Home Other Building Blocks 852475-26-4
852475-26-4,MFCD16875423
Catalog No.:AA004PQX

852475-26-4 | MC1568

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
96%
in stock  
$14.00   $10.00
- +
10mg
96%
in stock  
$51.00   $36.00
- +
50mg
96%
in stock  
$133.00   $93.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA004PQX
Chemical Name:
MC1568
CAS Number:
852475-26-4
Molecular Formula:
C17H15FN2O3
Molecular Weight:
314.3110
MDL Number:
MFCD16875423
SMILES:
ONC(=O)/C=C/c1ccc(n1C)/C=C/C(=O)c1cccc(c1)F
Properties
Properties
 
Form:
Solid  
Solubility:
DMSO: ≥10mg/mL  
Storage:
Inert atmosphere;2-8℃;  

Computed Properties
 
Complexity:
492  
Covalently-Bonded Unit Count:
1  
Defined Bond Stereocenter Count:
2  
Heavy Atom Count:
23  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
5  
XLogP3:
1.8  

Literature

Title: Synthesis and biological characterization of the histone deacetylase inhibitor largazole and C7- modified analogues.

Journal: Journal of medicinal chemistry 20100624

Title: Class II (IIa)-selective histone deacetylase inhibitors. 1. Synthesis and biological evaluation of novel (aryloxopropenyl)pyrrolyl hydroxyamides.

Journal: Journal of medicinal chemistry 20050505

Title: Nebbioso A, et al. Selective class II HDAC inhibitors impair myogenesis by modulating the stability and activity ofHDAC-MEF2 complexes. EMBO Rep. 2009 Jul;10(7):776-82.

Title: Venza I, et al. Class II-specific histone deacetylase inhibitors MC1568 and MC1575 suppress IL-8 expression in human melanoma cells. Pigment Cell Melanoma Res. 2013 Mar;26(2):193-204.

Title: Nebbioso A, et al. HDACs class II-selective inhibition alters nuclear receptor-dependent differentiation. J Mol Endocrinol. 2010 Oct;45(4):219-28.

Title: Kassis H, et al. Class IIa histone deacetylases affect neuronal remodeling and functional outcome after stroke. Neurochem Int. 2016 Jun;96:24-31.

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Related Products of 852475-26-4
Tags:852475-26-4 Molecular Formula|852475-26-4 MDL|852475-26-4 SMILES|852475-26-4 MC1568