Title: Discovery of 2-[1-(4-chlorophenyl)cyclopropyl]-3-hydroxy-8-(trifluoromethyl)quinoline-4-carboxylic acid (PSI-421), a P-selectin inhibitor with improved pharmacokinetic properties and oral efficacy in models of vascular injury.
Journal: Journal of medicinal chemistry 20100826
Title: P-selectin antagonism reduces thrombus formation in humans.
Journal: Journal of thrombosis and haemostasis : JTH 20091101
Title: Characterization of the novel P-selectin inhibitor PSI-697 [2-(4-chlorobenzyl)-3-hydroxy-7,8,9,10-tetrahydrobenzo[h] quinoline-4-carboxylic acid] in vitro and in rodent models of vascular inflammation and thrombosis.
Journal: The Journal of pharmacology and experimental therapeutics 20080201
Title: Resolution of venous thrombosis using a novel oral small-molecule inhibitor of P-selectin (PSI-697) without anticoagulation.
Journal: Thrombosis and haemostasis 20070301
Title: 2-(4-Chlorobenzyl)-3-hydroxy-7,8,9,10-tetrahydrobenzo[H]quinoline-4-carboxylic acid (PSI-697): identification of a clinical candidate from the quinoline salicylic acid series of P-selectin antagonists.
Journal: Journal of medicinal chemistry 20070111
Title: Treatment with an oral small molecule inhibitor of P selectin (PSI-697) decreases vein wall injury in a rat stenosis model of venous thrombosis.
Journal: Journal of vascular surgery 20060901
Title: Bedard PW et al. Characterization of the novel P-selectin inhibitor PSI-697 -(4-chlorobenzyl)-3-hydroxy-7,8,9,10-tetrahydrobenzo[h quinoline-4-carboxylic acid in vitro and in rodent models of vascular inflammation and thrombosis. J Pharmacol Exp Ther.
Title: Myers DD Jr et al. Resolution of venous thrombosis using a novel oral small-molecule inhibitor of P-selectin (PSI-697) without anticoagulation. Thromb Haemost. 2007 Mar;97(3):400-7.
Title: Myers DD Jr et al. Treatment with an oral small molecule inhibitor of P selectin (PSI-697) decreases vein wall injury in a rat stenosis model of venous thrombosis. J Vasc Surg. 2006 Sep;44(3):625-32.
