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851320-29-1,MFCD06411589
Catalog No.:AA01E5DU

851320-29-1 | O-2050

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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA01E5DU
Chemical Name:
O-2050
CAS Number:
851320-29-1
Molecular Formula:
C23H31NO4S
Molecular Weight:
417.5615
MDL Number:
MFCD06411589
SMILES:
CC1=CC[C@@H]2[C@@H](C1)c1c(O)cc(cc1OC2(C)C)CC#CCCCNS(=O)(=O)C
Properties
Computed Properties
 
Complexity:
783  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
2  
Heavy Atom Count:
29  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
5  
XLogP3:
3.7  

Literature

Title: Structural analogs of pyrazole and sulfonamide cannabinoids: effects on acute food intake in mice.

Journal: European journal of pharmacology 20121115

Title: Cytochrome P450-mediated oxidative metabolism of abused synthetic cannabinoids found in K2/Spice: identification of novel cannabinoid receptor ligands.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20121101

Title: The cannabinoid CB1 receptor antagonists rimonabant (SR141716) and AM251 directly potentiate GABA(A) receptors.

Journal: British journal of pharmacology 20120401

Title: Structural and pharmacological analysis of O-2050, a putative neutral cannabinoid CB(1) receptor antagonist.

Journal: European journal of pharmacology 20110125

Title: Increment of hypothalamic 2-arachidonoylglycerol induces the preference for a high-fat diet via activation of cannabinoid 1 receptors.

Journal: Behavioural brain research 20110101

Title: Cannabinoid CB1 receptor activation mediates the opposing effects of amphetamine on impulsive action and impulsive choice.

Journal: PloS one 20110101

Title: Evidence for both inverse agonism at the cannabinoid CB1 receptor and the lack of an endogenous cannabinoid tone in the rat and guinea-pig isolated ileum myenteric plexus-longitudinal muscle preparation.

Journal: British journal of pharmacology 20100601

Title: Physical and functional interaction between CB1 cannabinoid receptors and beta2-adrenoceptors.

Journal: British journal of pharmacology 20100601

Title: The cannabinoid 1-receptor silent antagonist O-2050 attenuates preference for high-fat diet and activated astrocytes in mice.

Journal: Journal of pharmacological sciences 20100101

Title: Glucocorticoids regulate glutamate and GABA synapse-specific retrograde transmission via divergent nongenomic signaling pathways.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20090114

Title: Suppression of feeding, drinking, and locomotion by a putative cannabinoid receptor 'silent antagonist'.

Journal: European journal of pharmacology 20060113

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Tags:851320-29-1 Molecular Formula|851320-29-1 MDL|851320-29-1 SMILES|851320-29-1 O-2050