induced arrhythmias in halothane-anesthetized dogs.

Journal: Canadian journal of veterinary research = Revue canadienne de recherche veterinaire 20010401

Title: Drugs and syringe drivers: a survey of adult specialist palliative care practice in the United Kingdom and Eire.

Journal: Palliative medicine 20010301

Title: Repeated episodes of hypothermia in a subject treated with haloperidol, levomepromazine, olanzapine, and thioridazine.

Journal: Journal of clinical psychopharmacology 20010201

Title: Methotrimeprazine in the treatment of agitation in acquired brain injury patients.

Journal: Brain injury 20010201

Title: Effect of pH and temperature on the interaction of methotrimeprazine with cyclodextrins.

Journal: Acta poloniae pharmaceutica 20010101

Title: Effects of butaclamol, clopenthixol, mepromazine and cannabinol stereoisomers on apoptosis induction.

Journal: Anticancer research 20010101

Title: Low dosage of levomepromazine did not increase plasma concentrations of fluvoxamine.

Journal: International clinical psychopharmacology 20000701

Title: Prolonged upper airway instability in the parenteral use of benzodiazepine with levomepromazine.

Journal: Journal of clinical psychopharmacology 20000201

Title: [Severe intoxication probably from olanzapine (Zyprexa). Beneficial effect of glucagon].

Journal: Annales francaises d'anesthesie et de reanimation 19990601

Title: A puzzling case of seizures and visual hallucinations during clomipramine treatment with a high dose but causing a low serum concentration.

Journal: Acta psychiatrica Scandinavica 19990501

Title: Methamphetamine-associated obsessional symptoms and effective risperidone treatment: a case report.

Journal: The Journal of clinical psychiatry 19990501

Title: [Treatment of post-herpes zoster pain with tramadol. Results of an open pilot study versus clomipramine with or without levomepromazine].

Journal: Drugs 19970101

Title: Acute dystonic reaction to methotrimeprazine in hypoparathyroidism.

Journal: The Annals of pharmacotherapy 19960901

Title: [Ventricular tachycardia after levomepromazine overdose].

Journal: Therapie 19940101

Title: Serotonin syndrome during clomipramine and lithium treatment.

Journal: The American journal of psychiatry 19931201

Title: [A case of life-threatening ventricular arrhythmias probably due to psychotropic drugs].

Journal: Kokyu to junkan. Respiration & circulation 19931101

Title: Effects of the combination of ketoconazole and calmodulin inhibitors against Candida albicans in vitro. Short communication.

Journal: Arzneimittel-Forschung 19930901

Title: Biologically active conformers of phenothiazines and thioxanthenes. Further evidence for a ligand model of dopamine D2 receptor antagonists.

Journal: Journal of medicinal chemistry 19930723

Title: Seizures induced by combined levomepromazine-fluvoxamine treatment.

Journal: International clinical psychopharmacology 19930101

Title: Is levomepromazine a useful drug in treatment-resistant schizophrenia?

Journal: Acta psychiatrica Scandinavica 19920301

Title: Restless legs syndrome induced by lithium.

Journal: Biological psychiatry 19911201

Title: Low melanin content of substantia nigra in a case of neuroleptic malignant syndrome.

Journal: Pharmacopsychiatry 19910501

Title: Zuclopenthixol and haloperidol/levomepromazine in the treatment of elderly patients with symptoms of aggressiveness and agitation: a double-blind, multi-centre study.

Journal: Pharmatherapeutica 19890101

Title: Toxic 'ictal' confusion in middle age: treatment with benzodiazepines.

Journal: Journal of neurology, neurosurgery, and psychiatry 19850501

Title: The Pisa syndrome: a report of two cases.

Journal: The British journal of psychiatry : the journal of mental science 19850101

Title: Avoiding psychic adverse effects during induction of neurolept anaesthesia with levomepromazine. A double-blind study of levomepromazine and droperidol.

Journal: Acta anaesthesiologica Scandinavica 19820401

Title: Cardiac arrest in a young woman treated with amitriptyline combined with levopromazine.

Journal: The British journal of psychiatry : the journal of mental science 19820301

Title: Effect of levomepromazine on EEG and on clinical side effects after lumbar myelography with metrizamide.

Journal: Acta radiologica: diagnosis 19820101

Title: Chronic treatment with antidepressants: protentiation of clonidine-induced aggression in mice via noradrenergic mechanism.

Journal: Journal of neural transmission 19810101

Title: Death attributed to ventricular arrhythmia induced by thioridazine in combination with a single Contac C capsule.

Journal: Canadian Medical Association journal 19781007

Title: Studies on antituberculotic action of some phenothiazine derivatives in vitro.

Journal: Zentralblatt fur Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene. Erste Abteilung Originale. Reihe A: Medizinische Mikrobiologie und Parasitologie 19771201

Title: A nonnarcotic analgesic agent: methotrimeprazine (levoprome).

Journal: JAMA 19680408

Title: [Correction by dihydroergotamine of arterial pressure disorders induced by psychiatric chemotherapy].

Journal: Annales medico-psychologiques 19680201

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Tags:851-68-3 Molecular Formula|851-68-3 MDL|851-68-3 SMILES|851-68-3 2-methoxy-N,N,beta-trimethyl-10H-phenothiazine-10-propylamine